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Zilkha Neurogenetic Institute
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Regulation of betaAPP and PrPc cleavage by alpha-secretase: mechanistic and therapeutic perspectives.
Current Alzheimer research Apr, 2008 | Pubmed ID: 18393805
TMP21 regulates Abeta production but does not affect caspase-3, p53, and neprilysin.
Biochemical and biophysical research communications Jun, 2008 | Pubmed ID: 18405662
p53-dependent control of cell death by nicastrin: lack of requirement for presenilin-dependent gamma-secretase complex.
Journal of neurochemistry Apr, 2009 | Pubmed ID: 19187441
The alpha-secretase-derived N-terminal product of cellular prion, N1, displays neuroprotective function in vitro and in vivo.
The Journal of biological chemistry Dec, 2009 | Pubmed ID: 19850936
The extracellular regulated kinase-1 (ERK1) controls regulated alpha-secretase-mediated processing, promoter transactivation, and mRNA levels of the cellular prion protein.
The Journal of biological chemistry Aug, 2011 | Pubmed ID: 21586567
α-Secretase-derived fragment of cellular prion, N1, protects against monomeric and oligomeric amyloid β (Aβ)-associated cell death.
The Journal of biological chemistry Feb, 2012 | Pubmed ID: 22184125
Ferulic acid is a nutraceutical β-secretase modulator that improves behavioral impairment and alzheimer-like pathology in transgenic mice.
PloS one , 2013 | Pubmed ID: 23409038
Innate immunity in Alzheimer's disease: a complex affair.
CNS & neurological disorders drug targets Aug, 2013 | Pubmed ID: 23574177
Brain injury, neuroinflammation and Alzheimer's disease.
Frontiers in aging neuroscience , 2013 | Pubmed ID: 23874297
The role of the immune system in neurodegenerative disorders: Adaptive or maladaptive?
Brain research Aug, 2015 | Pubmed ID: 25218556
Il10 deficiency rebalances innate immunity to mitigate Alzheimer-like pathology.
Neuron Feb, 2015 | Pubmed ID: 25619654
Innate Immunity Fights Alzheimer's Disease.
Trends in neurosciences Nov, 2015 | Pubmed ID: 26549882
University of Southern California (USC)
Marie-Victoire Guillot-Sestier1,
Tara M. Weitz1,
Terrence Town1
1Zilkha Neurogenetic Institute, University of Southern California (USC)
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