Department of Entomology,
College of Agriculture,
Food and Environment,
Department of Entomology, College of Agriculture, Food and Environment
Dr. Subba Reddy Palli received his doctorate from the University of Western Ontario and post-doctoral training at the University of Washington. Upon graduation, he worked as a research scientist at the Canadian Forest Service’s Great Lakes Forestry Centre and later at Rohm and Hass Company as the senior research scientist and group leader. Dr. Palli played a key role in development of Ecdysone Receptor based Gene Switch technology that is being tested in clinical trials for regulation of anticancer genes in humans and production of bioplastics in plants. Dr. Palli joined the University of Kentucky Department Of Entomology as an assistant professor in 2002 and was promoted to associate professor and professor in 2005 and 2008, respectively. He became Chairman of department of Entomology in 2015. He also served as the co-director of NSF I/UCRC on Arthropod Management Technologies.
He has received several prestigious awards at UK including a University Research Professorship, the Thomas Poe Cooper Research Award, Bobby Pass Excellence in Grantsmanship Award, High Impact Research/Extension Award and Wethington Award. Dr. Palli also serves as the co-director of the Center for Arthropod Management Technologies, a recently established National Science Foundation Industry and University Cooperative Research Center. Dr. Palli is also the recipient of Entomological Society of America (ESA) recognition award in Insect Physiology, Biochemistry and Toxicology. He was selected as a fellow of ESA and AAAS.
Dr. Palli’s research focuses on hormonal regulation of gene expression in insects with a goal to identify proteins that play key roles in signal transduction of ecdysteroids, juvenile hormones and other hormones and use them for developing novel environmentally safe pest management methods. He has published more than 250 peer-reviewed journal articles and book chapters and co-edited a book. He holds 25 patents. Recent research from Dr. Palli’s laboratory helped to develop RNA interference technology based methods for controlling insect pests as well as to fight insecticide resistance in beetles and bed bugs. He has organized and chaired several symposia at the ESA annual meetings as well as at international conferences. Dr. Palli also served as president of the ESA Physiology, Biochemistry, and Toxicology Section. He currently serves on the editorial boards of 12 journals and served on the grant review panels of the NSF, U.S. Department of Agriculture-National Research Initiative and National Institutes of Health.
Identification and characterization of juvenile hormone esterase gene from the yellow fever mosquito, Aedes aegypti.
Insect biochemistry and molecular biology Aug, 2007 | Pubmed ID: 17628281
Identification and characterization of nuclear receptors from the red flour beetle, Tribolium castaneum.
Insect biochemistry and molecular biology Apr, 2008 | Pubmed ID: 18342248
Ecdysone [corrected] receptor isoforms play distinct roles in controlling molting and metamorphosis in the red flour beetle, Tribolium castaneum.
Molecular and cellular endocrinology Sep, 2008 | Pubmed ID: 18583027
Interaction of proteins involved in ecdysone and juvenile hormone signal transduction.
Archives of insect biochemistry and physiology Feb, 2009 | Pubmed ID: 18980211
Molecular evidence for a functional ecdysone signaling system in Brugia malayi.
PLoS neglected tropical diseases Mar, 2010 | Pubmed ID: 20231890
Large-scale RNAi screen of G protein-coupled receptors involved in larval growth, molting and metamorphosis in the red flour beetle.
BMC genomics Aug, 2011 | Pubmed ID: 21806814
Juvenile hormone regulates vitellogenin gene expression through insulin-like peptide signaling pathway in the red flour beetle, Tribolium castaneum.
The Journal of biological chemistry Dec, 2011 | Pubmed ID: 22002054
Sex determination in beetles: production of all male progeny by parental RNAi knockdown of transformer.
Scientific reports , 2012 | Pubmed ID: 22924109
Proteomics of Tribolium castaneum seminal fluid proteins: identification of an angiotensin-converting enzyme as a key player in regulation of reproduction.
Journal of proteomics Jan, 2013 | Pubmed ID: 23195916
Doublesex target genes in the red flour beetle, Tribolium castaneum.
Scientific reports , 2012 | Pubmed ID: 23230513
Integrated analysis of cytochrome P450 gene superfamily in the red flour beetle, Tribolium castaneum.
BMC genomics Mar, 2013 | Pubmed ID: 23497158
Juvenile hormone and insulin regulate trehalose homeostasis in the red flour beetle, Tribolium castaneum.
