Department of Microbiology,
Department of Microbial Infection and Immunity
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Pseudomonas aeruginosa rugose small-colony variants have adaptations that likely promote persistence in the cystic fibrosis lung.
Journal of bacteriology , | Pubmed ID: 19329647
Genetic and biochemical analyses of the Pseudomonas aeruginosa Psl exopolysaccharide reveal overlapping roles for polysaccharide synthesis enzymes in Psl and LPS production.
Molecular microbiology , | Pubmed ID: 19659934
The sigma factor AlgU plays a key role in formation of robust biofilms by nonmucoid Pseudomonas aeruginosa.
Journal of bacteriology , | Pubmed ID: 20348252
AmrZ beta-sheet residues are essential for DNA binding and transcriptional control of Pseudomonas aeruginosa virulence genes.
Journal of bacteriology Oct, 2010 | Pubmed ID: 20709902
The Pseudomonas aeruginosa exopolysaccharide Psl facilitates surface adherence and NF-kappaB activation in A549 cells.
mBio , | Pubmed ID: 20802825
Epistatic roles for Pseudomonas aeruginosa MutS and DinB (DNA Pol IV) in coping with reactive oxygen species-induced DNA damage.
PloS one , | Pubmed ID: 21533111
Direct evaluation of Pseudomonas aeruginosa biofilm mediators in a chronic infection model.
Infection and immunity , | Pubmed ID: 21646454
Pseudomonas aeruginosa Psl polysaccharide reduces neutrophil phagocytosis and the oxidative response by limiting complement-mediated opsonization.
Cellular microbiology , | Pubmed ID: 21951860
Pseudomonas biofilm matrix composition and niche biology.
FEMS microbiology reviews , | Pubmed ID: 22212072
The transcription factor AmrZ utilizes multiple DNA binding modes to recognize activator and repressor sequences of Pseudomonas aeruginosa virulence genes.
PLoS pathogens , | Pubmed ID: 22511872
Synthesis of multiple Pseudomonas aeruginosa biofilm matrix exopolysaccharides is post-transcriptionally regulated.
Environmental microbiology , | Pubmed ID: 22513190
Crystallization of Pseudomonas aeruginosa AmrZ protein: development of a comprehensive method for obtaining and optimization of protein-DNA crystals.
Acta crystallographica. Section F, Structural biology and crystallization communications , | Pubmed ID: 22869139
Self-produced exopolysaccharide is a signal that stimulates biofilm formation in Pseudomonas aeruginosa.
Proceedings of the National Academy of Sciences of the United States of America , | Pubmed ID: 23175784
A spider web strategy of type IV pili-mediated migration to build a fibre-like Psl polysaccharide matrix in Pseudomonas aeruginosa biofilms.
Environmental microbiology , | Pubmed ID: 23425591
First evidence of sternal wound biofilm following cardiac surgery.
PloS one , 2013 | Pubmed ID: 23936415
Cationic antimicrobial peptides promote microbial mutagenesis and pathoadaptation in chronic infections.
PLoS pathogens , | Pubmed ID: 24763694
Mixed-species biofilm compromises wound healing by disrupting epidermal barrier function.
The Journal of pathology Aug, 2014 | Pubmed ID: 24771509
Surface-associated microbes continue to surprise us in their sophisticated strategies for assembling biofilm communities.
F1000prime reports , | Pubmed ID: 24860649
The exopolysaccharide Psl-eDNA interaction enables the formation of a biofilm skeleton in Pseudomonas aeruginosa.
Environmental microbiology reports Apr, 2015 | Pubmed ID: 25472701
Complete Genome Sequence of Pseudomonas aeruginosa Mucoid Strain FRD1, Isolated from a Cystic Fibrosis Patient.
Genome announcements , | Pubmed ID: 25792066
Identification of OprF as a complement component C3 binding acceptor molecule on the surface of Pseudomonas aeruginosa.
Infection and immunity , | Pubmed ID: 25964476
Development of a Novel Method for Analyzing Pseudomonas aeruginosa Twitching Motility and Its Application to Define the AmrZ Regulon.
PloS one , | Pubmed ID: 26309248
Pel is a cationic exopolysaccharide that cross-links extracellular DNA in the Pseudomonas aeruginosa biofilm matrix.
Proceedings of the National Academy of Sciences of the United States of America , | Pubmed ID: 26311845
Characterization of the Pseudomonas aeruginosa Glycoside Hydrolase PslG Reveals That Its Levels Are Critical for Psl Polysaccharide Biosynthesis and Biofilm Formation.
The Journal of biological chemistry , | Pubmed ID: 26424791
A novel technique using potassium permanganate and reflectance confocal microscopy to image biofilm extracellular polymeric matrix reveals non-eDNA networks in Pseudomonas aeruginosa biofilms.
