Volker Brinkmann

Targeting of the pro-apoptotic VDAC-like porin (PorB) of Neisseria gonorrhoeae to mitochondria of infected cells.

Limited mycobacterial infection of the liver as a consequence of its microanatomical structure causing restriction of mycobacterial growth to professional phagocytes.

Neisserial immunoglobulin A1 protease induces specific T-cell responses in humans.

Distinct mechanisms of internalization of Neisseria gonorrhoeae by members of the CEACAM receptor family involving Rac1- and Cdc42-dependent and -independent pathways.

The IFN-inducible Golgi- and endoplasmic reticulum- associated 47-kDa GTPase IIGP is transiently expressed during listeriosis.

The immune modulator FTY720 targets sphingosine 1-phosphate receptors.

Long-term islet graft survival in streptozotocin- and autoimmune-induced diabetes models by immunosuppressive and potential insulinotropic agent FTY720.

T-cell depletion and graft survival induced by anti-human CD3 immunotoxins in human CD3epsilon transgenic mice.

FTY720: targeting G-protein-coupled receptors for sphingosine 1-phosphate in transplantation and autoimmunity.

Argyrins, immunosuppressive cyclic peptides from myxobacteria. I. Production, isolation, physico-chemical and biological properties.

FTY720 pretreatment reduces warm hepatic ischemia reperfusion injury through inhibition of T-lymphocyte infiltration.

Oral efficacy of the new immunomodulator FTY720 in cynomolgus monkey kidney allotransplantation, given alone or in combination with cyclosporine or RAD.

Expression and translocation of chlamydial protease during acute and persistent infection of the epithelial HEp-2 cells with Chlamydophila (Chlamydia) pneumoniae.

Neutrophilia in LFA-1-deficient mice confers resistance to listeriosis: possible contribution of granulocyte-colony-stimulating factor and IL-17.

The immune modulator FYT720 prevents autoimmune diabetes in nonobese diabetic mice small star, filled.

Increased resistance of LFA-1-deficient mice to lipopolysaccharide-induced shock/liver injury in the presence of TNF-alpha and IL-12 is mediated by IL-10: a novel role for LFA-1 in the regulation of the proinflammatory and anti-inflammatory cytokine balance.

Apoptosis facilitates antigen presentation to T lymphocytes through MHC-I and CD1 in tuberculosis.

Phosphorylation and action of the immunomodulator FTY720 inhibits vascular endothelial cell growth factor-induced vascular permeability.

Highly biased type 1 immune responses in mice deficient in LFA-1 in Listeria monocytogenes infection are caused by elevated IL-12 production by granulocytes.

Inhibition of Th1- and Th2-mediated airway inflammation by the sphingosine 1-phosphate receptor agonist FTY720.

Saposin C is required for lipid presentation by human CD1b.

Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1.

From the inside out--processing of the Chlamydial autotransporter PmpD and its role in bacterial adhesion and activation of human host cells.

The sphingosine 1-phosphate receptor agonist FTY720 supports CXCR4-dependent migration and bone marrow homing of human CD34+ progenitor cells.

Neutrophil extracellular traps kill bacteria.

Efficacy and safety of ABI793, a novel human anti-human CD154 monoclonal antibody, in cynomolgus monkey renal allotransplantation.

Calcium and a calcium-dependent protein kinase regulate gamete formation and mosquito transmission in a malaria parasite.

Helicobacter pylori induces AGS cell motility and elongation via independent signaling pathways.

FTY720: sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function.

Interaction of Chlamydia trachomatis serovar L2 with the host autophagic pathway.

Lack of stage-specific proteins in coccoid Helicobacter pylori cells.

FTY720: mechanism of action and potential benefit in organ transplantation.

The heart rate decrease caused by acute FTY720 administration is mediated by the G protein-gated potassium channel I.

Modified immunohistological staining allows detection of Ziehl-Neelsen-negative Mycobacterium tuberculosis organisms and their precise localization in human tissue.

Immunomodulator FTY720 Induces eNOS-dependent arterial vasodilatation via the lysophospholipid receptor S1P3.

Protection of mouse small bowel allografts by FTY720 and costimulation blockade.

Prohibitin is required for Ras-induced Raf-MEK-ERK activation and epithelial cell migration.

Novel immunomodulator FTY720 is phosphorylated in rats and humans to form a single stereoisomer. Identification, chemical proof, and biological characterization of the biologically active species and its enantiomer.

FTY720 induces apoptosis in multiple myeloma cells and overcomes drug resistance.

Increased vaccine efficacy against tuberculosis of recombinant Mycobacterium bovis bacille Calmette-Guérin mutants that secrete listeriolysin.

The sphingosine-1-phosphate receptor agonist FTY720 modulates dendritic cell trafficking in vivo.

