Gordon Tomaselli

Phenotypic differences in transient outward K+ current of human and canine ventricular myocytes: insights into molecular composition of ventricular Ito.

ACC/AHA/ESC guidelines for the management of patients with supraventricular arrhythmias--executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Develop Guidelines for the Management of Patients With Supraventricular Arrhythmias).

ACC/AHA/ESC guidelines for the management of patients with supraventricular arrhythmias--executive summary. a report of the American college of cardiology/American heart association task force on practice guidelines and the European society of cardiology committee for practice guidelines (writing committee to develop guidelines for the management of patients with supraventricular arrhythmias) developed in collaboration with NASPE-Heart Rhythm Society.

Gene expression profiles in end-stage human idiopathic dilated cardiomyopathy: altered expression of apoptotic and cytoskeletal genes.

Using the deadly mu-conotoxins as probes of voltage-gated sodium channels.

Mechanisms underlying conduction slowing and arrhythmogenesis in nonischemic dilated cardiomyopathy.

What causes sudden death in heart failure?

Temporal repolarization lability differences among genotyped patients with the long QT syndrome.

In vivo cardiac gene transfer of Kv4.3 abrogates the hypertrophic response in rats after aortic stenosis.

Functional integration of electrically active cardiac derivatives from genetically engineered human embryonic stem cells with quiescent recipient ventricular cardiomyocytes: insights into the development of cell-based pacemakers.

Molecular correlates of altered expression of potassium currents in failing rabbit myocardium.

A multifunctional aromatic residue in the external pore vestibule of Na+ channels contributes to the local anesthetic receptor.

Molecular mechanisms underlying K+ current downregulation in canine tachycardia-induced heart failure.

Gene expression analysis of ischemic and nonischemic cardiomyopathy: shared and distinct genes in the development of heart failure.

Abnormal conduction and repolarization in late-activated myocardium of dyssynchronously contracting hearts.

Ventricularization of atrial gene expression in the fibrillating heart?

Ion channels as novel therapeutic targets in heart failure.

Drugs effects on ventricular repolarization: a critical evaluation of the strengths and weaknesses of current methodologies and regulatory practices.

Gene expression in giant cell myocarditis: Altered expression of immune response genes.

Transmural heterogeneity of Na+-Ca2+ exchange: evidence for differential expression in normal and failing hearts.

Non-equilibrium behavior of HCN channels: insights into the role of HCN channels in native and engineered pacemakers.

Clinical prediction of cavotricuspid isthmus dependence in patients referred for catheter ablation of "typical" atrial flutter.

Conduction abnormalities in nonischemic dilated cardiomyopathy: basic mechanisms and arrhythmic consequences.

Molecular basis of arrhythmias.

Transcriptomic profiling of the canine tachycardia-induced heart failure model: global comparison to human and murine heart failure.

Predictors of appropriate implantable defibrillator therapies in patients with arrhythmogenic right ventricular dysplasia.

Magnetic resonance assessment of the substrate for inducible ventricular tachycardia in nonischemic cardiomyopathy.

The mitochondrial origin of postischemic arrhythmias.

A conserved ring of charge in mammalian Na+ channels: a molecular regulator of the outer pore conformation during slow inactivation.

Bioartificial sinus node constructed via in vivo gene transfer of an engineered pacemaker HCN Channel reduces the dependence on electronic pacemaker in a sick-sinus syndrome model.

Cellular and molecular determinants of altered Ca2+ handling in the failing rabbit heart: primary defects in SR Ca2+ uptake and release mechanisms.

A failure to adapt: ankyrins in congenital and acquired arrhythmias.

Infarct tissue heterogeneity by magnetic resonance imaging identifies enhanced cardiac arrhythmia susceptibility in patients with left ventricular dysfunction.

Dynamic changes in conduction velocity and gap junction properties during development of pacing-induced heart failure.

Evidence for electrical remodeling of the native conduction system with cardiac resynchronization therapy.

Inappropriate implantable cardioverter-defibrillator discharge associated with a new ventricular tachycardia treatment algorithm.

Enhanced infarct border zone function and altered mechanical activation predict inducibility of monomorphic ventricular tachycardia in patients with ischemic cardiomyopathy.

Task force 7: training in cardiovascular research.

Calmodulin regulation of Nav1.4 current: role of binding to the carboxyl terminus.

Reversal of global apoptosis and regional stress kinase activation by cardiac resynchronization.

