Zora Modrusan

Notch signaling is required for normal prostatic epithelial cell proliferation and differentiation.

Epithelial versus mesenchymal phenotype determines in vitro sensitivity and predicts clinical activity of erlotinib in lung cancer patients.

Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis.

Regulation of ERK3/MAPK6 expression by BRAF.

The effects of IL-20 subfamily cytokines on reconstituted human epidermis suggest potential roles in cutaneous innate defense and pathogenic adaptive immunity in psoriasis.

Expression profiling of the mouse prostate after castration and hormone replacement: implication of H-cadherin in prostate tumorigenesis.

Identification of IGF2 signaling through phosphoinositide-3-kinase regulatory subunit 3 as a growth-promoting axis in glioblastoma.

Molecular signatures define two main classes of meningiomas.

Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens.

Intestinal epithelial cell up-regulation of LY6 molecules during colitis results in enhanced chemokine secretion.

Functional genomics identifies ABCC3 as a mediator of taxane resistance in HER2-amplified breast cancer.

Antixenograft tumor activity of a humanized anti-insulin-like growth factor-I receptor monoclonal antibody is associated with decreased AKT activation and glucose uptake.

Gene expression profile and angiogenic marker correlates with response to neoadjuvant bevacizumab followed by bevacizumab plus chemotherapy in breast cancer.

PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment.

Antitumor efficacy of the novel RAF inhibitor GDC-0879 is predicted by BRAFV600E mutational status and sustained extracellular signal-regulated kinase/mitogen-activated protein kinase pathway suppression.

Microarray analysis of RNA extracted from formalin-fixed, paraffin-embedded and matched fresh-frozen ovarian adenocarcinomas.

Deconvolution of blood microarray data identifies cellular activation patterns in systemic lupus erythematosus.

Oncogenic activating mutations are associated with local copy gain.

Exon array profiling detects EML4-ALK fusion in breast, colorectal, and non-small cell lung cancers.

Somatic mutations in p85alpha promote tumorigenesis through class IA PI3K activation.

A hierarchy of self-renewing tumor-initiating cell types in glioblastoma.

The mutation spectrum revealed by paired genome sequences from a lung cancer patient.

Diverse somatic mutation patterns and pathway alterations in human cancers.

Granulocyte-colony stimulating factor promotes lung metastasis through mobilization of Ly6G+Ly6C+ granulocytes.

Small molecule inhibition of GDC-0449 refractory smoothened mutants and downstream mechanisms of drug resistance.

Gene expression patterns of Th2 inflammation and intercellular communication in asthmatic airways.

Deep RNA sequencing analysis of readthrough gene fusions in human prostate adenocarcinoma and reference samples.

CD40 pathway activation status predicts response to CD40 therapy in diffuse large B cell lymphoma.

Canonical hedgehog signaling augments tumor angiogenesis by induction of VEGF-A in stromal perivascular cells.

Global defects in collagen secretion in a Mia3/TANGO1 knockout mouse.

TRPS1 targeting by miR-221/222 promotes the epithelial-to-mesenchymal transition in breast cancer.

Lung gene expression in a rhesus allergic asthma model correlates with physiologic parameters of disease and exhibits common and distinct pathways with human asthma and a mouse asthma model.

miR-221/222 targeting of trichorhinophalangeal 1 (TRPS1) promotes epithelial-to-mesenchymal transition in breast cancer.

A whole-genome RNAi screen identifies an 8q22 gene cluster that inhibits death receptor-mediated apoptosis.

IL-17C regulates the innate immune function of epithelial cells in an autocrine manner.

Evidence for sequenced molecular evolution of IDH1 mutant glioblastoma from a distinct cell of origin.

Androgen deprivation causes epithelial-mesenchymal transition in the prostate: implications for androgen-deprivation therapy.

DNA methylation profiling defines clinically relevant biological subsets of non-small cell lung cancer.

The effects of hepatitis B virus integration into the genomes of hepatocellular carcinoma patients.

Death receptors DR6 and TROY regulate brain vascular development.

CDK8 maintains tumor dedifferentiation and embryonic stem cell pluripotency.

Tumour-secreted miR-9 promotes endothelial cell migration and angiogenesis by activating the JAK-STAT pathway.

Loss of the tumor suppressor BAP1 causes myeloid transformation.

Recurrent R-spondin fusions in colon cancer.

