Yasuyuki Sakai

Muscarinic receptor activation in the lumbosacral spinal cord ameliorates bladder irritation in rat cystitis models.

Spontaneous formation of highly functional three-dimensional multilayer from human hepatoma Hep G2 cells cultured on an oxygen-permeable polydimethylsiloxane membrane.

A rapid and simple evaluation system for gas toxicity using luminous bacteria entrapped by a polyion complex membrane.

Simultaneous evaluation of toxicities using a mammalian cell array chip prepared by photocatalytic lithography.

Simple prophylactic procedure of inguinal hernia after radical retropubic prostatectomy: isolation of the spermatic cord.

A micropatterned cell array with an integrated oxygen-sensitive fluorescent membrane.

Initial experience of diffusion-weighted magnetic resonance imaging to assess therapeutic response to induction chemoradiotherapy against muscle-invasive bladder cancer.

On-chip single embryo coculture with microporous-membrane-supported endometrial cells.

Spontaneous formation of stably-attached and 3D-organized hepatocyte aggregates on oxygen-permeable polydimethylsiloxane membranes having 3D microstructures.

Modulation of hepatocarcinoma cell morphology and activity by parylene-C coating on PDMS.

Transplantation of a fetal liver cell-loaded hyaluronic acid sponge onto the mesentery recovers a Wilson's disease model rat.

Microfibrillated cellulose sheets coating oxygen-permeable PDMS membranes induce rat hepatocytes 3D aggregation into stably-attached 3D hemispheroids.

Electrochemical biosensor for the detection of H2O2 from living cancer cells based on ZnO nanosheets.

Enhanced effects of secreted soluble factor preserve better pluripotent state of embryonic stem cell culture in a membrane-based compartmentalized micro-bioreactor.

Cytotoxicity evaluation of reactive metabolites using rat liver homogenate microsome-encapsulated alginate gel microbeads.

Programming an in vitro DNA oscillator using a molecular networking strategy.

Towards single cell heat shock response by accurate control on thermal confinement with an on-chip microwire electrode.

Phthalocyanine-based fluorescence probes for detecting ascorbic acid: phthalocyaninatosilicon covalently linked to TEMPO radicals.

Establishment of self-organization system in rapidly formed multicellular heterospheroids.

Gas-permeable membranes and co-culture with fibroblasts enable high-density hepatocyte culture as multilayered liver tissues.

Kinetic modelling of in vitro cell-based assays to characterize non-specific bindings and ADME processes in a static and a perfused fluidic system.

Integration of a pump and an electrical sensor into a membrane-based PDMS microbioreactor for cell culture and drug testing.

Bile canaliculi formation by aligning rat primary hepatocytes in a microfluidic device.

Use of liposome encapsulated hemoglobin as an oxygen carrier for fetal and adult rat liver cell culture.

Engineering of implantable liver tissues.

Rapid aggregation of heterogeneous cells and multiple-sized microspheres in methylcellulose medium.

Enhanced bile canaliculi formation enabling direct recovery of biliary metabolites of hepatocytes in 3D collagen gel microcavities.

Direct synthesis of cup-stacked carbon nanofiber microspheres by the catalytic pyrolysis of poly(ethylene glycol).

Induction of alternative fate other than default neuronal fate of embryonic stem cells in a membrane-based two-chambered microbioreactor by cell-secreted BMP4.

Ubiquitin-specific peptidase 46 (Usp46) regulates mouse immobile behavior in the tail suspension test through the GABAergic system.

Direct oxygen supply with polydimethylsiloxane (PDMS) membranes induces a spontaneous organization of thick heterogeneous liver tissues from rat fetal liver cells in vitro.

Spatiotemporally controlled delivery of soluble factors for stem cell differentiation.

Human adipose tissue-derived mesenchymal stem cells secrete functional neprilysin-bound exosomes.

Importance of a diffusion-dominant small volume to activate cell-secreted soluble factor signaling in embryonic stem cell culture in microbioreactors: a mathematical model based study.

Induced pluripotent stem cell-derived hepatocytes as an alternative to human adult hepatocytes.

Biliary epithelial cells play an essential role in the reconstruction of hepatic tissue with a functional bile ductular network.

First experience of active surveillance before systemic target therapy in patients with metastatic renal cell carcinoma.

Combination of microwell structures and direct oxygenation enables efficient and size-regulated aggregate formation of an insulin-secreting pancreatic β-cell line.

Image-based evaluations of distribution and cytotoxicity of Irinotecan (CPT-11) in a multi-compartment micro-cell coculture device.

A novel 3-dimensional image analysis system for case-specific kidney anatomy and surgical simulation to facilitate clampless partial nephrectomy.

Proliferation, morphology, and pluripotency of mouse induced pluripotent stem cells in three different types of alginate beads for mass production.

Risk stratification for bladder recurrence of upper urinary tract urothelial carcinoma after radical nephroureterectomy.

Electrochemical properties of oxygenated cup-stacked carbon nanofiber-modified electrodes.

Adhesion of pancreatic cancer cells in a liver-microvasculature mimicking coculture correlates with their propensity to form liver-specific metastasis in vivo.

Equivalent survival and improved preservation of renal function after distal ureterectomy compared with nephroureterectomy in patients with urothelial carcinoma of the distal ureter: a propensity score-matched multicenter study.

The importance of physiological oxygen concentrations in the sandwich cultures of rat hepatocytes on gas-permeable membranes.

Bimodal pattern of the impact of body mass index on cancer-specific survival of upper urinary tract urothelial carcinoma patients.

An on-chip small intestine-liver model for pharmacokinetic studies.

Preparation of uniform-sized hemoglobin-albumin microspheres as oxygen carriers by Shirasu porous glass membrane emulsification technique.

Clinical Value of F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Upper Tract Urothelial Carcinoma: Impact on Detection of Metastases and Patient Management.

Organ/body-on-a-chip based on microfluidic technology for drug discovery.

Enhanced hepatic differentiation of human iPS cells using gas permeable membrane.