Whitehead Institute for Biomedical Research,
Department of Biology
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Cooperative kinetics of both Hsp104 ATPase domains and interdomain communication revealed by AAA sensor-1 mutants.
The EMBO journal Jan, 2002 | Pubmed ID: 11782421
Susan L. Lindquist.
Trends in cell biology Mar, 2002 | Pubmed ID: 11859028
Analysis of the AAA sensor-2 motif in the C-terminal ATPase domain of Hsp104 with a site-specific fluorescent probe of nucleotide binding.
Proceedings of the National Academy of Sciences of the United States of America Mar, 2002 | Pubmed ID: 11867765
Defining a pathway of communication from the C-terminal peptide binding domain to the N-terminal ATPase domain in a AAA protein.
Molecular cell Apr, 2002 | Pubmed ID: 11983167
Hsp90 as a capacitor of phenotypic variation.
Nature Jun, 2002 | Pubmed ID: 12050657
Analysis of prion factors in yeast.
Methods in enzymology , 2002 | Pubmed ID: 12073366
Prions as protein-based genetic elements.
Annual review of microbiology , 2002 | Pubmed ID: 12142498
Conversion of PrP to a self-perpetuating PrPSc-like conformation in the cytosol.
Science (New York, N.Y.) Nov, 2002 | Pubmed ID: 12386336
Neurotoxicity and neurodegeneration when PrP accumulates in the cytosol.
Science (New York, N.Y.) Nov, 2002 | Pubmed ID: 12386337
Changes in the middle region of Sup35 profoundly alter the nature of epigenetic inheritance for the yeast prion [PSI+].
Proceedings of the National Academy of Sciences of the United States of America Dec, 2002 | Pubmed ID: 12461168
Self-perpetuating structural states in biology, disease, and genetics.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2002 | Pubmed ID: 12475994
Conducting nanowires built by controlled self-assembly of amyloid fibers and selective metal deposition.
Proceedings of the National Academy of Sciences of the United States of America Apr, 2003 | Pubmed ID: 12672964
Hsp90 and chromatin: where is the link?
Cell cycle (Georgetown, Tex.) May-Jun, 2003 | Pubmed ID: 12734413
Prion protein gene polymorphisms in Saccharomyces cerevisiae.
Molecular microbiology Aug, 2003 | Pubmed ID: 12890024
Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein.
Science (New York, N.Y.) Dec, 2003 | Pubmed ID: 14657499
Yeast cells provide insight into alpha-synuclein biology and pathobiology.
Science (New York, N.Y.) Dec, 2003 | Pubmed ID: 14657500
A neuronal isoform of the aplysia CPEB has prion-like properties.
Cell Dec, 2003 | Pubmed ID: 14697205
Dominant gain-of-function mutations in Hsp104p reveal crucial roles for the middle region.
Molecular biology of the cell May, 2004 | Pubmed ID: 14978213
The elongation of yeast prion fibers involves separable steps of association and conversion.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2004 | Pubmed ID: 14983002
Under cover: causes, effects and implications of Hsp90-mediated genetic capacitance.
BioEssays : news and reviews in molecular, cellular and developmental biology Apr, 2004 | Pubmed ID: 15057933
Interactions among alpha-synuclein, dopamine, and biomembranes: some clues for understanding neurodegeneration in Parkinson's disease.
Journal of molecular neuroscience : MN , 2004 | Pubmed ID: 15126689
Hsp104 catalyzes formation and elimination of self-replicating Sup35 prion conformers.
Science (New York, N.Y.) Jun, 2004 | Pubmed ID: 15155912
Epigenetic regulation of translation reveals hidden genetic variation to produce complex traits.
Nature Sep, 2004 | Pubmed ID: 15311209
Effects of Q/N-rich, polyQ, and non-polyQ amyloids on the de novo formation of the [PSI+] prion in yeast and aggregation of Sup35 in vitro.
