Department of Biomedical Molecular Biology
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Smad4 induces the tumor suppressor E-cadherin and P-cadherin in colon carcinoma cells.
Oncogene Sep, 2002 | Pubmed ID: 12203117
Localization of the 17q breakpoint of a constitutional 1;17 translocation in a patient with neuroblastoma within a 25-kb segment located between the ACCN1 and TLK2 genes and near the distal breakpoints of two microdeletions in neurofibromatosis type 1 patients.
Genes, chromosomes & cancer Oct, 2002 | Pubmed ID: 12203774
Identification of excretory-secretory products of larval and adult Ostertagia ostertagi by immunoscreening of cDNA libraries.
Molecular and biochemical parasitology Feb, 2003 | Pubmed ID: 12615319
Functional and molecular characterization of the epithelioid to round transition in human colorectal cancer LoVo cells.
Oncogene Oct, 2003 | Pubmed ID: 14562048
Combined subtractive cDNA cloning and array CGH: an efficient approach for identification of overexpressed genes in DNA amplicons.
BMC genomics Feb, 2004 | Pubmed ID: 15018647
GATA-4 and MEF2C transcription factors control the tissue-specific expression of the alphaT-catenin gene CTNNA3.
Nucleic acids research , 2004 | Pubmed ID: 15302915
DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells.
Oncogene Mar, 2005 | Pubmed ID: 15674322
Unraveling signalling cascades for the Snail family of transcription factors.
Cellular signalling May, 2005 | Pubmed ID: 15683729
The transcription factor snail induces tumor cell invasion through modulation of the epithelial cell differentiation program.
Cancer research Jul, 2005 | Pubmed ID: 16024625
SIP1/ZEB2 induces EMT by repressing genes of different epithelial cell-cell junctions.
Nucleic acids research , 2005 | Pubmed ID: 16314317
Snail in the frame of malignant tumor recurrence.
Breast cancer research : BCR , 2006 | Pubmed ID: 16834762
A transient, EMT-linked loss of basement membranes indicates metastasis and poor survival in colorectal cancer.
Gastroenterology Sep, 2006 | Pubmed ID: 16952552
E-cadherin regulates human Nanos1, which interacts with p120ctn and induces tumor cell migration and invasion.
Cancer research Oct, 2006 | Pubmed ID: 17047063
VHL promotes E2 box-dependent E-cadherin transcription by HIF-mediated regulation of SIP1 and snail.
Molecular and cellular biology Jan, 2007 | Pubmed ID: 17060462
Direct repression of cyclin D1 by SIP1 attenuates cell cycle progression in cells undergoing an epithelial mesenchymal transition.
Molecular biology of the cell Nov, 2007 | Pubmed ID: 17855508
Pre-EMTing metastasis? Recapitulation of morphogenetic processes in cancer.
Clinical & experimental metastasis , 2007 | Pubmed ID: 17978854
Transforming growth factor-beta1-mediated Slug and Snail transcription factor up-regulation reduces the density of Langerhans cells in epithelial metaplasia by affecting E-cadherin expression.
The American journal of pathology May, 2008 | Pubmed ID: 18385519
A constitutional translocation t(1;17)(p36.2;q11.2) in a neuroblastoma patient disrupts the human NBPF1 and ACCN1 genes.
PloS one May, 2008 | Pubmed ID: 18493581
Molecular and pathological signatures of epithelial-mesenchymal transitions at the cancer invasion front.
Histochemistry and cell biology Sep, 2008 | Pubmed ID: 18648847
Efficient mouse transgenesis using Gateway-compatible ROSA26 locus targeting vectors and F1 hybrid ES cells.
Nucleic acids research Apr, 2009 | Pubmed ID: 19279185
Transforming growth factor-beta and mutant p53 conspire to induce metastasis by antagonizing p63: a (ternary) complex affair.
Breast cancer research : BCR , 2009 | Pubmed ID: 19664188
Alternatively activated macrophages engage in homotypic and heterotypic interactions through IL-4 and polyamine-induced E-cadherin/catenin complexes.
Blood Nov, 2009 | Pubmed ID: 19726720
The MCM-binding protein ETG1 aids sister chromatid cohesion required for postreplicative homologous recombination repair.
PLoS genetics Jan, 2010 | Pubmed ID: 20090939
Regulation of p63 isoforms by snail and slug transcription factors in human squamous cell carcinoma.
The American journal of pathology Apr, 2010 | Pubmed ID: 20150431
Module network inference from a cancer gene expression data set identifies microRNA regulated modules.
PloS one Apr, 2010 | Pubmed ID: 20418949
Involvement of members of the cadherin superfamily in cancer.
Cold Spring Harbor perspectives in biology Dec, 2009 | Pubmed ID: 20457567
Key signalling nodes in mammary gland development and cancer. The Snail1-Twist1 conspiracy in malignant breast cancer progression.
Breast cancer research : BCR , 2010 | Pubmed ID: 20594364
The EMT regulator Zeb2/Sip1 is essential for murine embryonic hematopoietic stem/progenitor cell differentiation and mobilization.
Blood May, 2011 | Pubmed ID: 21355089
Identification of putative cancer genes through data integration and comparative genomics between plants and humans.
Cellular and molecular life sciences : CMLS Jun, 2012 | Pubmed ID: 22218400
Evolutionary functional analysis and molecular regulation of the ZEB transcription factors.
