Bioengineering
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Heterogeneous connexin43 expression produces electrophysiological heterogeneities across ventricular wall.
American journal of physiology. Heart and circulatory physiology May, 2004 | Pubmed ID: 14704225
Altered connexin43 expression produces arrhythmia substrate in heart failure.
American journal of physiology. Heart and circulatory physiology Oct, 2004 | Pubmed ID: 15205174
Nature, significance, and mechanisms of electrical heterogeneities in ventricle.
The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology Oct, 2004 | Pubmed ID: 15368342
Transmural conduction is not a two-way street.
Journal of cardiovascular electrophysiology Apr, 2005 | Pubmed ID: 15828895
Optical measurements reveal nature of intercellular coupling across ventricular wall.
American journal of physiology. Heart and circulatory physiology Oct, 2005 | Pubmed ID: 15863452
IKs blockade reduces dispersion of repolarization in heart failure.
Heart rhythm : the official journal of the Heart Rhythm Society Jul, 2005 | Pubmed ID: 15992730
Cellular mechanisms of Torsade de Pointes.
Novartis Foundation symposium , 2005 | Pubmed ID: 16050270
SCN5A polymorphism restores trafficking of a Brugada syndrome mutation on a separate gene.
Circulation Aug, 2006 | Pubmed ID: 16864729
Heterogeneous ventricular chamber response to hypokalemia and inward rectifier potassium channel blockade underlies bifurcated T wave in guinea pig.
American journal of physiology. Heart and circulatory physiology Jun, 2007 | Pubmed ID: 17307991
Mechanisms underlying increased right ventricular conduction sensitivity to flecainide challenge.
Cardiovascular research Mar, 2008 | Pubmed ID: 18056761
Novel x-ray attenuation mechanism: role of interatomic distance.
Medical physics Oct, 2008 | Pubmed ID: 18975684
Are electrophysiologically distinct M-cells a characteristic of the wedge preparation?
Heart rhythm : the official journal of the Heart Rhythm Society Jul, 2009 | Pubmed ID: 19497787
The modulated dispersion hypothesis confirmed in humans.
Circulation. Arrhythmia and electrophysiology Apr, 2009 | Pubmed ID: 19808452
Status epilepticus induces cardiac myofilament damage and increased susceptibility to arrhythmias in rats.
American journal of physiology. Heart and circulatory physiology Dec, 2009 | Pubmed ID: 19820194
Gap junction heterogeneity as mechanism for electrophysiologically distinct properties across the ventricular wall.
American journal of physiology. Heart and circulatory physiology Mar, 2010 | Pubmed ID: 20035026
Pharmacological activation of IKr impairs conduction in guinea pig hearts.
Journal of cardiovascular electrophysiology Aug, 2010 | Pubmed ID: 20163495
Cytosolic calcium accumulation and delayed repolarization associated with ventricular arrhythmias in a guinea pig model of Andersen-Tawil syndrome.
Heart rhythm : the official journal of the Heart Rhythm Society Oct, 2010 | Pubmed ID: 20380896
NCX is an important determinant for premature ventricular activity in a drug-induced model of Andersen-Tawil syndrome.
Cardiovascular research Oct, 2011 | Pubmed ID: 21697145
A novel strategy using cardiac sodium channel polymorphic fragments to rescue trafficking-deficient SCN5A mutations.
Circulation. Cardiovascular genetics Oct, 2011 | Pubmed ID: 21840964
Interstitial volume modulates the conduction velocity-gap junction relationship.
American journal of physiology. Heart and circulatory physiology Jan, 2012 | Pubmed ID: 22021331
The perinexus: sign-post on the path to a new model of cardiac conduction?
Trends in cardiovascular medicine Aug, 2013 | Pubmed ID: 23490883
Combined inhibition of Na⁺ and Ca²⁺ channels: a novel paradigm for the treatment of incessant ventricular arrhythmias in Andersen-Tawil syndrome.
Heart rhythm Feb, 2014 | Pubmed ID: 24211314
Mechanisms of cardiac conduction: a history of revisions.
American journal of physiology. Heart and circulatory physiology Mar, 2014 | Pubmed ID: 24414064
Old cogs, new tricks: a scaffolding role for connexin43 and a junctional role for sodium channels?