Pathogens and disease , | Pubmed ID: 26536894
The Pseudomonas aeruginosa AmrZ C-terminal domain mediates tetramerization and is required for its activator and repressor functions.
Environmental microbiology reports , | Pubmed ID: 26549743
Prevention and treatment of Staphylococcus aureus biofilms.
Expert review of anti-infective therapy , | Pubmed ID: 26646248
What's on the Outside Matters: The Role of the Extracellular Polymeric Substance of Gram-negative Biofilms in Evading Host Immunity and as a Target for Therapeutic Intervention.
The Journal of biological chemistry , | Pubmed ID: 27129225
Pseudomonas aeruginosa AmrZ Binds to Four Sites in the algD Promoter, Inducing DNA-AmrZ Complex Formation and Transcriptional Activation.
Journal of bacteriology , | Pubmed ID: 27185826
Staphylococcus aureus Protein A Mediates Interspecies Interactions at the Cell Surface of Pseudomonas aeruginosa.
mBio , | Pubmed ID: 27222468
Histopathological comparisons of Staphylococcus aureus and Pseudomonas aeruginosa experimental infected porcine burn wounds.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 05, 2017 | Pubmed ID: 28466497
Modifications of Pseudomonas aeruginosa cell envelope in the cystic fibrosis airway alters interactions with immune cells.
Scientific reports , | Pubmed ID: 28684799
Congo Red Stain Identifies Matrix Overproduction and Is an Indirect Measurement for c-di-GMP in Many Species of Bacteria.
Methods in molecular biology (Clifton, N.J.) , | Pubmed ID: 28889292
Electric Field Based Dressing Disrupts Mixed-Species Bacterial Biofilm Infection and Restores Functional Wound Healing.
Annals of surgery Nov, 2017 | Pubmed ID: 29099398
Pseudomonas aeruginosa rugose small-colony variants evade host clearance, are hyper-inflammatory, and persist in multiple host environments.
PLoS pathogens 02, 2018 | Pubmed ID: 29394295
Mixed Communities of Mucoid and Nonmucoid Exhibit Enhanced Resistance to Host Antimicrobials.
mBio , | Pubmed ID: 29588399
Use of a leukocyte-targeted peptide probe as a potential tracer for imaging the tuberculosis granuloma.
Tuberculosis (Edinburgh, Scotland) , | Pubmed ID: 29623875
Synthesis and anti-staphylococcal activity of novel bacterial topoisomerase inhibitors with a 5-amino-1,3-dioxane linker moiety.
Bioorganic & medicinal chemistry letters , | Pubmed ID: 29871847
biofilms release leukocidins to elicit extracellular trap formation and evade neutrophil-mediated killing.
Proceedings of the National Academy of Sciences of the United States of America 07, 2018 | Pubmed ID: 29941565
Viscoelastic properties of Pseudomonas aeruginosa variant biofilms.
Scientific reports , | Pubmed ID: 29946126
CdrA Interactions within the Pseudomonas aeruginosa Biofilm Matrix Safeguard It from Proteolysis and Promote Cellular Packing.
mBio , | Pubmed ID: 30254118
Genomic and Phenotypic Diversity among Ten Laboratory Isolates of PAO1.
Journal of bacteriology , | Pubmed ID: 30530517
Staphylococcus aureus Biofilm Infection Compromises Wound Healing by Causing Deficiencies in Granulation Tissue Collagen.
Annals of surgery , | Pubmed ID: 30614873
Electroceutical Treatment of Pseudomonas aeruginosa Biofilms.
Scientific reports , | Pubmed ID: 30765750
Treatment with the Pseudomonas aeruginosa Glycoside Hydrolase PslG Combats Wound Infection by Improving Antibiotic Efficacy and Host Innate Immune Activity.
Antimicrobial agents and chemotherapy , | Pubmed ID: 30988141
Mucoid Pseudomonas aeruginosa and regional inflammation in the cystic fibrosis lung.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society , | Pubmed ID: 31036488
1,3-Dioxane-Linked Bacterial Topoisomerase Inhibitors with Enhanced Antibacterial Activity and Reduced hERG Inhibition.
ACS infectious diseases , | Pubmed ID: 31041863
Cystic Fibrosis and Pseudomonas aeruginosa: the Host-Microbe Interface.
Clinical microbiology reviews , | Pubmed ID: 31142499
Pseudomonas aeruginosa Interstrain Dynamics and Selection of Hyperbiofilm Mutants during a Chronic Infection.
mBio , | Pubmed ID: 31409682
Effect of Mycobacterium tuberculosis Enhancement of Macrophage P-Glycoprotein Expression and Activity on Intracellular Survival During Antituberculosis Drug Treatment.
