Department of Medicine,
Pulmonary and Critical Care Medicine,
Brigham and Women’s Hospital,
Department of Medicine, Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital
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Heme oxygenase/carbon monoxide signaling pathways: regulation and functional significance.
Molecular and cellular biochemistry May-Jun, 2002 | Pubmed ID: 12162441
Mitogen activated protein kinase (MAPK) pathway regulates heme oxygenase-1 gene expression by hypoxia in vascular cells.
Antioxidants & redox signaling Aug, 2002 | Pubmed ID: 12230870
Heme oxygenase-1: molecular mechanisms of gene expression in oxygen-related stress.
Antioxidants & redox signaling Aug, 2002 | Pubmed ID: 12230874
Necrotic cell death in response to oxidant stress involves the activation of the apoptogenic caspase-8/bid pathway.
The Journal of biological chemistry Aug, 2003 | Pubmed ID: 12754217
Heme oxygenase-1 and carbon monoxide in pulmonary medicine.
Respiratory research , 2003 | Pubmed ID: 12964953
Analysis of pulmonary heme oxygenase-1 and nitric oxide synthase alterations in experimental hepatopulmonary syndrome.
Gastroenterology Nov, 2003 | Pubmed ID: 14598260
Hepatocyte growth factor protects against hypoxia/reoxygenation-induced apoptosis in endothelial cells.
The Journal of biological chemistry Feb, 2004 | Pubmed ID: 14625309
Carbon monoxide in biology and medicine.
BioEssays : news and reviews in molecular, cellular and developmental biology Mar, 2004 | Pubmed ID: 14988928
Carbon monoxide: to boldly go where NO has gone before.
Science's STKE : signal transduction knowledge environment Apr, 2004 | Pubmed ID: 15114002
Caveolae compartmentalization of heme oxygenase-1 in endothelial cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Jul, 2004 | Pubmed ID: 15226268
Bcl-XL disrupts death-inducing signal complex formation in plasma membrane induced by hypoxia/reoxygenation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Dec, 2004 | Pubmed ID: 15576486
Heme oxygenase-1: redox regulation of a stress protein in lung and cell culture models.
Antioxidants & redox signaling Jan-Feb, 2005 | Pubmed ID: 15650398
FLIP protects against hypoxia/reoxygenation-induced endothelial cell apoptosis by inhibiting Bax activation.
Molecular and cellular biology Jun, 2005 | Pubmed ID: 15899875
Caveolin-1 expression by means of p38beta mitogen-activated protein kinase mediates the antiproliferative effect of carbon monoxide.
Proceedings of the National Academy of Sciences of the United States of America Aug, 2005 | Pubmed ID: 16051704
Heat shock protein-70 mediates the cytoprotective effect of carbon monoxide: involvement of p38 beta MAPK and heat shock factor-1.
Journal of immunology (Baltimore, Md. : 1950) Aug, 2005 | Pubmed ID: 16081837
CO as a cellular signaling molecule.
Annual review of pharmacology and toxicology , 2006 | Pubmed ID: 16402911
Therapeutic applications of carbon monoxide in lung disease.
Current opinion in pharmacology Jun, 2006 | Pubmed ID: 16580257
Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications.
Physiological reviews Apr, 2006 | Pubmed ID: 16601269
Carbon monoxide and bilirubin: potential therapies for pulmonary/vascular injury and disease.
American journal of respiratory cell and molecular biology Feb, 2007 | Pubmed ID: 16980550
Carbon monoxide differentially inhibits TLR signaling pathways by regulating ROS-induced trafficking of TLRs to lipid rafts.
The Journal of experimental medicine Oct, 2006 | Pubmed ID: 17000866
Mitochondrial localization and function of heme oxygenase-1 in cigarette smoke-induced cell death.
American journal of respiratory cell and molecular biology Apr, 2007 | Pubmed ID: 17079780
Mechanisms of cell death in oxidative stress.
Antioxidants & redox signaling Jan, 2007 | Pubmed ID: 17115887
Carbon monoxide protects against hyperoxia-induced endothelial cell apoptosis by inhibiting reactive oxygen species formation.
The Journal of biological chemistry Jan, 2007 | Pubmed ID: 17135272
Hemodynamic and molecular response to intermittent hypoxia (IH) versus continuous hypoxia (CH) in normal humans.