Transient T cell accumulation in lymph nodes and sustained lymphopenia in mice treated with FTY720.

Human neutrophils kill Bacillus anthracis.

The sphingosine 1-phosphate receptor agonist FTY720 differentially affects the sequestration of CD4+/CD25+ T-regulatory cells and enhances their functional activity.

Novel insights into the mechanism of action of FTY720 in a transgenic model of allograft rejection: implications for therapy of chronic rejection.

A novel low molecular weight inhibitor of dendritic cells and B cells blocks allergic inflammation.

Apoptotic vesicles crossprime CD8 T cells and protect against tuberculosis.

Neutrophil extracellular traps capture and kill Candida albicans yeast and hyphal forms.

Pulmonary and vascular pharmacology of sphingosine 1-phosphate.

Naturally occurring amino acids differentially influence the development of Chlamydia trachomatis and Chlamydia (Chlamydophila) pneumoniae.

A monoselective sphingosine-1-phosphate receptor-1 agonist prevents allograft rejection in a stringent rat heart transplantation model.

Sphingosine-1-phosphate stimulates the functional capacity of progenitor cells by activation of the CXCR4-dependent signaling pathway via the S1P3 receptor.

FTY720 preferentially depletes naive T cells from peripheral and lymphoid organs.

Critical role of methylglyoxal and AGE in mycobacteria-induced macrophage apoptosis and activation.

Novel cell death program leads to neutrophil extracellular traps.

The Helicobacter pylori CagA protein disrupts matrix adhesion of gastric epithelial cells by dephosphorylation of vinculin.

FTY720, a synthetic sphingosine 1 phosphate analogue, inhibits development of atherosclerosis in low-density lipoprotein receptor-deficient mice.

FTY720, an immunomodulatory sphingolipid mimetic: translation of a novel mechanism into clinical benefit in multiple sclerosis.

Sphingosine 1-phosphate receptors in health and disease: mechanistic insights from gene deletion studies and reverse pharmacology.

Insights into the mechanism of FTY720 and compatibility with regulatory T cells for the inhibition of graft-versus-host disease (GVHD).

Beneficial suicide: why neutrophils die to make NETs.

A small non-coding RNA of the invasion gene island (SPI-1) represses outer membrane protein synthesis from the Salmonella core genome.

Requirement of secondary lymphoid tissues for the induction of primary and secondary T cell responses against Listeria monocytogenes.

Long-term effects of natural amino acids on infection with Chlamydia trachomatis.

Role of interleukin-12 in determining differential kinetics of invariant natural killer T cells in response to differential burden of Listeria monocytogenes.

Modulation of T cell homeostasis and alloreactivity under continuous FTY720 exposure.

Delay of phagosome maturation by a mycobacterial lipid is reversed by nitric oxide.

Anticancer activity of FTY720: phosphorylated FTY720 inhibits autotaxin, a metastasis-enhancing and angiogenic lysophospholipase D.

Transgenic, fluorescent Leishmania mexicana allow direct analysis of the proteome of intracellular amastigotes.

Infection at the cellular level.

Sphingosine 1-phosphate receptor agonism impairs skin dendritic cell migration and homing to secondary lymphoid tissue: association with prolonged allograft survival.

Real-time imaging of Leishmania mexicana-infected early phagosomes: a study using primary macrophages generated from green fluorescent protein-Rab5 transgenic mice.

Chlamydia causes fragmentation of the Golgi compartment to ensure reproduction.

Bim and Bmf synergize to induce apoptosis in Neisseria gonorrhoeae infection.

Identifying activated T cells in reconstituted RAG deficient mice using retrovirally transduced Pax5 deficient pro-B cells.

Netting neutrophils in autoimmune small-vessel vasculitis.

The potent protein kinase C-selective inhibitor AEB071 (sotrastaurin) represents a new class of immunosuppressive agents affecting early T-cell activation.

Restoration of NET formation by gene therapy in CGD controls aspergillosis.

FTY720 (fingolimod) in Multiple Sclerosis: therapeutic effects in the immune and the central nervous system.

Rab6 and Rab11 regulate Chlamydia trachomatis development and golgin-84-dependent Golgi fragmentation.

Bacterial porin disrupts mitochondrial membrane potential and sensitizes host cells to apoptosis.

Neutrophil extracellular traps contain calprotectin, a cytosolic protein complex involved in host defense against Candida albicans.

Dynamic T cell migration program provides resident memory within intestinal epithelium.

Alpha-GalCer ameliorates listeriosis by accelerating infiltration of Gr-1+ cells into the liver.

The adaptor molecule CARD9 is essential for tuberculosis control.

Mouse neutrophil extracellular traps in microbial infections.

Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis.

A key role for lung-resident memory lymphocytes in protective immune responses after BCG vaccination.

Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases.

Tyrosine-phosphorylated caveolin-1 blocks bacterial uptake by inducing Vav2-RhoA-mediated cytoskeletal rearrangements.

Prevalence of Propionibacterium acnes in diseased prostates and its inflammatory and transforming activity on prostate epithelial cells.

Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis.

Fingolimod provides long-term protection in rodent models of cerebral ischemia.

Helicobacter pylori HP0518 affects flagellin glycosylation to alter bacterial motility.

Angiogenesis is present in experimental autoimmune encephalomyelitis and pro-angiogenic factors are increased in multiple sclerosis lesions.

Fingolimod provides long-term protection in rodent models of cerebral ischemia.

Impact of sphingosine 1-phosphate modulation on immune outcomes.

Sphingosine 1-phosphate (S1P): Physiology and the effects of S1P receptor modulation.

Autophagy-independent function of MAP-LC3 during intracellular propagation of Chlamydia trachomatis.

A mechanistically novel, first oral therapy for multiple sclerosis: the development of fingolimod (FTY720, Gilenya).

Optimal deconvolution of transcriptional profiling data using quadratic programming with application to complex clinical blood samples.

Therapeutic dosing of fingolimod (FTY720) prevents cell infiltration, rapidly suppresses ocular inflammation, and maintains the blood-ocular barrier.

Critical Role for Heat Shock Protein 20 (HSP20) in Migration of Malarial Sporozoites.

The exported Plasmodium berghei protein IBIS1 delineates membranous structures in infected red blood cells.

Propionibacterium acnes host cell tropism contributes to vimentin-mediated invasion and induction of inflammation.

Neutrophil extracellular traps: is immunity the second function of chromatin?

Automatic quantification of in vitro NET formation.

A proposed role for neutrophil extracellular traps in cancer immunoediting.

Comparative genomics reveals distinct host-interacting traits of three major human-associated propionibacteria.

The Spatiotemporal Dynamics and Membranous Features of the Plasmodium Liver Stage Tubovesicular Network.

IcsA is a Shigella flexneri adhesin regulated by the type III secretion system and required for pathogenesis.

Type I IFN signaling triggers immunopathology in tuberculosis-susceptible mice by modulating lung phagocyte dynamics.

AhR sensing of bacterial pigments regulates antibacterial defence.

Chlamydia trachomatis remodels stable microtubules to coordinate Golgi stack recruitment to the chlamydial inclusion surface.

Chlamydia infection depends on a functional MDM2-p53 axis.

Heparan Sulfate Modulates Neutrophil and Endothelial Function in Antibacterial Innate Immunity.

The Plasmodium berghei translocon of exported proteins reveals spatiotemporal dynamics of tubular extensions.

The Notch and Wnt pathways regulate stemness and differentiation in human fallopian tube organoids.

Genetic characterization of an adapted pandemic 2009 H1N1 influenza virus that reveals improved replication rates in human lung epithelial cells.

Comparative Plasmodium gene overexpression reveals distinct perturbation of sporozoite transmission by profilin.

Immunodetection of NETs in Paraffin-Embedded Tissue.

Optogenetic monitoring identifies phosphatidylthreonine-regulated calcium homeostasis in .

Diverse stimuli engage different neutrophil extracellular trap pathways.

ALPK1- and TIFA-Dependent Innate Immune Response Triggered by the Helicobacter pylori Type IV Secretion System.

Mycobacterium tuberculosis infection modulates adipose tissue biology.

Cell-Cycle Proteins Control Production of Neutrophil Extracellular Traps.

Prevalence of Flp Pili-Encoding Plasmids in Isolates Obtained from Prostatic Tissue.

The E3 ubiquitin ligase NEDD4 enhances killing of membrane-perturbing intracellular bacteria by promoting autophagy.

Efficacy Testing of H56 cDNA Tattoo Immunization against Tuberculosis in a Mouse Model.

Pan-genome analysis of the genus Finegoldia identifies two distinct clades, strain-specific heterogeneity, and putative virulence factors.

Unbiased classification of mosquito blood cells by single-cell genomics and high-content imaging.

Genomic features of the Helicobacter pylori strain PMSS1 and its virulence attributes as deduced from its in vivo colonisation patterns.

Midkine drives cardiac inflammation by promoting neutrophil trafficking and NETosis in myocarditis.

Dnase1-deficient mice spontaneously develop a systemic lupus erythematosus-like disease.

Chronic Chlamydia infection in human organoids increases stemness and promotes age-dependent CpG methylation.

Isolated From Blood Cultures and Prosthetic Joint Infections Exhibits Excessive Genome Decay.