Pooled shRNA Library Screening to Identify Factors that Modulate a Drug Resistance PhenotypeSaswati Das 1,2, Raveen Stephen Stallon Illangeswaran 1,2, Smitha Ijee 2,3, Sanjay Kumar 2,3, Shaji Ramachandran Velayudhan 1,2,3, Poonkuzhali Balasubramanian 1,2,3
1Department of Clinical Haematology, Christian Medical College, 2Department of Biotechnology, Thiruvalluvar University, 3Centre for Stem Cell Research, Christian Medical College
High-throughput RNA interference (RNAi) screening using a pool of lentiviral shRNAs can be a tool to detect therapeutically relevant synthetic lethal targets in malignancies. We provide a pooled shRNA screening approach to investigate the epigenetic effectors in acute myeloid leukemia (AML).
