Institut für Mikrobiologie
Since 2010, PD Dr. Simone Bergmann is a group leader and lecturer at the Institute of Microbiology, Technische Universität Braunschweig, Germany. After her studies on microbiology, cellbiology, biochemistry and genetics at the TU in Braunschweig, she started her research on streptococcus-host interaction with her diploma thesis at the “Gesellschaft für Biotechnologische Forschung” in Braunschweig, in Sven Hammerschmidt´s lab. After a short scientific stay at the “Menzies School of Health Research” in Darwin, Northern Territories, Australia in 2000, she achieved her PhD at the TU Braunschweig in 2002 with summa cum laude. Her PhD project was also honored with an advancement award from the Helmholtz association in 2003. She intensified her studies on the interaction of pneumococci with fibrinolytic enzymes and with extracellular matrix proteins as post doc fellow at the Zentrum für Infektionsforschung (ZINF) in Würzburg for four years and for another one year at the Max von Pettenkofer-Institute at the Ludwig-Maximillians-Universität (LMU) in Munich. In 2008 she moved back to the Helmholtz Center for Infection Research (HZI) in Braunschweig and joined the department of Singh Chhatwal as project leader on an EU-funded position within the “Carepneumo”- consortium. At that time she focused her scientific projects on the interplay between streptococci and primary endothelial cells. After she received the venia legendi for microbiology in 2010, she was recruited to the group of Michael Steinert at the TU in Braunschweig and started to study the impact of Streptococcus pneumoniae on hemostatic processes. One of her major scientific aims was to elucidate the function of the mechanosensitive Von Willebrand Factor in the bacterial infection process. In 2015 she became associated to the DFG-funded “Shenc” - consortium (Shear Flow Regulation of Hemostasis) and started to analyse the function of the Von Willebrand Factor using various cell culture infection systems including a microfluidic endothelial model system. In 2017, she received the Günther Landbeck Excellence award for experimental research on the pneumococcus interaction with Von Willebrand Factor, which was granted by the Hämophilie-Association in Hamburg.
An optimized in vitro blood-brain barrier model reveals bidirectional transmigration of African trypanosome strains.
Microbiology (Reading, England) Oct, 2011 | Pubmed ID: 21737496
Relevance of Bifidobacterium animalis subsp. lactis plasminogen binding activity in the human gastrointestinal microenvironment.
Applied and environmental microbiology Oct, 2011 | Pubmed ID: 21821753
Crystallization and preliminary X-ray diffraction analysis of phosphoglycerate kinase from Streptococcus pneumoniae.
Acta crystallographica. Section F, Structural biology and crystallization communications Oct, 2011 | Pubmed ID: 22102049
Tumor necrosis factor alpha modulates the dynamics of the plasminogen-mediated early interaction between Bifidobacterium animalis subsp. lactis and human enterocytes.
Applied and environmental microbiology Apr, 2012 | Pubmed ID: 22287006
Streptococcus pneumoniae endopeptidase O (PepO) is a multifunctional plasminogen- and fibronectin-binding protein, facilitating evasion of innate immunity and invasion of host cells.
The Journal of biological chemistry Mar, 2013 | Pubmed ID: 23341464
The interaction between bacterial enolase and plasminogen promotes adherence of Streptococcus pneumoniae to epithelial and endothelial cells.
International journal of medical microbiology : IJMM Dec, 2013 | Pubmed ID: 23906818
Pneumococcal phosphoglycerate kinase interacts with plasminogen and its tissue activator.
Thrombosis and haemostasis Mar, 2014 | Pubmed ID: 24196407
Interaction of streptococcal plasminogen binding proteins with the host fibrinolytic system.
Frontiers in cellular and infection microbiology , 2013 | Pubmed ID: 24319673
Binding of Streptococcus pneumoniae endopeptidase O (PepO) to complement component C1q modulates the complement attack and promotes host cell adherence.
The Journal of biological chemistry May, 2014 | Pubmed ID: 24739385
Streptococcus pneumoniae phosphoglycerate kinase is a novel complement inhibitor affecting the membrane attack complex formation.
The Journal of biological chemistry Nov, 2014 | Pubmed ID: 25281746
Polar Fixation of Plasmids during Recombinant Protein Production in Bacillus megaterium Results in Population Heterogeneity.
Applied and environmental microbiology Sep, 2015 | Pubmed ID: 26116677
From Single Cells to Engineered and Explanted Tissues: New Perspectives in Bacterial Infection Biology.
International review of cell and molecular biology , 2015 | Pubmed ID: 26404465
The biofilm inhibitor Carolacton inhibits planktonic growth of virulent pneumococci via a conserved target.
Scientific reports 07, 2016 | Pubmed ID: 27404808
Complete Genome Sequences of Three Multidrug-Resistant Clinical Isolates of Serotype 19A with Different Susceptibilities to the Myxobacterial Metabolite Carolacton.
Genome announcements Feb, 2017 | Pubmed ID: 28209832
Homophilic protein interactions facilitate bacterial aggregation and IgG-dependent complex formation by the Streptococcus canis M protein SCM.
Virulence 12, 2019 | Pubmed ID: 30829556
Von Willebrand Factor Mediates Pneumococcal Aggregation and Adhesion in Blood Flow.
Frontiers in microbiology , 2019 | Pubmed ID: 30972039
1Institut für Mikrobiologie, Technische Universität Braunschweig,
2Devision of Infection Medicine, Department of Clinical Science, Lund University,
3Medical Microbiology and Hospital Epidemiology, Max von Pettenkofer Institute, Ludwig Maximilians University,
4Department of Molecular Infection Biology, Helmholtz Center for Infection Research