PLoS genetics Jun, 2013 | Pubmed ID: 23754959
Tribolium castaneum Transformer-2 regulates sex determination and development in both males and females.
Insect biochemistry and molecular biology Dec, 2013 | Pubmed ID: 24056158
Production of all female progeny: evidence for the presence of the male sex determination factor on the Y chromosome.
The Journal of experimental biology May, 2014 | Pubmed ID: 24577442
Juvenile hormone regulates Aedes aegypti Krüppel homolog 1 through a conserved E box motif.
Insect biochemistry and molecular biology Sep, 2014 | Pubmed ID: 24931431
CYP18A1 regulates tissue-specific steroid hormone inactivation in Bombyx mori.
Insect biochemistry and molecular biology Nov, 2014 | Pubmed ID: 25173591
Nutrition regulation of male accessory gland growth and maturation in Tribolium castaneum.
Scientific reports Jun, 2015 | Pubmed ID: 26035685
Ectopic expression of ecdysone oxidase impairs tissue degeneration in Bombyx mori.
Proceedings. Biological sciences Jun, 2015 | Pubmed ID: 26041352
Transcription factors, CncC and Maf, regulate expression of CYP6BQ genes responsible for deltamethrin resistance in Tribolium castaneum.
Insect biochemistry and molecular biology Oct, 2015 | Pubmed ID: 26255690
Chitosan, Carbon Quantum Dot, and Silica Nanoparticle Mediated dsRNA Delivery for Gene Silencing in Aedes aegypti: A Comparative Analysis.
ACS applied materials & interfaces Sep, 2015 | Pubmed ID: 26291176
RNA interference in Colorado potato beetle: steps toward development of dsRNA as a commercial insecticide.
Current opinion in insect science Dec, 2014 | Pubmed ID: 26705514
Krüppel homolog 1 and E93 mediate Juvenile hormone regulation of metamorphosis in the common bed bug, Cimex lectularius.
Scientific reports 05, 2016 | Pubmed ID: 27185064
Reduced stability and intracellular transport of dsRNA contribute to poor RNAi response in lepidopteran insects.
RNA biology 07, 2016 | Pubmed ID: 27245473
Identification of G protein-coupled receptors required for vitellogenin uptake into the oocytes of the red flour beetle, Tribolium castaneum.
Scientific reports 06, 2016 | Pubmed ID: 27277501
RNA interference in the Colorado potato beetle, Leptinotarsa decemlineata: Identification of key contributors.
Insect biochemistry and molecular biology 11, 2016 | Pubmed ID: 27687845
Transcription factor cap n collar C regulates multiple cytochrome P450 genes conferring adaptation to potato plant allelochemicals and resistance to imidacloprid in Leptinotarsa decemlineata (Say).
Insect biochemistry and molecular biology 04, 2017 | Pubmed ID: 28189748
The FOXO transcription factor controls insect growth and development by regulating juvenile hormone degradation in the silkworm, .
The Journal of biological chemistry 07, 2017 | Pubmed ID: 28490635
Development of RNAi method for screening candidate genes to control emerald ash borer, Agrilus planipennis.
Scientific reports 08, 2017 | Pubmed ID: 28784998
RNA interference in the Asian Longhorned Beetle:Identification of Key RNAi Genes and Reference Genes for RT-qPCR.
Scientific reports 08, 2017 | Pubmed ID: 28827780
Cap n collar transcription factor regulates multiple genes coding for proteins involved in insecticide detoxification in the red flour beetle, Tribolium castaneum.
Insect biochemistry and molecular biology 11, 2017 | Pubmed ID: 28951207
Accumulation of dsRNA in endosomes contributes to inefficient RNA interference in the fall armyworm, Spodoptera frugiperda.
Insect biochemistry and molecular biology 11, 2017 | Pubmed ID: 28951282
New roles for old actors, ROS and PRMT1.
Proceedings of the National Academy of Sciences of the United States of America 10, 2017 | Pubmed ID: 28973953
BmILF and i-motif structure are involved in transcriptional regulation of BmPOUM2 in Bombyx mori.
Nucleic acids research 02, 2018 | Pubmed ID: 29194483
Comparative analysis of double-stranded RNA degradation and processing in insects.
Scientific reports 12, 2017 | Pubmed ID: 29213068
Multiple functions of CREB-binding protein during postembryonic development: identification of target genes.