Mechanisms of disease: ion channel remodeling in the failing ventricle.

Troponin-I elevation in a young man with arrhythmogenic right ventricular dysplasia/cardiomyopathy.

LQTS: better with age?

The year in arrhythmias--2007: Part I.

The year in arrhythmias 2007: Part II.

Late gadolinium enhancement by cardiovascular magnetic resonance heralds an adverse prognosis in nonischemic cardiomyopathy.

Post-transcriptional gene silencing of KChIP2 and Navbeta1 in neonatal rat cardiac myocytes reveals a functional association between Na and Ito currents.

Tissue sodium concentration in myocardial infarction in humans: a quantitative 23Na MR imaging study.

Key pathways associated with heart failure development revealed by gene networks correlated with cardiac remodeling.

Deciphering gene expression profiling in cardiac resynchronization therapy.

Profound hypotension due to slow atrioventricular nodal pathway conduction during atrial tachycardia.

Genetic variations in nitric oxide synthase 1 adaptor protein are associated with sudden cardiac death in US white community-based populations.

Electrophysiological consequences of dyssynchronous heart failure and its restoration by resynchronization therapy.

Mechanisms of enhanced beta-adrenergic reserve from cardiac resynchronization therapy.

Calcium-mediated dual-mode regulation of cardiac sodium channel gating.

Cardiac magnetic resonance assessment of dyssynchrony and myocardial scar predicts function class improvement following cardiac resynchronization therapy.

Ibutilide-induced changes in the temporal lability of ventricular repolarization in patients with and without structural heart disease.

Novel molecular determinants in the pore region of sodium channels regulate local anesthetic binding.

Mechanisms of gap junction traffic in health and disease.

Na+ channel regulation by Ca2+/calmodulin and Ca2+/calmodulin-dependent protein kinase II in guinea-pig ventricular myocytes.

ECG quantification of myocardial scar in cardiomyopathy patients with or without conduction defects: correlation with cardiac magnetic resonance and arrhythmogenesis.

Cardiac metabolism and arrhythmias.

The future of fellowship training in clinical cardiac electrophysiology: Program directors' perspective 2008.

Electrical remodeling in the failing heart.

Cyclic GMP/PKG-dependent inhibition of TRPC6 channel activity and expression negatively regulates cardiomyocyte NFAT activation Novel mechanism of cardiac stress modulation by PDE5 inhibition.

Cardiac I(to), KCNE2, and Brugada syndrome: promiscuous subunit interactions, or what happens in HEK cells stays in HEK cells?

Cardiac resynchronization therapy corrects dyssynchrony-induced regional gene expression changes on a genomic level.

Oxidant stress derails the cardiac connexon connection.

Defining and setting national goals for cardiovascular health promotion and disease reduction: the American Heart Association's strategic Impact Goal through 2020 and beyond.

Modulation of mitochondrial proteome and improved mitochondrial function by biventricular pacing of dyssynchronous failing hearts.

Ultrastructure and regulation of lateralized connexin43 in the failing heart.

The year in arrhythmias--2009: part I.

The year in arrhythmias-2009 part II.

Two-photon laser scanning microscopy of the transverse-axial tubule system in ventricular cardiomyocytes from failing and non-failing human hearts.

Reciprocal regulation of metabolic and signaling pathways.

Genome-wide association study identifies GPC5 as a novel genetic locus protective against sudden cardiac arrest.

Pacing-induced remodeling of the ventricle: fire in the matrix.

Dual antiplatelet therapy and heparin "bridging" significantly increase the risk of bleeding complications after pacemaker or implantable cardioverter-defibrillator device implantation.

Sudden cardio arrest: oxidative stress irritates the heart.

QRS prolongation in myotonic muscular dystrophy and diffuse fibrosis on cardiac magnetic resonance.

Beat-to-beat three-dimensional ECG variability predicts ventricular arrhythmia in ICD recipients.

Ventricular arrhythmia is predicted by sum absolute QRST integralbut not by QRS width.

Clinical predictors of conduction disease progression in type I myotonic muscular dystrophy.

Cell-based therapy of cardiac arrhythmias: designer cables and Zeno's paradox.

ACCF/ACG/AHA 2010 Expert Consensus Document on the concomitant use of proton pump inhibitors and thienopyridines: a focused update of the ACCF/ACG/AHA 2008 expert consensus document on reducing the gastrointestinal risks of antiplatelet therapy and NSAID use: a report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents.

