Oscar P. Kuipers

Regulation of the metC-cysK operon, involved in sulfur metabolism in Lactococcus lactis.

A novel class of heat and secretion stress-responsive genes is controlled by the autoregulated CssRS two-component system of Bacillus subtilis.

Transcriptome analysis and related databases of Lactococcus lactis.

Improving the predictive value of the competence transcription factor (ComK) binding site in Bacillus subtilis using a genomic approach.

Complete genome sequence of Lactobacillus plantarum WCFS1.

Controlling competence in Bacillus subtilis: shared use of regulators.

Cell wall attachment of a widely distributed peptidoglycan binding domain is hindered by cell wall constituents.

Novel mechanism of bacteriocin secretion and immunity carried out by lactococcal multidrug resistance proteins.

The extracellular proteome of Bacillus subtilis under secretion stress conditions.

UniFrag and GenomePrimer: selection of primers for genome-wide production of unique amplicons.

Genome engineering reveals large dispensable regions in Bacillus subtilis.

Functional analysis of the gene cluster involved in production of the bacteriocin circularin A by Clostridium beijerinckii ATCC 25752.

Projector: automatic contig mapping for gap closure purposes.

Differential expression of two paralogous genes of Bacillus subtilis encoding single-stranded DNA binding protein.

ArgR and AhrC are both required for regulation of arginine metabolism in Lactococcus lactis.

NisT, the transporter of the lantibiotic nisin, can transport fully modified, dehydrated, and unmodified prenisin and fusions of the leader peptide with non-lantibiotic peptides.

Sugar utilisation and conservation of the gal-lac gene cluster in Streptococcus thermophilus.

Molecular Genetics Information System (MOLGENIS): alternatives in developing local experimental genomics databases.

Genome2D: a visualization tool for the rapid analysis of bacterial transcriptome data.

MicroPreP: a cDNA microarray data pre-processing framework.

Proteomics of protein secretion by Bacillus subtilis: separating the "secrets" of the secretome.

Subcellular sites for bacterial protein export.

Autoregulation of subtilin biosynthesis in Bacillus subtilis: the role of the spa-box in subtilin-responsive promoters.

Resistance of Gram-positive bacteria to nisin is not determined by lipid II levels.

Visualization of differential gene expression by improved cyan fluorescent protein and yellow fluorescent protein production in Bacillus subtilis.

Autolysis of Lactococcus lactis is increased upon D-alanine depletion of peptidoglycan and lipoteichoic acids.

Probing direct interactions between CodY and the oppD promoter of Lactococcus lactis.

The Rok protein of Bacillus subtilis represses genes for cell surface and extracellular functions.

Interaction between ArgR and AhrC controls regulation of arginine metabolism in Lactococcus lactis.

Stripping Bacillus: ComK auto-stimulation is responsible for the bistable response in competence development.

Fructose utilization in Lactococcus lactis as a model for low-GC gram-positive bacteria: its regulator, signal, and DNA-binding site.

A generally applicable validation scheme for the assessment of factors involved in reproducibility and quality of DNA-microarray data.

Phosphatases modulate the bistable sporulation gene expression pattern in Bacillus subtilis.

Comparative and functional genomics of lactococci.

Tricksy business: transcriptome analysis reveals the involvement of thioredoxin A in redox homeostasis, oxidative stress, sulfur metabolism, and cellular differentiation in Bacillus subtilis.

Overview on sugar metabolism and its control in Lactococcus lactis - the input from in vivo NMR.

Lactic acid bacteria - Genetics, metabolism and application.

AcmA of Lactococcus lactis is an N-acetylglucosaminidase with an optimal number of LysM domains for proper functioning.

Lantibiotic structures as guidelines for the design of peptides that can be modified by lantibiotic enzymes.

Projector 2: contig mapping for efficient gap-closure of prokaryotic genome sequence assemblies.

The Lactococcus lactis CodY regulon: identification of a conserved cis-regulatory element.

Post-translational modification of therapeutic peptides by NisB, the dehydratase of the lantibiotic nisin.

Development and characterization of a subtilin-regulated expression system in Bacillus subtilis: strict control of gene expression by addition of subtilin.

