Department of Dermatology,
Department of Medicine,
Division of Infectious Diseases,
Department of Orthopaedic Surgery,
Department of Medicine, Division of Infectious Diseases, Department of Orthopaedic Surgery
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Monitoring Bacterial Burden, Inflammation and Bone Damage Longitudinally Using Optical and μCT Imaging in an Orthopaedic Implant Infection in Mice.
PloS one , 2012 | Pubmed ID: 23082163
In vivo bioluminescence imaging to evaluate systemic and topical antibiotics against community-acquired methicillin-resistant Staphylococcus aureus-infected skin wounds in mice.
Antimicrobial agents and chemotherapy Feb, 2013 | Pubmed ID: 23208713
Neutrophil-derived IL-1β is sufficient for abscess formation in immunity against Staphylococcus aureus in mice.
PLoS pathogens , 2012 | Pubmed ID: 23209417
Vancomycin plus Rifampin Combination Therapy has Enhanced Efficacy Against an Experimental Staphylococcus aureus Prosthetic Joint Infection.
Antimicrobial agents and chemotherapy Aug, 2013 | Pubmed ID: 23917317
Combination prophylactic therapy with rifampin increases efficacy against an experimental Staphylococcus epidermidis subcutaneous implant-related infection.
Antimicrobial agents and chemotherapy , 2014 | Pubmed ID: 24514089
dsRNA Released by Tissue Damage Activates TLR3 to Drive Skin Regeneration.
Cell stem cell Aug, 2015 | Pubmed ID: 26253200
Fibroblast growth factor 2 dimer with superagonist in vitro activity improves granulation tissue formation during wound healing.
Biomaterials Mar, 2016 | Pubmed ID: 26731578
In Vivo Efficacy of a "Smart" Antimicrobial Implant Coating.
The Journal of bone and joint surgery. American volume Jul, 2016 | Pubmed ID: 27440566
Collaborative Interferon-γ and Interleukin-17 Signaling Protects the Oral Mucosa from Staphylococcus aureus.
The American journal of pathology 09, 2016 | Pubmed ID: 27470712
IL-22 derived from γδ T cells restricts Staphylococcus aureus infection of mechanically injured skin.
The Journal of allergy and clinical immunology 10, 2016 | Pubmed ID: 27543072
Polymeric nanofiber coating with tunable combinatorial antibiotic delivery prevents biofilm-associated infection in vivo.
Proceedings of the National Academy of Sciences of the United States of America Nov, 2016 | Pubmed ID: 27791154
Innate Immune Memory Contributes to Host Defense against Recurrent Skin and Skin Structure Infections Caused by Methicillin-Resistant Staphylococcus aureus.
Infection and immunity 02, 2017 | Pubmed ID: 27849182
Preclinical Evaluation of Photoacoustic Imaging as a Novel Noninvasive Approach to Detect an Orthopaedic Implant Infection.
The Journal of the American Academy of Orthopaedic Surgeons Feb, 2017 | Pubmed ID: 27941556
NMR structure-based optimization of Staphylococcus aureus sortase A pyridazinone inhibitors.
Chemical biology & drug design Sep, 2017 | Pubmed ID: 28160417
Oral-Only Linezolid-Rifampin Is Highly Effective Compared with Other Antibiotics for Periprosthetic Joint Infection: Study of a Mouse Model.
The Journal of bone and joint surgery. American volume Apr, 2017 | Pubmed ID: 28419033
Mouse model of hematogenous implant-related biofilm infection reveals therapeutic targets.
Proceedings of the National Academy of Sciences of the United States of America 06, 2017 | Pubmed ID: 28607050
α-Toxin Regulates Local Granulocyte Expansion from Hematopoietic Stem and Progenitor Cells in Infected Wounds.
Journal of immunology (Baltimore, Md. : 1950) 09, 2017 | Pubmed ID: 28733486
Pushing the Envelope in Psoriasis: Late Cornified Envelope Proteins Possess Antimicrobial Activity.
The Journal of investigative dermatology 11, 2017 | Pubmed ID: 29055413
Staphylococcus aureus Epicutaneous Exposure Drives Skin Inflammation via IL-36-Mediated T Cell Responses.
Cell host & microbe Nov, 2017 | Pubmed ID: 29120743
Noninvasive optical and nuclear imaging of Staphylococcus-specific infection with a human monoclonal antibody-based probe.
Virulence 01, 2018 | Pubmed ID: 29166841
Neutralizing Alpha-Toxin Accelerates Healing of Staphylococcus aureus-Infected Wounds in Nondiabetic and Diabetic Mice.
Antimicrobial agents and chemotherapy 03, 2018 | Pubmed ID: 29311091
Clonally expanded γδ T cells protect against Staphylococcus aureus skin reinfection.
The Journal of clinical investigation Mar, 2018 | Pubmed ID: 29400698
Neutrophils in hot pursuit of MRSA in the lymph nodes.
Proceedings of the National Academy of Sciences of the United States of America 03, 2018 | Pubmed ID: 29476009
Molecularly specific detection of bacterial lipoteichoic acid for diagnosis of prosthetic joint infection of the bone.
Bone research , 2018 | Pubmed ID: 29707402
Syndecan-1 Regulates Psoriasiform Dermatitis by Controlling Homeostasis of IL-17-Producing γδ T Cells.
Journal of immunology (Baltimore, Md. : 1950) Sep, 2018 | Pubmed ID: 30045969
Mouse model of Gram-negative prosthetic joint infection reveals therapeutic targets.
JCI insight Sep, 2018 | Pubmed ID: 30185667
Injury, dysbiosis, and filaggrin deficiency drive skin inflammation through keratinocyte IL-1α release.
The Journal of allergy and clinical immunology Sep, 2018 | Pubmed ID: 30240702
The fungal ligand chitin directly binds TLR2 and triggers inflammation dependent on oligomer size.
EMBO reports Dec, 2018 | Pubmed ID: 30337494
Multimodal imaging guides surgical management in a preclinical spinal implant infection model.
JCI insight Feb, 2019 | Pubmed ID: 30728332
In Vivo Bioluminescence Imaging in a Rabbit Model of Orthopaedic Implant-Associated Infection to Monitor Efficacy of an Antibiotic-Releasing Coating.
The Journal of bone and joint surgery. American volume Feb, 2019 | Pubmed ID: 30801375
Nicholas M. Bernthal1,
Brad N. Taylor2,
Jeffrey A. Meganck2,
Yu Wang3,
Jonathan H. Shahbazian3,
Jared A. Niska1,
Kevin P. Francis2,
Lloyd S. Miller3,4
1Orthopaedic Hospital Research Center, Orthopaedic Hospital Department of Orthopaedic Surgery, David Geffen School of Medicine at University of California, Los Angeles (UCLA),
2, PerkinElmer,
3Department of Dermatology, Johns Hopkins University School of Medicine,
4Department of Medicine, Division of Infectious Diseases, Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine