Ryan Anderson

Antitumor activity of the novel vascular targeting agent ZD6126 in a panel of tumor models.

Total syntheses of angular [7]-, [8]-, and [9]phenylene by triple cobalt-catalyzed cycloisomerization: remarkably flexible heliphenes.

Chordin and noggin promote organizing centers of forebrain development in the mouse.

ZD6126: a novel small molecule vascular targeting agent.

Prevalence of anxiety in adults with diabetes: a systematic review.

Anxiety and poor glycemic control: a meta-analytic review of the literature.

ZD6474, an orally available inhibitor of KDR tyrosine kinase activity, efficiently blocks oncogenic RET kinases.

The role of chordin/Bmp signals in mammalian pharyngeal development and DiGeorge syndrome.

The mammalian twisted gastrulation gene functions in foregut and craniofacial development.

Acquired expression of periostin by human breast cancers promotes tumor angiogenesis through up-regulation of vascular endothelial growth factor receptor 2 expression.

Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway.

Single dose of the antivascular agent, ZD6126 (N-acetylcolchinol-O-phosphate), reduces perfusion for at least 96 hours in the GH3 prolactinoma rat tumor model.

Regulation of p27Kip1 protein levels contributes to mitogenic effects of the RET/PTC kinase in thyroid carcinoma cells.

Magnetic resonance imaging measurements of the response of murine and human tumors to the vascular-targeting agent ZD6126.

Disease associated mutations at valine 804 in the RET receptor tyrosine kinase confer resistance to selective kinase inhibitors.

ZD6474, a vascular endothelial growth factor receptor tyrosine kinase inhibitor with additional activity against epidermal growth factor receptor tyrosine kinase, inhibits orthotopic growth and angiogenesis of gastric cancer.

In vivo videomicroscopy reveals differential effects of the vascular-targeting agent ZD6126 and the anti-angiogenic agent ZD6474 on vascular function in a liver metastasis model.

Inhibition of SRC tyrosine kinase as treatment for human pancreatic cancer growing orthotopically in nude mice.

Effect of the tumor vascular-damaging agent, ZD6126, on the radioresponse of U87 glioblastoma.

Potential antagonism of tubulin-binding anticancer agents in combination therapies.

Differential effects of vascular endothelial growth factor receptor-2 inhibitor ZD6474 on circulating endothelial progenitors and mature circulating endothelial cells: implications for use as a surrogate marker of antiangiogenic activity.

ZD6474 suppresses oncogenic RET isoforms in a Drosophila model for type 2 multiple endocrine neoplasia syndromes and papillary thyroid carcinoma.

Acute tumor response to ZD6126 assessed by intrinsic susceptibility magnetic resonance imaging.

Cooperative antitumor effect of multitargeted kinase inhibitor ZD6474 and ionizing radiation in glioblastoma.

Vascular targeting in pancreatic cancer: the novel tubulin-binding agent ZD6126 reveals antitumor activity in primary and metastatic tumor models.

ZD6474, a novel tyrosine kinase inhibitor of vascular endothelial growth factor receptor and epidermal growth factor receptor, inhibits tumor growth of multiple nervous system tumors.

A longitudinal study of R2* and R2 magnetic resonance imaging relaxation rate measurements in murine liver after a single administration of 3 different iron oxide-based contrast agents.

Vascular-targeting agents and radiation therapy in lung cancer: where do we stand in 2005?

Antitumor vascular strategy for controlling experimental metastatic spread of human small-cell lung cancer cells with ZD6474 in natural killer cell-depleted severe combined immunodeficient mice.

Tumour overexpression of inducible nitric oxide synthase (iNOS) increases angiogenesis and may modulate the anti-tumour effects of the vascular disrupting agent ZD6126.

ZD6474, an inhibitor of vascular endothelial growth factor receptor tyrosine kinase, inhibits growth of experimental lung metastasis and production of malignant pleural effusions in a non-small cell lung cancer model.

The response of RIF-1 fibrosarcomas to the vascular-disrupting agent ZD6126 assessed by in vivo and ex vivo 1H magnetic resonance spectroscopy.

Endogenous bone morphogenetic protein antagonists regulate mammalian neural crest generation and survival.

Vandetanib (ZD6474): an orally available receptor tyrosine kinase inhibitor that selectively targets pathways critical for tumor growth and angiogenesis.

Targeted therapy of orthotopic human lung cancer by combined vascular endothelial growth factor and epidermal growth factor receptor signaling blockade.

Conditional targeted cell ablation in zebrafish: a new tool for regeneration studies.

Antiangiogenic and antitumor activity of a novel vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor ZD6474 in a metastatic human pancreatic tumor model.

Correlation of MRI biomarkers with tumor necrosis in Hras5 tumor xenograft in athymic rats.

Susceptibility contrast magnetic resonance imaging determination of fractional tumor blood volume: a noninvasive imaging biomarker of response to the vascular disrupting agent ZD6126.

Targeted therapy against VEGFR and EGFR with ZD6474 enhances the therapeutic efficacy of irradiation in an orthotopic model of human non-small-cell lung cancer.

Alpha 2-macroglobulin binds CpG oligodeoxynucleotides and enhances their immunostimulatory properties by a receptor-dependent mechanism.

Effect of pretreatment with atenolol and nifedipine on ZD6126-induced cardiac toxicity in rats.

Potent antitumor effects of ZD6474 on neuroblastoma via dual targeting of tumor cells and tumor endothelium.

Dual inhibition of VEGFR and EGFR signaling reduces the incidence and size of intestinal adenomas in Apc(Min/+) mice.

Novel dual targeting strategy with vandetanib induces tumor cell apoptosis and inhibits angiogenesis in malignant pleural mesothelioma cells expressing RET oncogenic rearrangement.

Oxidase, superoxide dismutase, and hydrogen peroxide reductase activities of methanobactin from types I and II methanotrophs.

Conserved C-terminal motifs required for avirulence and suppression of cell death by Phytophthora sojae effector Avr1b.

Monitoring the effects of component structure and source on formulation stability and adjuvant activity of oil-in-water emulsions.

Nitroreductase-mediated cell/tissue ablation in zebrafish: a spatially and temporally controlled ablation method with applications in developmental and regeneration studies.

BMP antagonism is required in both the node and lateral plate mesoderm for mammalian left-right axis establishment.

In-plane photonic transduction of silicon-on-insulator microcantilevers.

Vascular endothelial growth factor receptor-1 contributes to resistance to anti-epidermal growth factor receptor drugs in human cancer cells.

Vandetanib inhibits growth of adenoid cystic carcinoma in an orthotopic nude mouse model.

Longitudinal in vivo susceptibility contrast MRI measurements of LS174T colorectal liver metastasis in nude mice.

Identification of tyrosine 806 as a molecular determinant of RET kinase sensitivity to ZD6474.

Transcriptional silencing and reactivation in transgenic zebrafish.

Baseline vascular endothelial growth factor concentration as a potential predictive marker of benefit from vandetanib in non-small cell lung cancer.

Investigation of a grating-based stretcher/compressor for carrier-envelope phase stabilized fs pulses.

Impact of tumor cell VEGF expression on the in vivo efficacy of vandetanib (ZACTIMA; ZD6474).

Loss of Dnmt1 catalytic activity reveals multiple roles for DNA methylation during pancreas development and regeneration.

Distinct populations of quiescent and proliferative pancreatic beta-cells identified by HOTcre mediated labeling.

Demonstration of microcantilever array with simultaneous readout using an in-plane photonic transduction method.

Physicochemical characterization and biological activity of synthetic TLR4 agonist formulations.

Targeting vascular endothelial growth factor receptor-1 and -3 with cediranib (AZD2171): effects on migration and invasion of gastrointestinal cancer cell lines.

Combination of vandetanib, radiotherapy, and irinotecan in the LoVo human colorectal cancer xenograft model.

The effects of vandetanib on paclitaxel tumor distribution and antitumor activity in a xenograft model of human ovarian carcinoma.

The impact of genome defense on mobile elements in Microbotryum.

DCE-MRI assessment of the effect of vandetanib on tumor vasculature in patients with advanced colorectal cancer and liver metastases: a randomized phase I study.

Distinct patterns of cytokine and angiogenic factor modulation and markers of benefit for vandetanib and/or chemotherapy in patients with non-small-cell lung cancer.

In-plane all-photonic transduction with differential splitter using double-step rib waveguide for photonic microcantilever arrays.

Antidepressant pharmacotherapy in adults with type 2 diabetes: rates and predictors of initial response.

Antitumor and antiangiogenic activity of cediranib in a preclinical model of renal cell carcinoma.

Roles of bone morphogenetic protein signaling and its antagonism in holoprosencephaly.

Sensitivity enhancement of differential splitter-based transduction for photonic microcantilever arrays.

Primary contribution to zebrafish heart regeneration by gata4(+) cardiomyocytes.

Role of early surgical decompression of the intradural space after cervical spinal cord injury in an animal model.

BMP antagonism protects Nodal signaling in the gastrula to promote the tissue interactions underlying mammalian forebrain and craniofacial patterning.

Vascular endothelial growth factor receptors VEGFR-2 and VEGFR-3 are localized primarily to the vasculature in human primary solid cancers.

Effects of vandetanib on adenoma formation in a dextran sodium sulphate enhanced Apc(MIN/+) mouse model.

Assessment of acute antivascular effects of vandetanib with high-resolution dynamic contrast-enhanced computed tomographic imaging in a human colon tumor xenograft model in the nude rat.

The tyrosine kinase inhibitor ZD6474 blocks proliferation of RET mutant medullary thyroid carcinoma cells.

Uhrf1 and Dnmt1 are required for development and maintenance of the zebrafish lens.

Signatures of adaptation to obligate biotrophy in the Hyaloperonospora arabidopsidis genome.

Criminal thinking patterns, aggression styles, and the psychopathic traits of late high school bullies and bully-victims.

Investigating temporal fluctuations in tumor vasculature with combined carbogen and ultrasmall superparamagnetic iron oxide particle (CUSPIO) imaging.

Propagation, storage, and assays with Hyaloperonospora arabidopsidis: A model oomycete pathogen of Arabidopsis.

Suppression of Ptf1a activity induces acinar-to-endocrine conversion.

Vandetanib inhibits both VEGFR-2 and EGFR signalling at clinically relevant drug levels in preclinical models of human cancer.

Transient deflection response in microcantilever array integrated with polydimethylsiloxane (PDMS) microfluidics.

Minimally invasive methods for bulbar urethral strictures: a survey of members of the American Urological Association.

Natural products reveal cancer cell dependence on oxysterol-binding proteins.

Vandetanib in patients with locally advanced or metastatic medullary thyroid cancer: a randomized, double-blind phase III trial.

Combined MEK and VEGFR inhibition in orthotopic human lung cancer models results in enhanced inhibition of tumor angiogenesis, growth, and metastasis.

Evaluation of novel combined carbogen USPIO (CUSPIO) imaging biomarkers in assessing the antiangiogenic effects of cediranib (AZD2171) in rat C6 gliomas.

A monocarboxylate transporter required for hepatocyte secretion of ketone bodies during fasting.

Predictors of clinical pain in fibromyalgia: examining the role of sleep.

OCRL localizes to the primary cilium: a new role for cilia in Lowe syndrome.

Adenosine signaling promotes regeneration of pancreatic β cells in vivo.

Homologous RXLR effectors from Hyaloperonospora arabidopsidis and Phytophthora sojae suppress immunity in distantly related plants.

Inhibition of Aurora-B kinase activity confers antitumor efficacy in preclinical mouse models of early and advanced gastrointestinal neoplasia.

Information management strategies within conversations about cigarette smoking: parenting correlates and longitudinal associations with teen smoking.

Loss of CDKN2B promotes p53-dependent smooth muscle cell apoptosis and aneurysm formation.

The ubiquitin ligase PUB22 targets a subunit of the exocyst complex required for PAMP-triggered responses in Arabidopsis.

Hedgehog signaling alters reliance on EGF receptor signaling and mediates anti-EGFR therapeutic resistance in head and neck cancer.

A patient tumor transplant model of squamous cell cancer identifies PI3K inhibitors as candidate therapeutics in defined molecular bins.

Anesthetic considerations for electrophysiologic procedures.

Crosstalk between the circadian clock and innate immunity in Arabidopsis.

Compensatory Role of Inositol 5-Phosphatase INPP5B to OCRL in Primary Cilia Formation in Oculocerebrorenal Syndrome of Lowe.

Evaluation of alpha-fetoprotein staging system for hepatocellular carcinoma in noncirrhotic patients.

Changes in signaling pathways induced by vandetanib in a human medullary thyroid carcinoma model, as analyzed by reverse phase protein array.

Isotope ratios of H, C, and O in CO2 and H2O of the martian atmosphere.

The dual pathway inhibitor rigosertib is effective in direct patient tumor xenografts of head and neck squamous cell carcinomas.

Disease-related growth factor and embryonic signaling pathways modulate an enhancer of TCF21 expression at the 6q23.2 coronary heart disease locus.

Hepatocyte growth factor signaling in intrapancreatic ductal cells drives pancreatic morphogenesis.

Neocortical pathological high-frequency oscillations are associated with frequency-dependent alterations in functional network topology.

Clinical evaluation of somatostatin use in pancreatic resections: Clinical efficacy or limited benefit?

Erlotinib, gefitinib, and vandetanib inhibit human nucleoside transporters and protect cancer cells from gemcitabine cytotoxicity.

Dynamic modulation of epileptic high frequency oscillations by the phase of slower cortical rhythms.

An integrated inspection of the somatic mutations in a lung squamous cell carcinoma using next-generation sequencing.

Changes in signaling pathways induced by vandetanib in a human medullary thyroid carcinoma model, as analyzed by reverse phase protein array.

Replication stress and chromatin context link ATM activation to a role in DNA replication.

Microfluidic Valves Made From Polymerized Polyethylene Glycol Diacrylate.

The exocyst subunit Exo70B1 is involved in the immune response of Arabidopsis thaliana to different pathogens and cell death.

Identification of an arylalkylamine N-acyltransferase from Drosophila melanogaster that catalyzes the formation of long-chain N-acylserotonins.

Phase I study of oral rigosertib (ON 01910.Na), a dual inhibitor of the PI3K and Plk1 pathways, in adult patients with advanced solid malignancies.

Women's values in contraceptive choice: a systematic review of relevant attributes included in decision aids.

Peering into the black box: a meta-analysis of how clinicians use decision aids during clinical encounters.

Short-course treatment with gefitinib enhances curative potential of radiation therapy in a mouse model of human non-small cell lung cancer.

Drosophila melanogaster as a model system to study long-chain fatty acid amide metabolism.

Quality of care and racial disparities in medicare among potential ACOs.

Effectiveness of the Chest Pain Choice decision aid in emergency department patients with low-risk chest pain: study protocol for a multicenter randomized trial.

I want what she's having: evidence of human mate copying.

Combining AKT inhibition with chloroquine and gefitinib prevents compensatory autophagy and induces cell death in EGFR mutated NSCLC cells.

Hedgehog signaling drives radioresistance and stroma-driven tumor repopulation in head and neck squamous cancers.

Dynamic changes of interictal post-spike slow waves toward seizure onset in focal cortical dysplasia type II.

ATM and ATR as therapeutic targets in cancer.

A PCR assay for the quantification of growth of the oomycete pathogen Hyaloperonospora arabidopsidis in Arabidopsis thaliana.

Glucagon is essential for alpha cell transdifferentiation and beta cell neogenesis.

Bandgap Tuning of Silicon Quantum Dots by Surface Functionalization with Conjugated Organic Groups.

Epidermal Growth Factor Receptor (EGFR) Pathway Biomarkers in the Randomized Phase III Trial of Erlotinib Versus Observation in Ovarian Cancer Patients with No Evidence of Disease Progression after First-Line Platinum-Based Chemotherapy.

Recent Progress in RXLR Effector Research.

Vascular endothelial growth factor directly stimulates tumour cell proliferation in non-small cell lung cancer.

Microfluidic reflow pumps.

Polyamine biosynthesis is critical for growth and differentiation of the pancreas.

Acute vascular response to cediranib treatment in human non-small-cell lung cancer xenografts with different tumour stromal architecture.

Cognitive-Motivational Influences on Health Behavior Change in Adults with Chronic Pain.

A Novel Procedure for Rapid Imaging of Adult Mouse Brains with MicroCT Using Iodine-Based Contrast.

The RZZ complex requires the N-terminus of KNL1 to mediate optimal Mad1 kinetochore localization in human cells.

Inhibiting WEE1 Selectively Kills Histone H3K36me3-Deficient Cancers by dNTP Starvation.

An insulin signaling feedback loop regulates pancreas progenitor cell differentiation during islet development and regeneration.

Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds.

Glycine N-acyltransferase-like 3 is responsible for long-chain N-acylglycine formation in N18TG2 cells.

Hypoxia Potentiates the Radiation-Sensitizing Effect of Olaparib in Human Non-Small Cell Lung Cancer Xenografts by Contextual Synthetic Lethality.

Erratum to: Epidermal Growth Factor Receptor (EGFR) Pathway Biomarkers in the Randomized Phase III Trial of Erlotinib Versus Observation in Ovarian Cancer Patients with No Evidence of Disease Progression after First-Line Platinum-Based Chemotherapy.

Finite element analysis of a pseudoelastic compression-generating intramedullary ankle arthrodesis nail.

Grazing Incidence Cross-Sectioning of Thin-Film Solar Cells via Cryogenic Focused Ion Beam: A Case Study on CIGSe.

Cognitive Dysfunction, Medication Management, and the Risk of Readmission in Hospital Inpatients.

Coordinating cardiomyocyte interactions to direct ventricular chamber morphogenesis.

Second Generation Modifiers of Colistin Resistance Show Enhanced Activity and Lower Inherent Toxicity.

Phenotypic consequences of somatic mutations in the ataxia-telangiectasia mutated gene in non-small cell lung cancer.

Pulmonary hypertension: evolution of pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension.