Laboratory of Virology and Chemotherapy,
Department of Microbiology and Immunology,
Rega Institute for Medical Research,
Laboratory of Virology and Chemotherapy, Department of Microbiology and Immunology, Rega Institute for Medical Research,
Department of Microbiology,
Immunology and Transplantation,
Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy
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Mutational pathways, resistance profile, and side effects of cyanovirin relative to human immunodeficiency virus type 1 strains with N-glycan deletions in their gp120 envelopes.
Journal of virology Sep, 2006 | Pubmed ID: 16912292
Carbohydrate-binding agents efficiently prevent dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN)-directed HIV-1 transmission to T lymphocytes.
Molecular pharmacology Jan, 2007 | Pubmed ID: 17056872
Algal lectins as potential HIV microbicide candidates.
Marine drugs Jul, 2012 | Pubmed ID: 22851920
A multi-targeted drug candidate with dual anti-HIV and anti-HSV activity.
PLoS pathogens , 2013 | Pubmed ID: 23935482
Sulfated Escherichia coli K5 polysaccharide derivatives inhibit dengue virus infection of human microvascular endothelial cells by interacting with the viral envelope protein E domain III.
PloS one , 2013 | Pubmed ID: 24015314
Design, synthesis, antiviral and cytostatic activity of ω-(1H-1,2,3-triazol-1-yl)(polyhydroxy)alkylphosphonates as acyclic nucleotide analogues.
Bioorganic & medicinal chemistry Jul, 2014 | Pubmed ID: 24906510
Differential cytokine, chemokine and growth factor expression in phenotypes of chronic lung allograft dysfunction.
Transplantation Jan, 2015 | Pubmed ID: 25050473
2-(4-Chlorobenzyl)-6-arylimidazo[2,1-b][1,3,4]thiadiazoles: synthesis, cytotoxic activity and mechanism of action.
European journal of medicinal chemistry Sep, 2014 | Pubmed ID: 25064346
Signal peptide-binding drug as a selective inhibitor of co-translational protein translocation.
PLoS biology Dec, 2014 | Pubmed ID: 25460167
NICTABA and UDA, two GlcNAc-binding lectins with unique antiviral activity profiles.
The Journal of antimicrobial chemotherapy , 2015 | Pubmed ID: 25700718
Branched-chain sugar nucleosides: stereocontrolled synthesis and bioevaluation of novel 3'-C-trifluoromethyl and 3'-C-methyl pyranonucleosides.
Carbohydrate research Apr, 2015 | Pubmed ID: 25812993
An easy microwave-assisted synthesis of C8-alkynyl adenine pyranonucleosides as novel cytotoxic antitumor agents.
Frontiers in chemistry , 2015 | Pubmed ID: 25853123
Design, antiviral and cytostatic properties of isoxazolidine-containing amonafide analogues.
Bioorganic & medicinal chemistry Jul, 2015 | Pubmed ID: 26001344
BAL neutrophilia in azithromycin-treated lung transplant recipients: Clinical significance.
Transplant immunology Sep, 2015 | Pubmed ID: 26168736
Phosphonylated Acyclic Guanosine Analogues with the 1,2,3-Triazole Linker.
Molecules (Basel, Switzerland) Oct, 2015 | Pubmed ID: 26501246
Lipophilic prodrugs of nucleoside triphosphates as biochemical probes and potential antivirals.
Nature communications Oct, 2015 | Pubmed ID: 26503889
Design, Synthesis, and Antiviral Activity of Novel Ribonucleosides of 1,2,3-Triazolylbenzyl-aminophosphonates.
Archiv der Pharmazie Jan, 2016 | Pubmed ID: 26575425
Vascular endothelial growth factor pathway in endometriosis: genetic variants and plasma biomarkers.
Fertility and sterility Apr, 2016 | Pubmed ID: 26773192
Synthesis and Bioactivity of Novel Trisubstituted Triazole Nucleosides.
Nucleosides, nucleotides & nucleic acids , 2016 | Pubmed ID: 26854981
Discovery of antitumor anthra[2,3-b]furan-3-carboxamides: Optimization of synthesis and evaluation of antitumor properties.
