Charles L. Howe

Growth factor treatment of demyelinating disease: at last, a leap into the light.

Interleukin-6 protects anterior horn neurons from lethal virus-induced injury.

Depolarization of PC12 cells induces neurite outgrowth and enhances nerve growth factor-induced neurite outgrowth in rats.

Gamma interferon is critical for neuronal viral clearance and protection in a susceptible mouse strain following early intracranial Theiler's murine encephalomyelitis virus infection.

Human monoclonal IgM antibody promotes CNS myelin repair independent of Fc function.

Trafficking the NGF signal: implications for normal and degenerating neurons.

Signaling endosome hypothesis: A cellular mechanism for long distance communication.

Antiapoptotic signaling by a remyelination-promoting human antimyelin antibody.

Differences in the surface binding and endocytosis of neurotrophins by p75NTR.

Long-distance retrograde neurotrophic signaling.

Differential endocytic sorting of p75NTR and TrkA in response to NGF: a role for late endosomes in TrkA trafficking.

Modeling the signaling endosome hypothesis: why a drive to the nucleus is better than a (random) walk.

Picornaviruses and cell death.

Activated microglia stimulate transcriptional changes in primary oligodendrocytes via IL-1beta.

Disrupted spatial memory is a consequence of picornavirus infection.

Induction of a gene expression program in dendritic cells with a cross-linking IgM antibody to the co-stimulatory molecule B7-DC.

Absence of perforin expression confers axonal protection despite demyelination.

微镀膜的玻璃和裂伤纤维作为人工神经轴突。

Searching historical herbal texts for potential new drugs.

A high-throughput 3-parameter flow cytometry-based cell death assay.

Mechanisms of action of IVIG in adult onset Rasmussen's encephalitis.

Beta-methylamino-alanine (BMAA) injures hippocampal neurons in vivo.

CD8+ T cells directed against a viral peptide contribute to loss of motor function by disrupting axonal transport in a viral model of fulminant demyelination.

A randomized Phase I study of Atuna racemosa: a potential new anti-MRSA natural product extract.

TRAIL mediates liver injury by the innate immune system in the bile duct-ligated mouse.

Human HLA-DR transgenes protect mice from fatal virus-induced encephalomyelitis and chronic demyelination.

NKG2D contributes to efficient clearance of picornavirus from the acutely infected murine brain.

Aquaporin-4-binding autoantibodies in patients with neuromyelitis optica impair glutamate transport by down-regulating EAAT2.

TREM-2 mediated signaling induces antigen uptake and retention in mature myeloid dendritic cells.

Functional characterization of mouse spinal cord infiltrating CD8+ lymphocytes.

Apoptosis of hippocampal pyramidal neurons is virus independent in a mouse model of acute neurovirulent picornavirus infection.

Preparation of biologically active subcellular fractions using the Balch homogenizer.

Demyelinated axons and motor function are protected by genetic deletion of perforin in a mouse model of multiple sclerosis.

Subcutaneous IGF-1 is not beneficial in 2-year ALS trial.

Inflammatory changes in the central nervous system are associated with behavioral impairment in Plasmodium berghei (strain ANKA)-infected mice.

Retraction: TREM-2 mediated signaling induces antigen uptake and retention in mature myeloid dendritic cells.

CD8+ T cells cause disability and axon loss in a mouse model of multiple sclerosis.

Therapeutic doses of cranial irradiation induce hippocampus-dependent cognitive deficits in young mice.

The STAT3 beacon: IL-6 recurrently activates STAT 3 from endosomal structures.