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Cardiovascular Research Center
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Human A(2A) adenosine receptors: high-affinity agonist binding to receptor-G protein complexes containing Gbeta(4).
Molecular pharmacology Feb, 2002 | Pubmed ID: 11809871
Structure-activity relationships at human and rat A2B adenosine receptors of xanthine derivatives substituted at the 1-, 3-, 7-, and 8-positions.
Journal of medicinal chemistry May, 2002 | Pubmed ID: 12014951
Protection from ischemic liver injury by activation of A2A adenosine receptors during reperfusion: inhibition of chemokine induction.
American journal of physiology. Gastrointestinal and liver physiology Feb, 2004 | Pubmed ID: 14715520
Lipopolysaccharide rapidly modifies adenosine receptor transcripts in murine and human macrophages: role of NF-kappaB in A(2A) adenosine receptor induction.
The Biochemical journal Nov, 2005 | Pubmed ID: 16022683
Myocardial infarct-sparing effect of adenosine A2A receptor activation is due to its action on CD4+ T lymphocytes.
Circulation Nov, 2006 | Pubmed ID: 17060376
Adenosine A2A receptor activation reduces hepatic ischemia reperfusion injury by inhibiting CD1d-dependent NKT cell activation.
The Journal of experimental medicine Nov, 2006 | Pubmed ID: 17088433
Adenosine A2A receptor activation reduces infarct size in the isolated, perfused mouse heart by inhibiting resident cardiac mast cell degranulation.
American journal of physiology. Heart and circulatory physiology Nov, 2008 | Pubmed ID: 18757481
NADPH oxidase in bone marrow-derived cells mediates pulmonary ischemia-reperfusion injury.
American journal of respiratory cell and molecular biology Mar, 2009 | Pubmed ID: 18787174
NKT cells mediate pulmonary inflammation and dysfunction in murine sickle cell disease through production of IFN-gamma and CXCR3 chemokines.
Blood Jul, 2009 | Pubmed ID: 19433855
Adenosine A2B receptors are highly expressed on murine type II alveolar epithelial cells.
American journal of physiology. Lung cellular and molecular physiology Sep, 2009 | Pubmed ID: 19574419
P-selectin-mediated platelet-neutrophil aggregate formation activates neutrophils in mouse and human sickle cell disease.
Arteriosclerosis, thrombosis, and vascular biology Dec, 2010 | Pubmed ID: 21071696
The second extracellular loop of the adenosine A1 receptor mediates activity of allosteric enhancers.
Molecular pharmacology Feb, 2014 | Pubmed ID: 24217444
Multivalent site-specific phage modification enhances the binding affinity of receptor ligands.
Bioconjugate chemistry Mar, 2015 | Pubmed ID: 25692462
The infarct-sparing effect of IB-MECA against myocardial ischemia/reperfusion injury in mice is mediated by sequential activation of adenosine A3 and A 2A receptors.
Basic research in cardiology Mar, 2015 | Pubmed ID: 25711314
Adipocyte progenitor cells initiate monocyte chemoattractant protein-1-mediated macrophage accumulation in visceral adipose tissue.
Molecular metabolism Nov, 2015 | Pubmed ID: 26629403
Perivascular Adipose Tissue Harbors Atheroprotective IgM-Producing B Cells.
Frontiers in physiology , 2017 | Pubmed ID: 28970806
Diversification and CXCR4-Dependent Establishment of the Bone Marrow B-1a Cell Pool Governs Atheroprotective IgM Production Linked to Human Coronary Atherosclerosis.
Circulation research Oct, 2019 | Pubmed ID: 31549940
Importance of thorough tissue and cellular level characterization of targeted drugs in the evaluation of pharmacodynamic effects.
PloS one , 2019 | Pubmed ID: 31725756
liposomal delivery of PPARα/γ dual agonist tesaglitazar in a model of obesity enriches macrophage targeting and limits liver and kidney drug effects.
Theranostics , 2020 | Pubmed ID: 31903139
University of Virginia
Aditi Upadhye1,
Melissa Marshall2,
James C. Garmey2,
Timothy P. Bender3,
Coleen McNamara2
1Department of Microbiology, Immunology, Cancer Biology, University of Virginia,
2Cardiovascular Research Center, University of Virginia,
3Beirne B. Carter Center for Immunology Research, University of Virginia
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