European journal of medicinal chemistry Apr, 2016 | Pubmed ID: 26890118
Exploring the purine core of 3'-C-ethynyladenosine (EAdo) in search of novel nucleoside therapeutics.
Bioorganic & medicinal chemistry letters Apr, 2016 | Pubmed ID: 26965865
Tuning Side Arm Electronics in Unsymmetrical Cyclotriazadisulfonamide (CADA) Endoplasmic Reticulum (ER) Translocation Inhibitors to Improve their Human Cluster of Differentiation 4 (CD4) Receptor Down-Modulating Potencies.
Journal of medicinal chemistry Mar, 2016 | Pubmed ID: 26974263
Membrane-permeable Triphosphate Prodrugs of Nucleoside Analogues.
Angewandte Chemie (International ed. in English) Apr, 2016 | Pubmed ID: 27008042
The Viral Polymerase Inhibitor 7-Deaza-2'-C-Methyladenosine Is a Potent Inhibitor of In Vitro Zika Virus Replication and Delays Disease Progression in a Robust Mouse Infection Model.
PLoS neglected tropical diseases 05, 2016 | Pubmed ID: 27163257
Synthesis of Novel Chiral Sulfonamide-Bearing 1,2,4-Triazole-3-thione Analogs Derived from D- and L-Phenylalanine Esters as Potential Anti-Influenza Agents.
Chirality 06, 2016 | Pubmed ID: 27225330
Lectin-Glycan Interaction Network-Based Identification of Host Receptors of Microbial Pathogenic Adhesins.
mBio 07, 2016 | Pubmed ID: 27406561
New Isoxazolidine-Conjugates of Quinazolinones-Synthesis, Antiviral and Cytostatic Activity.
Molecules (Basel, Switzerland) Jul, 2016 | Pubmed ID: 27455228
Aspartate-Based CXCR4 Chemokine Receptor Binding of Cross-Bridged Tetraazamacrocyclic Copper(II) and Zinc(II) Complexes.
Chemistry (Weinheim an der Bergstrasse, Germany) Aug, 2016 | Pubmed ID: 27458983
Lectin-Like Molecules of Lactobacillus rhamnosus GG Inhibit Pathogenic Escherichia coli and Salmonella Biofilm Formation.
PloS one , 2016 | Pubmed ID: 27537843
Synthesis, anti-varicella-zoster virus and anti-cytomegalovirus activity of quinazoline-2,4-diones containing isoxazolidine and phosphonate substructures.
European journal of medicinal chemistry Jan, 2017 | Pubmed ID: 27750154
Synthesis and the Biological Activity of Phosphonylated 1,2,3-Triazolenaphthalimide Conjugates.
Molecules (Basel, Switzerland) Oct, 2016 | Pubmed ID: 27792200
Synthesis of different types of alkoxy fullerene derivatives from chlorofullerene CCl.
Organic & biomolecular chemistry Jan, 2017 | Pubmed ID: 27830866
High mannose-specific lectin Msl mediates key interactions of the vaginal Lactobacillus plantarum isolate CMPG5300.
Scientific reports Nov, 2016 | Pubmed ID: 27853317
The lectin-like protein 1 in Lactobacillus rhamnosus GR-1 mediates tissue-specific adherence to vaginal epithelium and inhibits urogenital pathogens.
Scientific reports Nov, 2016 | Pubmed ID: 27869151
Acyclic nucleoside phosphonates containing the amide bond.
Monatshefte fur chemie , 2016 | Pubmed ID: 27881885
Structure-activity relationship studies on a Trp dendrimer with dual activities against HIV and enterovirus A71. Modifications on the amino acid.
Antiviral research Mar, 2017 | Pubmed ID: 28017762
Synthesis and Ativiral Activity of 5-(Benzylthio)-4-carbamyl-1,2,3-triazoles Against Human Cytomegalovirus (CMV) and Varicella-zoster Virus (VZV).
Medicinal chemistry (Shariqah (United Arab Emirates)) , 2017 | Pubmed ID: 28290250
Comparison of cell-based assays for the identification and evaluation of competitive CXCR4 inhibitors.