Appropriate and inappropriate electrical therapies delivered by an implantable cardioverter-defibrillator: effect on intracardiac electrogram.

A new electrocardiogram marker to identify patients at low risk for ventricular tachyarrhythmias: sum magnitude of the absolute QRST integral.

Hospital certification for optimizing cardiovascular disease and stroke quality of care and outcomes.

ACCF/ACG/AHA 2010 expert consensus document on the concomitant use of proton pump inhibitors and thienopyridines: a focused update of the ACCF/ACG/AHA 2008 expert consensus document on reducing the gastrointestinal risks of antiplatelet therapy and NSAID use. A Report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents.

ACCF/ACG/AHA 2010 expert consensus document on the concomitant use of proton pump inhibitors and thienopyridines: a focused update of the ACCF/ACG/AHA 2008 expert consensus document on reducing the gastrointestinal risks of antiplatelet therapy and NSAID use.

Continuation of warfarin during pacemaker or implantable cardioverter-defibrillator implantation: a randomized clinical trial.

Coffee, alcohol, smoking, physical activity and QT interval duration: results from the Third National Health and Nutrition Examination Survey.

End-stage renal disease predicts complications in pacemaker and ICD implants.

Gaps in the ablation line as a potential cause of recovery from electrical isolation and their visualization using MRI.

Serum 25-hydroxyvitamin D, calcium, phosphorus, and electrocardiographic QT interval duration: findings from NHANES III and ARIC.

Electrocardiographic QT interval and mortality: a meta-analysis.

Identification of a sudden cardiac death susceptibility locus at 2q24.2 through genome-wide association in European ancestry individuals.

Influence of atrial function and mechanical synchrony on LV hemodynamic status in heart failure patients on resynchronization therapy.

Sex-steroid hormones and electrocardiographic QT-interval duration: findings from the third National Health and Nutrition Examination Survey and the Multi-Ethnic Study of Atherosclerosis.

Reciprocal transcriptional regulation of metabolic and signaling pathways correlates with disease severity in heart failure.

Speaking with one voice on worksite wellness: the American Cancer Society, the American Diabetes Association, and the American Heart Association.

The American Heart Association and the Million Hearts Initiative: a presidential advisory from the American Heart Association.

Galphas-biased beta2-adrenergic receptor signaling from restoring synchronous contraction in the failing heart.

QT-interval duration and mortality rate: results from the Third National Health and Nutrition Examination Survey.

Referral, enrollment, and delivery of cardiac rehabilitation/secondary prevention programs at clinical centers and beyond: a presidential advisory from the American Heart Association.

Prevention of cardiovascular disease and stroke: meeting the challenge.

Impact through discovery: a global challenge: Presidential Address at the American Heart Association 2011 Scientific Sessions.

Subcellular structures and function of myocytes impaired during heart failure are restored by cardiac resynchronization therapy.

Combined Cardiac MRI and C-Reactive Protein Levels Identify a Cohort at Low Risk for Defibrillator Firings and Death.

Electrical remodeling in dyssynchrony and resynchronization.

Transcriptome, proteome, and metabolome in dyssynchronous heart failure and CRT.

Letter by Tomaselli and Holmes regarding article, "2011 ASA/ACCF/AHA/AANN/AANS/ACR/CNS/SAIP/SCAI/SIR/SNIS/SVM/SVS guideline on the management of patients with extracranial carotid and vertebral artery disease".

ACCF and AHA Presidents' Letter on MEDCAC.

Assessment of cardiac involvement in myotonic muscular dystrophy by T1 mapping on magnetic resonance imaging.

Basic science of cardiac resynchronization therapy: molecular and electrophysiological mechanisms.

Ruled by the clock.

Response to catecholamine stimulation of polymorphisms of the beta-1 and beta-2 adrenergic receptors.

Modulation of hERG potassium channel gating normalizes action potential duration prolonged by dysfunctional KCNQ1 potassium channel.

Intracardiac J-point elevation before the onset of polymorphic ventricular tachycardia and ventricular fibrillation in patients with an implantable cardioverter-defibrillator.

Usefulness of medical conferences.

Pathological role of serum- and glucocorticoid-regulated kinase 1 in adverse ventricular remodeling.

Complex assessment of the temporal lability of repolarization.

Predictors of high defibrillation threshold in the modern era.

Calcium and arrhythmias: ignore at your peril.

Myocardial structural associations with local electrograms: a study of postinfarct ventricular tachycardia pathophysiology and magnetic resonance-based noninvasive mapping.