Expression of transcription activator ComK of Bacillus subtilis in the heterologous host Lactococcus lactis leads to a genome-wide repression pattern: a case study of horizontal gene transfer.

Novel surface display system for proteins on non-genetically modified gram-positive bacteria.

Mucosal vaccine delivery of antigens tightly bound to an adjuvant particle made from food-grade bacteria.

To have neighbour's fare: extending the molecular toolbox for Streptococcus pneumoniae.

Functional analysis of the competence transcription factor ComK of Bacillus subtilis by characterization of truncation variants.

Transformation of undomesticated strains of Bacillus subtilis by protoplast electroporation.

Phenotypic variation in bacteria: the role of feedback regulation.

Effects of phosphorelay perturbations on architecture, sporulation, and spore resistance in biofilms of Bacillus subtilis.

SIMAGE: simulation of DNA-microarray gene expression data.

Identification and functional characterization of the Lactococcus lactis CodY-regulated branched-chain amino acid permease BcaP (CtrA).

Transcriptome analysis reveals mechanisms by which Lactococcus lactis acquires nisin resistance.

Regulation of glutamine and glutamate metabolism by GlnR and GlnA in Streptococcus pneumoniae.

GlnR-mediated regulation of nitrogen metabolism in Lactococcus lactis.

Natural sweetening of food products by engineering Lactococcus lactis for glucose production.

BAGEL: a web-based bacteriocin genome mining tool.

LmrCD is a major multidrug resistance transporter in Lactococcus lactis.

Heterologous production and secretion of Clostridium perfringens beta-toxoid in closely related Gram-positive hosts.

An alternative bactericidal mechanism of action for lantibiotic peptides that target lipid II.

The alpha-phosphoglucomutase of Lactococcus lactis is unrelated to the alpha-D-phosphohexomutase superfamily and is encoded by the essential gene pgmH.

Different subcellular locations of secretome components of Gram-positive bacteria.

Iron starvation triggers the stringent response and induces amino acid biosynthesis for bacillibactin production in Bacillus subtilis.

Time-resolved determination of the CcpA regulon of Lactococcus lactis subsp. cremoris MG1363.

Sec-mediated transport of posttranslationally dehydrated peptides in Lactococcus lactis.

Regulation of gene expression in Streptococcus pneumoniae by response regulator 09 is strain dependent.

A disulfide bond-containing alkaline phosphatase triggers a BdbC-dependent secretion stress response in Bacillus subtilis.

Transcriptome analysis of temporal regulation of carbon metabolism by CcpA in Bacillus subtilis reveals additional target genes.

Changing a single amino acid in Clostridium perfringens beta-toxin affects the efficiency of heterologous secretion by Bacillus subtilis.

FIVA: Functional Information Viewer and Analyzer extracting biological knowledge from transcriptome data of prokaryotes.

Production of dehydroamino acid-containing peptides by Lactococcus lactis.

Development of genomic array footprinting for identification of conditionally essential genes in Streptococcus pneumoniae.

A derepression system based on the Bacillus subtilis sporulation pathway offers dynamic control of heterologous gene expression.

Complete genome sequence of the prototype lactic acid bacterium Lactococcus lactis subsp. cremoris MG1363.

Novel methods for genetic transformation of natural Bacillus subtilis isolates used to study the regulation of the mycosubtilin and surfactin synthetases.

The iturin and fengycin families of lipopeptides are key factors in antagonism of Bacillus subtilis toward Podosphaera fusca.

A single, specific thymine mutation in the ComK-binding site severely decreases binding and transcription activation by the competence transcription factor ComK of Bacillus subtilis.

SpxB regulates O-acetylation-dependent resistance of Lactococcus lactis peptidoglycan to hydrolysis.

Antirepression as a second mechanism of transcriptional activation by a minor groove binding protein.

Cell envelope stress induced by the bacteriocin Lcn972 is sensed by the Lactococcal two-component system CesSR.

Identification of a novel streptococcal gene cassette mediating SOS mutagenesis in Streptococcus uberis.

Temporal separation of distinct differentiation pathways by a dual specificity Rap-Phr system in Bacillus subtilis.