PloS one , 2017 | Pubmed ID: 28410420
Immunoregulatory effects of multipotent adult progenitor cells in a porcine ex vivo lung perfusion model.
Stem cell research & therapy Jul, 2017 | Pubmed ID: 28676074
Expanding the Antiviral Spectrum of 3-Fluoro-2-(phosphonomethoxy)propyl Acyclic Nucleoside Phosphonates: Diamyl Aspartate Amidate Prodrugs.
Journal of medicinal chemistry Jul, 2017 | Pubmed ID: 28682067
Design, Synthesis, and the Biological Evaluation of a New Series of Acyclic 1,2,3-Triazole Nucleosides.
Archiv der Pharmazie Sep, 2017 | Pubmed ID: 28763115
Signaling properties of the human chemokine receptors CXCR4 and CXCR7 by cellular electric impedance measurements.
PloS one , 2017 | Pubmed ID: 28945785
Aminomethylation of heliomycin: Preparation and anticancer characterization of the first series of semi-synthetic derivatives.
European journal of medicinal chemistry Jan, 2018 | Pubmed ID: 29137865
Chloro-1,4-dimethyl-9H-carbazole Derivatives Displaying Anti-HIV Activity.
Molecules (Basel, Switzerland) Jan, 2018 | Pubmed ID: 29385738
A Proteomic Survey Indicates Sortilin as a Secondary Substrate of the ER Translocation Inhibitor Cyclotriazadisulfonamide (CADA).
Molecular & cellular proteomics : MCP Feb, 2017 | Pubmed ID: 27998951
CXCR7/ACKR3-targeting ligands interfere with X7 HIV-1 and HIV-2 entry and replication in human host cells.
Heliyon Mar, 2018 | Pubmed ID: 29560468
Iterative Chemical Engineering of Vancomycin Leads to Novel Vancomycin Analogs With a High Therapeutic Index.
Frontiers in microbiology , 2018 | Pubmed ID: 29930540
Asymmetric Primaquine and Halogenaniline Fumardiamides as Novel Biologically Active Michael Acceptors.
Molecules (Basel, Switzerland) Jul, 2018 | Pubmed ID: 30011922
Engineering Lactobacillus rhamnosus GG and GR-1 to express HIV-inhibiting griffithsin.
International journal of antimicrobial agents Nov, 2018 | Pubmed ID: 30040991
Isoxazolidine Conjugates of N3-Substituted 6-Bromoquinazolinones-Synthesis, Anti-Varizella-Zoster Virus, and Anti-Cytomegalovirus Activity.
Molecules (Basel, Switzerland) Jul, 2018 | Pubmed ID: 30060562
Synthesis of a 3'-C-ethynyl-β-d-ribofuranose purine nucleoside library: Discovery of C7-deazapurine analogs as potent antiproliferative nucleosides.
European journal of medicinal chemistry Sep, 2018 | Pubmed ID: 30098481
Design, synthesis, in vitro antiproliferative activity and apoptosis-inducing studies of 1-(3',4',5'-trimethoxyphenyl)-3-(2'-alkoxycarbonylindolyl)-2-propen-1-one derivatives obtained by a molecular hybridisation approach.
Journal of enzyme inhibition and medicinal chemistry Dec, 2018 | Pubmed ID: 30141353
Peroxynitrite Exposure of CXCL12 Impairs Monocyte, Lymphocyte and Endothelial Cell Chemotaxis, Lymphocyte Extravasation and Anti-HIV-1 Activity.
Frontiers in immunology , 2018 | Pubmed ID: 30233568
Nanobody-Fc constructs targeting chemokine receptor CXCR4 potently inhibit signaling and CXCR4-mediated HIV-entry and induce antibody effector functions.
Biochemical pharmacology Dec, 2018 | Pubmed ID: 30342023
CXCR4-targeting nanobodies differentially inhibit CXCR4 function and HIV entry.
Biochemical pharmacology Dec, 2018 | Pubmed ID: 30342024
Synthesis, Anti-Varicella-Zoster Virus and Anti-Cytomegalovirus Activity of 4,5-Disubstituted 1,2,3-(1H)-Triazoles.
