Center for Cell and Gene Therapy
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Adverse events following infusion of T cells for adoptive immunotherapy: a 10-year experience.
Cytotherapy Oct, 2010 | Pubmed ID: 20429793
Generation of EBV-specific CD4+ cytotoxic T cells from virus naive individuals.
Journal of immunology (Baltimore, Md. : 1950) Jan, 2002 | Pubmed ID: 11777989
Epstein-Barr virus (EBV)-specific cytotoxic T lymphocytes for the prevention and treatment of EBV-associated post-transplant lymphomas.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer , 2002 | Pubmed ID: 11785836
Immunotherapy to reconstitute immunity to DNA viruses.
Seminars in hematology Jan, 2002 | Pubmed ID: 11799528
Diagnosis and treatment of posttransplantation lymphoproliferative disease after hematopoietic stem cell transplantation.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation , 2002 | Pubmed ID: 11846351
Epstein-Barr virus-specific human T lymphocytes expressing antitumor chimeric T-cell receptors: potential for improved immunotherapy.
Blood Mar, 2002 | Pubmed ID: 11877273
Adapting a transforming growth factor beta-related tumor protection strategy to enhance antitumor immunity.
Blood May, 2002 | Pubmed ID: 11964281
Immunotherapy for post-transplant lymphoproliferative disease.
British journal of haematology Sep, 2002 | Pubmed ID: 12181039
Autologous Epstein-Barr virus (EBV)-specific cytotoxic T cells for the treatment of persistent active EBV infection.
Blood Dec, 2002 | Pubmed ID: 12393655
Generating CTLs against the subdominant Epstein-Barr virus LMP1 antigen for the adoptive immunotherapy of EBV-associated malignancies.
Blood Mar, 2003 | Pubmed ID: 12411306
Identification of HLA-DP3-restricted peptides from EBNA1 recognized by CD4(+) T cells.
Cancer research Dec, 2002 | Pubmed ID: 12499257
New insights into EBV-associated post-transplant lymphoproliferative disease.
Lancet Jan, 2003 | Pubmed ID: 12547538
Immunotherapy for Epstein-Barr virus-associated cancers in children.
The oncologist , 2003 | Pubmed ID: 12604735
The dynamics of herpesvirus and polyomavirus reactivation and shedding in healthy adults: a 14-month longitudinal study.
The Journal of infectious diseases May, 2003 | Pubmed ID: 12721937
Selective depletion of donor alloreactive T cells without loss of antiviral or antileukemic responses.
Blood Sep, 2003 | Pubmed ID: 12763937
Identification of a naturally processed HLA-DR-restricted T-helper epitope in Epstein-Barr virus nuclear antigen type 1.
Journal of immunotherapy (Hagerstown, Md. : 1997) May-Jun, 2003 | Pubmed ID: 12806275
树突状细胞天生多克隆人类细胞毒 T 淋巴细胞行使用的过继免疫治疗的永生细胞株的大规模扩张。
Journal of immunotherapy (Hagerstown, Md. : 1997) May-Jun, 2003 | Pubmed ID: 12806278
Induction of antigen-specific regulatory T cells following overexpression of a Notch ligand by human B lymphocytes.
Journal of virology Oct, 2003 | Pubmed ID: 14512537
Fiber-modified adenoviruses generate subgroup cross-reactive, adenovirus-specific cytotoxic T lymphocytes for therapeutic applications.
Blood Feb, 2004 | Pubmed ID: 14525768
Human telomerase reverse transcriptase-specific T-helper responses induced by promiscuous major histocompatibility complex class II-restricted epitopes.
Clinical cancer research : an official journal of the American Association for Cancer Research Oct, 2003 | Pubmed ID: 14581345
Adoptive T-cell therapy for EBV-associated post-transplant lymphoproliferative disease.
Acta haematologica , 2003 | Pubmed ID: 14583674
Adoptive T-cell therapy for Epstein-Barr virus-positive Hodgkin's disease.
