Molecular Signalling and Gene Therapy
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Efficient in vivo gene expression by trans-splicing adeno-associated viral vectors.
Nature biotechnology Nov, 2005 | Pubmed ID: 16244658
Viral serotype and the transgene sequence influence overlapping adeno-associated viral (AAV) vector-mediated gene transfer in skeletal muscle.
The journal of gene medicine Mar, 2006 | Pubmed ID: 16385549
Efficient whole-body transduction with trans-splicing adeno-associated viral vectors.
Molecular therapy : the journal of the American Society of Gene Therapy Apr, 2007 | Pubmed ID: 17264855
A hybrid vector system expands adeno-associated viral vector packaging capacity in a transgene-independent manner.
Molecular therapy : the journal of the American Society of Gene Therapy Jan, 2008 | Pubmed ID: 17984978
Expanding adeno-associated viral vector capacity: a tale of two vectors.
Biotechnology & genetic engineering reviews , 2007 | Pubmed ID: 18059632
A single intravenous injection of adeno-associated virus serotype-9 leads to whole body skeletal muscle transduction in dogs.
Molecular therapy : the journal of the American Society of Gene Therapy Dec, 2008 | Pubmed ID: 18827804
Transduction efficiency of AAV 2/6, 2/8 and 2/9 vectors for delivering genes in human corneal fibroblasts.
Brain research bulletin Feb, 2010 | Pubmed ID: 19616080
Adeno-associated virus serotype-9 efficiently transduces the retinal outer plexiform layer.
Molecular vision , 2009 | Pubmed ID: 19626133
Systemic Trans-splicing adeno-associated viral delivery efficiently transduces the heart of adult mdx mouse, a model for duchenne muscular dystrophy.
Human gene therapy Nov, 2009 | Pubmed ID: 19627234
Adeno-associated virus serotype-9 mediated retinal outer plexiform layer transduction is mainly through the photoreceptors.
Advances in experimental medicine and biology , 2010 | Pubmed ID: 20238072
AAV serotype influences gene transfer in corneal stroma in vivo.
Experimental eye research Sep, 2010 | Pubmed ID: 20599959
Telomere-independent Rap1 is an IKK adaptor and regulates NF-kappaB-dependent gene expression.
Nature cell biology Aug, 2010 | Pubmed ID: 20622870
Efficient transgene reconstitution with hybrid dual AAV vectors carrying the minimized bridging sequences.
Human gene therapy Jan, 2011 | Pubmed ID: 20662564
Telomerase directly regulates NF-κB-dependent transcription.
Nature cell biology Dec, 2012 | Pubmed ID: 23159929
Nanomaterial processing using self-assembly-bottom-up chemical and biological approaches.
Reports on progress in physics. Physical Society (Great Britain) Jun, 2013 | Pubmed ID: 23722189
Proteomic and gene expression patterns of keratoconus.
Indian journal of ophthalmology Aug, 2013 | Pubmed ID: 23925320
Biomechanics of the cornea evaluated by spectral analysis of waveforms from ocular response analyzer and Corvis-ST.
PloS one , 2014 | Pubmed ID: 25162229
Attenuation of lysyl oxidase and collagen gene expression in keratoconus patient corneal epithelium corresponds to disease severity.
Molecular vision , 2015 | Pubmed ID: 25593510
Elevated expression of matrix metalloproteinase-9 and inflammatory cytokines in keratoconus patients is inhibited by cyclosporine A.
Investigative ophthalmology & visual science Feb, 2015 | Pubmed ID: 25648341
A common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome.
Nature genetics Apr, 2015 | Pubmed ID: 25706626
Identification of Novel Mutations in ABCA4 Gene: Clinical and Genetic Analysis of Indian Patients with Stargardt Disease.
BioMed research international , 2015 | Pubmed ID: 25922843
Two novel missense substitutions in the VSX1 gene: clinical and genetic analysis of families with Keratoconus from India.
BMC medical genetics , 2015 | Pubmed ID: 25963163
Corrigendum: a common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome.
Nature genetics Jun, 2015 | Pubmed ID: 26018902
A novel zernike application to differentiate between three-dimensional corneal thickness of normal corneas and corneas with keratoconus.
American journal of ophthalmology Sep, 2015 | Pubmed ID: 26067190
Management of Ocular Neuropathic Pain With Vitamin B12 Supplements: A Case Report.