Medicinal chemistry (Shariqah (United Arab Emirates)) , 2019 | Pubmed ID: 30411688
Synthesis and Anti-HIV Activity of Guanine Modified Fluorinated Acyclic Nucleoside Phosphonate Derivatives.
Chemistry & biodiversity Feb, 2019 | Pubmed ID: 30431702
A yellow fever-Zika chimeric virus vaccine candidate protects against Zika infection and congenital malformations in mice.
NPJ vaccines , 2018 | Pubmed ID: 30564463
Acetate as a model for aspartate-based CXCR4 chemokine receptor binding of cobalt and nickel complexes of cross-bridged tetraazamacrocycles.
Dalton transactions (Cambridge, England : 2003) Feb, 2019 | Pubmed ID: 30729243
Design, Synthesis, and Biological Evaluation of Novel C5-Modified Pyrimidine Ribofuranonucleosides as Potential Antitumor or/and Antiviral Agents.
Medicinal chemistry (Shariqah (United Arab Emirates)) , 2020 | Pubmed ID: 30799795
Highly stable hexitol based XNA aptamers targeting the vascular endothelial growth factor.
Nucleic acids research Jun, 2019 | Pubmed ID: 30968117
Advantages and shortcomings of cell-based electrical impedance measurements as a GPCR drug discovery tool.
Biosensors & bioelectronics Jul, 2019 | Pubmed ID: 31077988
Diversion of the Arbuzov reaction: alkylation of C-Cl instead of phosphonic ester formation on the fullerene cage.
Organic & biomolecular chemistry Aug, 2019 | Pubmed ID: 31169856
Cu PET Imaging of the CXCR4 Chemokine Receptor Using a Cross-Bridged Cyclam Bis-Tetraazamacrocyclic Antagonist.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine Jan, 2020 | Pubmed ID: 31201250
Modifications in the branched arms of a class of dual inhibitors of HIV and EV71 replication expand their antiviral spectrum.
Antiviral research Aug, 2019 | Pubmed ID: 31228490
Design, synthesis and antiviral evaluation of novel acyclic phosphonate nucleotide analogs with triazolo[4,5-]pyridine, imidazo[4,5-]pyridine and imidazo[4,5-]pyridin-2(3)-one systems.
Nucleosides, nucleotides & nucleic acids , 2020 | Pubmed ID: 31550993
Antitumor and antiviral activities of 4-substituted 1,2,3-triazolyl-2,3-dibenzyl-L-ascorbic acid derivatives.
European journal of medicinal chemistry Dec, 2019 | Pubmed ID: 31586832
A unique class of lignin derivatives displays broad anti-HIV activity by interacting with the viral envelope.
Virus research Dec, 2019 | Pubmed ID: 31618614
Preprotein signature for full susceptibility to the co-translational translocation inhibitor cyclotriazadisulfonamide.
Traffic (Copenhagen, Denmark) Feb, 2020 | Pubmed ID: 31675144
Novel Isoxazolidine and γ-Lactam Analogues of Homonucleosides.
Molecules (Basel, Switzerland) Nov, 2019 | Pubmed ID: 31698778
Tryptophan Trimers and Tetramers Inhibit Dengue and Zika Virus Replication by Interfering with Viral Attachment Processes.
Antimicrobial agents and chemotherapy Feb, 2020 | Pubmed ID: 31932383
Design, synthesis and biological evaluation of 2-alkoxycarbonyl-3-anilinoindoles as a new class of potent inhibitors of tubulin polymerization.
Bioorganic chemistry Apr, 2020 | Pubmed ID: 32086053
A chimeric yellow fever-Zika virus vaccine candidate fully protects against yellow fever virus infection in mice.
Emerging microbes & infections , 2020 | Pubmed ID: 32116148
Synthesis, antiviral, cytotoxic and cytostatic evaluation of -(phosphonoalkyl)uracil derivatives.
Monatshefte fur chemie , 2016 | Pubmed ID: 32214481
Acyclic nucleoside phosphonates containing the amide bond: hydroxy derivatives.
