Department of Microbiology and Immunology
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Immunisation of two rodent species with new live-attenuated mutants of CO92 induces protective long-term humoral- and cell-mediated immunity against pneumonic plague.
NPJ vaccines , 2016 | Pubmed ID: 29263858
Treg cell-IgA axis in maintenance of host immune homeostasis with microbiota.
International immunopharmacology May, 2011 | Pubmed ID: 21111079
Interleukin-12 converts Foxp3+ regulatory T cells to interferon-γ-producing Foxp3+ T cells that inhibit colitis.
Gastroenterology Jun, 2011 | Pubmed ID: 21419767
Microbiota: dual-faceted player in experimental colitis.
Gut microbes Nov-Dec, 2010 | Pubmed ID: 21468221
Th17 cells induce colitis and promote Th1 cell responses through IL-17 induction of innate IL-12 and IL-23 production.
Journal of immunology (Baltimore, Md. : 1950) Jun, 2011 | Pubmed ID: 21531892
Luminal-applied flagellin is internalized by polarized intestinal epithelial cells and elicits immune responses via the TLR5 dependent mechanism.
PloS one , 2011 | Pubmed ID: 21949773
Microbiota downregulates dendritic cell expression of miR-10a, which targets IL-12/IL-23p40.
Journal of immunology (Baltimore, Md. : 1950) Dec, 2011 | Pubmed ID: 22068236
Immunomodulation for gastrointestinal infections.
Expert review of anti-infective therapy Mar, 2012 | Pubmed ID: 22397571
Regulation of Toll-like receptor 5 gene expression and function on mucosal dendritic cells.
PloS one , 2012 | Pubmed ID: 22545147
Th17 cells upregulate polymeric Ig receptor and intestinal IgA and contribute to intestinal homeostasis.
Journal of immunology (Baltimore, Md. : 1950) Nov, 2012 | Pubmed ID: 22993206
Deletion of the Braun lipoprotein-encoding gene and altering the function of lipopolysaccharide attenuate the plague bacterium.
Infection and immunity Mar, 2013 | Pubmed ID: 23275092
ERK differentially regulates Th17- and Treg-cell development and contributes to the pathogenesis of colitis.
European journal of immunology Jul, 2013 | Pubmed ID: 23620016
A West Nile virus NS4B-P38G mutant strain induces adaptive immunity via TLR7-MyD88-dependent and independent signaling pathways.
Vaccine Aug, 2013 | Pubmed ID: 23845800
Immunomodulatory and anti-bacterial effects of cystatin-9 against F. tularensis.
Molecular medicine (Cambridge, Mass.) Aug, 2013 | Pubmed ID: 23922243
Microbiota regulation of inflammatory bowel disease and colorectal cancer.
Seminars in cancer biology Dec, 2013 | Pubmed ID: 24071482
Downregulation of microRNA-107 in intestinal CD11c(+) myeloid cells in response to microbiota and proinflammatory cytokines increases IL-23p19 expression.
European journal of immunology Mar, 2014 | Pubmed ID: 24293139
Microbiota regulation of inflammatory bowel disease.
Inflammation & allergy drug targets Feb, 2014 | Pubmed ID: 24438006
Attenuation of intestinal inflammation in interleukin-10-deficient mice infected with Citrobacter rodentium.
Infection and immunity May, 2014 | Pubmed ID: 24566625
Intrahepatic innate lymphoid cells secrete IL-17A and IL-17F that are crucial for T cell priming in viral infection.
Journal of immunology (Baltimore, Md. : 1950) Apr, 2014 | Pubmed ID: 24600029
Deletion of Braun lipoprotein and plasminogen-activating protease-encoding genes attenuates Yersinia pestis in mouse models of bubonic and pneumonic plague.
Infection and immunity Jun, 2014 | Pubmed ID: 24686064
TLR4 regulates IFN-γ and IL-17 production by both thymic and induced Foxp3+ Tregs during intestinal inflammation.
