Heiko Lemcke

Design, synthesis, and bioactivity of putative tubulin ligands with adamantane core.

Novel derivatives of 1,3,4-oxadiazoles are potent mitostatic agents featuring strong microtubule depolymerizing activity in the sea urchin embryo and cell culture assays.

Synthesis and SAR requirements of adamantane-colchicine conjugates with both microtubule depolymerizing and tubulin clustering activities.

Neuronal differentiation requires a biphasic modulation of gap junctional intercellular communication caused by dynamic changes of connexin43 expression.

Unusual tubulin-clustering ability of specifically c7-modified colchicine analogues.

Involvement of connexin43 in the EGF/EGFR signalling during self-renewal and differentiation of neural progenitor cells.

Ca2+-mediated mitochondrial reactive oxygen species metabolism augments Wnt/β-catenin pathway activation to facilitate cell differentiation.

Spatio-temporal model of endogenous ROS and raft-dependent WNT/beta-catenin signaling driving cell fate commitment in human neural progenitor cells.

Gap junctional shuttling of miRNA--A novel pathway of intercellular gene regulation and its prospects in clinical application.

Non-viral magnetic engineering of endothelial cells with microRNA and plasmid-DNA-An optimized targeting approach.

Applying 3D-FRAP microscopy to analyse gap junction-dependent shuttling of small antisense RNAs between cardiomyocytes.

GMP-conformant on-site manufacturing of a CD133(+) stem cell product for cardiovascular regeneration.

Intramyocardial fate and effect of iron nanoparticles co-injected with MACS(®) purified stem cell products.

Data on the fate of MACS® MicroBeads intramyocardially co-injected with stem cell products.

Mechanisms of stem cell based cardiac repair-gap junctional signaling promotes the cardiac lineage specification of mesenchymal stem cells.

Cardiac Mesenchymal Stem Cells Proliferate Early in the Ischemic Heart.

Intramyocardial angiogenetic stem cells and epicardial erythropoietin save the acute ischemic heart.

Stem Cell Therapy in Heart Diseases - Cell Types, Mechanisms and Improvement Strategies.

Vimentin-Induced Cardiac Mesenchymal Stem Cells Proliferate in the Acute Ischemic Myocardium.

18F-FDG PET-Based Imaging of Myocardial Inflammation Predicts a Functional Outcome Following Transplantation of mESC-Derived Cardiac Induced Cells in a Mouse Model of Myocardial Infarction.

RNA-Based Strategies for Cardiac Reprogramming of Human Mesenchymal Stromal Cells.

SNX27 regulates DRA activity and mediates its direct recycling by PDZ-interaction in early endosomes at the apical pole of Caco2 cells.

Quantitative Evaluation of the Sarcomere Network of Human hiPSC-Derived Cardiomyocytes Using Single-Molecule Localization Microscopy.

[Ga]-NODAGA-RGD Positron Emission Tomography (PET) for Assessment of Post Myocardial Infarction Angiogenesis as a Predictor for Left Ventricular Remodeling in Mice after Cardiac Stem Cell Therapy.