Translational research : the journal of laboratory and clinical medicine Feb, 2007 | Pubmed ID: 17240318
Cytoprotective and anti-inflammatory actions of carbon monoxide in organ injury and sepsis models.
Novartis Foundation symposium , 2007 | Pubmed ID: 17380794
FLIP inhibits endothelial cell apoptosis during hyperoxia by suppressing Bax.
Free radical biology & medicine May, 2007 | Pubmed ID: 17448907
Thioredoxin catalyzes the denitrosation of low-molecular mass and protein S-nitrosothiols.
Biochemistry Jul, 2007 | Pubmed ID: 17580965
Carbon monoxide in sepsis.
Antioxidants & redox signaling Nov, 2007 | Pubmed ID: 17822362
Protective functions of heme oxygenase-1 and carbon monoxide in the respiratory system.
Antioxidants & redox signaling Dec, 2007 | Pubmed ID: 17845132
Nitric oxide-deficiency regulates hepatic heme oxygenase-1.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society Feb, 2008 | Pubmed ID: 17999922
Functional significance of apoptosis in chronic obstructive pulmonary disease.
COPD Dec, 2007 | Pubmed ID: 18027162
Mitogen-activated protein kinases regulate susceptibility to ventilator-induced lung injury.
PloS one , 2008 | Pubmed ID: 18270588
Caveolin-1: a critical regulator of pulmonary vascular architecture and nitric oxide bioavailability in pulmonary hypertension.
American journal of physiology. Lung cellular and molecular physiology May, 2008 | Pubmed ID: 18296499
Deletion of caveolin-1 protects against oxidative lung injury via up-regulation of heme oxygenase-1.
American journal of respiratory cell and molecular biology Aug, 2008 | Pubmed ID: 18323531
Protein kinase C alpha and zeta differentially regulate death-inducing signaling complex formation in cigarette smoke extract-induced apoptosis.
Journal of immunology (Baltimore, Md. : 1950) Apr, 2008 | Pubmed ID: 18354190
Carbon monoxide protects against ventilator-induced lung injury via PPAR-gamma and inhibition of Egr-1.
American journal of respiratory and critical care medicine Jun, 2008 | Pubmed ID: 18356564
Inducing hypoxemia in healthy humans: a method for intermittently lowering arterial blood oxygenation during physiological studies.
Wilderness & environmental medicine , 2008 | Pubmed ID: 18715123
Autophagic proteins regulate cigarette smoke-induced apoptosis: protective role of heme oxygenase-1.
Autophagy Oct, 2008 | Pubmed ID: 18769149
Network analysis of temporal effects of intermittent and sustained hypoxia on rat lungs.
Physiological genomics Dec, 2008 | Pubmed ID: 18826996
Egr-1 regulates autophagy in cigarette smoke-induced chronic obstructive pulmonary disease.
PloS one , 2008 | Pubmed ID: 18830406
Identifying targets for COPD treatment through gene expression analyses.
International journal of chronic obstructive pulmonary disease , 2008 | Pubmed ID: 18990963
Autophagy in chronic obstructive pulmonary disease: homeostatic or pathogenic mechanism?
Autophagy Feb, 2009 | Pubmed ID: 19066468
Analyzing autophagy in clinical tissues of lung and vascular diseases.
Methods in enzymology , 2009 | Pubmed ID: 19216908
The heme oxygenase-1/carbon monoxide pathway suppresses TLR4 signaling by regulating the interaction of TLR4 with caveolin-1.
Journal of immunology (Baltimore, Md. : 1950) Mar, 2009 | Pubmed ID: 19265160
Carbon monoxide prevents ventilator-induced lung injury via caveolin-1.
Critical care medicine May, 2009 | Pubmed ID: 19325477
Heme oxygenase-1, a critical arbitrator of cell death pathways in lung injury and disease.
Free radical biology & medicine Jul, 2009 | Pubmed ID: 19362144
Heme oxygenase-1/carbon monoxide: from metabolism to molecular therapy.
American journal of respiratory cell and molecular biology Sep, 2009 | Pubmed ID: 19617398
Autophagy in the lung.
Proceedings of the American Thoracic Society Feb, 2010 | Pubmed ID: 20160144
Autophagy in vascular disease.
