Department of Pathology,
MitoCare Center,
Department of Pathology, MitoCare Center
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MICU1 controls both the threshold and cooperative activation of the mitochondrial Ca²⁺ uniporter.
Cell metabolism Jun, 2013 | Pubmed ID: 23747253
The retinal pigment epithelium utilizes fatty acids for ketogenesis.
The Journal of biological chemistry Jul, 2014 | Pubmed ID: 24898254
Reliance of ER-mitochondrial calcium signaling on mitochondrial EF-hand Ca2+ binding proteins: Miros, MICUs, LETM1 and solute carriers.
Current opinion in cell biology Aug, 2014 | Pubmed ID: 24999559
Acyl-CoA thioesterase-2 facilitates mitochondrial fatty acid oxidation in the liver.
Journal of lipid research Dec, 2014 | Pubmed ID: 25114170
Lower mitochondrial proton leak and decreased glutathione redox in primary muscle cells of obese diet-resistant versus diet-sensitive humans.
The Journal of clinical endocrinology and metabolism Nov, 2014 | Pubmed ID: 25148230
Functional mitochondrial analysis in acute brain sections from adult rats reveals mitochondrial dysfunction in a rat model of migraine.
American journal of physiology. Cell physiology Dec, 2014 | Pubmed ID: 25252946
The mitochondrial phosphate carrier: Role in oxidative metabolism, calcium handling and mitochondrial disease.
Biochemical and biophysical research communications Aug, 2015 | Pubmed ID: 26091567
IL-15Rα is a determinant of muscle fuel utilization, and its loss protects against obesity.
American journal of physiology. Regulatory, integrative and comparative physiology Oct, 2015 | Pubmed ID: 26269523
Mitochondrial functions modulate neuroendocrine, metabolic, inflammatory, and transcriptional responses to acute psychological stress.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2015 | Pubmed ID: 26627253
MICU1 regulation of mitochondrial Ca(2+) uptake dictates survival and tissue regeneration.
Nature communications Mar, 2016 | Pubmed ID: 26956930
Hypoxia promotes noncanonical autophagy in nucleus pulposus cells independent of MTOR and HIF1A signaling.
Autophagy 09, 2016 | Pubmed ID: 27314664
Natural and Induced Mitochondrial Phosphate Carrier Loss: DIFFERENTIAL DEPENDENCE OF MITOCHONDRIAL METABOLISM AND DYNAMICS AND CELL SURVIVAL ON THE EXTENT OF DEPLETION.
The Journal of biological chemistry Dec, 2016 | Pubmed ID: 27780865
Tissue-Specific Mitochondrial Decoding of Cytoplasmic Ca Signals Is Controlled by the Stoichiometry of MICU1/2 and MCU.
Cell reports 03, 2017 | Pubmed ID: 28273446
Cyclin D1 Restrains Oncogene-Induced Autophagy by Regulating the AMPK-LKB1 Signaling Axis.
Cancer research May, 2017 | Pubmed ID: 28522753
MSTO1 is a cytoplasmic pro-mitochondrial fusion protein, whose mutation induces myopathy and ataxia in humans.
EMBO molecular medicine 07, 2017 | Pubmed ID: 28554942
Posttranscriptional Upregulation of IDH1 by HuR Establishes a Powerful Survival Phenotype in Pancreatic Cancer Cells.
Cancer research 08, 2017 | Pubmed ID: 28652247
Bicarbonate Recycling by HIF-1-Dependent Carbonic Anhydrase Isoforms 9 and 12 Is Critical in Maintaining Intracellular pH and Viability of Nucleus Pulposus Cells.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 02, 2018 | Pubmed ID: 28940640
Loss of PINK1 causes age-dependent decrease of dopamine release and mitochondrial dysfunction.
Neurobiology of aging 03, 2019 | Pubmed ID: 30504091
Dysregulation of Mitochondrial Ca Uptake and Sarcolemma Repair Underlie Muscle Weakness and Wasting in Patients and Mice Lacking MICU1.
Cell reports 10, 2019 | Pubmed ID: 31665639
Multiple mitochondrial thioesterases have distinct tissue and substrate specificity and CoA regulation, suggesting unique functional roles.
The Journal of biological chemistry 12, 2019 | Pubmed ID: 31676684
Quantification of lactoyl-CoA (lactyl-CoA) by liquid chromatography mass spectrometry in mammalian cells and tissues.
Open biology 09, 2020 | Pubmed ID: 32961073
Adaptation of the heart to Frataxin depletion: Evidence that integrated stress response can predominate over mTORC1 activation.
Human molecular genetics Sep, 2021 | Pubmed ID: 34550363
A Novel Role for DNA-PK in Metabolism by Regulating Glycolysis in Castration-Resistant Prostate Cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research Apr, 2022 | Pubmed ID: 35078861
Frataxin deficiency lowers lean mass and triggers the integrated stress response in skeletal muscle.
JCI insight May, 2022 | Pubmed ID: 35531957