Proceedings of the National Academy of Sciences of the United States of America Aug, 2004 | Pubmed ID: 15326312
Potent inhibition of huntingtin aggregation and cytotoxicity by a disulfide bond-free single-domain intracellular antibody.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2004 | Pubmed ID: 15598740
Navigating the ClpB channel to solution.
Nature structural & molecular biology Jan, 2005 | Pubmed ID: 15689967
A chaperone pathway in protein disaggregation. Hsp26 alters the nature of protein aggregates to facilitate reactivation by Hsp104.
The Journal of biological chemistry Jun, 2005 | Pubmed ID: 15845535
Prions as adaptive conduits of memory and inheritance.
Nature reviews. Genetics Jun, 2005 | Pubmed ID: 15931169
Structural insights into a yeast prion illuminate nucleation and strain diversity.
Nature Jun, 2005 | Pubmed ID: 15944694
Prion proteins: one surprise after another.
Harvey lectures -2003, 2002 | Pubmed ID: 16033161
HSP90 and the chaperoning of cancer.
Nature reviews. Cancer Oct, 2005 | Pubmed ID: 16175177
Hsp90 potentiates the rapid evolution of new traits: drug resistance in diverse fungi.
Science (New York, N.Y.) Sep, 2005 | Pubmed ID: 16195452
Increase in activity during calorie restriction requires Sirt1.
Science (New York, N.Y.) Dec, 2005 | Pubmed ID: 16339438
Harnessing natural diversity to probe metabolic pathways.
PLoS genetics Dec, 2005 | Pubmed ID: 16429164
Prion protein is expressed on long-term repopulating hematopoietic stem cells and is important for their self-renewal.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2006 | Pubmed ID: 16467153
Prion protein (PrPc) positively regulates neural precursor proliferation during developmental and adult mammalian neurogenesis.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2006 | Pubmed ID: 16492732
Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models.
Science (New York, N.Y.) Jul, 2006 | Pubmed ID: 16794039
A network of protein interactions determines polyglutamine toxicity.
Proceedings of the National Academy of Sciences of the United States of America Jul, 2006 | Pubmed ID: 16832049
Flanking sequences profoundly alter polyglutamine toxicity in yeast.
Proceedings of the National Academy of Sciences of the United States of America Jul, 2006 | Pubmed ID: 16832050
Destruction or potentiation of different prions catalyzed by similar Hsp104 remodeling activities.
Molecular cell Aug, 2006 | Pubmed ID: 16885031
Green tea (-)-epigallocatechin-gallate modulates early events in huntingtin misfolding and reduces toxicity in Huntington's disease models.
Human molecular genetics Sep, 2006 | Pubmed ID: 16893904
Genetic architecture of Hsp90-dependent drug resistance.
Eukaryotic cell Dec, 2006 | Pubmed ID: 17056742
Asymmetric deceleration of ClpB or Hsp104 ATPase activity unleashes protein-remodeling activity.
Nature structural & molecular biology Feb, 2007 | Pubmed ID: 17259993
The power of automated high-resolution behavior analysis revealed by its application to mouse models of Huntington's and prion diseases.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2007 | Pubmed ID: 17261803
A natively unfolded yeast prion monomer adopts an ensemble of collapsed and rapidly fluctuating structures.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2007 | Pubmed ID: 17299036
Prion recognition elements govern nucleation, strain specificity and species barriers.
Nature May, 2007 | Pubmed ID: 17495929
A suite of Gateway cloning vectors for high-throughput genetic analysis in Saccharomyces cerevisiae.
Yeast (Chichester, England) Oct, 2007 | Pubmed ID: 17583893
Phenotypic diversity and altered environmental plasticity in Arabidopsis thaliana with reduced Hsp90 levels.
PloS one , 2007 | Pubmed ID: 17653275
Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis.
Cell Sep, 2007 | Pubmed ID: 17889646
Probing the role of PrP repeats in conformational conversion and amyloid assembly of chimeric yeast prions.
The Journal of biological chemistry Nov, 2007 | Pubmed ID: 17893150
Alternative assembly pathways of the amyloidogenic yeast prion determinant Sup35-NM.