Proceedings of the American Thoracic Society Feb, 2010 | Pubmed ID: 20160147
Inhaled hydrogen sulfide protects against ventilator-induced lung injury.
Anesthesiology Jul, 2010 | Pubmed ID: 20574227
Heme oxygenase-1/carbon monoxide: novel therapeutic strategies in critical care medicine.
Current drug targets Dec, 2010 | Pubmed ID: 20704552
Evaluation of inhaled carbon monoxide as an anti-inflammatory therapy in a nonhuman primate model of lung inflammation.
American journal of physiology. Lung cellular and molecular physiology Dec, 2010 | Pubmed ID: 20729385
Autophagic protein LC3B confers resistance against hypoxia-induced pulmonary hypertension.
American journal of respiratory and critical care medicine Mar, 2011 | Pubmed ID: 20889906
Autophagy in cigarette smoke-induced chronic obstructive pulmonary disease.
Expert review of respiratory medicine Oct, 2010 | Pubmed ID: 20923337
Autophagy protein microtubule-associated protein 1 light chain-3B (LC3B) activates extrinsic apoptosis during cigarette smoke-induced emphysema.
Proceedings of the National Academy of Sciences of the United States of America Nov, 2010 | Pubmed ID: 20956295
Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome.
Nature immunology Mar, 2011 | Pubmed ID: 21151103
Deadly triplex: smoke, autophagy and apoptosis.
Autophagy Apr, 2011 | Pubmed ID: 21200154
Exhaled carbon monoxide as a biomarker of inflammatory lung disease.
Journal of breath research Dec, 2007 | Pubmed ID: 21383438
Special issue on carbon monoxide and exhaled biomarkers in human disease.
Journal of breath research Dec, 2010 | Pubmed ID: 21383483
Carbon monoxide activates autophagy via mitochondrial reactive oxygen species formation.
American journal of respiratory cell and molecular biology Oct, 2011 | Pubmed ID: 21441382
Carbon monoxide, a reaction product of heme oxygenase-1, suppresses the expression of C-reactive protein by endoplasmic reticulum stress through modulation of the unfolded protein response.
Molecular immunology Sep, 2011 | Pubmed ID: 21640381
Beclin 1 deficiency is associated with increased hypoxia-induced angiogenesis.
Autophagy Aug, 2011 | Pubmed ID: 21685724
Autophagy in pulmonary diseases.
Annual review of physiology Mar, 2012 | Pubmed ID: 22035347
Hyperoxia Induced LC3B Interacts with the Fas Apoptotic Pathway in Epithelial Cell Death.
American journal of respiratory cell and molecular biology Nov, 2011 | Pubmed ID: 22095627
Carbon monoxide inhibits Fas activating antibody-induced apoptosis in endothelial cells.
Medical gas research , 2011 | Pubmed ID: 22146483
Autophagy in inflammatory diseases.
International journal of cell biology , 2011 | Pubmed ID: 22190939
Heme Oxygenase-1/CO as Protective Mediators in Cigarette Smoke-Induced Lung Cell Injury and Chronic Obstructive Pulmonary Disease.
Current pharmaceutical biotechnology Sep, 2012 | Pubmed ID: 22201606
Statins and Pulmonary Fibrosis: The Potential Role of NLRP3 Inflammasome Activation.
American journal of respiratory and critical care medicine Jan, 2012 | Pubmed ID: 22246178
Pretreatment with carbon monoxide releasing molecules suppresses hepcidin expression during inflammation and endoplasmic reticulum stress through inhibition of the STAT3 and CREBH pathways.
Blood Jan, 2012 | Pubmed ID: 22262759
Autophagic proteins: New facets of the oxygen paradox.
Autophagy Mar, 2012 | Pubmed ID: 22302001
Ilias I. Siempos1,3,
Hilaire C. Lam1,
Yan Ding2,
Mary E. Choi2,
Augustine M. K. Choi1,
Stefan W. Ryter1
1Department of Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital,
2Department of Medicine, Renal Division, Brigham and Women's Hospital, Harvard Medical School,
3First Department of Critical Care Medicine and Pulmonary Services, University of Athens Medical School, Evangelismos Hospital, Athens, Greece