Department of Chemistry & Biochemistry,
The Biodesign Institute – Center for Personalized Diagnostics,
Department of Chemistry & Biochemistry, The Biodesign Institute – Center for Personalized Diagnostics
Dr. Borges received a B.S. in Chemistry from Walla Walla College (WA) in 1997. He went on to complete a Ph.D. in Analytical Toxicology (2001) at the University of Utah under Prof. Douglas Rollins, the medical director in charge of doping control for the 2002 Olympic Games. Dr. Borges’ dissertation research focused on the role of hair pigments and cellular transport in drug incorporation into hair. He continued his education as a postdoctoral fellow at Michigan State University under pioneering mass spectrometrist J. Throck Watson, where he studied protein mass spectrometry with an emphasis on characterizing protein posttranslational modifications. In 2003, he returned to Utah where he helped establish the Olympic-level certified Sports Medicine Research and Testing Laboratory. Following successful laboratory accreditation he transitioned to The Biodesign Institute at Arizona State University in 2007 where he worked for several years as a research faculty member at The Biodesign Institute with Dr. Randall Nelson before joining the Department of Chemistry & Biochemistry (now School of Molecular Sciences) in 2013. His current research focuses on the roles of protein post-translational modifications in human health and disease as well as the development of markers and approaches for ensuring biospecimen integrity.
Influx and efflux of amphetamine and N-acetylamphetamine in keratinocytes, pigmented melanocytes, and nonpigmented melanocytes.
Journal of pharmaceutical sciences Jun, 2002 | Pubmed ID: 12115851
Dopamine biosynthesis is regulated by S-glutathionylation. Potential mechanism of tyrosine hydroxylast inhibition during oxidative stress.
The Journal of biological chemistry Dec, 2002 | Pubmed ID: 12376535
Mass mapping sites of nitration in tyrosine hydroxylase: random vs selective nitration of three tyrosine residues.
Chemical research in toxicology Apr, 2003 | Pubmed ID: 12703971
Cocaine, benzoylecgonine, amphetamine, and N-acetylamphetamine binding to melanin subtypes.
Journal of analytical toxicology Apr, 2003 | Pubmed ID: 12731652
Ofloxacin as a reference marker in hair of various colors.
Journal of analytical toxicology Apr, 2003 | Pubmed ID: 12731656
Recognition of cysteine-containing peptides through prompt fragmentation of the 4-dimethylaminophenylazophenyl-4'-maleimide derivative during analysis by MALDI-MS.
Protein science : a publication of the Protein Society Jul, 2003 | Pubmed ID: 12824503
Automated data interpretation based on the concept of "negative signature mass" for mass-mapping disulfide structures of cystinyl proteins.
Journal of the American Society for Mass Spectrometry Sep, 2003 | Pubmed ID: 12954171
The effect of hair color on the incorporation of codeine into human hair.
Journal of analytical toxicology Nov-Dec, 2003 | Pubmed ID: 14670132
Algorithm-assisted elucidation of disulfide structure: application of the negative signature mass algorithm to mass-mapping the disulfide structure of the 12-cysteine transforming growth factor beta type II receptor extracellular domain.
Analytical biochemistry Jun, 2004 | Pubmed ID: 15136171
Concept for facilitating analyst-mediated interpretation of qualitative chromatographic-mass spectral data: an alternative to manual examination of extracted ion chromatograms.
Analytical chemistry Jul, 2007 | Pubmed ID: 17542552
Analysis of a challenging subset of World Anti-Doping Agency-banned steroids and antiestrogens by LC-MS-MS.
Journal of analytical toxicology Apr, 2007 | Pubmed ID: 17579958
Detection of bumetanide in an over-the-counter dietary supplement.
Journal of analytical toxicology Nov-Dec, 2007 | Pubmed ID: 18093421
Population studies of Vitamin D Binding Protein microheterogeneity by mass spectrometry lead to characterization of its genotype-dependent O-glycosylation patterns.
Journal of proteome research Sep, 2008 | Pubmed ID: 18686987
Population studies of intact vitamin D binding protein by affinity capture ESI-TOF-MS.
Journal of biomolecular techniques : JBT Jul, 2008 | Pubmed ID: 19137103
Glycosylation status of vitamin D binding protein in cancer patients.
Protein science : a publication of the Protein Society Oct, 2009 | Pubmed ID: 19642159
Full-length characterization of proteins in human populations.
Clinical chemistry Feb, 2010 | Pubmed ID: 19926773
Possibilities and pitfalls in quantifying the extent of cysteine sulfenic acid modification of specific proteins within complex biofluids.
BMC biochemistry , 2010 | Pubmed ID: 20594348
Cysteine sulfenic acid as an intermediate in disulfide bond formation and nonenzymatic protein folding.
Biochemistry Sep, 2010 | Pubmed ID: 20712299
Intrapersonal and populational heterogeneity of the chemokine RANTES.
Clinical chemistry Sep, 2010 | Pubmed ID: 20802101
C-peptide microheterogeneity in type 2 diabetes populations.
Proteomics. Clinical applications Jan, 2010 | Pubmed ID: 21137020
Building multidimensional biomarker views of type 2 diabetes on the basis of protein microheterogeneity.
Clinical chemistry May, 2011 | Pubmed ID: 21402800
Mass spectrometric immunoassay of intact insulin and related variants for population proteomics studies.
Proteomics. Clinical applications Aug, 2011 | Pubmed ID: 21656909
Mass spectrometric immunoassay revisited.
Journal of the American Society for Mass Spectrometry Jun, 2011 | Pubmed ID: 21953037
Revealing the allosterome: systematic identification of metabolite-protein interactions.
Biochemistry Jan, 2012 | Pubmed ID: 22122470
RNA-protein binding interface in the telomerase ribonucleoprotein.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2011 | Pubmed ID: 22123986
Multiplexed surrogate analysis of glycotransferase activity in whole biospecimens.
Analytical chemistry Mar, 2013 | Pubmed ID: 23368525
Mass spectrometric immunoassay and MRM as targeted MS-based quantitative approaches in biomarker development: potential applications to cardiovascular disease and diabetes.
Proteomics. Clinical applications Aug, 2013 | Pubmed ID: 23696124
Techniques for the analysis of cysteine sulfhydryls and oxidative protein folding.
Antioxidants & redox signaling Jul, 2014 | Pubmed ID: 24383618
The application of multiple reaction monitoring and multi-analyte profiling to HDL proteins.
Lipids in health and disease , 2014 | Pubmed ID: 24397693
Parallel workflow for high-throughput (>1,000 samples/day) quantitative analysis of human insulin-like growth factor 1 using mass spectrometric immunoassay.
PloS one , 2014 | Pubmed ID: 24664114
Elevated plasma albumin and apolipoprotein A-I oxidation under suboptimal specimen storage conditions.
Molecular & cellular proteomics : MCP Jul, 2014 | Pubmed ID: 24736286
Oxidative protein folding: nature's knotty challenge.
Antioxidants & redox signaling Jul, 2014 | Pubmed ID: 24766375
Mass Spectrometric Immunoassay for the qualitative and quantitative analysis of the cytokine Macrophage Migration Inhibitory Factor (MIF).
Proteome science , 2014 | Pubmed ID: 25328446
Serum amyloid a truncations in type 2 diabetes mellitus.
PloS one , 2015 | Pubmed ID: 25607823
Gamma-carboxylation and fragmentation of osteocalcin in human serum defined by mass spectrometry.
Molecular & cellular proteomics : MCP Jun, 2015 | Pubmed ID: 25855755
Ebselen inhibits QSOX1 enzymatic activity and suppresses invasion of pancreatic and renal cancer cell lines.
Oncotarget Jul, 2015 | Pubmed ID: 26158899
Characterization of additional vitamin D binding protein variants.
The Journal of steroid biochemistry and molecular biology May, 2016 | Pubmed ID: 26924582
Development of quantitative mass spectrometric immunoassay for serum amyloid A.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals Dec, 2016 | Pubmed ID: 27308834
Glycan structure of Gc Protein-derived Macrophage Activating Factor as revealed by mass spectrometry.
Archives of biochemistry and biophysics 09, 2016 | Pubmed ID: 27503803
Chicken albumin exhibits natural resistance to glycation.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology Jan, 2017 | Pubmed ID: 27773732
Bacterial expression, correct membrane targeting and functional folding of the HIV-1 membrane protein Vpu using a periplasmic signal peptide.
PloS one , 2017 | Pubmed ID: 28225803
Variations in native protein glycation and plasma antioxidants in several birds of prey.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology Aug, 2017 | Pubmed ID: 28529085
A spin column-free approach to sodium hydroxide-based glycan permethylation.
The Analyst Jul, 2017 | Pubmed ID: 28635997
Ex vivo instability of glycated albumin: A role for autoxidative glycation.
Archives of biochemistry and biophysics 09, 2017 | Pubmed ID: 28712850
Stage Dependence, Cell-Origin Independence, and Prognostic Capacity of Serum Glycan Fucosylation, β1-4 Branching, β1-6 Branching, and α2-6 Sialylation in Cancer.
Journal of proteome research 01, 2018 | Pubmed ID: 29129073
Behavior of blood plasma glycan features in bladder cancer.
PloS one , 2018 | Pubmed ID: 30040854
Delta-S-Cys-Albumin: A Lab Test that Quantifies Cumulative Exposure of Archived Human Blood Plasma and Serum Samples to Thawed Conditions.
Molecular & cellular proteomics : MCP 10, 2019 | Pubmed ID: 31324658
Diagnostic and Prognostic Performance of Blood Plasma Glycan Features in the Women Epidemiology Lung Cancer (WELCA) Study.
Journal of proteome research 11, 2019 | Pubmed ID: 31566983