Emerging Infectious Diseases Program
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Therapeutic vaccination and novel strategies to treat chronic HBV infection.
Expert review of gastroenterology & hepatology Oct, 2009 | Pubmed ID: 19817676
Contribution of herpesvirus specific CD8 T cells to anti-viral T cell response in humans.
PLoS pathogens , 2010 | Pubmed ID: 20808900
Targeting hepatitis B virus-infected cells with a T-cell receptor-like antibody.
Journal of virology Mar, 2011 | Pubmed ID: 21159876
HBV-Specific Adaptive Immunity.
Viruses Sep, 2009 | Pubmed ID: 21994540
Preserved T-cell function in children and young adults with immune-tolerant chronic hepatitis B.
Gastroenterology Sep, 2012 | Pubmed ID: 22710188
Human tissues contain CD141hi cross-presenting dendritic cells with functional homology to mouse CD103+ nonlymphoid dendritic cells.
Immunity Jul, 2012 | Pubmed ID: 22795876
Differential targeting of viral components by CD4+ versus CD8+ T lymphocytes in dengue virus infection.
Journal of virology Mar, 2013 | Pubmed ID: 23255803
Conditional ligands for Asian HLA variants facilitate the definition of CD8+ T-cell responses in acute and chronic viral diseases.
European journal of immunology Apr, 2013 | Pubmed ID: 23280567
IL-1β production through the NLRP3 inflammasome by hepatic macrophages links hepatitis C virus infection with liver inflammation and disease.
PLoS pathogens , 2013 | Pubmed ID: 23633957
Mobilizing monocytes to cross-present circulating viral antigen in chronic infection.
The Journal of clinical investigation Sep, 2013 | Pubmed ID: 23908113
A practical approach to immunotherapy of hepatocellular carcinoma using T cells redirected against hepatitis B virus.
Molecular therapy. Nucleic acids Aug, 2013 | Pubmed ID: 23941866
Reduction of HBV replication prolongs the early immunological response to IFNα therapy.
Journal of hepatology Jan, 2014 | Pubmed ID: 23994382
Immunoprevalence and immunodominance of HLA-Cw*0801-restricted T cell response targeting the hepatitis B virus envelope transmembrane region.
Journal of virology Jan, 2014 | Pubmed ID: 24227846
Immune therapeutic strategies in chronic hepatitis B virus infection: virus or inflammation control?
PLoS pathogens , 2013 | Pubmed ID: 24367255
Building and optimizing a virus-specific T cell receptor library for targeted immunotherapy in viral infections.
Scientific reports Feb, 2014 | Pubmed ID: 24566718
Parallel T-cell cloning and deep sequencing of human MAIT cells reveal stable oligoclonal TCRβ repertoire.
Nature communications May, 2014 | Pubmed ID: 24832684
Toll-like receptor 8 agonist and bacteria trigger potent activation of innate immune cells in human liver.
PLoS pathogens Jun, 2014 | Pubmed ID: 24967632
Cancer immunotherapy: targeting the difference.
Journal of hepatology Nov, 2014 | Pubmed ID: 24993529
Immunological aspects of antiviral therapy of chronic hepatitis B virus and hepatitis C virus infections.
Hepatology (Baltimore, Md.) Feb, 2015 | Pubmed ID: 25048716
The immune tolerant phase of chronic HBV infection: new perspectives on an old concept.
Cellular & molecular immunology May, 2015 | Pubmed ID: 25176526
Age-Dependent Immune Events during HBV Infection from Birth to Adulthood: An Alternative Interpretation.
Frontiers in immunology , 2014 | Pubmed ID: 25295036
Hepatitis B: future curative strategies.
Current opinion in infectious diseases Dec, 2014 | Pubmed ID: 25304392
Immunotherapy of HCC metastases with autologous T cell receptor redirected T cells, targeting HBsAg in a liver transplant patient.
Journal of hepatology Feb, 2015 | Pubmed ID: 25308176
Reply to: "To target or not to target viral antigens in HBV related HCC?".
Journal of hepatology Jun, 2015 | Pubmed ID: 25711420
Virus-specific T lymphocytes home to the skin during natural dengue infection.
Science translational medicine Mar, 2015 | Pubmed ID: 25761891
Trained immunity in newborn infants of HBV-infected mothers.
Nature communications Mar, 2015 | Pubmed ID: 25807344
Overview of the special issue on HBV immunity.
Cellular & molecular immunology May, 2015 | Pubmed ID: 25864914
Understanding the T cell immune response in SARS coronavirus infection.
Emerging microbes & infections Sep, 2012 | Pubmed ID: 26038429
Immune Response in Hepatitis B Virus Infection.