Comparative transcriptomic analyses of atopic dermatitis and psoriasis reveal shared neutrophilic inflammation.

Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer.

Genome and transcriptome sequencing of lung cancers reveal diverse mutational and splicing events.

Identification of mutant K-Ras-dependent phenotypes using a panel of isogenic cell lines.

DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury.

A requirement for wild-type Ras isoforms in mutant KRas-driven signalling and transformation.

Biomarkers of residual disease, disseminated tumor cells, and metastases in the MMTV-PyMT breast cancer model.

Oncogenic ERBB3 mutations in human cancers.

Identification and analysis of in vivo VEGF downstream markers link VEGF pathway activity with efficacy of anti-VEGF therapies.

Host genetic background impacts modulation of the TLR4 pathway by RON in tissue-associated macrophages.

Histone Deacetylase (HDAC) Inhibitor Kinetic Rate Constants Correlate with Cellular Histone Acetylation but Not Transcription and Cell Viability.

Integrated genomic analysis of triple-negative breast cancers reveals novel microRNAs associated with clinical and molecular phenotypes and sheds light on the pathways they control.

Specification of type 2 innate lymphocytes by the transcriptional determinant Gfi1.

NRROS negatively regulates reactive oxygen species during host defence and autoimmunity.

Comparative oncogenomics identifies PSMB4 and SHMT2 as potential cancer driver genes.

An integrative analysis of colon cancer identifies an essential function for PRPF6 in tumor growth.

Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer.

Endogenously expressed IL-13Rα2 attenuates IL-13-mediated responses but does not activate signaling in human lung fibroblasts.

Diverse modes of genomic alteration in hepatocellular carcinoma.

Heterogeneous gene expression signatures correspond to distinct lung pathologies and biomarkers of disease severity in idiopathic pulmonary fibrosis.

Regulation of neuronal gene expression and survival by basal NMDA receptor activity: a role for histone deacetylase 4.

Spectrum of diverse genomic alterations define non-clear cell renal carcinoma subtypes.

Predicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing.

Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells.

A comprehensive transcriptional portrait of human cancer cell lines.

Genomic analysis of smoothened inhibitor resistance in basal cell carcinoma.

IL-13 mediates IL-33-dependent mast cell and type 2 innate lymphoid cell effects on bronchial epithelial cells.

β-Cell Insulin Secretion Requires the Ubiquitin Ligase COP1.

Comprehensive genomic analysis of malignant pleural mesothelioma identifies recurrent mutations, gene fusions and splicing alterations.

Untangling the brain's neuroinflammatory and neurodegenerative transcriptional responses.

A Putative Bacterial ABC Transporter Circumvents the Essentiality of Signal Peptidase.

Building proteomic tool boxes to monitor MHC class I and class II peptides.

A broadly protective therapeutic antibody against influenza B virus with two mechanisms of action.

A distinct role for Lgr5 stem cells in primary and metastatic colon cancer.

Single-cell RNA sequencing identifies distinct mouse medial ganglionic eminence cell types.

Btk-specific inhibition blocks pathogenic plasma cell signatures and myeloid cell-associated damage in IFN-driven lupus nephritis.

The kinase TPL2 activates ERK and p38 signaling to promote neutrophilic inflammation.

Dual leucine zipper kinase-dependent PERK activation contributes to neuronal degeneration following insult.

Stem cell plasticity enables hair regeneration following Lgr5 cell loss.

Massively parallel nanowell-based single-cell gene expression profiling.

Cross-species gene expression analysis identifies a novel set of genes implicated in human insulin sensitivity.

Progranulin deficiency causes impairment of autophagy and TDP-43 accumulation.

Loss of dual leucine zipper kinase signaling is protective in animal models of neurodegenerative disease.

Therapeutic Targeting of the CBP/p300 Bromodomain Blocks the Growth of Castration-Resistant Prostate Cancer.

Silencing of retrotransposons by SETDB1 inhibits the interferon response in acute myeloid leukemia.

Ubiquilin1 promotes antigen-receptor mediated proliferation by eliminating mislocalized mitochondrial proteins.

Host-derived fatty acids activate type VII secretion in .

PRC2-mediated repression of SMARCA2 predicts EZH2 inhibitor activity in SWI/SNF mutant tumors.

mutant genetically engineered mouse models of human cancers are genomically heterogeneous.