The Journal of infectious diseases , | Pubmed ID: 31412123
Mucin glycans attenuate the virulence of Pseudomonas aeruginosa in infection.
Nature microbiology , | Pubmed ID: 31611643
Sequential ubiquitination of NLRP3 by RNF125 and Cbl-b limits inflammasome activation and endotoxemia.
The Journal of experimental medicine , | Pubmed ID: 31999304
Novel Bacterial Diversity and Fragmented eDNA Identified in Hyperbiofilm-Forming Pseudomonas aeruginosa Rugose Small Colony Variant.
iScience , | Pubmed ID: 32058950
Novel bacterial topoisomerase inhibitors derived from isomannide.
European journal of medicinal chemistry Aug, 2020 | Pubmed ID: 32402932
Elevated exopolysaccharide levels in Pseudomonas aeruginosa flagellar mutants have implications for biofilm growth and chronic infections.
PLoS genetics 06, 2020 | Pubmed ID: 32530919
Novel Aminoglycoside-Tolerant Phoenix Colony Variants of Pseudomonas aeruginosa.
Antimicrobial agents and chemotherapy 08, 2020 | Pubmed ID: 32540981
Ultrastructure imaging of Pseudomonas aeruginosa lawn biofilms and eradication of the tobramycin-resistant variants under in vitro electroceutical treatment.
Scientific reports 06, 2020 | Pubmed ID: 32555250
Evaluation of Peptide-Based Probes toward Diagnostic Imaging of Bacterial Biofilm-Associated Infections.
ACS infectious diseases 08, 2020 | Pubmed ID: 32603591
The Versatile Pseudomonas aeruginosa Biofilm Matrix Protein CdrA Promotes Aggregation through Different Extracellular Exopolysaccharide Interactions.
Journal of bacteriology 09, 2020 | Pubmed ID: 32661078
Leukocidins and the Nuclease Nuc Prevent Neutrophil-Mediated Killing of Staphylococcus aureus Biofilms.
Infection and immunity 09, 2020 | Pubmed ID: 32719153
Dioxane-Linked Amide Derivatives as Novel Bacterial Topoisomerase Inhibitors against Gram-Positive .
ACS medicinal chemistry letters Dec, 2020 | Pubmed ID: 33335666
Biofilm mechanics: Implications in infection and survival.
Biofilm Dec, 2020 | Pubmed ID: 33447803
Pseudomonas aeruginosa aggregates in cystic fibrosis sputum produce exopolysaccharides that likely impede current therapies.
Cell reports 02, 2021 | Pubmed ID: 33626358
Mycobacterium abscessus biofilms have viscoelastic properties which may contribute to their recalcitrance in chronic pulmonary infections.
Scientific reports 03, 2021 | Pubmed ID: 33658597
Improving Phage-Biofilm In Vitro Experimentation.
Viruses 06, 2021 | Pubmed ID: 34205417
Optimization of TopoIV Potency, ADMET Properties, and hERG Inhibition of 5-Amino-1,3-dioxane-Linked Novel Bacterial Topoisomerase Inhibitors: Identification of a Lead with Efficacy against MRSA.
Journal of medicinal chemistry 10, 2021 | Pubmed ID: 34614347
Phage Cocktail Development for Bacteriophage Therapy: Toward Improving Spectrum of Activity Breadth and Depth.
Pharmaceuticals (Basel, Switzerland) Oct, 2021 | Pubmed ID: 34681243
Arginine Induced Biofilm Detachment Using a Novel Rotating-Disc Rheometry Method.
Frontiers in cellular and infection microbiology , 2021 | Pubmed ID: 34805002
Friends or Foes? Rapid Determination of Dissimilar Colistin and Ciprofloxacin Antagonism of Phages.
Pharmaceuticals (Basel, Switzerland) Nov, 2021 | Pubmed ID: 34832944
Treating Bacterial Infections with Bacteriophage-Based Enzybiotics: In Vitro, In Vivo and Clinical Application.
Antibiotics (Basel, Switzerland) Dec, 2021 | Pubmed ID: 34943709
Mucoid Pseudomonas aeruginosa Can Produce Calcium-Gelled Biofilms Independent of the Matrix Components Psl and CdrA.
Journal of bacteriology May, 2022 | Pubmed ID: 35416688
The Wsp system of links surface sensing and cell envelope stress.
Proceedings of the National Academy of Sciences of the United States of America 05, 2022 | Pubmed ID: 35476526
Author Correction: Viscoelastic properties of Pseudomonas aeruginosa variant biofilms.
Scientific reports May, 2022 | Pubmed ID: 35585192
Mucin O-glycans are natural inhibitors of Candida albicans pathogenicity.
Nature chemical biology Jun, 2022 | Pubmed ID: 35668191