Asrar B. Malik

Toll-like receptor-4 (TLR4) signaling augments chemokine-induced neutrophil migration by modulating cell surface expression of chemokine receptors.

Role of neutrophil NADPH oxidase in the mechanism of tumor necrosis factor-alpha -induced NF-kappa B activation and intercellular adhesion molecule-1 expression in endothelial cells.

Albumin transcytosis in mesothelium: further evidence of a transcellular pathway in polarized cells.

Protein kinase C-delta (PKC-delta ) is activated by type I interferons and mediates phosphorylation of Stat1 on serine 727.

Time-dependent reversal of sepsis-induced PMN uptake and lung vascular injury by expression of CD18 antagonist.

Modulatory role of focal adhesion kinase in regulating human pulmonary arterial endothelial barrier function.

Vesicle formation and trafficking in endothelial cells and regulation of endothelial barrier function.

Role of NADPH oxidase in the mechanism of lung neutrophil sequestration and microvessel injury induced by Gram-negative sepsis: studies in p47phox-/- and gp91phox-/- mice.

PKCzeta regulates TNF-alpha-induced activation of NADPH oxidase in endothelial cells.

Thrombin receptors activate G(o) proteins in endothelial cells to regulate intracellular calcium and cell shape changes.

Impairment of store-operated Ca2+ entry in TRPC4(-/-) mice interferes with increase in lung microvascular permeability.

Nitric oxide stimulates macrophage inflammatory protein-2 expression in sepsis.

Galpha(q) and Gbetagamma regulate PAR-1 signaling of thrombin-induced NF-kappaB activation and ICAM-1 transcription in endothelial cells.

Transport of nitrated albumin across continuous vascular endothelium.

Quantitative analysis of albumin uptake and transport in the rat microvessel endothelial monolayer.

Protein transport across the lung epithelial barrier.

VE-cadherin-induced Cdc42 signaling regulates formation of membrane protrusions in endothelial cells.

Tumor necrosis factor-alpha induces early-onset endothelial adhesivity by protein kinase Czeta-dependent activation of intercellular adhesion molecule-1.

Protein kinase C modifications of VE-cadherin, p120, and beta-catenin contribute to endothelial barrier dysregulation induced by thrombin.

Role of Ca2+ signaling in the regulation of endothelial permeability.

Protein kinase Calpha-induced p115RhoGEF phosphorylation signals endothelial cytoskeletal rearrangement.

RhoA interaction with inositol 1,4,5-trisphosphate receptor and transient receptor potential channel-1 regulates Ca2+ entry. Role in signaling increased endothelial permeability.

Two waves of platelet secretion induced by thromboxane A2 receptor and a critical role for phosphoinositide 3-kinases.

E. coli pneumonia induces CD18-independent airway neutrophil migration in the absence of increased lung vascular permeability.

Tumor necrosis factor-alpha induces nuclear factor-kappaB-dependent TRPC1 expression in endothelial cells.

Intersectin regulates fission and internalization of caveolae in endothelial cells.

TLR4 signaling induces TLR2 expression in endothelial cells via neutrophil NADPH oxidase.

Caveolin regulation of endothelial function.

Oxidant signaling in lung cells.

Cdc42 regulates the restoration of endothelial barrier function.

Albumin endocytosis in endothelial cells induces TGF-beta receptor II signaling.

Role of Src-induced dynamin-2 phosphorylation in caveolae-mediated endocytosis in endothelial cells.

Protein kinase Calpha phosphorylates the TRPC1 channel and regulates store-operated Ca2+ entry in endothelial cells.

Albumin mediates the transcytosis of myeloperoxidase by means of caveolae in endothelial cells.

cAMP targeting of p38 MAP kinase inhibits thrombin-induced NF-kappaB activation and ICAM-1 expression in endothelial cells.

Gbetagamma activation of Src induces caveolae-mediated endocytosis in endothelial cells.

Tumor necrosis factor-alpha-induced TRPC1 expression amplifies store-operated Ca2+ influx and endothelial permeability.

Functional and morphological studies of protein transcytosis in continuous endothelia.

RNA interference targeting transforming growth factor-beta type II receptor suppresses ocular inflammation and fibrosis.

Integrated control of lung fluid balance.

SHIP2 is recruited to the cell membrane upon macrophage colony-stimulating factor (M-CSF) stimulation and regulates M-CSF-induced signaling.

RhoA/Rho-associated kinase pathway selectively regulates thrombin-induced intercellular adhesion molecule-1 expression in endothelial cells via activation of I kappa B kinase beta and phosphorylation of RelA/p65.

