Sang Hee Lee
National Leading Research Laboratory,
Department of Biological Sciences,
National Leading Research Laboratory, Department of Biological Sciences
Myongji University
Prof. Lee is a director in the Drug Resistance Proteomics Laboratory (National Leading Research Laboratory) and a professor in the Department of Biological Sciences at Myongji University. He received his Ph.D. in 1993 in Fermentation Biochemistry from Seoul National University, Seoul, South Korea, where he worked an natural product chemistry and molecular biology. From 1993 until 1995, he worked on antibiotic chemistry and X-ray crystallography in the School of Pharmacy at the University of Wisconsin-Madison. From 1995 to 2003, he was a professor in the Department of Biochemistry at Youngdong University.
In 2003, he moved to Myongji University. His recent work has focused on antimicrobials, multidrug resistance, biochemistry and X-ray crystal structure of ESBLs (extended-spectrum β-lactamases) and carbapenemases as well as structure-based drug design, and stem cells (regenerative medicine).
He has authored more than 130 scientific papers published in peer-reviewed journals (books), many of which were the first in the field of Infectious Diseases, Drug Resistance, and Stem Cells. Prof. Lee is currently a Deputy Director General and Scientific Adviser of IBC, an evaluator in French National Research Agency, and the Editor in several peer-reviewed journals.
Molecular characterization of extended-spectrum beta-lactamases produced by clinical isolates of Klebsiella pneumoniae and Escherichia coli from a Korean nationwide survey.
Journal of clinical microbiology Jul, 2004 | Pubmed ID: 15243036
Dissemination of transferable AmpC-type beta-lactamase (CMY-10) in a Korean hospital.
Microbial drug resistance (Larchmont, N.Y.) , 2004 | Pubmed ID: 15383166
Purification and characterization of NADPH-dependent Cr(VI) reductase from Escherichia coli ATCC 33456.
Journal of microbiology (Seoul, Korea) Feb, 2005 | Pubmed ID: 15765053
Impact of clarithromycin resistance on eradication of Helicobacter pylori in infected adults.
Antimicrobial agents and chemotherapy Apr, 2005 | Pubmed ID: 15793150
Investigation of a nosocomial outbreak of imipenem-resistant Acinetobacter baumannii producing the OXA-23 beta-lactamase in korea.
Journal of clinical microbiology May, 2005 | Pubmed ID: 15872249
Molecular characterization of TEM-type beta-lactamases identified in cold-seep sediments of Edison Seamount (south of Lihir Island, Papua New Guinea).
Journal of microbiology (Seoul, Korea) Apr, 2005 | Pubmed ID: 15880093
Removal of contaminating TEM-la beta-lactamase gene from commercial Taq DNA polymerase.
Journal of microbiology (Seoul, Korea) Feb, 2006 | Pubmed ID: 16554728
Detection of extended-spectrum beta-lactamases by using boronic acid as an AmpC beta-lactamase inhibitor in clinical isolates of Klebsiella spp. and Escherichia coli.
Journal of clinical microbiology Apr, 2007 | Pubmed ID: 17301276
Novel complex class 1 integron bearing an ISCR1 element in an Escherichia coli isolate carrying the blaCTX-M-14 gene.
Antimicrobial agents and chemotherapy Aug, 2007 | Pubmed ID: 17517851
Analyses of Mlc-IIBGlc interaction and a plausible molecular mechanism of Mlc inactivation by membrane sequestration.
Proceedings of the National Academy of Sciences of the United States of America Mar, 2008 | Pubmed ID: 18319344
Genetic organization of the putative salbostatin biosynthetic gene cluster including the 2-epi-5-epi-valiolone synthase gene in Streptomyces albus ATCC 21838.
Applied microbiology and biotechnology Sep, 2008 | Pubmed ID: 18648803
Crystal structure of filamentous aggregates of human DJ-1 formed in an inorganic phosphate-dependent manner.
The Journal of biological chemistry Dec, 2008 | Pubmed ID: 18922803
New disturbing trend in antimicrobial resistance of gram-negative pathogens.
PLoS pathogens Mar, 2009 | Pubmed ID: 19325878
Nomenclature of ISCRl elements capable of mobilizing antibiotic resistance genes present in complex class 1 integrons.
Journal of microbiology (Seoul, Korea) Aug, 2009 | Pubmed ID: 19763428
New definitions of extended-spectrum β-lactamase conferring worldwide emerging antibiotic resistance.
Medicinal research reviews Jan, 2012 | Pubmed ID: 20577973
Characterization of a chromosomal toxin-antitoxin, Rv1102c-Rv1103c system in Mycobacterium tuberculosis.