Journal of leukocyte biology Nov, 2014 | Pubmed ID: 25015957
miR-10a inhibits dendritic cell activation and Th1/Th17 cell immune responses in IBD.
Gut Nov, 2015 | Pubmed ID: 25281418
Exchange protein directly activated by cAMP modulates regulatory T-cell-mediated immunosuppression.
The Biochemical journal Jan, 2015 | Pubmed ID: 25339598
Interleukin (IL)-21 promotes intestinal IgA response to microbiota.
Mucosal immunology Sep, 2015 | Pubmed ID: 25586558
TGF-β converts Th1 cells into Th17 cells through stimulation of Runx1 expression.
European journal of immunology Apr, 2015 | Pubmed ID: 25605286
Endomicroscopy Will Track Injected Mesenchymal Stem Cells in Rat Colitis Models.
Inflammatory bowel diseases Sep, 2015 | Pubmed ID: 25993690
IL-17A promotes protective IgA responses and expression of other potential effectors against the lumen-dwelling enteric parasite Giardia.
Experimental parasitology Sep, 2015 | Pubmed ID: 26071205
Unexpected Regulatory Role of CCR9 in Regulatory T Cell Development.
PloS one , 2015 | Pubmed ID: 26230654
Gut Homing Molecule Regulation of the Pathogenesis and Treatment of Inflammatory Bowel Diseases.
Inflammation & allergy drug targets , 2015 | Pubmed ID: 26296210
miR-301a promotes intestinal mucosal inflammation through induction of IL-17A and TNF-α in IBD.
Gut 12, 2016 | Pubmed ID: 26338824
Divalent metal-ion transporter 1 is decreased in intestinal epithelial cells and contributes to the anemia in inflammatory bowel disease.
Scientific reports Nov, 2015 | Pubmed ID: 26572590
Dysregulation of Toll-Like Receptor 7 Compromises Innate and Adaptive T Cell Responses and Host Resistance to an Attenuated West Nile Virus Infection in Old Mice.
Journal of virology 02, 2016 | Pubmed ID: 26581984
Commensal A4 bacteria inhibit intestinal Th2-cell responses through induction of dendritic cell TGF-β production.
European journal of immunology 05, 2016 | Pubmed ID: 26840377
TLR5 mediates CD172α(+) intestinal lamina propria dendritic cell induction of Th17 cells.
Scientific reports Feb, 2016 | Pubmed ID: 26907705
Microbiota-specific Th17 Cells: Yin and Yang in Regulation of Inflammatory Bowel Disease.
Inflammatory bowel diseases 06, 2016 | Pubmed ID: 27057688
mTOR Mediates IL-23 Induction of Neutrophil IL-17 and IL-22 Production.
Journal of immunology (Baltimore, Md. : 1950) 05, 2016 | Pubmed ID: 27067005
Microbiota metabolite short chain fatty acids, GPCR, and inflammatory bowel diseases.
Journal of gastroenterology Jan, 2017 | Pubmed ID: 27448578
Protective Immunity Elicited by Oral Immunization of Mice with Serovar Typhimurium Braun Lipoprotein (Lpp) and Acetyltransferase (MsbB) Mutants.
Frontiers in cellular and infection microbiology , 2016 | Pubmed ID: 27891321
Microbiota metabolite short-chain fatty acid acetate promotes intestinal IgA response to microbiota which is mediated by GPR43.
Mucosal immunology 07, 2017 | Pubmed ID: 27966553
MicroRNA 301A Promotes Intestinal Inflammation and Colitis-Associated Cancer Development by Inhibiting BTG1.
Gastroenterology 05, 2017 | Pubmed ID: 28193514
Retinoic Acid Regulates Immune Responses by Promoting IL-22 and Modulating S100 Proteins in Viral Hepatitis.
Journal of immunology (Baltimore, Md. : 1950) 05, 2017 | Pubmed ID: 28363907
CD177 neutrophils as functionally activated neutrophils negatively regulate IBD.
Gut 06, 2018 | Pubmed ID: 28468761
A tightly regulated IL-22 response maintains immune functions and homeostasis in systemic viral infection.
