Christoph E. Hagemeyer

Synaptic vesicle protein synaptoporin is differently expressed by subpopulations of mouse hippocampal neurons.

Fibrin-targeted direct factor Xa inhibition: construction and characterization of a recombinant factor Xa inhibitor composed of an anti-fibrin single-chain antibody and tick anticoagulant peptide.

Conformation-specific blockade of the integrin GPIIb/IIIa: a novel antiplatelet strategy that selectively targets activated platelets.

A mechanistic model for paradoxical platelet activation by ligand-mimetic alphaIIb beta3 (GPIIb/IIIa) antagonists.

Targeting ligand-induced binding sites on GPIIb/IIIa via single-chain antibody allows effective anticoagulation without bleeding time prolongation.

Single-chain antibodies as new antithrombotic drugs.

Single-chain antibodies as diagnostic tools and therapeutic agents.

Dissociation of pentameric to monomeric C-reactive protein on activated platelets localizes inflammation to atherosclerotic plaques.

Ex-vivo thrombolytic gene therapy for vein graft patency: the frontier for development of selective, localised therapeutic approaches.

7-Benzyloxyresorufin-O-dealkylase activity as a marker for measuring cytochrome P450 CYP3A induction in mouse liver.

Genetic transfer of fusion proteins effectively inhibits VCAM-1-mediated cell adhesion and transmigration via inhibition of cytoskeletal anchorage.

MRI of inducible P-selectin expression in human activated platelets involved in the early stages of atherosclerosis.

Targeting the platelet integrin GPIIb/IIIa.

Activated platelets in carotid artery thrombosis in mice can be selectively targeted with a radiolabeled single-chain antibody.

GPVI and GPIbα mediate staphylococcal superantigen-like protein 5 (SSL5) induced platelet activation and direct toward glycans as potential inhibitors.

An activation-specific platelet inhibitor that can be turned on/off by medically used hypothermia.

Novel single-chain antibody-targeted microbubbles for molecular ultrasound imaging of thrombosis: validation of a unique noninvasive method for rapid and sensitive detection of thrombi and monitoring of success or failure of thrombolysis in mice.

Bio-Click Chemistry: Enzymatic Functionalization of PEGylated Capsules for Targeting Applications.

Enzymatic antibody tagging: toward a universal biocompatible targeting tool.

Delayed targeting of CD39 to activated platelet GPIIb/IIIa via a single-chain antibody: breaking the link between antithrombotic potency and bleeding?

Detection of activated platelets in a mouse model of carotid artery thrombosis with 18 F-labeled single-chain antibodies.

Towards effective and safe thrombolysis and thromboprophylaxis: preclinical testing of a novel antibody-targeted recombinant plasminogen activator directed against activated platelets.

Engineering multifunctional capsules through the assembly of metal-phenolic networks.

Enzyme-mediated site-specific bioconjugation of metal complexes to proteins: sortase-mediated coupling of copper-64 to a single-chain antibody.

Single-chain antibody conjugated to a cage amine chelator and labeled with positron-emitting copper-64 for diagnostic imaging of activated platelets.

Particle generation, functionalization and sortase A-mediated modification with targeting of single-chain antibodies for diagnostic and therapeutic use.

Targeted antithrombotic protein micelles.

Engineering poly(ethylene glycol) particles for improved biodistribution.

A Versatile Approach for the Site-Specific Modification of Recombinant Antibodies Using a Combination of Enzyme-Mediated Bioconjugation and Click Chemistry.

Boronate-Phenolic Network Capsules with Dual Response to Acidic pH and cis-Diols.