Acta haematologica , 2003 | Pubmed ID: 14583675
A strategy for treatment of Epstein-Barr virus-positive Hodgkin's disease by targeting interleukin 12 to the tumor environment using tumor antigen-specific T cells.
Cancer gene therapy Feb, 2004 | Pubmed ID: 14685154
Prompt versus preemptive intervention for EBV lymphoproliferative disease.
Blood May, 2004 | Pubmed ID: 14751931
Evidence for the presentation of major histocompatibility complex class I-restricted Epstein-Barr virus nuclear antigen 1 peptides to CD8+ T lymphocytes.
The Journal of experimental medicine Feb, 2004 | Pubmed ID: 14769850
Adoptive immunotherapy for posttransplantation viral infections.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation Mar, 2004 | Pubmed ID: 14993880
The generation and characterization of LMP2-specific CTLs for use as adoptive transfer from patients with relapsed EBV-positive Hodgkin disease.
Journal of immunotherapy (Hagerstown, Md. : 1997) Jul-Aug, 2004 | Pubmed ID: 15235393
Conserved CTL epitopes on the adenovirus hexon protein expand subgroup cross-reactive and subgroup-specific CD8+ T cells.
Blood Oct, 2004 | Pubmed ID: 15265797
Treatment of Epstein-Barr virus lymphoproliferative disease after hematopoietic stem-cell transplantation with hydroxyurea and cytotoxic T-cell lymphocytes.
Transplantation Sep, 2004 | Pubmed ID: 15371682
Cellular therapy of Epstein-Barr-virus-associated post-transplant lymphoproliferative disease.
Best practice & research. Clinical haematology Sep, 2004 | Pubmed ID: 15498712
A comparison of gene transfer and antigen-loaded dendritic cells for the generation of CD4+ and CD8+ cytomegalovirus-specific T cells in HLA-A2+ and HLA-A2- donors.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation Nov, 2004 | Pubmed ID: 15505607
Treatment of nasopharyngeal carcinoma with Epstein-Barr virus--specific T lymphocytes.
Blood Mar, 2005 | Pubmed ID: 15542583
Cytotoxic T lymphocyte therapy for Epstein-Barr virus+ Hodgkin's disease.
The Journal of experimental medicine Dec, 2004 | Pubmed ID: 15611290
Adoptive immunotherapy for EBV-associated malignancies.
Leukemia & lymphoma Jan, 2005 | Pubmed ID: 15621775
Adenovirus as an emerging pathogen in immunocompromised patients.
British journal of haematology Jan, 2005 | Pubmed ID: 15638847
Post-transplant lymphoproliferative disorders.
Annual review of medicine , 2005 | Pubmed ID: 15660500
Cellular immunity to Epstein-Barr virus in liver transplant recipients treated with rituximab for post-transplant lymphoproliferative disease.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons Mar, 2005 | Pubmed ID: 15707412
Human cytotoxic T lymphocytes with reduced sensitivity to Fas-induced apoptosis.
Blood Jun, 2005 | Pubmed ID: 15713795
An inducible caspase 9 safety switch for T-cell therapy.
Blood Jun, 2005 | Pubmed ID: 15728125
HLA type-independent generation of antigen-specific T cells for adoptive immunotherapy.
European journal of immunology Jul, 2005 | Pubmed ID: 15915543
A chimeric T cell antigen receptor that augments cytokine release and supports clonal expansion of primary human T cells.
Molecular therapy : the journal of the American Society of Gene Therapy Nov, 2005 | Pubmed ID: 15979412
Quantitative EBV viral loads and immunosuppression alterations can decrease PTLD incidence in pediatric liver transplant recipients.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons Sep, 2005 | Pubmed ID: 16095501
Characterization of latent membrane protein 2 specificity in CTL lines from patients with EBV-positive nasopharyngeal carcinoma and lymphoma.
Journal of immunology (Baltimore, Md. : 1950) Sep, 2005 | Pubmed ID: 16148164
Hitchhiker's guide to the T cell.
Nature medicine Oct, 2005 | Pubmed ID: 16211037
Target antigen expression on a professional antigen-presenting cell induces superior proliferative antitumor T-cell responses via chimeric T-cell receptors.