EMBO reports Dec, 2007 | Pubmed ID: 17975557
Diminishing apoptosis by deletion of Bax or overexpression of Bcl-2 does not protect against infectious prion toxicity in vivo.
The Journal of neuroscience : the official journal of the Society for Neuroscience Nov, 2007 | Pubmed ID: 18032675
Illuminating aggregate heterogeneity in neurodegenerative disease.
Nature methods Dec, 2007 | Pubmed ID: 18049468
Atypical AAA+ subunit packing creates an expanded cavity for disaggregation by the protein-remodeling factor Hsp104.
Cell Dec, 2007 | Pubmed ID: 18160044
The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis.
Proceedings of the National Academy of Sciences of the United States of America Jan, 2008 | Pubmed ID: 18162536
HSP90-buffered genetic variation is common in Arabidopsis thaliana.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2008 | Pubmed ID: 18287064
HSP90 affects the expression of genetic variation and developmental stability in quantitative traits.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2008 | Pubmed ID: 18287065
Hsp110 chaperones regulate prion formation and propagation in S. cerevisiae by two discrete activities.
PloS one , 2008 | Pubmed ID: 18335038
Detection of compounds that rescue Rab1-synuclein toxicity.
Methods in enzymology , 2008 | Pubmed ID: 18374176
A yeast TDP-43 proteinopathy model: Exploring the molecular determinants of TDP-43 aggregation and cellular toxicity.
Proceedings of the National Academy of Sciences of the United States of America Apr, 2008 | Pubmed ID: 18434538
Chaperone-dependent amyloid assembly protects cells from prion toxicity.
Proceedings of the National Academy of Sciences of the United States of America May, 2008 | Pubmed ID: 18480252
Direct and selective elimination of specific prions and amyloids by 4,5-dianilinophthalimide and analogs.
Proceedings of the National Academy of Sciences of the United States of America May, 2008 | Pubmed ID: 18480256
Hsp104 antagonizes alpha-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease.
The Journal of clinical investigation Sep, 2008 | Pubmed ID: 18704197
Heat shock factor 1 regulates lifespan as distinct from disease onset in prion disease.
Proceedings of the National Academy of Sciences of the United States of America Sep, 2008 | Pubmed ID: 18757733
The role of calorie restriction and SIRT1 in prion-mediated neurodegeneration.
Experimental gerontology Dec, 2008 | Pubmed ID: 18799131
Hsp104, Hsp70 and Hsp40 interplay regulates formation, growth and elimination of Sup35 prions.
The EMBO journal Oct, 2008 | Pubmed ID: 18833196
Impaired ERAD and ER stress are early and specific events in polyglutamine toxicity.
Genes & development Dec, 2008 | Pubmed ID: 19015277
Using yeast to understand protein folding diseases: an interview with Susan Lindquist by Kristin Kain.
Disease models & mechanisms Jul-Aug, 2008 | Pubmed ID: 19048046
Prion switching in response to environmental stress.
PLoS biology Nov, 2008 | Pubmed ID: 19067491
Lymphotoxin-dependent prion replication in inflammatory stromal cells of granulomas.
Immunity Dec, 2008 | Pubmed ID: 19100703
Evidence that alpha-synuclein does not inhibit phospholipase D.
Biochemistry Feb, 2009 | Pubmed ID: 19146388
The prion protein knockout mouse: a phenotype under challenge.
Prion Apr-Jun, 2007 | Pubmed ID: 19164918
Prion pathogenesis is independent of caspase-12.
Prion Oct-Dec, 2007 | Pubmed ID: 19164919
Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity.
Nature genetics Mar, 2009 | Pubmed ID: 19182805
Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2009 | Pubmed ID: 19196973
Bridging high-throughput genetic and transcriptional data reveals cellular responses to alpha-synuclein toxicity.
Nature genetics Mar, 2009 | Pubmed ID: 19234470
BETASCAN: probable beta-amyloids identified by pairwise probabilistic analysis.
