William S. James

Interferon-stimulated gene products as regulators of central carbon metabolism.

Derivation and characterisation of the human embryonic stem cell line, OxF1.

Episomal transgene expression in pluripotent stem cells.

Differentially expressed, variant U1 snRNAs regulate gene expression in human cells.

The productive entry pathway of HIV-1 in macrophages is dependent on endocytosis through lipid rafts containing CD4.

Physiological characterisation of human iPS-derived dopaminergic neurons.

CRISPR-mediated genotypic and phenotypic correction of a chronic granulomatous disease mutation in human iPS cells.

LRRK2 in peripheral and central nervous system innate immunity: its link to Parkinson's disease.

A Highly Efficient Human Pluripotent Stem Cell Microglia Model Displays a Neuronal-Co-culture-Specific Expression Profile and Inflammatory Response.

Excess α-synuclein compromises phagocytosis in iPSC-derived macrophages.

RIPK1 is a critical modulator of both tonic and TLR-responsive inflammatory and cell death pathways in human macrophage differentiation.

Lentiviral gene therapy vector with UCOE stably restores function in iPSC-derived neutrophils of a CDG patient.

Mechanism of Diol Dehydration by a Promiscuous Radical-SAM Enzyme Homologue of the Antiviral Enzyme Viperin (RSAD2).

Viperin, through its radical-SAM activity, depletes cellular nucleotide pools and interferes with mitochondrial metabolism to inhibit viral replication.

ddhCTP produced by the radical-SAM activity of RSAD2 (viperin) inhibits the NAD -dependent activity of enzymes to modulate metabolism.

LRRK2 Is Recruited to Phagosomes and Co-recruits RAB8 and RAB10 in Human Pluripotent Stem Cell-Derived Macrophages.

TREM2 Alzheimer's variant R47H causes similar transcriptional dysregulation to knockout, yet only subtle functional phenotypes in human iPSC-derived macrophages.

Honing the Double-Edged Sword: Improving Human iPSC-Microglia Models.