the-detection-5-hydroxymethylcytosine-neural-stem-cells-brains

The Detection of 5-Hydroxymethylcytosine in Neural Stem Cells and Brains of Mice

Multiple&#160;DNA modifications have been identified in the mammalian genome. Of that, 5-methylcytosine and 5-hydroxymethylcytosine-mediated epigenetic ...

Zhejiang University

DNA demethylation, the conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC), plays important roles in diverse biological processes and multiple diseases by regulating gene expression.

The Dynamic DNA Demethylation during Postnatal Neuronal Development and Neural Stem Cell Differentiation.

Long non-coding RNAs (lncRNAs) are transcripts which are usually more than 200 nt in length, and which do not have the protein-coding capacity. LncRNAs can be categorized based on their generation from distinct DNA elements, or derived from specific RNA processing pathways. During the past several decades, dramatic progress has been made in understanding the regulatory functions of lncRNAs in diverse biological processes, including RNA processing and editing, cell fate determination, dosage compensation, genomic imprinting and development etc. Dysregulation of lncRNAs is involved in multiple human diseases, especially neurological disorders. In this review, we summarize the recent progress made with regards to the function of lncRNAs and associated molecular mechanisms, focusing on neuronal development and neurological disorders.

Yingliang Zhuang

The Children's Hospital,
School of Medicine,
The Institute of Translational Medicine,
The Children's Hospital, School of Medicine,
The Institute of Translational Medicine, School of Medicine

Zhejiang University

The Detection of 5-Hydroxymethylcytosine in Neural Stem Cells and Brains of Mice

Yingliang Zhuang

.css-o250i3{font-size:18px;font-family:Open Sans,sans-serif;line-height:21.6px;}The Children's Hospital,School of Medicine,The Institute of Translational Medicine,The Children's Hospital, School of Medicine,The Institute of Translational Medicine, School of Medicine

Zhejiang University

The Detection of 5-Hydroxymethylcytosine in Neural Stem Cells and Brains of Mice

The Children's Hospital,
School of Medicine,
The Institute of Translational Medicine,
The Children's Hospital, School of Medicine,
The Institute of Translational Medicine, School of Medicine