Origins of medical innovation: the case of coronary artery stents.

ACCF/AHA clinical practice guideline methodology summit report: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines.

ACCF/AHA clinical practice guideline methodology summit report: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines.

Cardiac MRI scar patterns differ by sex in an implantable cardioverter-defibrillator and cardiac resynchronization therapy cohort.

Associations between NOS1AP single nucleotide polymorphisms (SNPs) and QT interval duration in four racial/ethnic groups in the Multi-Ethnic Study of Atherosclerosis (MESA).

Significance of Leukocytosis After Cardiac Device Implantation.

Prospective observational study of implantable cardioverter-defibrillators in primary prevention of sudden cardiac death: study design and cohort description.

Localization of myocardial scar in patients with cardiomyopathy and left bundle branch block using electrocardiographic Selvester QRS scoring.

Thyroid hormones and electrocardiographic parameters: findings from the third national health and nutrition examination survey.

Cardiac resynchronization therapy improves altered Na channel gating in canine model of dyssynchronous heart failure.

Dynamic analysis of cardiac rhythms for discriminating atrial fibrillation from lethal ventricular arrhythmias.

Right, but not left, bundle branch block is associated with large anteroseptal scar.

Left ventricular mechanical dyssynchrony by cardiac magnetic resonance is greater in patients with strict vs nonstrict electrocardiogram criteria for left bundle-branch block.

Executive summary: HRS/EHRA/APHRS expert consensus statement on the diagnosis and management of patients with inherited primary arrhythmia syndromes.

Executive summary: HRS/EHRA/APHRS expert consensus statement on the diagnosis and management of patients with inherited primary arrhythmia syndromes.

HRS/EHRA/APHRS expert consensus statement on the diagnosis and management of patients with inherited primary arrhythmia syndromes: document endorsed by HRS, EHRA, and APHRS in May 2013 and by ACCF, AHA, PACES, and AEPC in June 2013.

Mechanistic basis of excitation-contraction coupling in human pluripotent stem cell-derived ventricular cardiomyocytes revealed by Ca2+ spark characteristics: direct evidence of functional Ca2+-induced Ca2+ release.

2013 AHA/ACC guideline on lifestyle management to reduce cardiovascular risk: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines.

2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines.

2013 AHA/ACC/TOS guideline for the management of overweight and obesity in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and The Obesity Society.

2013 ACC/AHA guideline on the assessment of cardiovascular risk: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines.

Impact of nonischemic scar features on local ventricular electrograms and scar-related ventricular tachycardia circuits in patients with nonischemic cardiomyopathy.

Mechanisms of a human skeletal myotonia produced by mutation in the C-terminus of NaV1.4: is Ca2+ regulation defective?

Desmin modifications associate with amyloid-like oligomers deposition in heart failure.

Risk stratification for sudden cardiac death: a plan for the future.

A 14-3-3 mode-1 binding motif initiates gap junction internalization during acute cardiac ischemia.

Remodeling of the sarcomeric cytoskeleton in cardiac ventricular myocytes during heart failure and after cardiac resynchronization therapy.

Comparison of the relation between left ventricular anatomy and QRS duration in patients with cardiomyopathy with versus without left bundle branch block.

Phosphodiesterase 5 inhibition ameliorates angiontensin II-induced podocyte dysmotility via the protein kinase G-mediated downregulation of TRPC6 activity.

Outcomes in African Americans undergoing cardioverter-defibrillator implantation for primary prevention of sudden cardiac death: findings from the Prospective Observational Study of Implantable Cardioverter-Defibrillators (PROSE-ICD).

A mutation causing Brugada syndrome identifies a mechanism for altered autonomic and oxidant regulation of cardiac sodium currents.

An enhancer polymorphism at the cardiomyocyte intercalated disc protein NOS1AP locus is a major regulator of the QT interval.

Incidental findings on cardiac computed tomography in incident hemodialysis patients: the predictors of arrhythmic and cardiovascular events in end-stage renal disease (PACE) study.

The consequences of contracting early and often.

Protein biomarkers identify patients unlikely to benefit from primary prevention implantable cardioverter defibrillators: findings from the Prospective Observational Study of Implantable Cardioverter Defibrillators (PROSE-ICD).

Regulation of the NaV1.5 cytoplasmic domain by calmodulin.

Clinical and serum-based markers are associated with death within 1 year of de novo implant in primary prevention ICD recipients.