BMC genomics 12, 2017 | Pubmed ID: 29284404
Selection of housekeeping genes and demonstration of RNAi in cotton leafhopper, Amrasca biguttula biguttula (Ishida).
PloS one , 2018 | Pubmed ID: 29329327
CREB-binding protein plays key roles in juvenile hormone action in the red flour beetle, Tribolium Castaneum.
Scientific reports 01, 2018 | Pubmed ID: 29362416
A model species for agricultural pest genomics: the genome of the Colorado potato beetle, Leptinotarsa decemlineata (Coleoptera: Chrysomelidae).
Scientific reports 01, 2018 | Pubmed ID: 29386578
Improving RNAi in the Brown Marmorated Stink Bug: Identification of target genes and reference genes for RT-qPCR.
Scientific reports 02, 2018 | Pubmed ID: 29487333
Cap 'n' collar C regulates genes responsible for imidacloprid resistance in the Colorado potato beetle, Leptinotarsa decemlineata.
Insect biochemistry and molecular biology 08, 2018 | Pubmed ID: 29852222
Double-stranded RNA binding protein, Staufen, is required for the initiation of RNAi in coleopteran insects.
Proceedings of the National Academy of Sciences of the United States of America 08, 2018 | Pubmed ID: 30061410
Author Correction: CREB-binding protein plays key roles in juvenile hormone action in the red flour beetle, Tribolium Castaneum.
Scientific reports Aug, 2018 | Pubmed ID: 30068930
Correction to: Multiple functions of CREB-binding protein during postembryonic development: identification of target genes.
BMC genomics 08, 2018 | Pubmed ID: 30081819
Disruption of sex-specific doublesex exons results in male- and female-specific defects in the black cutworm, Agrotis ipsilon.
Pest management science Jun, 2019 | Pubmed ID: 30520231
Epigenetic modifications acetylation and deacetylation play important roles in juvenile hormone action.
BMC genomics Dec, 2018 | Pubmed ID: 30547764
RNA sequencing, selection of reference genes and demonstration of feeding RNAi in Thrips tabaci (Lind.) (Thysanoptera: Thripidae).
BMC molecular biology 02, 2019 | Pubmed ID: 30777032
A determining factor for insect feeding preference in the silkworm, Bombyx mori.
PLoS biology 02, 2019 | Pubmed ID: 30811402
A Δ9 desaturase (SlitDes11) is associated with the biosynthesis of ester sex pheromone components in Spodoptera litura.
Pesticide biochemistry and physiology May, 2019 | Pubmed ID: 31027575
Development of CS-TPP-dsRNA nanoparticles to enhance RNAi efficiency in the yellow fever mosquito, Aedes aegypti.
Scientific reports 06, 2019 | Pubmed ID: 31217512
Histone deacetylase 1 suppresses Krüppel homolog 1 gene expression and influences juvenile hormone action in .
Proceedings of the National Academy of Sciences of the United States of America 09, 2019 | Pubmed ID: 31439816
Knockout of juvenile hormone receptor, Methoprene-tolerant, induces black larval phenotype in the yellow fever mosquito, .
Proceedings of the National Academy of Sciences of the United States of America 10, 2019 | Pubmed ID: 31570611
Mechanisms, Applications, and Challenges of Insect RNA Interference.
Annual review of entomology 01, 2020 | Pubmed ID: 31610134
Identification and characterization of multiple dsRNases from a lepidopteran insect, the tobacco cutworm, Spodoptera litura (Lepidoptera: Noctuidae).
Pesticide biochemistry and physiology Jan, 2020 | Pubmed ID: 31836059
Identification and functional analysis of promoters of heat-shock genes from the fall armyworm, Spodoptera frugiperda.
Scientific reports 02, 2020 | Pubmed ID: 32047182
Genome editing in the fall armyworm, Spodoptera frugiperda: Multiple sgRNA/Cas9 method for identification of knockouts in one generation.
Insect biochemistry and molecular biology 07, 2020 | Pubmed ID: 32276113
CncC/Maf-mediated xenobiotic response pathway in insects.
Archives of insect biochemistry and physiology Jun, 2020 | Pubmed ID: 32281173
Lipids help double-stranded RNA in endosomal escape and improve RNA interference in the fall armyworm, Spodoptera frugiperda.