SUV420H2 is an epigenetic regulator of epithelial/mesenchymal states in pancreatic cancer.

NF-κB inducing kinase is a therapeutic target for systemic lupus erythematosus.

Diverse Brain Myeloid Expression Profiles Reveal Distinct Microglial Activation States and Aspects of Alzheimer's Disease Not Evident in Mouse Models.

Mitochondrial CoQ deficiency is a common driver of mitochondrial oxidants and insulin resistance.

Comprehensive genomic analysis identifies pathogenic variants in maturity-onset diabetes of the young (MODY) patients in South India.

Homozygous KSR1 deletion attenuates morbidity but does not prevent tumor development in a mouse model of RAS-driven pancreatic cancer.

A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells.

Tumor suppressor BAP1 is essential for thymic development and proliferative responses of T lymphocytes.

Publisher Correction: A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells.

ERK Mutations and Amplification Confer Resistance to ERK-Inhibitor Therapy.

CRISPR off-target analysis in genetically engineered rats and mice.

Therapeutic interleukin-6 blockade reverses transforming growth factor-beta pathway activation in dermal fibroblasts: insights from the faSScinate clinical trial in systemic sclerosis.

An Empirical Approach Leveraging Tumorgrafts to Dissect the Tumor Microenvironment in Renal Cell Carcinoma Identifies Missing Link to Prognostic Inflammatory Factors.

The tumor suppressor BAP1 cooperates with BRAFV600E to promote tumor formation in cutaneous melanoma.

Ubiquitin ligase COP1 coordinates transcriptional programs that control cell type specification in the developing mouse brain.

Therapeutic resistance and susceptibility is shaped by cooperative multi-compartment tumor adaptation.

Regulation of Tumor-Associated Myeloid Cell Activity by CBP/EP300 Bromodomain Modulation of H3K27 Acetylation.

The Gag protein PEG10 binds to RNA and regulates trophoblast stem cell lineage specification.

Intrinsic apoptosis shapes the tumor spectrum linked to inactivation of the deubiquitinase BAP1.

A Clinically Applicable Gene-Expression Classifier Reveals Intrinsic and Extrinsic Contributions to Consensus Molecular Subtypes in Primary and Metastatic Colon Cancer.

Coexpression of Inhibitory Receptors Enriches for Activated and Functional CD8 T Cells in Murine Syngeneic Tumor Models.

IRF2 transcriptionally induces expression for pyroptosis.

NRG1 is a critical regulator of differentiation in TP63-driven squamous cell carcinoma.

Adaptive adipose tissue stromal plasticity in response to cold stress and antibody-based metabolic therapy.

SCINA: A Semi-Supervised Subtyping Algorithm of Single Cells and Bulk Samples.

Therapeutic Ligands Antagonize Estrogen Receptor Function by Impairing Its Mobility.

An Nfil3-Zeb2-Id2 pathway imposes Irf8 enhancer switching during cDC1 development.

Massively parallel single-cell B-cell receptor sequencing enables rapid discovery of diverse antigen-reactive antibodies.

CD3 bispecific antibody-induced cytokine release is dispensable for cytotoxic T cell activity.

Single-Cell RNA Sequencing Reveals Stromal Evolution into LRRC15 Myofibroblasts as a Determinant of Patient Response to Cancer Immunotherapy.

Activity of caspase-8 determines plasticity between cell death pathways.

S100a4 upregulation in Pik3caH1047R;Trp53R270H;MMTV-Cre-driven mammary tumors promotes metastasis.

The Indian cobra reference genome and transcriptome enables comprehensive identification of venom toxins.

Trem2 Deletion Reduces Late-Stage Amyloid Plaque Accumulation, Elevates the Aβ42:Aβ40 Ratio, and Exacerbates Axonal Dystrophy and Dendritic Spine Loss in the PS2APP Alzheimer's Mouse Model.

Integration of eQTL and a Single-Cell Atlas in the Human Eye Identifies Causal Genes for Age-Related Macular Degeneration.

Heterogeneity of Satellite Cells Implicates DELTA1/NOTCH2 Signaling in Self-Renewal.

Restricted epitope specificity determined by variable region germline segment pairing in rodent antibody repertoires.

Blockade of the Phagocytic Receptor MerTK on Tumor-Associated Macrophages Enhances P2X7R-Dependent STING Activation by Tumor-Derived cGAMP.

