Nuclear Dynamics Programme,
The Babraham Institute,
Nuclear Dynamics Programme, The Babraham Institute
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Active genes dynamically colocalize to shared sites of ongoing transcription.
Nature genetics Oct, 2004 | Pubmed ID: 15361872
The Corfu deltabeta thalassemia deletion disrupts gamma-globin gene silencing and reveals post-transcriptional regulation of HbF expression.
Blood Mar, 2005 | Pubmed ID: 15536151
Replication and transcription: shaping the landscape of the genome.
Nature reviews. Genetics Sep, 2005 | Pubmed ID: 16094312
The pre-B-cell receptor induces silencing of VpreB and lambda5 transcription.
The EMBO journal Nov, 2005 | Pubmed ID: 16281060
Constricting restricted transcription: the (actively?) shrinking web.
Genes & development Jun, 2006 | Pubmed ID: 16751176
Transcriptional control thrown for a loop.
Current opinion in genetics & development Oct, 2006 | Pubmed ID: 16904310
Intergenic transcription, cell-cycle and the developmentally regulated epigenetic profile of the human beta-globin locus.
PloS one , 2007 | Pubmed ID: 17637845
The role of transcription factories in large-scale structure and dynamics of interphase chromatin.
Seminars in cell & developmental biology Oct, 2007 | Pubmed ID: 17950637
Gene regulation through nuclear organization.
Nature structural & molecular biology Nov, 2007 | Pubmed ID: 17984967
The role of long non-coding RNAs in chromatin structure and gene regulation: variations on a theme.
Biological chemistry Apr, 2008 | Pubmed ID: 18225988
Kcnq1ot1/Lit1 noncoding RNA mediates transcriptional silencing by targeting to the perinucleolar region.
Molecular and cellular biology Jun, 2008 | Pubmed ID: 18299392
Brushed aside and silenced.
Developmental cell Apr, 2008 | Pubmed ID: 18410721
Interchromosomal huddle kickstarts antiviral defense.
Cell Jul, 2008 | Pubmed ID: 18614003
The Air noncoding RNA epigenetically silences transcription by targeting G9a to chromatin.
Science (New York, N.Y.) Dec, 2008 | Pubmed ID: 18988810
Emerging similarities in epigenetic gene silencing by long noncoding RNAs.
Mammalian genome : official journal of the International Mammalian Genome Society Sep-Oct, 2009 | Pubmed ID: 19727951
Preferential associations between co-regulated genes reveal a transcriptional interactome in erythroid cells.
Nature genetics Jan, 2010 | Pubmed ID: 20010836
Chromosome conformation capture.
Cold Spring Harbor protocols Feb, 2009 | Pubmed ID: 20147067
The yin and yang of chromatin spatial organization.
Genome biology , 2010 | Pubmed ID: 20353545
Organization of transcription.
Cold Spring Harbor perspectives in biology Sep, 2010 | Pubmed ID: 20668006
Replication stress induces 53BP1-containing OPT domains in G1 cells.
The Journal of cell biology Apr, 2011 | Pubmed ID: 21444690
No-nonsense functions for long noncoding RNAs.
Cell Apr, 2011 | Pubmed ID: 21496640
Ultrastructural study of transcription factories in mouse erythroblasts.
Journal of cell science Nov, 2011 | Pubmed ID: 22045738
Transcription factories: genetic programming in three dimensions.
Current opinion in genetics & development Apr, 2012 | Pubmed ID: 22365496
Nuclear RNA sequencing of the mouse erythroid cell transcriptome.
PloS one , 2012 | Pubmed ID: 23209567
Sixty years of genome biology.
Genome biology Apr, 2013 | Pubmed ID: 23651518
The impact of chromosomal rearrangements on regulation of gene expression.
Human molecular genetics Sep, 2014 | Pubmed ID: 24907073
The pluripotent regulatory circuitry connecting promoters to their long-range interacting elements.
Genome research Apr, 2015 | Pubmed ID: 25752748
3D genome architecture from populations to single cells.
Current opinion in genetics & development Apr, 2015 | Pubmed ID: 25966907
Comparison of Hi-C results using in-solution versus in-nucleus ligation.
Genome biology Aug, 2015 | Pubmed ID: 26306623
Three Dimensional Organization of the Nucleus: adding DNA sequences to the big picture.
Genome biology Aug, 2015 | Pubmed ID: 26319739
Integrated genome-scale analysis of the transcriptional regulatory landscape in a blood stem/progenitor cell model.
Blood Mar, 2016 | Pubmed ID: 26809507
Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters.
Cell 11, 2016 | Pubmed ID: 27863249
Dynamic Rewiring of Promoter-Anchored Chromatin Loops during Adipocyte Differentiation.
Molecular cell May, 2017 | Pubmed ID: 28475875
Hi-C as a tool for precise detection and characterisation of chromosomal rearrangements and copy number variation in human tumours.
Genome biology 06, 2017 | Pubmed ID: 28655341
Platelet function is modified by common sequence variation in megakaryocyte super enhancers.
Nature communications Jul, 2017 | Pubmed ID: 28703137
Chromosome contacts in activated T cells identify autoimmune disease candidate genes.
Genome biology Sep, 2017 | Pubmed ID: 28870212
Topologically associating domains and chromatin loops depend on cohesin and are regulated by CTCF, WAPL, and PDS5 proteins.
The EMBO journal 12, 2017 | Pubmed ID: 29217591
Allele-specific control of replication timing and genome organization during development.
Genome research 06, 2018 | Pubmed ID: 29735606
The reference epigenome and regulatory chromatin landscape of chronic lymphocytic leukemia.
Nature medicine Jun, 2018 | Pubmed ID: 29785028
Stefan Schoenfelder*,1,
Biola-Maria Javierre*,1,2,
Mayra Furlan-Magaril1,3,
Steven W. Wingett1,4,
Peter Fraser1,5
1Nuclear Dynamics Programme, The Babraham Institute, Babraham Research Campus,
2IJC Building, Campus ICO-Germans Trias i Pujol, Josep Carreras Leukemia Research Institute,
3Departamento de Genética Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México,
4Bioinformatics Group, The Babraham Institute, Babraham Research Campus,
5Department of Biological Science, Florida State University