Cellular and molecular life sciences : CMLS Aug, 2012 | Pubmed ID: 22349261
Concepts of metastasis in flux: the stromal progression model.
Seminars in cancer biology Jun, 2012 | Pubmed ID: 22374376
Gene expression profiling to dissect the complexity of cancer biology: pitfalls and promise.
Seminars in cancer biology Jun, 2012 | Pubmed ID: 22459768
Directed migration of cortical interneurons depends on the cell-autonomous action of Sip1.
Neuron Jan, 2013 | Pubmed ID: 23312517
Regulatory networks defining EMT during cancer initiation and progression.
Nature reviews. Cancer Feb, 2013 | Pubmed ID: 23344542
Interplay between KLF4 and ZEB2/SIP1 in the regulation of E-cadherin expression.
Biochemical and biophysical research communications Feb, 2013 | Pubmed ID: 23376074
Cadherins and epithelial-to-mesenchymal transition.
Progress in molecular biology and translational science , 2013 | Pubmed ID: 23481201
ZEB2-transgene expression in the epidermis compromises the integrity of the epidermal barrier through the repression of different tight junction proteins.
Cellular and molecular life sciences : CMLS Sep, 2014 | Pubmed ID: 24573695
Strategies for immortalization of primary hepatocytes.
Journal of hepatology Oct, 2014 | Pubmed ID: 24911463
Deregulation of the replisome factor MCMBP prompts oncogenesis in colorectal carcinomas through chromosomal instability.
Neoplasia (New York, N.Y.) Sep, 2014 | Pubmed ID: 25246271
Melanoma cells revive an embryonic transcriptional network to dictate phenotypic heterogeneity.
Frontiers in oncology , 2014 | Pubmed ID: 25538895
ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling.
Nature communications Jan, 2015 | Pubmed ID: 25565005
Snai1 regulates cell lineage allocation and stem cell maintenance in the mouse intestinal epithelium.
The EMBO journal May, 2015 | Pubmed ID: 25759216
Tumor-environment biomimetics delay peritoneal metastasis formation by deceiving and redirecting disseminated cancer cells.
Biomaterials Jun, 2015 | Pubmed ID: 25907048
NBPF1, a tumor suppressor candidate in neuroblastoma, exerts growth inhibitory effects by inducing a G1 cell cycle arrest.
BMC cancer May, 2015 | Pubmed ID: 25958384
Terminal NK cell maturation is controlled by concerted actions of T-bet and Zeb2 and is essential for melanoma rejection.
The Journal of experimental medicine Nov, 2015 | Pubmed ID: 26503444
Development and characterization of a new human hepatic cell line.
EXCLI journal , 2015 | Pubmed ID: 26869867
LIN28B is over-expressed in specific subtypes of pediatric leukemia and regulates lncRNA H19.
Haematologica Jun, 2016 | Pubmed ID: 26969084
Vaccination with Necroptotic Cancer Cells Induces Efficient Anti-tumor Immunity.
Cell reports Apr, 2016 | Pubmed ID: 27050509
The transcription factor Zeb2 regulates development of conventional and plasmacytoid DCs by repressing Id2.
The Journal of experimental medicine May, 2016 | Pubmed ID: 27185854
Tissue Factor Induced by Epithelial-Mesenchymal Transition Triggers a Procoagulant State That Drives Metastasis of Circulating Tumor Cells.
Cancer research Jul, 2016 | Pubmed ID: 27221703
p120 Catenin-Mediated Stabilization of E-Cadherin Is Essential for Primitive Endoderm Specification.
PLoS genetics Aug, 2016 | Pubmed ID: 27556156
Elevated ΔNp63α Levels Facilitate Epidermal and Biliary Oncogenic Transformation.
The Journal of investigative dermatology Feb, 2017 | Pubmed ID: 27725202
Zeb2 Regulates Cell Fate at the Exit from Epiblast State in Mouse Embryonic Stem Cells.
Stem cells (Dayton, Ohio) Mar, 2017 | Pubmed ID: 27739137
Oncogenic ZEB2 activation drives sensitivity toward KDM1A inhibition in T-cell acute lymphoblastic leukemia.
Blood Feb, 2017 | Pubmed ID: 28069602
EV-TRACK: transparent reporting and centralizing knowledge in extracellular vesicle research.
Nature methods Feb, 2017 | Pubmed ID: 28245209
Tim Pieters1,2,3,4,
Lieven Haenebalcke1,2,
Kenneth Bruneel1,2,4,
Niels Vandamme1,2,4,
Tino Hochepied1,2,
Jolanda van Hengel5,
Dagmar Wirth6,
Geert Berx1,2,4,
Jody J. Haigh7,
Frans van Roy1,2,4,
Steven Goossens1,2,3,4
1Department of Biomedical Molecular Biology, Ghent University,
2Inflammation Research Center, VIB,
3Center for Medical Genetics, Ghent University Hospital,
4, Cancer Research Institute Ghent (CRIG),
5Department of Basic Medical Sciences, Faculty of Medicine and Health Sciences, Ghent University,
6, Helmholtz Center for Infection Research,
7Mammalian Functional Genetics Laboratory, Division of Blood Cancers, Australian Centre for Blood Diseases, Department of Clinical Haematology, Monash University and Alfred Health Alfred Centre