Biochemical and biophysical research communications Sep, 2010 | Pubmed ID: 20705052
Regulation of polar peptidoglycan biosynthesis by Wag31 phosphorylation in mycobacteria.
BMC microbiology , 2010 | Pubmed ID: 21190553
Crystallization and preliminary X-ray crystallographic analysis of CTX-M-15, an extended-spectrum β-lactamase conferring worldwide emerging antibiotic resistance.
Protein and peptide letters Sep, 2011 | Pubmed ID: 21443499
Determination of pentapeptide repeat units in Qnr proteins by the structure-based alignment approach.
Antimicrobial agents and chemotherapy Sep, 2011 | Pubmed ID: 21709088
Novel metagenome-derived carboxylesterase that hydrolyzes β-lactam antibiotics.
Applied and environmental microbiology Nov, 2011 | Pubmed ID: 21908637
Crystal structure of malonyl CoA-Acyl carrier protein transacylase from Xanthomanous oryzae pv. oryzae and its proposed binding with ACP.
Molecules and cells Jan, 2012 | Pubmed ID: 22134719
Preparation, crystallization and preliminary X-ray crystallographic analysis of OXA-23, a carbapenemase conferring widespread antibiotic resistance.
Indian journal of biochemistry & biophysics Dec, 2011 | Pubmed ID: 22329241
Crystallization and preliminary diffraction studies of SFC-1, a carbapenemase conferring antibiotic resistance.
Acta crystallographica. Section F, Structural biology and crystallization communications Sep, 2012 | Pubmed ID: 22949211
Crystallization and preliminary diffraction studies of GIM-1, a class B carbapenem-hydrolyzing β-lactamase.
Acta crystallographica. Section F, Structural biology and crystallization communications Oct, 2012 | Pubmed ID: 23027753
A novel biological approach to treat chondromalacia patellae.
PloS one , 2013 | Pubmed ID: 23700485
Lipid a biosynthesis of multidrug-resistant pathogens - a novel drug target.
Current pharmaceutical design , 2013 | Pubmed ID: 23829374
Expression, crystallization and preliminary X-ray crystallographic analysis of alanine racemase from Acinetobacter baumannii OXA-23.
Acta crystallographica. Section F, Structural biology and crystallization communications Sep, 2013 | Pubmed ID: 23989159
Acquired esophagobronchial fistula without Ono's sign and with unusual cause.
BMJ case reports Sep, 2013 | Pubmed ID: 24022907
Strategies to minimize antibiotic resistance.
International journal of environmental research and public health Sep, 2013 | Pubmed ID: 24036486
Safety reporting on implantation of autologous adipose tissue-derived stem cells with platelet-rich plasma into human articular joints.
BMC musculoskeletal disorders Dec, 2013 | Pubmed ID: 24289766
Comment on: current initiatives to improve prudent antibiotic use amongst school-aged children.
The Journal of antimicrobial chemotherapy Jun, 2014 | Pubmed ID: 24468862
Regenerative repair of damaged meniscus with autologous adipose tissue-derived stem cells.
BioMed research international , 2014 | Pubmed ID: 24592390
Expression, crystallization and preliminary X-ray crystallographic analysis of D-alanine-D-alanine ligase from OXA-23-producing Acinetobacter baumannii K0420859.
Acta crystallographica. Section F, Structural biology communications Apr, 2014 | Pubmed ID: 24699750
Crystallization and preliminary X-ray crystallographic analysis of the XoGroEL chaperonin from Xanthomonas oryzae pv. oryzae.
Acta crystallographica. Section F, Structural biology communications May, 2014 | Pubmed ID: 24817719
Complete resolution of avascular necrosis of the human femoral head treated with adipose tissue-derived stem cells and platelet-rich plasma.
The Journal of international medical research Dec, 2014 | Pubmed ID: 25281062
Expression, crystallization and preliminary X-ray crystallographic analysis of cystathionine β-lyase from Acinetobacter baumannii OXA-23.
Acta crystallographica. Section F, Structural biology communications Oct, 2014 | Pubmed ID: 25286941
Structure of ADC-68, a novel carbapenem-hydrolyzing class C extended-spectrum β-lactamase isolated from Acinetobacter baumannii.
Acta crystallographica. Section D, Biological crystallography Nov, 2014 | Pubmed ID: 25372683
Phosphorylation-dependent interaction between a serine/threonine kinase PknA and a putative cell division protein Wag31 in Mycobacterium tuberculosis.
The new microbiologica Oct, 2014 | Pubmed ID: 25387290
Structural basis for carbapenem-hydrolyzing mechanisms of carbapenemases conferring antibiotic resistance.