Production and secretion stress caused by overexpression of heterologous alpha-amylase leads to inhibition of sporulation and a prolonged motile phase in Bacillus subtilis.

Search for genes essential for pneumococcal transformation: the RADA DNA repair protein plays a role in genomic recombination of donor DNA.

The novel transcriptional regulator SczA mediates protection against Zn2+ stress by activation of the Zn2+-resistance gene czcD in Streptococcus pneumoniae.

Dissection and modulation of the four distinct activities of nisin by mutagenesis of rings A and B and by C-terminal truncation.

MOVE: a multi-level ontology-based visualization and exploration framework for genomic networks.

NisC, the cyclase of the lantibiotic nisin, can catalyze cyclization of designed nonlantibiotic peptides.

LmrR is a transcriptional repressor of expression of the multidrug ABC transporter LmrCD in Lactococcus lactis.

CodY of Streptococcus pneumoniae: link between nutritional gene regulation and colonization.

A minimal Tat system from a gram-positive organism: a bifunctional TatA subunit participates in discrete TatAC and TatA complexes.

The Escherichia coli TatABC system and a Bacillus subtilis TatAC-type system recognise three distinct targeting determinants in twin-arginine signal peptides.

A facile reporter system for the experimental identification of twin-arginine translocation (Tat) signal peptides from all kingdoms of life.

Site-specific contributions of glutamine-dependent regulator GlnR and GlnR-regulated genes to virulence of Streptococcus pneumoniae.

Supervised Lowess normalization of comparative genome hybridization data--application to lactococcal strain comparisons.

Bet-hedging and epigenetic inheritance in bacterial cell development.

Transient heterogeneity in extracellular protease production by Bacillus subtilis.

Assessment of CcpA-mediated catabolite control of gene expression in Bacillus cereus ATCC 14579.

The relative value of operon predictions.

LysM, a widely distributed protein motif for binding to (peptido)glycans.

Opposite effects of Mn2+ and Zn2+ on PsaR-mediated expression of the virulence genes pcpA, prtA, and psaBCA of Streptococcus pneumoniae.

Increased D-alanylation of lipoteichoic acid and a thickened septum are main determinants in the nisin resistance mechanism of Lactococcus lactis.

Bistability, epigenetics, and bet-hedging in bacteria.

Transcriptome analysis of the Lactococcus lactis ArgR and AhrC regulons.

Reduced lysis upon growth of Lactococcus lactis on galactose is a consequence of decreased binding of the autolysin AcmA.

Influence of shifting positions of Ser, Thr, and Cys residues in prenisin on the efficiency of modification reactions and on the antimicrobial activities of the modified prepeptides.

Improvement of Lactobacillus plantarum aerobic growth as directed by comprehensive transcriptome analysis.

9th International Symposium on Lactic Acid Bacteria.

The ABC-type multidrug resistance transporter LmrCD is responsible for an extrusion-based mechanism of bile acid resistance in Lactococcus lactis.

Prosecutor: parameter-free inference of gene function for prokaryotes using DNA microarray data, genomic context and multiple gene annotation sources.

Relaxed specificity of the Bacillus subtilis TatAdCd translocase in Tat-dependent protein secretion.

MINOMICS: visualizing prokaryote transcriptomics and proteomics data in a genomic context.

The twin-arginine translocation (Tat) systems from Bacillus subtilis display a conserved mode of complex organization and similar substrate recognition requirements.

Characterization of the individual glucose uptake systems of Lactococcus lactis: mannose-PTS, cellobiose-PTS and the novel GlcU permease.

Optimization of protein secretion by Bacillus subtilis.

DISCLOSE : DISsection of CLusters Obtained by SEries of transcriptome data using functional annotations and putative transcription factor binding sites.

Copper acquisition is mediated by YcnJ and regulated by YcnK and CsoR in Bacillus subtilis.

MOTIFATOR: detection and characterization of regulatory motifs using prokaryote transcriptome data.

Strain-specific impact of PsaR of Streptococcus pneumoniae on global gene expression and virulence.

Effects of altered TatC proteins on protein secretion efficiency via the twin-arginine translocation pathway of Bacillus subtilis.