Cornea Oct, 2015 | Pubmed ID: 26266431
Contemporary Animal Models For Human Gene Therapy Applications.
Current gene therapy , 2015 | Pubmed ID: 26415576
Corneal Dendritic Cell Density Is Associated with Subbasal Nerve Plexus Features, Ocular Surface Disease Index, and Serum Vitamin D in Evaporative Dry Eye Disease.
BioMed research international , 2016 | Pubmed ID: 26904676
An In Vivo Confocal Microscopic Study of Corneal Nerve Morphology in Unilateral Keratoconus.
BioMed research international , 2016 | Pubmed ID: 26904679
Genome-wide association study identifies five new susceptibility loci for primary angle closure glaucoma.
Nature genetics May, 2016 | Pubmed ID: 27064256
Author Response: Causal Management of Keratoconus: Controlling Inflammation.
Investigative ophthalmology & visual science Apr, 2016 | Pubmed ID: 27111564
Correlation of Clinical and Biomechanical Outcomes of Accelerated Crosslinking (9 mW/cm(2) in 10 minutes) in Keratoconus with Molecular Expression of Ectasia-Related Genes.
Current eye research May, 2016 | Pubmed ID: 27159267
Tear biomarkers for keratoconus.
Eye and vision (London, England) , 2016 | Pubmed ID: 27493978
A distinct cytokines profile in tear film of dry eye disease (DED) patients with HIV infection.
Cytokine Dec, 2016 | Pubmed ID: 27585367
Correlation between tear fluid and serum vitamin D levels.
Eye and vision (London, England) , 2016 | Pubmed ID: 27595117
Differential Molecular Expression of Extracellular Matrix and Inflammatory Genes at the Corneal Cone Apex Drives Focal Weakening in Keratoconus.
Investigative ophthalmology & visual science Oct, 2016 | Pubmed ID: 27732724
Reverse phase protein arrays enable glioblastoma molecular subtyping.
Journal of neuro-oncology Feb, 2017 | Pubmed ID: 27858266
Dataset of tear film cytokine levels in dry eye disease (DED) patients with and without HIV infection.
Data in brief Feb, 2017 | Pubmed ID: 27942559
Lower Vitamin D Level and Distinct Tear Cytokine Profile Were Observed in Patients with Mild Dry Eye Signs but Exaggerated Symptoms.
Translational vision science & technology Dec, 2016 | Pubmed ID: 27980879
Efficient Whole-body Transduction with Trans-splicing Adeno-associated Viral Vectors.
Molecular therapy : the journal of the American Society of Gene Therapy Jun, 2007 | Pubmed ID: 28182924
Dataset of longitudinal analysis of tear cytokine levels, CD4, CD8 counts and HIV viral load in dry eye patients with HIV infection.
Data in brief Apr, 2017 | Pubmed ID: 28224132
Targeted AAV5-Smad7 gene therapy inhibits corneal scarring in vivo.
PloS one , 2017 | Pubmed ID: 28339457
In vivo confocal microscopy and tear cytokine analysis in post-LASIK ectasia.
The British journal of ophthalmology Apr, 2017 | Pubmed ID: 28450380
Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci.
Nature genetics 07, 2017 | Pubmed ID: 28553957
Biofluid lipidome: a source for potential diagnostic biomarkers.
Clinical and translational medicine Dec, 2017 | Pubmed ID: 28639235
Oxidative stress induces dysregulated autophagy in corneal epithelium of keratoconus patients.
PloS one , 2017 | Pubmed ID: 28902914
Martin H. M. Sailer1,
Durga Sarvepalli2,
Catherine Brégère3,
Urs Fisch3,
Marin Guentchev4,
Michael Weller6,
Raphael Guzman3,
Bernhard Bettler1,
Arkasubhra Ghosh*,2,
Gregor Hutter*,5
1Dept. of Biomedicine, Pharmacenter, University of Basel,
2Molecular Signalling and Gene Therapy, Narayana Nethralaya Foundation, Narayana Health City,
3Brain Ischemia and Regeneration, Department of Biomedicine, University Hospital Basel,
4Department of Neurosurgery, Klinikum Idar-Oberstein,
5Department of Neurosurgery and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University,
6Department of Neurology, Laboratory of Molecular Neuro Oncology, University Hospital of Zurich