FEBS letters Apr, 2014 | Pubmed ID: 24486012
Intercellular electrical communication in the heart: a new, active role for the intercalated disk.
Cell communication & adhesion Jun, 2014 | Pubmed ID: 24735129
Novel ligands for zipping and unzipping the intercalated disk: today's experimental tools, tomorrow's therapies?
Cardiovascular research Nov, 2014 | Pubmed ID: 25280893
Sex differences in β-adrenergic responsiveness of action potentials and intracellular calcium handling in isolated rabbit hearts.
PloS one , 2014 | Pubmed ID: 25340795
Moving beyond the reductionist approach-Time to put the pieces back together in a broken (infarcted) heart.
Heart rhythm Jan, 2015 | Pubmed ID: 25446156
Neuronal Na+ channel blockade suppresses arrhythmogenic diastolic Ca2+ release.
Cardiovascular research Apr, 2015 | Pubmed ID: 25538156
Sodium channels in the Cx43 gap junction perinexus may constitute a cardiac ephapse: an experimental and modeling study.
Pflugers Archiv : European journal of physiology Oct, 2015 | Pubmed ID: 25578859
Distinguishing between overdrive excited and suppressed ventricular beats in guinea pig ventricular myocardium.
Frontiers in physiology , 2015 | Pubmed ID: 25741282
Extracellular sodium and potassium levels modulate cardiac conduction in mice heterozygous null for the Connexin43 gene.
Pflugers Archiv : European journal of physiology Nov, 2015 | Pubmed ID: 25771952
Visualizing virus particle mobility in liquid at the nanoscale.
Chemical communications (Cambridge, England) Nov, 2015 | Pubmed ID: 26355472
Orientation dependence of microcirculation-induced diffusion signal in anisotropic tissues.
Magnetic resonance in medicine 10, 2016 | Pubmed ID: 26511215
Temporal response of ectopic activity in guinea pig ventricular myocardium in response to isoproterenol and acetylcholine.
Frontiers in physiology , 2015 | Pubmed ID: 26539122
Cardiac conduction in isolated hearts of genetically modified mice--Connexin43 and salts.
Progress in biophysics and molecular biology Jan, 2016 | Pubmed ID: 26627143
Heart Rate and Extracellular Sodium and Potassium Modulation of Gap Junction Mediated Conduction in Guinea Pigs.
Frontiers in physiology , 2016 | Pubmed ID: 26869934
Extracellular sodium dependence of the conduction velocity-calcium relationship: evidence of ephaptic self-attenuation.
American journal of physiology. Heart and circulatory physiology 05, 2016 | Pubmed ID: 26945081
Potassium channels in the Cx43 gap junction perinexus modulate ephaptic coupling: an experimental and modeling study.
Pflugers Archiv : European journal of physiology 10, 2016 | Pubmed ID: 27510622
Electrophysiologic effects of the IK1 inhibitor PA-6 are modulated by extracellular potassium in isolated guinea pig hearts.
Physiological reports Jan, 2017 | Pubmed ID: 28087819
Revealing the Concealed Nature of Long-QT Type 3 Syndrome.
Circulation. Arrhythmia and electrophysiology Feb, 2017 | Pubmed ID: 28213505
TNFα Modulates Cardiac Conduction by Altering Electrical Coupling between Myocytes.
Frontiers in physiology , 2017 | Pubmed ID: 28588504
Design and validation of a tissue bath 3-D printed with PLA for optically mapping suspended whole heart preparations.
American journal of physiology. Heart and circulatory physiology Dec, 2017 | Pubmed ID: 28939646
Whole-exome sequencing reveals microsatellite DNA markers for response to dofetilide initiation in patients with persistent atrial fibrillation: A pilot study.
Clinical cardiology Jun, 2018 | Pubmed ID: 29671888
Intercalated Disk Extracellular Nanodomain Expansion in Patients With Atrial Fibrillation.
Frontiers in physiology , 2018 | Pubmed ID: 29780324
The adhesion function of the sodium channel beta subunit (β1) contributes to cardiac action potential propagation.
eLife Aug, 2018 | Pubmed ID: 30106376
The role of the gap junction perinexus in cardiac conduction: Potential as a novel anti-arrhythmic drug target.
Progress in biophysics and molecular biology Sep, 2018 | Pubmed ID: 30241906