International journal of molecular sciences Apr, 2015 | Pubmed ID: 25938965
Educational effectiveness, target, and content for prudent antibiotic use.
BioMed research international , 2015 | Pubmed ID: 25945327
Fast and Accurate Large-Scale Detection of β-Lactamase Genes Conferring Antibiotic Resistance.
Antimicrobial agents and chemotherapy Oct, 2015 | Pubmed ID: 26169415
Urgent need for β-lactam-β-lactamase inhibitors.
The Lancet. Infectious diseases Aug, 2015 | Pubmed ID: 26227756
Quantitative proteomic view associated with resistance to clinically important antibiotics in Gram-positive bacteria: a systematic review.
Frontiers in microbiology , 2015 | Pubmed ID: 26322035
The crystal structure of the D-alanine-D-alanine ligase from Acinetobacter baumannii suggests a flexible conformational change in the central domain before nucleotide binding.
Journal of microbiology (Seoul, Korea) Nov, 2015 | Pubmed ID: 26502962
How to minimise antibiotic resistance.
The Lancet. Infectious diseases Jan, 2016 | Pubmed ID: 26738826
Epidemiology and Clinical Burden of Malaria in the War-Torn Area, Orakzai Agency in Pakistan.
PLoS neglected tropical diseases Jan, 2016 | Pubmed ID: 26809063
Cartilage Regeneration in Human with Adipose Tissue-Derived Stem Cells: Current Status in Clinical Implications.
BioMed research international , 2016 | Pubmed ID: 26881220
Time-resolved pathogenic gene expression analysis of the plant pathogen Xanthomonas oryzae pv. oryzae.
BMC genomics 05, 2016 | Pubmed ID: 27165035
A novel family VIII carboxylesterase hydrolysing third- and fourth-generation cephalosporins.
SpringerPlus , 2016 | Pubmed ID: 27186489
Global Dissemination of Carbapenemase-Producing Klebsiella pneumoniae: Epidemiology, Genetic Context, Treatment Options, and Detection Methods.
Frontiers in microbiology , 2016 | Pubmed ID: 27379038
Complex Class 1 Integron Carrying qnrB62 and blaVIM-2 in a Citrobacter freundii Clinical Isolate.
Antimicrobial agents and chemotherapy 11, 2016 | Pubmed ID: 27572415
Regeneration of Cartilage in Human Knee Osteoarthritis with Autologous Adipose Tissue-Derived Stem Cells and Autologous Extracellular Matrix.
BioResearch open access , 2016 | Pubmed ID: 27588219
Why cannot a β-lactamase gene be detected using an efficient molecular diagnostic method?
Pakistan journal of medical sciences Sep-Oct, 2016 | Pubmed ID: 27882043
Erratum for Lee et al., Fast and Accurate Large-Scale Detection of β-Lactamase Genes Conferring Antibiotic Resistance.
Antimicrobial agents and chemotherapy 11, 2016 | Pubmed ID: 28045668
Current use of autologous adipose tissue-derived stromal vascular fraction cells for orthopedic applications.
Journal of biomedical science Jan, 2017 | Pubmed ID: 28143470
Surveillance of Crimean-Congo haemorrhagic fever in Pakistan.
The Lancet. Infectious diseases 04, 2017 | Pubmed ID: 28346174
Biology of : Pathogenesis, Antibiotic Resistance Mechanisms, and Prospective Treatment Options.
Frontiers in cellular and infection microbiology , 2017 | Pubmed ID: 28348979
Potential use of mesenchymal stem cells in human meniscal repair: current insights.
Open access journal of sports medicine , 2017 | Pubmed ID: 28356779
Unique Features of Plasmid pAC3 and Expression of the Plasmid-Mediated Quinolone Resistance Genes.
mSphere May-Jun, 2017 | Pubmed ID: 28567445
Antimicrobial Resistance of Hypervirulent : Epidemiology, Hypervirulence-Associated Determinants, and Resistance Mechanisms.
Frontiers in cellular and infection microbiology , 2017 | Pubmed ID: 29209595
PNGM-1, a novel subclass B3 metallo-β-lactamase from a deep-sea sediment metagenome.
Journal of global antimicrobial resistance Sep, 2018 | Pubmed ID: 29842976
Commentary: Malaria elimination in India and regional implications.
Frontiers in microbiology , 2018 | Pubmed ID: 29867890
Cartilage Regeneration in Humans with Adipose Tissue-Derived Stem Cells and Adipose Stromal Vascular Fraction Cells: Updated Status.
International journal of molecular sciences Jul, 2018 | Pubmed ID: 30041472
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