Scientific reports 06, 2017 | Pubmed ID: 28634408
Tripartite motif-containing (TRIM) 21 negatively regulates intestinal mucosal inflammation through inhibiting T1/T17 cell differentiation in patients with inflammatory bowel diseases.
The Journal of allergy and clinical immunology 10, 2018 | Pubmed ID: 29113905
CD177+ neutrophils suppress epithelial cell tumourigenesis in colitis-associated cancer and predict good prognosis in colorectal cancer.
Carcinogenesis 02, 2018 | Pubmed ID: 29228136
Critical role of ROCK2 activity in facilitating mucosal CD4 T cell activation in inflammatory bowel disease.
Journal of autoimmunity 05, 2018 | Pubmed ID: 29269245
IL-33 induces immunosuppressive neutrophils via a type 2 innate lymphoid cell/IL-13/STAT6 axis and protects the liver against injury in LCMV infection-induced viral hepatitis.
Cellular & molecular immunology 02, 2019 | Pubmed ID: 29400707
GPR43 mediates microbiota metabolite SCFA regulation of antimicrobial peptide expression in intestinal epithelial cells via activation of mTOR and STAT3.
Mucosal immunology 05, 2018 | Pubmed ID: 29411774
Anti-TNF Therapy Induces CD4+ T-Cell Production of IL-22 and Promotes Epithelial Repairs in Patients With Crohn's Disease.
Inflammatory bowel diseases 07, 2018 | Pubmed ID: 29718341
Neonatal Colonic Inflammation Epigenetically Aggravates Epithelial Inflammatory Responses to Injury in Adult Life.
Cellular and molecular gastroenterology and hepatology , | Pubmed ID: 29928672
Neutrophils Promote Amphiregulin Production in Intestinal Epithelial Cells through TGF-β and Contribute to Intestinal Homeostasis.
Journal of immunology (Baltimore, Md. : 1950) 10, 2018 | Pubmed ID: 30171165
Microbiota-derived short-chain fatty acids promote Th1 cell IL-10 production to maintain intestinal homeostasis.
Nature communications 09, 2018 | Pubmed ID: 30177845
Microbiota dysbiosis and its pathophysiological significance in bowel obstruction.
Scientific reports 09, 2018 | Pubmed ID: 30177854
NIK signaling axis regulates dendritic cell function in intestinal immunity and homeostasis.
Nature immunology 11, 2018 | Pubmed ID: 30250187
Different flavors of IL-21 in regulation of intestinal IgA to commensals.
Mucosal immunology 01, 2019 | Pubmed ID: 30361536
Critical Role of CD6highCD4+ T Cells in Driving Th1/Th17 Cell Immune Responses and Mucosal Inflammation in IBD.
Journal of Crohn's & colitis Mar, 2019 | Pubmed ID: 30395204
RORγt Represses IL-10 Production in Th17 Cells To Maintain Their Pathogenicity in Inducing Intestinal Inflammation.
Journal of immunology (Baltimore, Md. : 1950) 01, 2019 | Pubmed ID: 30478092
MicroRNA-31 Reduces Inflammatory Signaling and Promotes Regeneration in Colon Epithelium, and Delivery of Mimics in Microspheres Reduces Colitis in Mice.
Gastroenterology 06, 2019 | Pubmed ID: 30779922
Interleukin-33 Promotes REG3γ Expression in Intestinal Epithelial Cells and Regulates Gut Microbiota.
Cellular and molecular gastroenterology and hepatology , 2019 | Pubmed ID: 30831322
Microbiota Metabolite Butyrate Differentially Regulates Th1 and Th17 Cells' Differentiation and Function in Induction of Colitis.
Inflammatory bowel diseases 08, 2019 | Pubmed ID: 30918945
MicroRNA-125a suppresses intestinal mucosal inflammation through targeting ETS-1 in patients with inflammatory bowel diseases.
Journal of autoimmunity 07, 2019 | Pubmed ID: 31014918
Microbiota Metabolite Short-Chain Fatty Acids Facilitate Mucosal Adjuvant Activity of Cholera Toxin through GPR43.