Subcellular localization of TatAd of Bacillus subtilis depends on the presence of TatCd or TatCy.

Ubiquitous late competence genes in Bacillus species indicate the presence of functional DNA uptake machineries.

Directionality and coordination of dehydration and ring formation during biosynthesis of the lantibiotic nisin.

Mechanisms and evolution of control logic in prokaryotic transcriptional regulation.

Response of Bacillus cereus ATCC 14579 to challenges with sublethal concentrations of enterocin AS-48.

Generic and specific adaptive responses of Streptococcus pneumoniae to challenge with three distinct antimicrobial peptides, bacitracin, LL-37, and nisin.

Adaptation of Hansenula polymorpha to methanol: a transcriptome analysis.

Production of a class II two-component lantibiotic of Streptococcus pneumoniae using the class I nisin synthetic machinery and leader sequence.

Heterochronic phosphorelay gene expression as a source of heterogeneity in Bacillus subtilis spore formation.

Gene position within a long transcript as a determinant for stochastic switching in bacteria.

Copper stress affects iron homeostasis by destabilizing iron-sulfur cluster formation in Bacillus subtilis.

Genetic tool development for a new host for biotechnology, the thermotolerant bacterium Bacillus coagulans.

BAGEL2: mining for bacteriocins in genomic data.

Penicillin-binding protein folding is dependent on the PrsA peptidyl-prolyl cis-trans isomerase in Bacillus subtilis.

How mathematical modelling elucidates signalling in Bacillus subtilis.

Towards enhanced galactose utilization by Lactococcus lactis.

SpotXplore: a Cytoscape plugin for visual exploration of hotspot expression in gene regulatory networks.

Rok regulates yuaB expression during architecturally complex colony development of Bacillus subtilis 168.

Biofilm formation and dispersal in Gram-positive bacteria.

Bacterial spores in food: how phenotypic variability complicates prediction of spore properties and bacterial behavior.

Targeting diseases with genetically engineered Lactococcus lactis and its course towards medical translation.

Bet hedging or not? A guide to proper classification of microbial survival strategies.

Induction of natural competence in Bacillus cereus ATCC14579.

Understanding microbial behavior within and outside the host to improve food functionality and safety.

Deletion of a cation transporter promotes lysis in Streptococcus pneumoniae.

Evaluating the feasibility of lantibiotics as an alternative therapy against bacterial infections in humans.

Regulon of the N-acetylglucosamine utilization regulator NagR in Bacillus subtilis.

Transcriptional response of Streptococcus pneumoniae to Zn2+) limitation and the repressor/activator function of AdcR.

A novel screening system for secretion of heterologous proteins in Bacillus subtilis.

The cop operon is required for copper homeostasis and contributes to virulence in Streptococcus pneumoniae.

Distinct roles of ComK1 and ComK2 in gene regulation in Bacillus cereus.

pSEUDO, a genetic integration standard for Lactococcus lactis.

CelR-mediated activation of the cellobiose-utilization gene cluster in Streptococcus pneumoniae.

Efficient overproduction of membrane proteins in Lactococcus lactis requires the cell envelope stress sensor/regulator couple CesSR.

The Lcn972 bacteriocin-encoding plasmid pBL1 impairs cellobiose metabolism in Lactococcus lactis.

The response of Lactococcus lactis to membrane protein production.

Transcriptional responses of Bacillus cereus towards challenges with the polysaccharide chitosan.

Determining sites of interaction between prenisin and its modification enzymes NisB and NisC.

CcpA ensures optimal metabolic fitness of Streptococcus pneumoniae.

Regulation of arginine acquisition and virulence gene expression in the human pathogen Streptococcus pneumoniae by transcription regulators ArgR1 and AhrC.

Time-resolved transcriptomics and bioinformatic analyses reveal intrinsic stress responses during batch culture of Bacillus subtilis.

Heterologous protein expression by Lactococcus lactis.

From meadows to milk to mucosa - adaptation of Streptococcus and Lactococcus species to their nutritional environments.

Pneumococcal gene complex involved in resistance to extracellular oxidative stress.