PLoS computational biology Mar, 2009 | Pubmed ID: 19325876
Inhibiting the transcription factor HSF1 as an anticancer strategy.
Expert opinion on therapeutic targets Apr, 2009 | Pubmed ID: 19335068
A systematic survey identifies prions and illuminates sequence features of prionogenic proteins.
Cell Apr, 2009 | Pubmed ID: 19345193
A nucleolar protein allows viability in the absence of the essential ER-residing molecular chaperone calnexin.
Journal of cell science May, 2009 | Pubmed ID: 19351719
Motor mechanism for protein threading through Hsp104.
Molecular cell Apr, 2009 | Pubmed ID: 19362537
Amyloid deposits: protection against toxic protein species?
Cell cycle (Georgetown, Tex.) Jun, 2009 | Pubmed ID: 19411847
Unraveling infectious structures, strain variants and species barriers for the yeast prion [PSI+].
Nature structural & molecular biology Jun, 2009 | Pubmed ID: 19491937
Rapid selection of cyclic peptides that reduce alpha-synuclein toxicity in yeast and animal models.
Nature chemical biology Sep, 2009 | Pubmed ID: 19597508
Loss of Hsp70 exacerbates pathogenesis but not levels of fibrillar aggregates in a mouse model of Huntington's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jul, 2009 | Pubmed ID: 19605647
Spontaneous generation of prion infectivity in fatal familial insomnia knockin mice.
Neuron Aug, 2009 | Pubmed ID: 19709627
The Schizosaccharomyces pombe Hsp104 disaggregase is unable to propagate the [PSI] prion.
PloS one , 2009 | Pubmed ID: 19759825
A heritable switch in carbon source utilization driven by an unusual yeast prion.
Genes & development Oct, 2009 | Pubmed ID: 19797769
Context-dependent perturbation of neural systems in transgenic mice expressing a cytosolic prion protein.
NeuroImage Feb, 2010 | Pubmed ID: 19835963
Context dependent neuroprotective properties of prion protein (PrP).
Prion Oct-Dec, 2009 | Pubmed ID: 19901559
Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease models.
Disease models & mechanisms Mar-Apr, 2010 | Pubmed ID: 20038714
Prions, protein homeostasis, and phenotypic diversity.
Trends in cell biology Mar, 2010 | Pubmed ID: 20071174
Prion induction involves an ancient system for the sequestration of aggregated proteins and heritable changes in prion fragmentation.
Proceedings of the National Academy of Sciences of the United States of America May, 2010 | Pubmed ID: 20421488
Modelling neurodegeneration in Saccharomyces cerevisiae: why cook with baker's yeast?
Nature reviews. Neuroscience Jun, 2010 | Pubmed ID: 20424620
Conversion of a yeast prion protein to an infectious form in bacteria.
Proceedings of the National Academy of Sciences of the United States of America Jun, 2010 | Pubmed ID: 20484678
α-Synuclein: membrane interactions and toxicity in Parkinson's disease.
Annual review of cell and developmental biology Nov, 2010 | Pubmed ID: 20500090
HSP90 at the hub of protein homeostasis: emerging mechanistic insights.
Nature reviews. Molecular cell biology Jul, 2010 | Pubmed ID: 20531426
Polyamine pathway contributes to the pathogenesis of Parkinson disease.
Proceedings of the National Academy of Sciences of the United States of America Sep, 2010 | Pubmed ID: 20837543
Biochemical, cell biological, and genetic assays to analyze amyloid and prion aggregation in yeast.
Methods in enzymology , 2010 | Pubmed ID: 20946833
Epigenetics in the extreme: prions and the inheritance of environmentally acquired traits.
Science (New York, N.Y.) Oct, 2010 | Pubmed ID: 21030648
Protein homeostasis and the phenotypic manifestation of genetic diversity: principles and mechanisms.
Annual review of genetics , 2010 | Pubmed ID: 21047258
Three quite different things that matter to me.
Molecular biology of the cell Nov, 2010 | Pubmed ID: 21079020
Optical trapping with high forces reveals unexpected behaviors of prion fibrils.