LPS activation of Toll-like receptor 4 signals CD11b/CD18 expression in neutrophils.

Protease-activated receptor-1 activation of endothelial cells induces protein kinase Calpha-dependent phosphorylation of syntaxin 4 and Munc18c: role in signaling p-selectin expression.

Sphingosine 1-phosphate-induced mobilization of intracellular Ca2+ mediates rac activation and adherens junction assembly in endothelial cells.

Lysophosphatidylcholine modulates neutrophil oxidant production through elevation of cyclic AMP.

Inactivation of CD11b in a mouse transgenic model protects against sepsis-induced lung PMN infiltration and vascular injury.

Angiopoietin-1 opposes VEGF-induced increase in endothelial permeability by inhibiting TRPC1-dependent Ca2 influx.

G alpha12 interaction with alphaSNAP induces VE-cadherin localization at endothelial junctions and regulates barrier function.

Functional role of TRPC channels in the regulation of endothelial permeability.

Constitutive eNOS-derived nitric oxide is a determinant of endothelial junctional integrity.

Cholesterol-dependent syntaxin-4 and SNAP-23 clustering regulates caveolar fusion with the endothelial plasma membrane.

siRNA-induced caveolin-1 knockdown in mice increases lung vascular permeability via the junctional pathway.

Role of phosphatidylinositol 3-kinase-gamma in mediating lung neutrophil sequestration and vascular injury induced by E. coli sepsis.

Suppression of RhoA activity by focal adhesion kinase-induced activation of p190RhoGAP: role in regulation of endothelial permeability.

Cdc42 regulates adherens junction stability and endothelial permeability by inducing alpha-catenin interaction with the vascular endothelial cadherin complex.

Cellular and molecular biology for intensivists: a primer--endothelial cells.

Signaling mechanisms regulating endothelial permeability.

Phosphatidylinositol 3-kinase gamma signaling through protein kinase Czeta induces NADPH oxidase-mediated oxidant generation and NF-kappaB activation in endothelial cells.

NF-kappa B activation as a pathological mechanism of septic shock and inflammation.

Ca2+ influx induced by protease-activated receptor-1 activates a feed-forward mechanism of TRPC1 expression via nuclear factor-kappaB activation in endothelial cells.

De novo ICAM-1 synthesis in the mouse lung: model of assessment of protein expression in lungs.

Regulation of lung neutrophil recruitment by VE-cadherin.

Caveolin-1 regulates store-operated Ca2+ influx by binding of its scaffolding domain to transient receptor potential channel-1 in endothelial cells.

p38 MAPK activation coupled to endocytosis is a determinant of endothelial monolayer integrity.

Endothelial cell-restricted disruption of FoxM1 impairs endothelial repair following LPS-induced vascular injury.

Novel mechanism of endothelial nitric oxide synthase activation mediated by caveolae internalization in endothelial cells.

Caveolin-1 regulates NF-kappaB activation and lung inflammatory response to sepsis induced by lipopolysaccharide.

Ca2+ signaling, TRP channels, and endothelial permeability.

Blockade of class IA phosphoinositide 3-kinase in neutrophils prevents NADPH oxidase activation- and adhesion-dependent inflammation.

Galphaq-TRPC6-mediated Ca2+ entry induces RhoA activation and resultant endothelial cell shape change in response to thrombin.

Myocardium defects and ventricular hypoplasia in mice homozygous null for the Forkhead Box M1 transcription factor.

Protease-activated receptor-3 (PAR3) regulates PAR1 signaling by receptor dimerization.

Intersectin-1s regulates the mitochondrial apoptotic pathway in endothelial cells.

RhoGDI-1 modulation of the activity of monomeric RhoGTPase RhoA regulates endothelial barrier function in mouse lungs.

Cdc42 regulates the restoration of endothelial adherens junctions and permeability.

Regulation of cyclooxygenase-2 expression by small GTPase Rac2 in bone marrow macrophages.

Interrelations/cross talk between transcellular transport function and paracellular tight junctional properties in lung epithelial and endothelial barriers.

E3 ubiquitin ligase Cblb regulates the acute inflammatory response underlying lung injury.

GDI-1 phosphorylation switch at serine 96 induces RhoA activation and increased endothelial permeability.

Molecular determinants of endothelial transcytosis and their role in endothelial permeability.

Neutrophil caveolin-1 expression contributes to mechanism of lung inflammation and injury.

Dual regulation of endothelial junctional permeability.

Role of TRPM2 channel in mediating H2O2-induced Ca2+ entry and endothelial hyperpermeability.

Role of NF-kappaB-dependent caveolin-1 expression in the mechanism of increased endothelial permeability induced by lipopolysaccharide.