Journal of immunotherapy (Hagerstown, Md. : 1997) Jan-Feb, 2006 | Pubmed ID: 16365597
Adenoviral infections in hematopoietic stem cell transplantation.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation Mar, 2006 | Pubmed ID: 16503493
Improving T cell therapy for cancer.
Expert opinion on biological therapy Mar, 2006 | Pubmed ID: 16503732
Administration of latent membrane protein 2-specific cytotoxic T lymphocytes to patients with relapsed Epstein-Barr virus-positive lymphoma.
Clinical lymphoma & myeloma Jan, 2006 | Pubmed ID: 16507214
Assessing the safety of cytotoxic T lymphocytes transduced with a dominant negative transforming growth factor-beta receptor.
Journal of immunotherapy (Hagerstown, Md. : 1997) May-Jun, 2006 | Pubmed ID: 16699368
In vivo expansion of LMP 1- and 2-specific T-cells in a patient who received donor-derived EBV-specific T-cells after allogeneic stem cell transplantation.
Leukemia & lymphoma May, 2006 | Pubmed ID: 16753867
Adoptive immunotherapy for Hodgkin's lymphoma.
International journal of hematology Jun, 2006 | Pubmed ID: 16787867
Use of cytokine polymorphisms and Epstein-Barr virus viral load to predict development of post-transplant lymphoproliferative disorder in paediatric liver transplant recipients.
Clinical transplantation May-Jun, 2006 | Pubmed ID: 16824159
Treatment of solid organ transplant recipients with autologous Epstein Barr virus-specific cytotoxic T lymphocytes (CTLs).
Blood Nov, 2006 | Pubmed ID: 16835376
T lymphocytes redirected against the kappa light chain of human immunoglobulin efficiently kill mature B lymphocyte-derived malignant cells.
Blood Dec, 2006 | Pubmed ID: 16926291
Monoculture-derived T lymphocytes specific for multiple viruses expand and produce clinically relevant effects in immunocompromised individuals.
Nature medicine Oct, 2006 | Pubmed ID: 16998485
Quantification of a low cellular immune response to aid in identification of pediatric liver transplant recipients at high-risk for EBV infection.
Clinical transplantation Nov-Dec, 2006 | Pubmed ID: 17100717
Improving T cell therapy for cancer.
Annual review of immunology , 2007 | Pubmed ID: 17129181
Contact-activated monocytes: efficient antigen presenting cells for the stimulation of antigen-specific T cells.
Journal of immunotherapy (Hagerstown, Md. : 1997) Jan, 2007 | Pubmed ID: 17198088
Dendritic cell function after gene transfer with adenovirus-calcium phosphate co-precipitates.
Molecular therapy : the journal of the American Society of Gene Therapy Feb, 2007 | Pubmed ID: 17235318
Epstein Barr virus specific cytotoxic T lymphocytes expressing the anti-CD30zeta artificial chimeric T-cell receptor for immunotherapy of Hodgkin disease.
Blood Oct, 2007 | Pubmed ID: 17507664
Regression of experimental medulloblastoma following transfer of HER2-specific T cells.
Cancer research Jun, 2007 | Pubmed ID: 17575166
Autologous designer antigen-presenting cells by gene modification of T lymphocyte blasts with IL-7 and IL-12.
Journal of immunotherapy (Hagerstown, Md. : 1997) Jul-Aug, 2007 | Pubmed ID: 17589291
Complete responses of relapsed lymphoma following genetic modification of tumor-antigen presenting cells and T-lymphocyte transfer.
Blood Oct, 2007 | Pubmed ID: 17609424
What influence has B-cell depletion on viral infections?
Leukemia & lymphoma Jul, 2007 | Pubmed ID: 17613749
Co-expression of cytokine and suicide genes to enhance the activity and safety of tumor-specific cytotoxic T lymphocytes.
Blood Oct, 2007 | Pubmed ID: 17638856
Inducible caspase 9 suicide gene to improve the safety of allodepleted T cells after haploidentical stem cell transplantation.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation Aug, 2007 | Pubmed ID: 17640595
Gene-engineered varicella-zoster virus reactive CD4+ cytotoxic T cells exert tumor-specific effector function.
Cancer research Sep, 2007 | Pubmed ID: 17804749
Identification of hexon-specific CD4 and CD8 T-cell epitopes for vaccine and immunotherapy.
Journal of virology Jan, 2008 | Pubmed ID: 17942545
Using dendritic cell maturation and IL-12 producing capacity as markers of function: a cautionary tale.
Journal of immunotherapy (Hagerstown, Md. : 1997) May, 2008 | Pubmed ID: 18391760
An inducible caspase 9 safety switch can halt cell therapy-induced autoimmune disease.
Journal of immunology (Baltimore, Md. : 1950) May, 2008 | Pubmed ID: 18424760
Antitumor activity of EBV-specific T lymphocytes transduced with a dominant negative TGF-beta receptor.
Journal of immunotherapy (Hagerstown, Md. : 1997) Jun, 2008 | Pubmed ID: 18463534
Cytotoxic T lymphocytes directed to the preferentially expressed antigen of melanoma (PRAME) target chronic myeloid leukemia.
Blood Sep, 2008 | Pubmed ID: 18591381
Exploiting cytokine secretion to rapidly produce multivirus-specific T cells for adoptive immunotherapy.
Journal of immunotherapy (Hagerstown, Md. : 1997) Sep, 2008 | Pubmed ID: 18600178
Enhancing the in vivo expansion of adoptively transferred EBV-specific CTL with lymphodepleting CD45 monoclonal antibodies in NPC patients.
Blood Mar, 2009 | Pubmed ID: 18971421
Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma.
Nature medicine Nov, 2008 | Pubmed ID: 18978797
In vivo fluorescent optical imaging of cytotoxic T lymphocyte migration using IRDye800CW near-infrared dye.
Applied optics Nov, 2008 | Pubmed ID: 19122737
Production Assistance for Cellular Therapies (PACT): four-year experience from the United States National Heart, Lung, and Blood Institute (NHLBI) contract research program in cell and tissue therapies.
Transfusion Apr, 2009 | Pubmed ID: 19170985
Genetic manipulation of tumor-specific cytotoxic T lymphocytes to restore responsiveness to IL-7.
Molecular therapy : the journal of the American Society of Gene Therapy May, 2009 | Pubmed ID: 19259067
T lymphocytes coexpressing CCR4 and a chimeric antigen receptor targeting CD30 have improved homing and antitumor activity in a Hodgkin tumor model.
Blood Jun, 2009 | Pubmed ID: 19377047
Functionally active virus-specific T cells that target CMV, adenovirus, and EBV can be expanded from naive T-cell populations in cord blood and will target a range of viral epitopes.
Blood Aug, 2009 | Pubmed ID: 19443656
Immunotherapy for osteosarcoma: genetic modification of T cells overcomes low levels of tumor antigen expression.
Molecular therapy : the journal of the American Society of Gene Therapy Oct, 2009 | Pubmed ID: 19532139
Genetic modification of T cells with IL-21 enhances antigen presentation and generation of central memory tumor-specific cytotoxic T-lymphocytes.
Journal of immunotherapy (Hagerstown, Md. : 1997) Sep, 2009 | Pubmed ID: 19561536
Nucleofection of DCs to generate Multivirus-specific T cells for prevention or treatment of viral infections in the immunocompromised host.
Molecular therapy : the journal of the American Society of Gene Therapy Sep, 2009 | Pubmed ID: 19584818
Cytotoxic T lymphocyte therapy with donor T cells prevents and treats adenovirus and Epstein-Barr virus infections after haploidentical and matched unrelated stem cell transplantation.
Blood Nov, 2009 | Pubmed ID: 19700662
Genome-wide mapping of PiggyBac transposon integrations in primary human T cells.