Monatshefte fur chemie , 2019 | Pubmed ID: 32214483
Synthesis of novel -acyl--d-glucopyranosylamines and ureas as potential lead cytostatic agents.
Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents , 2016 | Pubmed ID: 32214768
Early protein expression profile in bronchoalveolar lavage fluid and clinical outcomes in primary graft dysfunction after lung transplantation.
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery Aug, 2020 | Pubmed ID: 32267918
Novel isoxazolidine analogues of homonucleosides and homonucleotides.
Tetrahedron Dec, 2016 | Pubmed ID: 32287430
Prodrugs of γ-Alkyl-Modified Nucleoside Triphosphates: Improved Inhibition of HIV Reverse Transcriptase.
Angewandte Chemie (International ed. in English) Dec, 2020 | Pubmed ID: 32379948
Anti-HIV-Active Nucleoside Triphosphate Prodrugs.
Journal of medicinal chemistry Jun, 2020 | Pubmed ID: 32421343
Lipophilic Triphosphate Prodrugs of Various Nucleoside Analogues.
Journal of medicinal chemistry Jul, 2020 | Pubmed ID: 32515595
Water-soluble fullerene-based nanostructures with promising antiviral and myogenic activity.
Chemical communications (Cambridge, England) Sep, 2020 | Pubmed ID: 32748905
Discovery of HIV entry inhibitors via a hybrid CXCR4 and CCR5 receptor pharmacophore-based virtual screening approach.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences Dec, 2020 | Pubmed ID: 32890663
Synthesis of new riboflavin modified ODNs: Effect of riboflavin moiety on the G-quadruplex arrangement and stability.
Bioorganic chemistry Nov, 2020 | Pubmed ID: 32919132
Membrane Permeable, Bioreversibly Modified Prodrugs of Nucleoside Diphosphate-γ-Phosphonates.
Journal of medicinal chemistry Oct, 2020 | Pubmed ID: 32991174
Itaconic acid hybrids as potential anticancer agents.
Molecular diversity Feb, 2022 | Pubmed ID: 33043404
Alkylated benzimidazoles: Design, synthesis, docking, DFT analysis, ADMET property, molecular dynamics and activity against HIV and YFV.
Computational biology and chemistry Dec, 2020 | Pubmed ID: 33068917
Thiophene-based water-soluble fullerene derivatives as highly potent antiherpetic pharmaceuticals.
Organic & biomolecular chemistry Nov, 2020 | Pubmed ID: 33084716
γ-Non-Symmetrically Dimasked TriPPPro Prodrugs as Potential Antiviral Agents against HIV.
ChemMedChem Feb, 2021 | Pubmed ID: 33089929
Development of a Novel SPR Assay to Study CXCR4-Ligand Interactions.
Biosensors Oct, 2020 | Pubmed ID: 33096938
γ-Ketobenzyl-Modified Nucleoside Triphosphate Prodrugs as Potential Antivirals.
Journal of medicinal chemistry Nov, 2020 | Pubmed ID: 33186038
STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters.
Nature communications 11, 2020 | Pubmed ID: 33203860
A single-dose live-attenuated YF17D-vectored SARS-CoV-2 vaccine candidate.
Nature 02, 2021 | Pubmed ID: 33260195
Synthesis, Molecular Docking and Preliminary Antileukemic Activity of 4-Methoxybenzyl Derivatives Bearing Imidazo[2,1-b][1,3,4]thiadiazole.
Chemistry & biodiversity Feb, 2021 | Pubmed ID: 33274824
Characterization of the Carbohydrate-Binding Agents HHA, GNA, and UDA as Inhibitors of Influenza A and B Virus Replication.
Antimicrobial agents and chemotherapy Feb, 2021 | Pubmed ID: 33288640
Palladium-catalyzed cross-coupling reactions on a bromo-naphthalene scaffold in the search for novel human CC chemokine receptor 8 (CCR8) antagonists.
Bioorganic chemistry Feb, 2021 | Pubmed ID: 33383325
Discovery of 3-phenyl- and 3-N-piperidinyl-isothiazolo[4,3-b]pyridines as highly potent inhibitors of cyclin G-associated kinase.