Nature structural & molecular biology Dec, 2010 | Pubmed ID: 21113168
Hsp90 and environmental stress transform the adaptive value of natural genetic variation.
Science (New York, N.Y.) Dec, 2010 | Pubmed ID: 21205668
Cyclin-G-associated kinase modifies α-synuclein expression levels and toxicity in Parkinson's disease: results from the GenePD Study.
Human molecular genetics Apr, 2011 | Pubmed ID: 21258085
Protein-only mechanism induces self-perpetuating changes in the activity of neuronal Aplysia cytoplasmic polyadenylation element binding protein (CPEB).
Proceedings of the National Academy of Sciences of the United States of America Feb, 2011 | Pubmed ID: 21270333
The cellular prion protein mediates neurotoxic signalling of β-sheet-rich conformers independent of prion replication.
The EMBO journal May, 2011 | Pubmed ID: 21441896
A yeast model of FUS/TLS-dependent cytotoxicity.
PLoS biology Apr, 2011 | Pubmed ID: 21541368
ResponseNet: revealing signaling and regulatory networks linking genetic and transcriptomic screening data.
Nucleic acids research Jul, 2011 | Pubmed ID: 21576238
A flurry of folding problems: an interview with Susan Lindquist by Jane Gitschier.
PLoS genetics May, 2011 | Pubmed ID: 21589898
Prion formation and polyglutamine aggregation are controlled by two classes of genes.
PLoS genetics May, 2011 | Pubmed ID: 21625618
A method for probing the mutational landscape of amyloid structure.
Bioinformatics (Oxford, England) Jul, 2011 | Pubmed ID: 21685090
Opposing effects of glutamine and asparagine govern prion formation by intrinsically disordered proteins.
Molecular cell Jul, 2011 | Pubmed ID: 21726811
Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations.
Cell Jul, 2011 | Pubmed ID: 21757228
Physical properties of polymorphic yeast prion amyloid fibers.
Biophysical journal Jul, 2011 | Pubmed ID: 21767497
Piperazinyl quinolines as chemosensitizers to increase fluconazole susceptibility of Candida albicans clinical isolates.
Bioorganic & medicinal chemistry letters Sep, 2011 | Pubmed ID: 21802942
TorsinA and the torsinA-interacting protein printor have no impact on endoplasmic reticulum stress or protein trafficking in yeast.
PloS one , 2011 | Pubmed ID: 21818381
Chemical and biological approaches for adapting proteostasis to ameliorate protein misfolding and aggregation diseases: progress and prognosis.
Cold Spring Harbor perspectives in biology Dec, 2011 | Pubmed ID: 21900404
Functional links between Aβ toxicity, endocytic trafficking, and Alzheimer's disease risk factors in yeast.
Science (New York, N.Y.) Dec, 2011 | Pubmed ID: 22033521
High levels of nuclear heat-shock factor 1 (HSF1) are associated with poor prognosis in breast cancer.
Proceedings of the National Academy of Sciences of the United States of America Nov, 2011 | Pubmed ID: 22042860
Using the Heat-Shock Response To Discover Anticancer Compounds that Target Protein Homeostasis.
ACS chemical biology Nov, 2011 | Pubmed ID: 22050377
STITCHER: Dynamic assembly of likely amyloid and prion β-structures from secondary structure predictions.
Proteins Sep, 2011 | Pubmed ID: 22095906
QnAs with Susan L. Lindquist. Interviewed by Prashant Nair.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2011 | Pubmed ID: 22123945
Different 8-Hydroxyquinolines Protect Models of TDP-43 Protein, α-Synuclein, and Polyglutamine Proteotoxicity through Distinct Mechanisms.
The Journal of biological chemistry Feb, 2012 | Pubmed ID: 22147697
SIRT1 protects against α-synuclein aggregation by activating molecular chaperones.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jan, 2012 | Pubmed ID: 22219275
Prions are a common mechanism for phenotypic inheritance in wild yeasts.
Nature Feb, 2012 | Pubmed ID: 22337056