David L. Sacks

Vaccination with DNA encoding the immunodominant LACK parasite antigen confers protective immunity to mice infected with Leishmania major.

Uptake of Leishmania major amastigotes results in activation and interleukin 12 release from murine skin-derived dendritic cells: implications for the initiation of anti-Leishmania immunity.

Development of a natural model of cutaneous leishmaniasis: powerful effects of vector saliva and saliva preexposure on the long-term outcome of Leishmania major infection in the mouse ear dermis.

The role of antigen and IL-12 in sustaining Th1 memory cells in vivo: IL-12 is required to maintain memory/effector Th1 cells sufficient to mediate protection to an infectious parasite challenge.

Toward a defined anti-Leishmania vaccine targeting vector antigens: characterization of a protective salivary protein.

The role of interleukin (IL)-10 in the persistence of Leishmania major in the skin after healing and the therapeutic potential of anti-IL-10 receptor antibody for sterile cure.

Vaccination with heat-killed leishmania antigen or recombinant leishmanial protein and CpG oligodeoxynucleotides induces long-term memory CD4+ and CD8+ T cell responses and protection against leishmania major infection.

CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity.

Immunological and pathological evaluation of rhesus macaques infected with Leishmania major.

Coinjection with CpG-containing immunostimulatory oligodeoxynucleotides reduces the pathogenicity of a live vaccine against cutaneous Leishmaniasis but maintains its potency and durability.

Nonhealing infection despite Th1 polarization produced by a strain of Leishmania major in C57BL/6 mice.

Conditions influencing the efficacy of vaccination with live organisms against Leishmania major infection.

Prevention and treatment of cutaneous leishmaniasis in primates by using synthetic type D/A oligodeoxynucleotides expressing CpG motifs.

Antigen requirements for efficient priming of CD8+ T cells by Leishmania major-infected dendritic cells.

A Leishmania amazonensis ZIP family iron transporter is essential for parasite replication within macrophage phagolysosomes.

Uninfected mosquito bites confer protection against infection with malaria parasites.

Vector transmission of leishmania abrogates vaccine-induced protective immunity.

The impact of vector-mediated neutrophil recruitment on cutaneous leishmaniasis.

Leishmania major survival in selective Phlebotomus papatasi sand fly vector requires a specific SCG-encoded lipophosphoglycan galactosylation pattern.

Infection parameters in the sand fly vector that predict transmission of Leishmania major.

Evaluation of recombinant Leishmania polyprotein plus glucopyranosyl lipid A stable emulsion vaccines against sand fly-transmitted Leishmania major in C57BL/6 mice.

Tracking antigen-specific CD4+ T cells throughout the course of chronic Leishmania major infection in resistant mice.

Site-dependent recruitment of inflammatory cells determines the effective dose of Leishmania major.

Vaccines against tropical parasitic diseases: a persisting answer to a persisting problem.

Cross-species genetic exchange between visceral and cutaneous strains of Leishmania in the sand fly vector.

Chronic parasitic infection maintains high frequencies of short-lived Ly6C+CD4+ effector T cells that are required for protection against re-infection.

Cutaneous Infection with Leishmania major Mediates Heterologous Protection against Visceral Infection with Leishmania infantum.

The Nlrp3 inflammasome, IL-1β, and neutrophil recruitment are required for susceptibility to a nonhealing strain of Leishmania major in C57BL/6 mice.

The Transcriptome of Developmental Stages in Their Natural Sand Fly Vector.

Divergent roles for Ly6C+CCR2+CX3CR1+ inflammatory monocytes during primary or secondary infection of the skin with the intra-phagosomal pathogen Leishmania major.

Gene Expression in Is Regulated Predominantly by Gene Dosage.

NOX2-Derived Reactive Oxygen Species Control Inflammation during Infection by Mediating Infection-Induced Neutrophil Apoptosis.

Mannose receptor high, M2 dermal macrophages mediate nonhealing infection in a Th1 immune environment.

Inflammasomes and Leishmania: in good times or bad, in sickness or in health.

CRISPR/Cas9 Mutagenesis in Phlebotomus papatasi: the Immune Deficiency Pathway Impacts Vector Competence for Leishmania major.

M2-like, dermal macrophages are maintained via IL-4/CCL24-mediated cooperative interaction with eosinophils in cutaneous leishmaniasis.

The Null Hypothesis of IFN-γ and Monocyte Function in Leishmaniasis.