European journal of medicinal chemistry Mar, 2021 | Pubmed ID: 33497888
A novel experimental porcine model to assess the impact of differential pulmonary blood flow on ischemia-reperfusion injury after unilateral lung transplantation.
Intensive care medicine experimental Feb, 2021 | Pubmed ID: 33543363
Synthesis, in silico ADME, molecular docking and in vitro cytotoxicity evaluation of stilbene linked 1,2,3-triazoles.
Heliyon Jan, 2021 | Pubmed ID: 33553718
FO-SPR biosensor calibrated with recombinant extracellular vesicles enables specific and sensitive detection directly in complex matrices.
Journal of extracellular vesicles Feb, 2021 | Pubmed ID: 33664936
Corrigendum to 'Discovery of HIV entry inhibitors via a hybrid CXCR4 and CCR5 receptor pharmacophore-based virtual screening approach' [European Journal of Pharmaceutical Sciences 155 (2020) 105537].
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences Jul, 2021 | Pubmed ID: 33814256
Biological characterization of ligands targeting the human CC chemokine receptor 8 (CCR8) reveals the biased signaling properties of small molecule agonists.
Biochemical pharmacology Jun, 2021 | Pubmed ID: 33872569
Small Molecule Cyclotriazadisulfonamide Abrogates the Upregulation of the Human Receptors CD4 and 4-1BB and Suppresses In Vitro Activation and Proliferation of T Lymphocytes.
Frontiers in immunology , 2021 | Pubmed ID: 33968048
A Novel Series of Indole Alkaloid Derivatives Inhibit Dengue and Zika Virus Infection by Interference with the Viral Replication Complex.
Antimicrobial agents and chemotherapy Jul, 2021 | Pubmed ID: 34001508
Active Components from Prevent HIV-1 Entry by Distinct Mechanisms of Action.
International journal of molecular sciences May, 2021 | Pubmed ID: 34068829
Discovery of ( ±)-3-(1H-pyrazol-1-yl)-6,7-dihydro-5H-[1,2,4]triazolo[3,4-b][1,3,4] thiadiazine derivatives with promising in vitro anticoronavirus and antitumoral activity.
Molecular diversity Jun, 2022 | Pubmed ID: 34165689
Broad spectrum anti-coronavirus activity of a series of anti-malaria quinoline analogues.
Antiviral research Sep, 2021 | Pubmed ID: 34217752
Labyrinthopeptin A1 inhibits dengue and Zika virus infection by interfering with the viral phospholipid membrane.
Virology Oct, 2021 | Pubmed ID: 34274562
Internal Disulfide Bonding and Glycosylation of Interleukin-7 Protect Against Proteolytic Inactivation by Neutrophil Metalloproteinases and Serine Proteases.
Frontiers in immunology , 2021 | Pubmed ID: 34276694
Novel N-Substituted 3-Aryl-4-(diethoxyphosphoryl)azetidin-2-ones as Antibiotic Enhancers and Antiviral Agents in Search for a Successful Treatment of Complex Infections.
International journal of molecular sciences Jul, 2021 | Pubmed ID: 34360797
Exploring the dNTP -binding site of HIV-1 reverse transcriptase for inhibitor design.
European journal of medicinal chemistry Dec, 2021 | Pubmed ID: 34425311
Water-Promoted Reaction of CArCl Compounds with Thiophenes Delivers a Family of Multifunctional Fullerene Derivatives with Selective Antiviral Properties.
Organic letters Sep, 2021 | Pubmed ID: 34468156
A Proteomic Study on the Membrane Protein Fraction of T Cells Confirms High Substrate Selectivity for the ER Translocation Inhibitor Cyclotriazadisulfonamide.
Molecular & cellular proteomics : MCP , 2021 | Pubmed ID: 34481949
D-Peptide-Based Probe for CXCR4-Targeted Molecular Imaging and Radionuclide Therapy.
Pharmaceutics Oct, 2021 | Pubmed ID: 34683912
Synthesis and Anti-HIV Activity of a Novel Series of Isoquinoline-Based CXCR4 Antagonists.
