Jeffrey Parvin

The BRCA1 and BARD1 association with the RNA polymerase II holoenzyme.

Creating a tool-kit for exploring BRCA1 function.

Overexpression of a protein fragment of RNA helicase A causes inhibition of endogenous BRCA1 function and defects in ploidy and cytokinesis in mammary epithelial cells.

The multiple nuclear functions of BRCA1: transcription, ubiquitination and DNA repair.

Transcription from the perspective of the DNA: twists and bumps in the road.

Elongation by RNA polymerase II on chromatin templates requires topoisomerase activity.

Phosphorylation of histone H2A inhibits transcription on chromatin templates.

Expression of an amino-terminal BRCA1 deletion mutant causes a dominant growth inhibition in MCF10A cells.

A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II.

Overview of history and progress in BRCA1 research: the first BRCA1 decade.

BRCA1-dependent ubiquitination of gamma-tubulin regulates centrosome number.

The tumor suppressor protein p53 functions similarly to p63 and p73 in activating transcription in vitro.

Direct DNA binding activity of the Fanconi anemia D2 protein.

Degradation of Cdt1 during S phase is Skp2-independent and is required for efficient progression of mammalian cells through S phase.

BRCA1/BARD1 ubiquitinate phosphorylated RNA polymerase II.

Centrosomal microtubule nucleation activity is inhibited by BRCA1-dependent ubiquitination.

Recruitment of ORC or CDC6 to DNA is sufficient to create an artificial origin of replication in mammalian cells.

Direct stimulation of transcription initiation by BRCA1 requires both its amino and carboxyl termini.

Substrates of the BRCA1-dependent ubiquitin ligase.

BRCA1 DNA-binding activity is stimulated by BARD1.

Identification of domains of BRCA1 critical for the ubiquitin-dependent inhibition of centrosome function.

Oncoprotein EWS-FLI1 activity is enhanced by RNA helicase A.

Centrosome function in normal and tumor cells.

Alpha-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity.

The BRCA1 E3 ubiquitin ligase controls centrosome dynamics.

A mechanism for transcriptional repression dependent on the BRCA1 E3 ubiquitin ligase.

BRCA1 control of steroid receptor ubiquitination.

Network modeling links breast cancer susceptibility and centrosome dysfunction.

Aurora-A kinase regulates breast cancer associated gene 1 inhibition of centrosome-dependent microtubule nucleation.

BRCA1 regulates gamma-tubulin binding to centrosomes.

Multiple mechanisms contribute to inhibit transcription in response to DNA damage.

Regulation of centrosomes by the BRCA1-dependent ubiquitin ligase.

The BRCA1-dependent ubiquitin ligase, gamma-tubulin, and centrosomes.

Comparative study on ChIP-seq data: normalization and binding pattern characterization.

Cdk1 participates in BRCA1-dependent S phase checkpoint control in response to DNA damage.

BRCA1/BARD1 E3 ubiquitin ligase can modify histones H2A and H2B in the nucleosome particle.

Identification of breast tumor mutations in BRCA1 that abolish its function in homologous DNA recombination.

BRCA1 represses amphiregulin gene expression.

PI 3 kinase related kinases-independent proteolysis of BRCA1 regulates Rad51 recruitment during genotoxic stress in human cells.

Enabling Data Analysis on High-Throughput Data in Large Data Depository Using Web-Based Analysis Platform - A Case Study on Integrating QUEST with GenePattern in Epigenetics Research.

Inference of hierarchical regulatory network of estrogen-dependent breast cancer through ChIP-based data.

Histone deacetylases 9 and 10 are required for homologous recombination.

Fanconi anemia protein FANCD2 inhibits TRF1 polyADP-ribosylation through tankyrase1-dependent manner.

Comparing multiple ChIP-sequencing experiments.

KIAA0101 interacts with BRCA1 and regulates centrosome number.

BRCA1 contributes to transcription-coupled repair of DNA damage through polyubiquitination and degradation of Cockayne syndrome B protein.