Archives of insect biochemistry and physiology Aug, 2020 | Pubmed ID: 32297364
Orally delivered dsRNA induces knockdown of target genes and mortality in the Asian long-horned beetle, Anoplophora glabripennis.
Archives of insect biochemistry and physiology Aug, 2020 | Pubmed ID: 32297387
CREB-binding protein regulates metamorphosis and compound eye development in the yellow fever mosquito, Aedes aegypti.
Biochimica et biophysica acta. Gene regulatory mechanisms 08, 2020 | Pubmed ID: 32389826
Development of RNAi methods to control the harlequin bug, Murgantia histrionica.
Archives of insect biochemistry and physiology Aug, 2020 | Pubmed ID: 32394499
The effect of E93 knockdown on female reproduction in the red flour beetle, Tribolium castaneum.
Archives of insect biochemistry and physiology Aug, 2020 | Pubmed ID: 32394503
Transport of orally delivered dsRNA in southern green stink bug, Nezara viridula.
Archives of insect biochemistry and physiology Aug, 2020 | Pubmed ID: 32441400
Xenobiotic transcription factors CncC and maf regulate expression of CYP321A16 and CYP332A1 that mediate chlorpyrifos resistance in Spodoptera exigua.
Journal of hazardous materials 11, 2020 | Pubmed ID: 32512455
Histone deacetylase 3 is required for development and metamorphosis in the red flour beetle, Tribolium castaneum.
BMC genomics Jun, 2020 | Pubmed ID: 32571203
Histone Deacetylase 11 Knockdown Blocks Larval Development and Metamorphosis in the Red Flour Beetle, .
Frontiers in genetics , 2020 | Pubmed ID: 32719718
Identification and characterization of highly active promoters from the fall armyworm, Spodoptera frugiperda.
Insect biochemistry and molecular biology 11, 2020 | Pubmed ID: 32827641
Epigenetic regulation of post-embryonic development.
Current opinion in insect science 02, 2021 | Pubmed ID: 33068783
Insulin/IGF signaling and TORC1 promote vitellogenesis via inducing juvenile hormone biosynthesis in the American cockroach.
Development (Cambridge, England) 10, 2020 | Pubmed ID: 33097549
systemic RNA interference defective protein 1 enhances RNAi efficiency in a lepidopteran insect, the fall armyworm, in a tissue-specific manner.
RNA biology 09, 2021 | Pubmed ID: 33111632
Off-target effects of RNAi correlate with the mismatch rate between dsRNA and non-target mRNA.
RNA biology Jan, 2021 | Pubmed ID: 33397184
Expanding the Toolkit for Genome Editing in a Disease Vector, Transgenic Lines Expressing Cas9 and Single Guide RNA Induce Efficient Mutagenesis.
The CRISPR journal Jan, 2021 | Pubmed ID: 33450159
Intragenic DNA methylation regulates insect gene expression and reproduction through the MBD/Tip60 complex.
iScience Feb, 2021 | Pubmed ID: 33521602
Changes in both trans- and cis-regulatory elements mediate insecticide resistance in a lepidopteron pest, Spodoptera exigua.
PLoS genetics 03, 2021 | Pubmed ID: 33690635
Stage-specific action of juvenile hormone analogs.
Journal of pesticide science Feb, 2021 | Pubmed ID: 33746542
Identification of juvenile hormone-induced posttranslational modifications of methoprene tolerant and Krüppel homolog 1 in the yellow fever mosquito, Aedes aegypti.
Journal of proteomics 06, 2021 | Pubmed ID: 33957312
Transcript level is a key factor affecting RNAi efficiency.
Pesticide biochemistry and physiology Jul, 2021 | Pubmed ID: 34119217
MicroRNA miR-8 promotes cell growth of corpus allatum and juvenile hormone biosynthesis independent of insulin/IGF signaling in Drosophila melanogaster.
Insect biochemistry and molecular biology 09, 2021 | Pubmed ID: 34182107
Coleopteran-specific StaufenC functions like Loquacious-PD in dsRNA processing.
RNA biology Aug, 2021 | Pubmed ID: 34376105
Juvenile hormone signaling promotes ovulation and maintains egg shape by inducing expression of extracellular matrix genes.
Proceedings of the National Academy of Sciences of the United States of America Sep, 2021 | Pubmed ID: 34544864