Department of Chemical Engineering,
Departments of Bioengineering
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Shear-induced endothelial NOS activation and remodeling via heparan sulfate, glypican-1, and syndecan-1.
Integrative biology : quantitative biosciences from nano to macro Mar, 2014 | Pubmed ID: 24480876
Endothelial glycocalyx conditions influence nanoparticle uptake for passive targeting.
International journal of nanomedicine , 2016 | Pubmed ID: 27499624
Targeted Delivery of Shear Stress-Inducible Micrornas by Nanoparticles to Prevent Vulnerable Atherosclerotic Lesions.
Methodist DeBakey cardiovascular journal Sep, 2016 | Pubmed ID: 27826369
Regeneration of glycocalyx by heparan sulfate and sphingosine 1-phosphate restores inter-endothelial communication.
PloS one , 2017 | Pubmed ID: 29023478
Glycocalyx in Atherosclerosis-Relevant Endothelium Function and as a Therapeutic Target.
Current atherosclerosis reports Nov, 2017 | Pubmed ID: 29127504
Pro-atherosclerotic disturbed flow disrupts caveolin-1 expression, localization, and function via glycocalyx degradation.
Journal of translational medicine Dec, 2018 | Pubmed ID: 30563532
Ultrasmall gold nanorods: synthesis and glycocalyx-related permeability in human endothelial cells.
International journal of nanomedicine , 2019 | Pubmed ID: 30697044
The comparative effects of high fat diet or disturbed blood flow on glycocalyx integrity and vascular inflammation.
Translational medicine communications , 2018 | Pubmed ID: 30957020
Endothelial barrier reinforcement relies on flow-regulated glycocalyx, a potential therapeutic target.
Biorheology , 2019 | Pubmed ID: 30988234
Metastatic cancer cell attachment to endothelium is promoted by endothelial glycocalyx sialic acid degradation.
AIChE journal. American Institute of Chemical Engineers Aug, 2019 | Pubmed ID: 31367063
Targeted Intravenous Nanoparticle Delivery: Role of Flow and Endothelial Glycocalyx Integrity.
Annals of biomedical engineering Jul, 2020 | Pubmed ID: 32072383
Flow-regulated endothelial glycocalyx determines metastatic cancer cell activity.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology May, 2020 | Pubmed ID: 32167209
Endothelial Glycocalyx-Mediated Intercellular Interactions: Mechanisms and Implications for Atherosclerosis and Cancer Metastasis.
Cardiovascular engineering and technology Feb, 2021 | Pubmed ID: 33000443
Blood-Brain Barrier Damage in Ischemic Stroke and Its Regulation by Endothelial Mechanotransduction.
Frontiers in physiology , 2020 | Pubmed ID: 33424628
Endothelial Dysfunction in Atherosclerotic Cardiovascular Diseases and Beyond: From Mechanism to Pharmacotherapies.
Pharmacological reviews Jul, 2021 | Pubmed ID: 34088867
Diosmin and its glycocalyx restorative and anti-inflammatory effects on injured blood vessels.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Dec, 2022 | Pubmed ID: 36315163
Developing a transwell millifluidic device for studying blood-brain barrier endothelium.
Lab on a chip Nov, 2022 | Pubmed ID: 36326069
Atherosclerosis and endothelial mechanotransduction: current knowledge and models for future research.
American journal of physiology. Cell physiology Feb, 2023 | Pubmed ID: 36440856
Endothelial glycocalyx sensitivity to chemical and mechanical sub-endothelial substrate properties.
Frontiers in bioengineering and biotechnology , 2023 | Pubmed ID: 38026846
Lack of Laminar Shear Stress Facilitates the Endothelial Uptake of Very Small Superparamagnetic Iron Oxide Nanoparticles by Modulating the Endothelial Surface Layer.
International journal of nanomedicine , 2024 | Pubmed ID: 38585474
Mechanisms of triple-negative breast cancer extravasation: Impact of the physical environment and endothelial glycocalyx.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Jul, 2024 | Pubmed ID: 38949120
Unraveling neurovascular mysteries: the role of endothelial glycocalyx dysfunction in Alzheimer's disease pathogenesis.
Frontiers in physiology , 2024 | Pubmed ID: 39027900
1Department of Chemical Engineering, Northeastern University,
2Nanomedicine Science and Technology Center, Northeastern University,
3Department of Physics, Northeastern University,
4Departments of Bioengineering, Northeastern University,
5Department of Neuroscience, Albert Einstein College of Medicine
Mohammad Hamrangsekachaee1,
Yu Chen1,
Emily R. Tressler2,
Sidi A. Bencherif1,2,3,4,
Eno E. Ebong1,2,5
1Chemical Engineering Department, Northeastern University,
2Bioengineering Department, Northeastern University,
3Laboratoire de BioMécanique et BioIngénierie (BMBI), UMR CNRS, Sorbonne Universités, Université de Technologie of Compiègne (UTC),
4Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University,
5Neuroscience Department, Albert Einstein College of Medicine