Molecules (Basel, Switzerland) Oct, 2021 | Pubmed ID: 34684878
Lung Microenvironments and Disease Progression in Fibrotic Hypersensitivity Pneumonitis.
American journal of respiratory and critical care medicine Jan, 2022 | Pubmed ID: 34724391
Atypical response to bacterial coinfection and persistent neutrophilic bronchoalveolar inflammation distinguish critical COVID-19 from influenza.
JCI insight Jan, 2022 | Pubmed ID: 34793331
Peripherally-driven myeloid NFkB and IFN/ISG responses predict malignancy risk, survival, and immunotherapy regime in ovarian cancer.
Journal for immunotherapy of cancer Nov, 2021 | Pubmed ID: 34795003
Skeleton binding protein-1-mediated parasite sequestration inhibits spontaneous resolution of malaria-associated acute respiratory distress syndrome.
PLoS pathogens Nov, 2021 | Pubmed ID: 34843584
Sliding of HIV-1 reverse transcriptase over DNA creates a transient P pocket - targeting P-pocket by fragment screening.
Nature communications Dec, 2021 | Pubmed ID: 34880240
Deciphering the Role of Extracellular Vesicles Derived from ZIKV-Infected hcMEC/D3 Cells on the Blood-Brain Barrier System.
Viruses Nov, 2021 | Pubmed ID: 34960632
Anthranilamides with quinoline and β-carboline scaffolds: design, synthesis, and biological activity.
Molecular diversity Oct, 2022 | Pubmed ID: 34997441
Synthesis, in vitro cytotoxicity, molecular docking and ADME study of some indolin-2-one linked 1,2,3-triazole derivatives.
Computational biology and chemistry Apr, 2022 | Pubmed ID: 35168158
Targeting chemokine receptors from the inside-out: discovery and development of small-molecule intracellular antagonists.
Chemical communications (Cambridge, England) Mar, 2022 | Pubmed ID: 35274633
Circulating Donor-Specific Anti-HLA Antibodies Associate With Immune Activation Independent of Kidney Transplant Histopathological Findings.
Frontiers in immunology , 2022 | Pubmed ID: 35281018
Identification of novel chemotypes as CXCR2 antagonists via a scaffold hopping approach from a thiazolo[4,5-d]pyrimidine.
European journal of medicinal chemistry May, 2022 | Pubmed ID: 35313168
A Set of Experimentally Validated Decoys for the Human CC Chemokine Receptor 7 (CCR7) Obtained by Virtual Screening.
Frontiers in pharmacology , 2022 | Pubmed ID: 35370691
Innate Lymphoid Cells Are Required to Induce Airway Hyperreactivity in a Murine Neutrophilic Asthma Model.
Frontiers in immunology , 2022 | Pubmed ID: 35371094
In silico design, synthesis and anti-HIV activity of quinoline derivatives as non-nucleoside reverse transcriptase inhibitors (NNRTIs).
Computational biology and chemistry Jun, 2022 | Pubmed ID: 35395595
Effect of Particle Carriers for Intraperitoneal Drug Delivery on the Course of Ovarian Cancer and Its Immune Microenvironment in a Mouse Model.
Pharmaceutics Mar, 2022 | Pubmed ID: 35456521
Stimulation of the atypical chemokine receptor 3 (ACKR3) by a small-molecule agonist attenuates fibrosis in a preclinical liver but not lung injury model.
Cellular and molecular life sciences : CMLS May, 2022 | Pubmed ID: 35562519
Discovery of 2-Phenylquinolines with Broad-Spectrum Anti-coronavirus Activity.
ACS medicinal chemistry letters May, 2022 | Pubmed ID: 35571875
The discovery of Zika virus NS2B-NS3 inhibitors with antiviral activity via an integrated virtual screening approach.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences Aug, 2022 | Pubmed ID: 35618201
SARS-CoV-2 Virion Infectivity and Cytokine Production in Primary Human Airway Epithelial Cells.