Constitutive BDNF/TrkB signaling is required for normal cardiac contraction and relaxation.

Coins of the realm in atrioventricular junction development.

Cardiac resynchronization therapy restores sympathovagal balance in the failing heart by differential remodeling of cholinergic signaling.

Proteomic Analysis of Human Pluripotent Stem Cell-Derived, Fetal, and Adult Ventricular Cardiomyocytes Reveals Pathways Crucial for Cardiac Metabolism and Maturation.

Stem cell impregnated nanofiber stent sleeve for on-stent production and intravascular delivery of paracrine factors.

Rationale and design for the Predictors of Arrhythmic and Cardiovascular Risk in End Stage Renal Disease (PACE) study.

Association of common variations on chromosome 4q25 and left atrial volume in patients with atrial fibrillation.

Introduction to a compendium on sudden cardiac death: epidemiology, mechanisms, and management.

Clinical management and prevention of sudden cardiac death.

A rendezvous with the queen of ion channels: Three decades of ion channel research by David T Yue and his Calcium Signals Laboratory.

Predictors of mortality, LVAD implant, or heart transplant in primary prevention cardiac resynchronization therapy recipients: The HF-CRT score.

Calmodulin and Ca(2+) control of voltage gated Na(+) channels.

Changes in Follow-Up Left Ventricular Ejection Fraction Associated With Outcomes in Primary Prevention Implantable Cardioverter-Defibrillator and Cardiac Resynchronization Therapy Device Recipients.

Gene scanning and heart attack risk.

Cardiac Resynchronization Therapy Reduces Subcellular Heterogeneity of Ryanodine Receptors, T-Tubules, and Ca2+ Sparks Produced by Dyssynchronous Heart Failure.

Serum amine-based metabolites and their association with outcomes in primary prevention implantable cardioverter-defibrillator patients.

Baseline Troponin T Levels Modulate the Effects of ICD Shocks on All-Cause Mortality.

Orchestrated regulation of energy supply and energy expenditure: Transcriptional coexpression of metabolism, ion homeostasis, and sarcomeric genes in mammalian myocardium.

Ion Channel Diseases: an Update for 2016.

Association of Left Atrial Local Conduction Velocity With Late Gadolinium Enhancement on Cardiac Magnetic Resonance in Patients With Atrial Fibrillation.

Entropy of cardiac repolarization predicts ventricular arrhythmias and mortality in patients receiving an implantable cardioverter-defibrillator for primary prevention of sudden death.

Associations between scar characteristics by cardiac magnetic resonance and changes in left ventricular ejection fraction in primary prevention defibrillator recipients.

Electrophysiologic Substrate and Risk of Mortality in Incident Hemodialysis.

Cardiovascular implantable electronic device function and longevity at autopsy: an underestimated resource.

Serum-Based Oxylipins Are Associated with Outcomes in Primary Prevention Implantable Cardioverter Defibrillator Patients.

Clinical Inferences of Cardiovascular Implantable Electronic Device Analysis at Autopsy.

Kidney function and sudden cardiac death in the community: The Atherosclerosis Risk in Communities (ARIC) Study.

Non-cell autonomous cues for enhanced functionality of human embryonic stem cell-derived cardiomyocytes via maturation of sarcolemmal and mitochondrial KATP channels.

A Precision Medicine Approach to the Rescue of Function on Malignant Calmodulinopathic Long-QT Syndrome.

Left Ventricular Dysfunction and Conduction Disturbances in Patients With Myotonic Muscular Dystrophy Type I and II.

Multilevel analyses of SCN5A mutations in arrhythmogenic right ventricular dysplasia/cardiomyopathy suggest non-canonical mechanisms for disease pathogenesis.

Neonatal Transplantation Confers Maturation of PSC-Derived Cardiomyocytes Conducive to Modeling Cardiomyopathy.

Cdon deficiency causes cardiac remodeling through hyperactivation of WNT/β-catenin signaling.

Clinical decision tool for CRT-P vs. CRT-D implantation: Findings from PROSE-ICD.

Impaired left atrial function predicts inappropriate shocks in primary prevention implantable cardioverter-defibrillator candidates.

The Controversial Epidemiology of Left Ventricular Dysfunction in Patients With Myotonic Dystrophy Type 1-Reply.

Current management and clinical outcomes for catheter ablation of atrioventricular nodal re-entrant tachycardia.

Clinical recognition of pacemaker battery depletion and automatic reprogramming.