Increased pulmonary vascular resistance and defective pulmonary artery filling in caveolin-1-/- mice.

Regulation of endothelial junctional permeability.

Augmented inducible nitric oxide synthase expression and increased NO production reduce sepsis-induced lung injury and mortality in myeloperoxidase-null mice.

Intercellular adhesion molecule-1-dependent neutrophil adhesion to endothelial cells induces caveolae-mediated pulmonary vascular hyperpermeability.

Critical role of Cdc42 in mediating endothelial barrier protection in vivo.

Nonmuscle myosin light-chain kinase mediates neutrophil transmigration in sepsis-induced lung inflammation by activating beta2 integrins.

NADPH oxidase-dependent signaling in endothelial cells: role in physiology and pathophysiology.

FGF signaling preserves the integrity of endothelial adherens junctions.

Activation of sphingosine kinase-1 reverses the increase in lung vascular permeability through sphingosine-1-phosphate receptor signaling in endothelial cells.

Ca2+ entry via TRPC channels is necessary for thrombin-induced NF-kappaB activation in endothelial cells through AMP-activated protein kinase and protein kinase Cdelta.

Caveolin-1 scaffold domain interacts with TRPC1 and IP3R3 to regulate Ca2+ store release-induced Ca2+ entry in endothelial cells.

Tiam1 and Rac1 are required for platelet-activating factor-induced endothelial junctional disassembly and increase in vascular permeability.

Role of H(2)O(2)-activated TRPM2 calcium channel in oxidant-induced endothelial injury.

NF-kappaB regulates thrombin-induced ICAM-1 gene expression in cooperation with NFAT by binding to the intronic NF-kappaB site in the ICAM-1 gene.

Persistent eNOS activation secondary to caveolin-1 deficiency induces pulmonary hypertension in mice and humans through PKG nitration.

Lipopolysaccharide stimulates platelet secretion and potentiates platelet aggregation via TLR4/MyD88 and the cGMP-dependent protein kinase pathway.

Intersectin-2L regulates caveola endocytosis secondary to Cdc42-mediated actin polymerization.

LIM kinase 1 promotes endothelial barrier disruption and neutrophil infiltration in mouse lungs.

Bone marrow progenitor cells induce endothelial adherens junction integrity by sphingosine-1-phosphate-mediated Rac1 and Cdc42 signaling.

A non-redundant role for MKP5 in limiting ROS production and preventing LPS-induced vascular injury.

Toll-like receptor 4 mediates neutrophil sequestration and lung injury induced by endotoxin and hyperinflation.

Requirement of alpha(4)beta(1) and alpha(5)beta(1) integrin expression in bone-marrow-derived progenitor cells in preventing endotoxin-induced lung vascular injury and edema in mice.

Bone marrow-derived progenitor cells prevent thrombin-induced increase in lung vascular permeability.

Size and dynamics of caveolae studied using nanoparticles in living endothelial cells.

Requisite role of the cholinergic alpha7 nicotinic acetylcholine receptor pathway in suppressing Gram-negative sepsis-induced acute lung inflammatory injury.

Ca2+ influx via TRPC channels induces NF-kappaB-dependent A20 expression to prevent thrombin-induced apoptosis in endothelial cells.

TRP channels and the control of vascular function.

Lipid phosphate phosphatase 3 stabilization of beta-catenin induces endothelial cell migration and formation of branching point structures.

Regulation of endothelial permeability via paracellular and transcellular transport pathways.

TRPM2 channel regulates endothelial barrier function.

A novel function of sphingosine kinase 1 suppression of JNK activity in preventing inflammation and injury.

Caveolin-1 deficiency dampens Toll-like receptor 4 signaling through eNOS activation.

A novel insight into the mechanism of pulmonary hypertension involving caveolin-1 deficiency and endothelial nitric oxide synthase activation.

Role of protein kinase Czeta in thrombin-induced RhoA activation and inter-endothelial gap formation of human dermal microvessel endothelial cell monolayers.

FoxM1 regulates re-annealing of endothelial adherens junctions through transcriptional control of beta-catenin expression.

Kruppel-like factor-4 transcriptionally regulates VE-cadherin expression and endothelial barrier function.

NANOG induction of fetal liver kinase-1 (FLK1) transcription regulates endothelial cell proliferation and angiogenesis.

Regulation of dynamin-2 assembly-disassembly and function through the SH3A domain of intersectin-1s.

Interaction of a specific population of human embryonic stem cell-derived progenitor cells with CD11b+ cells ameliorates sepsis-induced lung inflammatory injury.

Innate immune function of the adherens junction protein p120-catenin in endothelial response to endotoxin.

Src phosphorylation of endothelial cell surface intercellular adhesion molecule-1 mediates neutrophil adhesion and contributes to the mechanism of lung inflammation.

Role of endothelial injury in disease mechanisms and contribution of progenitor cells in mediating endothelial repair.

Caveolin-1-eNOS signaling promotes p190RhoGAP-A nitration and endothelial permeability.

FoxM1 mediates the progenitor function of type II epithelial cells in repairing alveolar injury induced by Pseudomonas aeruginosa.

Delivery of nanoparticle: complexed drugs across the vascular endothelial barrier via caveolae.

Improvement of cardiac function in mouse myocardial infarction after transplantation of epigenetically-modified bone marrow progenitor cells.

Permeability of endothelial barrier: cell culture and in vivo models.

The redox-sensitive cation channel TRPM2 modulates phagocyte ROS production and inflammation.

The Ca(2+) sensor stromal interaction molecule 1 (STIM1) is necessary and sufficient for the store-operated Ca(2+) entry function of transient receptor potential canonical (TRPC) 1 and 4 channels in endothelial cells.

Nitric oxide-dependent Src activation and resultant caveolin-1 phosphorylation promote eNOS/caveolin-1 binding and eNOS inhibition.

Sphingosine kinase 1 mediation of expression of the anaphylatoxin receptor C5L2 dampens the inflammatory response to endotoxin.

Bidirectional regulation of neutrophil migration by mitogen-activated protein kinases.

PKCα activation of p120-catenin serine 879 phospho-switch disassembles VE-cadherin junctions and disrupts vascular integrity.

ICAM-1-activated Src and eNOS signaling increase endothelial cell surface PECAM-1 adhesivity and neutrophil transmigration.

A Critical Role for P-Rex1 in Endothelial Junction Disruption and Vascular Hyper-Permeability.

TLR4 activation of TRPC6-dependent calcium signaling mediates endotoxin-induced lung vascular permeability and inflammation.

VE-Cadherin Signaling Induces EB3 Phosphorylation to Suppress Microtubule Growth and Assemble Adherens Junctions.

Nanoparticles squeezing across the blood-endothelial barrier via caveolae.

Activation of NLRP3 inflammasome in alveolar macrophages contributes to mechanical stretch-induced lung inflammation and injury.

Bioluminescent detection of peroxynitrite with a boronic acid-caged luciferin.

Store-operated Ca2+ entry (SOCE) induced by protease-activated receptor-1 mediates STIM1 protein phosphorylation to inhibit SOCE in endothelial cells through AMP-activated protein kinase and p38β mitogen-activated protein kinase.

Transcriptional regulation of endothelial cell and vascular development.

Cytoskeletal dynamics and lung fluid balance.

Reactive oxygen species in inflammation and tissue injury.

A critical role for Lyn kinase in strengthening endothelial integrity and barrier function.

Caveolin-1 Tyr14 phosphorylation induces interaction with TLR4 in endothelial cells and mediates MyD88-dependent signaling and sepsis-induced lung inflammation.

Cooperative interaction of trp melastatin channel transient receptor potential (TRPM2) with its splice variant TRPM2 short variant is essential for endothelial cell apoptosis.

Flk1+ and VE-cadherin+ endothelial cells derived from iPSCs recapitulates vascular development during differentiation and display similar angiogenic potential as ESC-derived cells.

The transcription factor DREAM represses the deubiquitinase A20 and mediates inflammation.

Genetic variation is the major determinant of individual differences in leukocyte endothelial adhesion.

Prevention of vascular inflammation by nanoparticle targeting of adherent neutrophils.

Therapeutic administration of the chemokine CXCL1/KC abrogates autoimmune inflammatory heart disease.

Evidence of a common mechanism of disassembly of adherens junctions through Gα13 targeting of VE-cadherin.

Endothelial progenitor cells and vascular repair.

Regulating the regulator of ROS production.

Combinatorial therapy with acetylation and methylation modifiers attenuates lung vascular hyperpermeability in endotoxemia-induced mouse inflammatory lung injury.

Differential role for p120-catenin in regulation of TLR4 signaling in macrophages.

Cooperative signaling via transcription factors NF-κB and AP1/c-Fos mediates endothelial cell STIM1 expression and hyperpermeability in response to endotoxin.

KIF13B regulates angiogenesis through Golgi to plasma membrane trafficking of VEGFR2.

Reprogramming fibroblasts to endothelial cells: converted or born again?

Microfluidic platform generates oxygen landscapes for localized hypoxic activation.