Jeannie Chen

Abnormal photoresponses and light-induced apoptosis in rods lacking rhodopsin kinase.

Expression of Bcl-2 protects against photoreceptor degeneration in retinal degeneration slow (rds) mice.

Role of guanylate cyclase-activating proteins (GCAPs) in setting the flash sensitivity of rod photoreceptors.

The carboxyl-terminal domain is essential for rhodopsin transport in rod photoreceptors.

Mouse models to study GCAP functions in intact photoreceptors.

Structural organization of alpha-synuclein fibrils studied by site-directed spin labeling.

Structure of membrane-bound alpha-synuclein studied by site-directed spin labeling.

Light-dependent redistribution of arrestin in vertebrate rods is an energy-independent process governed by protein-protein interactions.

Drusen deposits associated with aging and age-related macular degeneration contain nonfibrillar amyloid oligomers.

Stable rhodopsin/arrestin complex leads to retinal degeneration in a transgenic mouse model of autosomal dominant retinitis pigmentosa.

Molecular properties of rhodopsin and rod function.

Functional comparisons of visual arrestins in rod photoreceptors of transgenic mice.

Investigation of alpha-synuclein fibril structure by site-directed spin labeling.

Signaling properties of a short-wave cone visual pigment and its role in phototransduction.

Formation of soluble amyloid oligomers and amyloid fibrils by the multifunctional protein vitronectin.

Structure of membrane-bound alpha-synuclein from site-directed spin labeling and computational refinement.

Enhanced arrestin facilitates recovery and protects rods lacking rhodopsin phosphorylation.

Soluble and mature amyloid fibrils in drusen deposits.

Engineering a polarity-sensitive biosensor for time-lapse imaging of apoptotic processes and degeneration.

Q344ter mutation causes mislocalization of rhodopsin molecules that are catalytically active: a mouse model of Q344ter-induced retinal degeneration.

Monitoring apoptosis and neuronal degeneration by real-time detection of phosphatidylserine externalization using a polarity-sensitive indicator of viability and apoptosis.

Arrestin-1 expression level in rods: balancing functional performance and photoreceptor health.

Channel modulation and the mechanism of light adaptation in mouse rods.

Rod outer segment retinol formation is independent of Abca4, arrestin, rhodopsin kinase, and rhodopsin palmitylation.

Role of guanylyl cyclase modulation in mouse cone phototransduction.

Progressive reduction of its expression in rods reveals two pools of arrestin-1 in the outer segment with different roles in photoresponse recovery.

Effect of the ILE86TER mutation in the γ subunit of cGMP phosphodiesterase (PDE6) on rod photoreceptor signaling.

Diurnal, localized exposure of phosphatidylserine by rod outer segment tips in wild-type but not Itgb5-/- or Mfge8-/- mouse retina.

Functional comparison of rod and cone Gα(t) on the regulation of light sensitivity.

Visual arrestin interaction with clathrin adaptor AP-2 regulates photoreceptor survival in the vertebrate retina.

Rapid degeneration of rod photoreceptors expressing self-association-deficient arrestin-1 mutant.

The physiological roles of arrestin-1 in rod photoreceptor cells.

Functional EF-hands in neuronal calcium sensor GCAP2 determine its phosphorylation state and subcellular distribution in vivo, and are essential for photoreceptor cell integrity.

Induction of the unfolded protein response by constitutive G-protein signaling in rod photoreceptor cells.

Regulation of Mammalian cone phototransduction by recoverin and rhodopsin kinase.

C-terminal threonines and serines play distinct roles in the desensitization of rhodopsin, a G protein-coupled receptor.

A new mouse model for stationary night blindness with mutant Slc24a1 explains the pathophysiology of the associated human disease.

Effect of Rhodopsin Phosphorylation on Dark Adaptation in Mouse Rods.

The Na(+)/Ca(2+), K(+) exchanger 2 modulates mammalian cone phototransduction.

Effects of Prolonged GRP78 Haploinsufficiency on Organ Homeostasis, Behavior, Cancer and Chemotoxic Resistance in Aged Mice.

The GCaMP-R Family of Genetically Encoded Ratiometric Calcium Indicators.

Two pathways of rod photoreceptor cell death induced by elevated cGMP.

Separation of photoreceptor cell compartments in mouse retina for protein analysis.

The Na/Ca, K exchanger NCKX4 is required for efficient cone-mediated vision.

Phenotypic characterization of P23H and S334ter rhodopsin transgenic rat models of inherited retinal degeneration.

Guanylate cyclase-activating protein 2 contributes to phototransduction and light adaptation in mouse cone photoreceptors.

Regulation of calcium homeostasis in the outer segments of rod and cone photoreceptors.

Enhanced Mutant Compensates for Defects in Rhodopsin Phosphorylation in the Presence of Endogenous Arrestin-1.

The PDE6 mutation in the rd10 retinal degeneration mouse model causes protein mislocalization and instability and promotes cell death through increased ion influx.

Elementary response triggered by transducin in retinal rods.

Activation of Rod Input in a Model of Retinal Degeneration Reverses Retinal Remodeling and Induces Formation of Functional Synapses and Recovery of Visual Signaling in the Adult Retina.

Diminished Cone Sensitivity in cpfl3 Mice Is Caused by Defective Transducin Signaling.

Dark noise and retinal degeneration from D190N-rhodopsin.

Biological Role of Arrestin-1 Oligomerization.

Isoelectric Focusing to Quantify Rhodopsin Phosphorylation in Mouse Retina.

Huntingtin fibrils with different toxicity, structure, and seeding potential can be interconverted.