Journal of immunology (Baltimore, Md. : 1950) 07, 2019 | Pubmed ID: 31076530
Dissemination of non-typhoidal Salmonella during Plasmodium chabaudi infection affects anti-malarial immunity.
Parasitology research Jul, 2019 | Pubmed ID: 31119381
Gut microbiota metabolite regulation of host defenses at mucosal surfaces: implication in precision medicine.
Precision clinical medicine Jun, 2019 | Pubmed ID: 31281735
Enteroendocrine Cells: Sensing Gut Microbiota and Regulating Inflammatory Bowel Diseases.
Inflammatory bowel diseases 01, 2020 | Pubmed ID: 31560044
Matrix metalloproteinases cleave membrane-bound PD-L1 on CD90+ (myo-)fibroblasts in Crohn's disease and regulate Th1/Th17 cell responses.
International immunology 01, 2020 | Pubmed ID: 31633754
Neonatal Injury Increases Gut Permeability by Epigenetically Suppressing E-Cadherin in Adulthood.
Journal of immunology (Baltimore, Md. : 1950) , | Pubmed ID: 31889022
Secreted stromal protein ISLR promotes intestinal regeneration by suppressing epithelial Hippo signaling.
The EMBO journal 04, 2020 | Pubmed ID: 32128839
Mucoadhesive-to-penetrating controllable peptosomes-in-microspheres co-loaded with anti-miR-31 oligonucleotide and Curcumin for targeted colorectal cancer therapy.
Theranostics , 2020 | Pubmed ID: 32206110
Increased Ileal Immunoglobulin A Production and Immunoglobulin A-Coated Bacteria in Diarrhea-Predominant Irritable Bowel Syndrome.
Clinical and translational gastroenterology 03, 2020 | Pubmed ID: 32352710
COVID-19 and the Digestive System.
The American journal of gastroenterology 07, 2020 | Pubmed ID: 32618648
Cycling Stem Cells Are Radioresistant and Regenerate the Intestine.
Cell reports 07, 2020 | Pubmed ID: 32726617
Acute stress disrupts intestinal homeostasis via GDNF-RET.
Cell proliferation Oct, 2020 | Pubmed ID: 32808420
IL-21 Promotes Intestinal Memory IgA Responses.
Journal of immunology (Baltimore, Md. : 1950) 10, 2020 | Pubmed ID: 32859726
Intestinal microbiota-derived short-chain fatty acids regulation of immune cell IL-22 production and gut immunity.
Nature communications 09, 2020 | Pubmed ID: 32901017
STING controls intestinal homeostasis through promoting antimicrobial peptide expression in epithelial cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 11, 2020 | Pubmed ID: 32969062
Propionate Enhances Cell Speed and Persistence to Promote Intestinal Epithelial Turnover and Repair.
Cellular and molecular gastroenterology and hepatology , 2021 | Pubmed ID: 33238220
Gut microbiota-derived metabolites in the regulation of host immune responses and immune-related inflammatory diseases.
Cellular & molecular immunology 04, 2021 | Pubmed ID: 33707689
L-lactate promotes intestinal epithelial cell migration to inhibit colitis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 04, 2021 | Pubmed ID: 33742715
MicroRNA-10a Negatively Regulates CD4 T Cell IL-10 Production through Suppression of Blimp1.
Journal of immunology (Baltimore, Md. : 1950) 08, 2021 | Pubmed ID: 34301843
IL-33 activates mTORC1 and modulates glycolytic metabolism in CD8 T cells.
Immunology Jan, 2022 | Pubmed ID: 34411293
GPR120 Inhibits Colitis Through Regulation of CD4 T Cell Interleukin 10 Production.
Gastroenterology Jan, 2022 | Pubmed ID: 34536451
Target-Based Small Molecule Drug Discovery Towards Novel Therapeutics for Inflammatory Bowel Diseases.
Inflammatory bowel diseases 11, 2021 | Pubmed ID: 34791293