Christopher S. Chen

Fabrication of aligned microstructures with a single elastomeric stamp.

Patterning the cellular microenvironment.

Cell-cell signaling by direct contact increases cell proliferation via a PI3K-dependent signal.

Engineering cellular microenvironments to improve cell-based drug testing.

Cells lying on a bed of microneedles: an approach to isolate mechanical force.

Cell shape provides global control of focal adhesion assembly.

VE-cadherin simultaneously stimulates and inhibits cell proliferation by altering cytoskeletal structure and tension.

Repositioning of cells by mechanotaxis on surfaces with micropatterned Young's modulus.

Dielectrophoretic registration of living cells to a microelectrode array.

Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment.

Vascular endothelial-cadherin regulates cytoskeletal tension, cell spreading, and focal adhesions by stimulating RhoA.

Dielectrophoretic registration of living cells to a microelectrode array.

Mechanotransduction at cell-matrix and cell-cell contacts.

Simple approach to micropattern cells on common culture substrates by tuning substrate wettability.

Characterization of the nuclear deformation caused by changes in endothelial cell shape.

Facile modification of collagen directed by collagen mimetic peptides.

Optimization of yield in magnetic cell separations using nickel nanowires of different lengths.

Nanopattern-induced changes in morphology and motility of smooth muscle cells.

Strategies for engineering the adhesive microenvironment.

Assembly of multicellular constructs and microarrays of cells using magnetic nanowires.

T cell-to-T cell clustering enhances NF-kappaB activity by a PI3K signal mediated by Cbl-b and Rho.

Emergent patterns of growth controlled by multicellular form and mechanics.

Finite-element analysis of the adhesion-cytoskeleton-nucleus mechanotransduction pathway during endothelial cell rounding: axisymmetric model.

Nanotechnology for cell-substrate interactions.

E-cadherin engagement stimulates proliferation via Rac1.

Shear force at the cell-matrix interface: enhanced analysis for microfabricated post array detectors.

Heparin binding directs activation of T cells against adeno-associated virus serotype 2 capsid.

An inhibitory role for FAK in regulating proliferation: a link between limited adhesion and RhoA-ROCK signaling.

Using microenvironment to engineer stem cell function.

Separate but not equal: differential mechanical roles for Myosin isoforms.

Manipulation of cell-cell adhesion using bowtie-shaped microwells.

Bait and switch: synthetic GEFs divert an input signal to diverse cellular responses.

Microfabricated silicone elastomeric post arrays for measuring traction forces of adherent cells.

Activation of ROCK by RhoA is regulated by cell adhesion, shape, and cytoskeletal tension.

Cadherins, RhoA, and Rac1 are differentially required for stretch-mediated proliferation in endothelial versus smooth muscle cells.

Magnetic microposts as an approach to apply forces to living cells.

Cellular and multicellular form and function.

Versatile, fully automated, microfluidic cell culture system.

Rac-dependent cyclin D1 gene expression regulated by cadherin- and integrin-mediated adhesion.

Spatial patterning of gene expression using surface-immobilized recombinant adenovirus.

Magnetic microposts for mechanical stimulation of biological cells: fabrication, characterization, and analysis.

Myofibrillar architecture in engineered cardiac myocytes.

Engineering amount of cell-cell contact demonstrates biphasic proliferative regulation through RhoA and the actin cytoskeleton.

Biotechnology: remote control of living cells.

Emergence of patterned stem cell differentiation within multicellular structures.

Immobilization of growth factors on collagen scaffolds mediated by polyanionic collagen mimetic peptides and its effect on endothelial cell morphogenesis.

Mechanotransduction - a field pulling together?

Cell traction forces direct fibronectin matrix assembly.

Mechanotransduction in development: a growing role for contractility.

Using self-assembled monolayers to pattern ECM proteins and cells on substrates.

Cell polarity triggered by cell-cell adhesion via E-cadherin.

Microfabricated tissue gauges to measure and manipulate forces from 3D microtissues.

Control of stem cell fate by physical interactions with the extracellular matrix.

Cytoskeleton-based forecasting of stem cell lineage fates.

Stem cell shape regulates a chondrogenic versus myogenic fate through Rac1 and N-cadherin.

Bioactive hydrogels made from step-growth derived PEG-peptide macromers.

Geometrically controlled endothelial tubulogenesis in micropatterned gels.

Mechanical tugging force regulates the size of cell-cell junctions.

Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics.

Mechanical regulation of cell function with geometrically modulated elastomeric substrates.

Decoupling diffusional from dimensional control of signaling in 3D culture reveals a role for myosin in tubulogenesis.

Mechanical Forces in Endothelial Cells during Firm Adhesion and Early Transmigration of Human Monocytes.

Micropatterned dynamically adhesive substrates for cell migration.

Engineered materials and the cellular microenvironment: a strengthening interface between cell biology and bioengineering.

Measurement of mechanical tractions exerted by cells in three-dimensional matrices.

几何调制刚性测定干细胞美国超微型弹性衬底上。

Subcellular spatial segregation of integrin subtypes by patterned multicomponent surfaces.

Cell shape and substrate rigidity both regulate cell stiffness.

The Cdc42 guanine nucleotide exchange factor FGD1 regulates osteogenesis in human mesenchymal stem cells.

Measurement and analysis of traction force dynamics in response to vasoactive agonists.

Decreased cell adhesion promotes angiogenesis in a Pyk2-dependent manner.

A hitchhiker's guide to mechanobiology.

Repressor transcription factor 7-like 1 promotes adipogenic competency in precursor cells.

Bone Morphogenetic Protein-2-Induced Signaling and Osteogenesis Is Regulated by Cell Shape, RhoA/ROCK, and Cytoskeletal Tension.

Bioresponsive mesoporous silica nanoparticles for triggered drug release.

A Microfabricated Platform to Measure and Manipulate the Mechanics of Engineered Cardiac Microtissues.

Matrix rigidity regulates a switch between TGF-β1-induced apoptosis and epithelial-mesenchymal transition.

Probing cellular traction forces with magnetic nanowires and microfabricated force sensor arrays.

Measuring traction forces of motile dendritic cells on micropost arrays.

miR-125b is an Adhesion-Regulated microRNA that Protects Mesenchymal Stem Cells from Anoikis.