Journal of immunotherapy (Hagerstown, Md. : 1997) Oct, 2009 | Pubmed ID: 19752750
Optimization of the PiggyBac transposon system for the sustained genetic modification of human T lymphocytes.
Journal of immunotherapy (Hagerstown, Md. : 1997) Oct, 2009 | Pubmed ID: 19752751
Generation of Epstein-Barr virus-specific cytotoxic T lymphocytes resistant to the immunosuppressive drug tacrolimus (FK506).
Blood Nov, 2009 | Pubmed ID: 19759356
Long-term outcome of EBV-specific T-cell infusions to prevent or treat EBV-related lymphoproliferative disease in transplant recipients.
Blood Feb, 2010 | Pubmed ID: 19880495
Derivation of human T lymphocytes from cord blood and peripheral blood with antiviral and antileukemic specificity from a single culture as protection against infection and relapse after stem cell transplantation.
Blood Apr, 2010 | Pubmed ID: 20110422
Challenges of T cell therapies for virus-associated diseases after hematopoietic stem cell transplantation.
Expert opinion on biological therapy Mar, 2010 | Pubmed ID: 20132056
Antigen-specific cytotoxic T lymphocytes can target chemoresistant side-population tumor cells in Hodgkin lymphoma.
Leukemia & lymphoma May, 2010 | Pubmed ID: 20367572
Accelerated production of antigen-specific T cells for preclinical and clinical applications using gas-permeable rapid expansion cultureware (G-Rex).
Journal of immunotherapy (Hagerstown, Md. : 1997) Apr, 2010 | Pubmed ID: 20445351
Allogeneic virus-specific T cells with HLA alloreactivity do not produce GVHD in human subjects.
Blood Nov, 2010 | Pubmed ID: 20709906
IRAK-M removal counteracts dendritic cell vaccine deficits in migration and longevity.
Journal of immunology (Baltimore, Md. : 1950) Oct, 2010 | Pubmed ID: 20817880
Enhanced tumor trafficking of GD2 chimeric antigen receptor T cells by expression of the chemokine receptor CCR2b.
Journal of immunotherapy (Hagerstown, Md. : 1997) Oct, 2010 | Pubmed ID: 20842059
T cells expressing constitutively active Akt resist multiple tumor-associated inhibitory mechanisms.
Molecular therapy : the journal of the American Society of Gene Therapy Nov, 2010 | Pubmed ID: 20842106
Immunotherapeutic options for Epstein-Barr virus-associated lymphoproliferative disease following transplantation.
Immunotherapy Sep, 2010 | Pubmed ID: 20874650
Adoptive transfer of EBV-specific T cells results in sustained clinical responses in patients with locoregional nasopharyngeal carcinoma.
Journal of immunotherapy (Hagerstown, Md. : 1997) Nov-Dec, 2010 | Pubmed ID: 20948438
A Th1-inducing adenoviral vaccine for boosting adoptively transferred T cells.
Molecular therapy : the journal of the American Society of Gene Therapy Jan, 2011 | Pubmed ID: 20959814
Enhancement of dendritic cells as vaccines for cancer.
Immunotherapy Nov, 2010 | Pubmed ID: 21091116
High-avidity cytotoxic T lymphocytes specific for a new PRAME-derived peptide can target leukemic and leukemic-precursor cells.
Blood Mar, 2011 | Pubmed ID: 21278353
Good manufacturing practice-grade cytotoxic T lymphocytes specific for latent membrane proteins (LMP)-1 and LMP2 for patients with Epstein-Barr virus-associated lymphoma.
Cytotherapy May, 2011 | Pubmed ID: 21361747
Ex vivo gene transfer for improved adoptive immunotherapy of cancer.
Human molecular genetics Apr, 2011 | Pubmed ID: 21415041
Characterization and treatment of chronic active Epstein-Barr virus disease: a 28-year experience in the United States.
Blood Jun, 2011 | Pubmed ID: 21454450
Posttransplant lymphoproliferative disease following liver transplantation.
Current opinion in organ transplantation Jun, 2011 | Pubmed ID: 21467936
Thunder and lightning: immunotherapy and oncolytic viruses collide.