Viruses May, 2022 | Pubmed ID: 35632693
Potent neutralizing anti-SARS-CoV-2 human antibodies cure infection with SARS-CoV-2 variants in hamster model.
iScience Aug, 2022 | Pubmed ID: 35813873
Cryo-EM structures of wild-type and E138K/M184I mutant HIV-1 RT/DNA complexed with inhibitors doravirine and rilpivirine.
Proceedings of the National Academy of Sciences of the United States of America Jul, 2022 | Pubmed ID: 35858448
Cellular Electrical Impedance as a Method to Decipher CCR7 Signalling and Biased Agonism.
International journal of molecular sciences Aug, 2022 | Pubmed ID: 36012168
Triphosphate Prodrugs of the Anti-HIV-Active Compound 3'-Deoxy-3'-fluorothymidine (FLT).
Journal of medicinal chemistry Sep, 2022 | Pubmed ID: 36099330
Carbohydrate-binding protein from stinging nettle as fusion inhibitor for SARS-CoV-2 variants of concern.
Frontiers in cellular and infection microbiology , 2022 | Pubmed ID: 36111239
Corrigendum: Innate lymphoid cells are required to induce airway hyperreactivity in a murine neutrophilic asthma model.
Frontiers in immunology , 2022 | Pubmed ID: 36211405
Can we attenuate ischaemia-reperfusion injury of allografts in a porcine left lung transplant models by adsorption of cytokines?
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery Dec, 2022 | Pubmed ID: 36214633
Design, Synthesis, Anti-Varicella-Zoster and Antimicrobial Activity of (Isoxazolidin-3-yl)Phosphonate Conjugates of N1-Functionalised Quinazoline-2,4-Diones.
Molecules (Basel, Switzerland) Oct, 2022 | Pubmed ID: 36235061
A stabilized CXCL9(74-103)-derived peptide selectively inhibits proliferation, adhesion and metastasis of tumor cells that express high levels of heparan sulfate.
International journal of biological macromolecules Dec, 2022 | Pubmed ID: 36272565
Synthesis and evaluation of 3-alkynyl-5-aryl-7-aza-indoles as broad-spectrum antiviral agents.
Frontiers in chemistry , 2022 | Pubmed ID: 36385995
Development of a live biotherapeutic throat spray with lactobacilli targeting respiratory viral infections.
Microbial biotechnology Jan, 2023 | Pubmed ID: 36468246
Systemic cytokines and GlycA discriminate disease status and predict corticosteroid response in HTLV-1-associated neuroinflammation.
Journal of neuroinflammation Dec, 2022 | Pubmed ID: 36482436
Design and synthesis of a new series of hybrids of functionalised N-[(1H-1,2,3-triazol-4-yl)methyl]quinazoline-2,4-dione with antiviral activity against Respiratory Syncytial Virus.
Antiviral research Jan, 2023 | Pubmed ID: 36587900
Identification of Polyphenol Derivatives as Novel SARS-CoV-2 and DENV Non-Nucleoside RdRp Inhibitors.
Molecules (Basel, Switzerland) Dec, 2022 | Pubmed ID: 36615354
FLUIDOT: A Modular Microfluidic Platform for Single-Cell Study and Retrieval, with Applications in Drug Tolerance Screening and Antibody Mining.
Small methods Mar, 2023 | Pubmed ID: 36642827
Visible-Light-Promoted Tandem Thiol-Ene Click Reaction/Transannular Cyclization and Regioselective Cyclopropane Ring-Opening to Construct Sulfur-Containing Diterpenes.
Organic letters Feb, 2023 | Pubmed ID: 36662155
Exploration of Pyrido[3,4-]pyrimidines as Antagonists of the Human Chemokine Receptor CXCR2.
Molecules (Basel, Switzerland) Feb, 2023 | Pubmed ID: 36903345
A regioselective step-by-step CCl functionalization approach affords a novel family of CArTh'Th''H fullerene derivatives with promising antiviral properties.
Chemical communications (Cambridge, England) Mar, 2023 | Pubmed ID: 36916636
Optimization of triazolo[4,5-d]pyrimidines towards human CC chemokine receptor 7 (CCR7) antagonists.
European journal of medicinal chemistry Mar, 2023 | Pubmed ID: 36924670