Peripheral T cell expansion predicts tumour infiltration and clinical response.

IRE1α Disruption in Triple-Negative Breast Cancer Cooperates with Antiangiogenic Therapy by Reversing ER Stress Adaptation and Remodeling the Tumor Microenvironment.

Proteogenomics analysis unveils a TFG-RET gene fusion and druggable targets in papillary thyroid carcinomas.

High systemic and tumor-associated IL-8 correlates with reduced clinical benefit of PD-L1 blockade.

Alzheimer's Patient Microglia Exhibit Enhanced Aging and Unique Transcriptional Activation.

Single-Cell Transcriptome Profiling of the Kidney Glomerulus Identifies Key Cell Types and Reactions to Injury.

Inducers of the endothelial cell barrier identified through chemogenomic screening in genome-edited hPSC-endothelial cells.

Ubiquitin Ligase COP1 Suppresses Neuroinflammation by Degrading c/EBPβ in Microglia.

Integrated genomic analysis reveals mutated ELF3 as a potential gallbladder cancer vaccine candidate.

Unstable Mechanisms of Resistance to Inhibitors of Escherichia coli Lipoprotein Signal Peptidase.

Transcriptional Subtypes Resolve Tumor Heterogeneity and Identify Vulnerabilities to MEK Inhibition in Lung Adenocarcinoma.

Functional characterization of SMARCA4 variants identified by targeted exome-sequencing of 131,668 cancer patients.

Machine-Learning and Chemicogenomics Approach Defines and Predicts Cross-Talk of Hippo and MAPK Pathways.

Osteopontin Links Myeloid Activation and Disease Progression in Systemic Sclerosis.

The peptide symporter SLC15a4 is essential for the development of systemic lupus erythematosus in murine models.

NINJ1 mediates plasma membrane rupture during lytic cell death.

Author Correction: High systemic and tumor-associated IL-8 correlates with reduced clinical benefit of PD-L1 blockade.

Development of a targeted integration Chinese hamster ovary host directly targeting either one or two vectors simultaneously to a single locus using the Cre/Lox recombinase-mediated cassette exchange system.

Multiple sclerosis risk gene Mertk is required for microglial activation and subsequent remyelination.

Molecular mapping of interstitial lung disease reveals a phenotypically distinct senescent basal epithelial cell population.

Age-related changes in polycomb gene regulation disrupt lineage fidelity in intestinal stem cells.

Intratumoral CD103+ CD8+ T cells predict response to PD-L1 blockade.

Gremlin 1 fibroblastic niche maintains dendritic cell homeostasis in lymphoid tissues.

ARAF mutations confer resistance to the RAF inhibitor belvarafenib in melanoma.

Cross-tissue organization of the fibroblast lineage.

Homeostatic functions of monocytes and interstitial lung macrophages are regulated via collagen domain-binding receptor LAIR1.

ADAR and hnRNPC deficiency synergize in activating endogenous dsRNA-induced type I IFN responses.

TGFβ2 and TGFβ3 isoforms drive fibrotic disease pathogenesis.

Dual targeting of lymphocyte homing and retention through α4β7 and αEβ7 inhibition in inflammatory bowel disease.

Identifying transcriptional programs underlying cancer drug response with TraCe-seq.

Determinants of renal cell carcinoma invasion and metastatic competence.

A renal cell carcinoma tumorgraft platform to advance precision medicine.

Decoding non-canonical mRNA decay by the endoplasmic-reticulum stress sensor IRE1α.

TREM2-independent oligodendrocyte, astrocyte, and T cell responses to tau and amyloid pathology in mouse models of Alzheimer disease.

Oncostatin M expression induced by bacterial triggers drives airway inflammatory and mucus secretion in severe asthma.

Loss of the intracellular enzyme QPCTL limits chemokine function and reshapes myeloid infiltration to augment tumor immunity.

Distinct resistance mechanisms arise to allosteric vs. ATP-competitive AKT inhibitors.

Steroid-induced fibroblast growth factors drive an epithelial-mesenchymal inflammatory axis in severe asthma.

Antigen-derived peptides engage the ER stress sensor IRE1α to curb dendritic cell cross-presentation.

Genome-wide association study identifies kallikrein 5 in type 2 inflammation-low asthma.

Activation-Induced Cytidine Deaminase Impacts the Primary Antibody Repertoire in Naive Mice.