Cold Spring Harbor perspectives in medicine Jul, 2015 | Pubmed ID: 26134480
Advances in therapeutics for chronic hepatitis B.
Hepatology international Mar, 2016 | Pubmed ID: 26363922
T cell fitness in the liver: How can T cells keep it up?
Journal of hepatology 06, 2016 | Pubmed ID: 26943972
Memory T cell responses targeting the SARS coronavirus persist up to 11 years post-infection.
Vaccine Apr, 2016 | Pubmed ID: 26954467
Adaptive immunity in HBV infection.
Journal of hepatology Apr, 2016 | Pubmed ID: 27084039
Microfluidic models for adoptive cell-mediated cancer immunotherapies.
Drug discovery today 09, 2016 | Pubmed ID: 27185084
Redirecting T Cell Specificity Using T Cell Receptor Messenger RNA Electroporation.
Methods in molecular biology (Clifton, N.J.) , 2016 | Pubmed ID: 27236807
Advanced Design of Dumbbell-shaped Genetic Minimal Vectors Improves Non-coding and Coding RNA Expression.
Molecular therapy : the journal of the American Society of Gene Therapy 09, 2016 | Pubmed ID: 27357627
HBV in 2016: Global and immunotherapeutic insights into hepatitis B.
Nature reviews. Gastroenterology & hepatology 02, 2017 | Pubmed ID: 28053337
An accelerated rabies vaccine schedule based on toll-like receptor 3 (TLR3) agonist PIKA adjuvant augments rabies virus specific antibody and T cell response in healthy adult volunteers.
Vaccine 02, 2017 | Pubmed ID: 28118938
Hepatitis C Virus-Specific T Cell Receptor mRNA-Engineered Human T Cells: Impact of Antigen Specificity on Functional Properties.
Journal of virology 05, 2017 | Pubmed ID: 28228595
Immune Tolerant Chronic Hepatitis B: The Unrecognized Risks.
Viruses 04, 2017 | Pubmed ID: 28468285
A 3D microfluidic model for preclinical evaluation of TCR-engineered T cells against solid tumors.
JCI insight Jun, 2017 | Pubmed ID: 28614795
T-cell therapy for chronic viral hepatitis.
Cytotherapy 11, 2017 | Pubmed ID: 28847469
Targeted Therapy of Hepatitis B Virus-Related Hepatocellular Carcinoma: Present and Future.
Diseases (Basel, Switzerland) Feb, 2016 | Pubmed ID: 28933390
CD137L dendritic cells induce potent response against cancer-associated viruses and polarize human CD8 T cells to Tc1 phenotype.
Cancer immunology, immunotherapy : CII 06, 2018 | Pubmed ID: 29508025
Nonlytic Lymphocytes Engineered to Express Virus-Specific T-Cell Receptors Limit HBV Infection by Activating APOBEC3.
Gastroenterology 07, 2018 | Pubmed ID: 29550589
Editorial overview: Antiviral strategies: Virological and immunological basis for HBV cure.
Current opinion in virology Jun, 2018 | Pubmed ID: 29866361
Nonstimulatory peptide-MHC enhances human T-cell antigen-specific responses by amplifying proximal TCR signaling.
Nature communications 07, 2018 | Pubmed ID: 30006605
Molecular Recalibration of PD-1+ Antigen-Specific T Cells from Blood and Liver.
Molecular therapy : the journal of the American Society of Gene Therapy Nov, 2018 | Pubmed ID: 30217730
Spatiotemporal Differences in Presentation of CD8 T Cell Epitopes during Hepatitis B Virus Infection.
Journal of virology Feb, 2019 | Pubmed ID: 30518652
Use of Expression Profiles of HBV DNA Integrated Into Genomes of Hepatocellular Carcinoma Cells to Select T Cells for Immunotherapy.
Gastroenterology Jan, 2019 | Pubmed ID: 30711630
Xiang Zhao1,
Maryam Hamidinia1,
Joanna Ai Ling Choo1,
Chien Tei Too1,2,
Zi Zong Ho3,
Ee Chee Ren4,
Antonio Bertoletti3,
Paul A. MacAry1,2,5,
Keith G. Gould6,
Joanna Brzostek1,
Nicholas R.J. Gascoigne1,2,5
1Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore,
2Immunology Programme, Life Sciences Institute, National University of Singapore,
3Emerging Infectious Diseases Program, Duke-NUS Graduate Medical School,
4Singapore Immunology Network, A*STAR,
5NUS Graduate School for Integrative Sciences and Engineering (NGS), National University of Singapore,
6Department of Immunology, Wright-Fleming Institute, Imperial College London