Kevin Strange

STIM1 和 Orai1 同源及恒温恒湿空调系统渠道秀丽隐杆线虫的遗传模型生物有机体的生理作用。

Primary culture of Caenorhabditis elegans developing embryo cells for electrophysiological, cell biological and molecular studies.

Of mice and worms: novel insights into ClC-2 anion channel physiology.

A primary culture system for functional analysis of C. elegans neurons and muscle cells.

Cell cycle- and swelling-induced activation of a Caenorhabditis elegans ClC channel is mediated by CeGLC-7alpha/beta phosphatases.

From genes to integrative physiology: ion channel and transporter biology in Caenorhabditis elegans.

Identification of store-independent and store-operated Ca2+ conductances in Caenorhabditis elegans intestinal epithelial cells.

Alternative splicing of N- and C-termini of a C. elegans ClC channel alters gating and sensitivity to external Cl- and H+.

Adaptation of the nematode Caenorhabditis elegans to extreme osmotic stress.

Inositol 1,4,5-trisphosphate signaling regulates rhythmic contractile activity of myoepithelial sheath cells in Caenorhabditis elegans.

Transcriptional targets of DAF-16 insulin signaling pathway protect C. elegans from extreme hypertonic stress.

Cellular volume homeostasis.

GCK-3, a newly identified Ste20 kinase, binds to and regulates the activity of a cell cycle-dependent ClC anion channel.

The end of "naive reductionism": rise of systems biology or renaissance of physiology?

Calcium feedback mechanisms regulate oscillatory activity of a TRP-like Ca2+ conductance in C. elegans intestinal cells.

Oscillatory Ca2+ signaling in the isolated Caenorhabditis elegans intestine: role of the inositol-1,4,5-trisphosphate receptor and phospholipases C beta and gamma.

The Rho/Rac-family guanine nucleotide exchange factor VAV-1 regulates rhythmic behaviors in C. elegans.

Altered gating and regulation of a carboxy-terminal ClC channel mutant expressed in the Caenorhabditis elegans oocyte.

Isolation of C. elegans deletion mutants following ENU mutagenesis and thermostable restriction enzyme PCR screening.

Ste20-type kinases: evolutionarily conserved regulators of ion transport and cell volume.

Carboxy terminus splice variation alters ClC channel gating and extracellular cysteine reactivity.

Genome-wide RNAi screening identifies protein damage as a regulator of osmoprotective gene expression.

Characterization of a novel voltage-dependent outwardly rectifying anion current in Caenorhabditis elegans oocytes.

Function of a STIM1 homologue in C. elegans: evidence that store-operated Ca2+ entry is not essential for oscillatory Ca2+ signaling and ER Ca2+ homeostasis.

An overview of C. elegans biology.

In vitro culture of C. elegans somatic cells.

CRAC channel activity in C. elegans is mediated by Orai1 and STIM1 homologues and is essential for ovulation and fertility.

Functional analysis of the aquaporin gene family in Caenorhabditis elegans.

Revisiting the Krogh Principle in the post-genome era: Caenorhabditis elegans as a model system for integrative physiology research.

Evolutionarily conserved WNK and Ste20 kinases are essential for acute volume recovery and survival after hypertonic shrinkage in Caenorhabditis elegans.

Molecular and genetic characterization of osmosensing and signal transduction in the nematode Caenorhabditis elegans.

Highly Ca2+-selective TRPM channels regulate IP3-dependent oscillatory Ca2+ signaling in the C. elegans intestine.

Authorship: why not just toss a coin?

Genome-wide RNAi screen and in vivo protein aggregation reporters identify degradation of damaged proteins as an essential hypertonic stress response.

Identification of regulatory phosphorylation sites in a cell volume- and Ste20 kinase-dependent ClC anion channel.

The WD40 repeat protein WDR-23 functions with the CUL4/DDB1 ubiquitin ligase to regulate nuclear abundance and activity of SKN-1 in Caenorhabditis elegans.

Increased age reduces DAF-16 and SKN-1 signaling and the hormetic response of Caenorhabditis elegans to the xenobiotic juglone.

Phosphatidylinositol 4,5-bisphosphate and loss of PLCgamma activity inhibit TRPM channels required for oscillatory Ca2+ signaling.

Unique gating properties of C. elegans ClC anion channel splice variants are determined by altered CBS domain conformation and the R-helix linker.

Cell physiology at the Mount Desert Island Biological Laboratory: a brief look back and forward.

C. elegans STK39/SPAK ortholog-mediated inhibition of ClC anion channel activity is regulated by WNK-independent ERK kinase signaling.

Putting the pieces together: a crystal clear window into CLC anion channel regulation.

Hypertonic stress induces rapid and widespread protein damage in C. elegans.