Samuel Pfaff

Transcriptional codes and the control of neuronal identity.

LIM factor Lhx3 contributes to the specification of motor neuron and interneuron identity through cell-type-specific protein-protein interactions.

Inhibition of retroviral pathogenesis by RNA interference.

Fine-tuning motor neuron properties: signaling from the periphery.

Synchronization of neurogenesis and motor neuron specification by direct coupling of bHLH and homeodomain transcription factors.

Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart.

A postmitotic role for Isl-class LIM homeodomain proteins in the assignment of visceral spinal motor neuron identity.

Analysis of embryonic motoneuron gene regulation: derepression of general activators function in concert with enhancer factors.

Recognition and accommodation at the androgen receptor coactivator binding interface.

Axon fasciculation defects and retinal dysplasias in mice lacking the immunoglobulin superfamily adhesion molecule BEN/ALCAM/SC1.

Beta1 integrins in muscle, but not in motor neurons, are required for skeletal muscle innervation.

Magnitude of binocular vision controlled by islet-2 repression of a genetic program that specifies laterality of retinal axon pathfinding.

Homeodomain transcription factors in the development of subsets of hindbrain reticulospinal neurons.

Olig2 and Ngn2 function in opposition to modulate gene expression in motor neuron progenitor cells.

Small CTD phosphatases function in silencing neuronal gene expression.

The LIM domain-only protein LMO4 is required for neural tube closure.

Development of circuits that generate simple rhythmic behaviors in vertebrates.

Coexpressed EphA receptors and ephrin-A ligands mediate opposing actions on growth cone navigation from distinct membrane domains.

Cholinergic input is required during embryonic development to mediate proper assembly of spinal locomotor circuits.

Hox genes: the instructors working at motor pools.

FGF as a target-derived chemoattractant for developing motor axons genetically programmed by the LIM code.

Reduced expression of the LIM-homeobox gene Lhx3 impairs growth and differentiation of Rathke's pouch and increases cell apoptosis during mouse pituitary development.

Calcium activation of the LMO4 transcription complex and its role in the patterning of thalamocortical connections.

T-Box transcription factor Tbx20 regulates a genetic program for cranial motor neuron cell body migration.

Determinants for dephosphorylation of the RNA polymerase II C-terminal domain by Scp1.

Cloning and developmental expression of a chick G-protein-coupled receptor SCGPR1.

A functional study of miR-124 in the developing neural tube.

Notch and MAML signaling drives Scl-dependent interneuron diversity in the spinal cord.

Distinct target-derived signals organize formation, maturation, and maintenance of motor nerve terminals.

The ubiquitin ligase Phr1 regulates axon outgrowth through modulation of microtubule dynamics.

Instructive role of aPKCzeta subcellular localization in the assembly of adherens junctions in neural progenitors.

Regulation of motor neuron specification by phosphorylation of neurogenin 2.

Segregation of axial motor and sensory pathways via heterotypic trans-axonal signaling.

A regulatory network to segregate the identity of neuronal subtypes.

Developmental neuroscience: Hox and Fox.

YAP regulates neural progenitor cell number via the TEA domain transcription factor.

Islet-to-LMO stoichiometries control the function of transcription complexes that specify motor neuron and V2a interneuron identity.

Structural and functional analysis of the phosphoryl transfer reaction mediated by the human small C-terminal domain phosphatase, Scp1.

Motor axon pathfinding.

Hormone binding and co-regulator binding to the glucocorticoid receptor are allosterically coupled.

Defining rhythmic locomotor burst patterns using a continuous wavelet transform.

Atypical cadherins Celsr1-3 differentially regulate migration of facial branchiomotor neurons in mice.

Presenilin-dependent receptor processing is required for axon guidance.

Endogenous retroviruses and neighboring genes are coordinately repressed by LSD1/KDM1A.

Isl1 is required for multiple aspects of motor neuron development.

Identification of a microRNA that activates gene expression by repressing nonsense-mediated RNA decay.

SnapShot: spinal cord development.

Rapid and efficient generation of functional motor neurons from human pluripotent stem cells using gene delivered transcription factor codes.

Islet1-mediated activation of the β-catenin pathway is necessary for hindlimb initiation in mice.

Protease regulation: the Yin and Yang of neural development and disease.

Ret Is a Multifunctional Coreceptor that Integrates Diffusible- and Contact-Axon Guidance Signals.