Molecular therapy : the journal of the American Society of Gene Therapy Jun, 2011 | Pubmed ID: 21505424
CD28 costimulation improves expansion and persistence of chimeric antigen receptor-modified T cells in lymphoma patients.
The Journal of clinical investigation May, 2011 | Pubmed ID: 21540550
PiggyBac-mediated cancer immunotherapy using EBV-specific cytotoxic T-cells expressing HER2-specific chimeric antigen receptor.
Molecular therapy : the journal of the American Society of Gene Therapy Dec, 2011 | Pubmed ID: 21772253
Combining mTor inhibitors with rapamycin-resistant T cells: a two-pronged approach to tumor elimination.
Molecular therapy : the journal of the American Society of Gene Therapy Dec, 2011 | Pubmed ID: 21878902
Improving T-cell therapy for relapsed EBV-negative Hodgkin lymphoma by targeting upregulated MAGE-A4.
Clinical cancer research : an official journal of the American Association for Cancer Research Nov, 2011 | Pubmed ID: 21908573
Cytotoxic T lymphocytes simultaneously targeting multiple tumor-associated antigens to treat EBV negative lymphoma.
Molecular therapy : the journal of the American Society of Gene Therapy Dec, 2011 | Pubmed ID: 21915103
Antitumor activity and long-term fate of chimeric antigen receptor-positive T cells in patients with neuroblastoma.
Blood Dec, 2011 | Pubmed ID: 21984804
Aggressive peripheral CD70-positive t-cell lymphoma associated with severe chronic active EBV infection.
Pediatric blood & cancer Oct, 2011 | Pubmed ID: 21994111
Inducible apoptosis as a safety switch for adoptive cell therapy.
The New England journal of medicine Nov, 2011 | Pubmed ID: 22047558
Adoptive transfer of virus-directed T cells: will this fly for flu?
Cytotherapy Feb, 2012 | Pubmed ID: 22149160
Production of good manufacturing practice-grade cytotoxic T lymphocytes specific for Epstein-Barr virus, cytomegalovirus and adenovirus to prevent or treat viral infections post-allogeneic hematopoietic stem cell transplant.
Cytotherapy Jan, 2012 | Pubmed ID: 22172091
Replication-competent retroviruses in gene-modified T cells used in clinical trials: is it time to revise the testing requirements?
Molecular therapy : the journal of the American Society of Gene Therapy Feb, 2012 | Pubmed ID: 22297819
Generation of Polyclonal CMV-specific T Cells for the Adoptive Immunotherapy of Glioblastoma.
Journal of immunotherapy (Hagerstown, Md. : 1997) Feb, 2012 | Pubmed ID: 22306904
Rapidly generated multivirus-specific cytotoxic T lymphocytes for the prophylaxis and treatment of viral infections.
Molecular therapy : the journal of the American Society of Gene Therapy Aug, 2012 | Pubmed ID: 22801446
T-cell therapy in the treatment of post-transplant lymphoproliferative disease.
Nature reviews. Clinical oncology Sep, 2012 | Pubmed ID: 22801669
Large-scale ex vivo expansion and characterization of natural killer cells for clinical applications.
Cytotherapy Aug, 2012 | Pubmed ID: 22900959
Sunandan Saha1,2,
Yozo Nakazawa3,
Leslie E. Huye4,5,
Joseph E. Doherty2,6,
Daniel L. Galvan2,
Cliona M. Rooney4,5,7,
Matthew H. Wilson1,2,4,8
1Program in Translational Biology and Molecular Medicine, Baylor College of Medicine ,
2Department of Medicine, Division of Nephrology, Baylor College of Medicine ,
3Department of Immunology and Pathology, Shinshu University School of Medicine,
4Center for Cell and Gene Therapy, Baylor College of Medicine ,
5Department of Pediatrics, Baylor College of Medicine ,
6Program in Cell and Molecular Biology, Baylor College of Medicine ,
7Department of Molecular Virology and Microbiology, Baylor College of Medicine ,
8, Michael E. DeBakey VA Medical Center