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School of Life Sciences
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The non-protein amino acid BMAA is misincorporated into human proteins in place of L-serine causing protein misfolding and aggregation.
PloS one , 2013 | Pubmed ID: 24086518
Non-protein amino acids and neurodegeneration: the enemy within.
Experimental neurology Mar, 2014 | Pubmed ID: 24374297
Using an in vitro model to study oxidised protein accumulation in ageing fibroblasts.
Biochimica et biophysica acta Nov, 2015 | Pubmed ID: 26187876
The use of L-serine to prevent β-methylamino-L-alanine (BMAA)-induced proteotoxic stress in vitro.
Toxicon : official journal of the International Society on Toxinology Jan, 2016 | Pubmed ID: 26559613
Plaque stabilizing effects of apolipoprotein A-IV.
Atherosclerosis Aug, 2016 | Pubmed ID: 27240254
Cyanobacterial Neurotoxins: Their Occurrence and Mechanisms of Toxicity.
Neurotoxicity research Jan, 2018 | Pubmed ID: 28585115
Assessing the Combined Toxicity of BMAA and Its Isomers 2,4-DAB and AEG In Vitro Using Human Neuroblastoma Cells.
Neurotoxicity research Jan, 2018 | Pubmed ID: 28634653
Investigation of the interaction of β-methylamino-L-alanine with eukaryotic and prokaryotic proteins.
Amino acids Apr, 2018 | Pubmed ID: 29235019
Detection of the suspected neurotoxin β-methylamino-l-alanine (BMAA) in cyanobacterial blooms from multiple water bodies in Eastern Australia.
Harmful algae Apr, 2018 | Pubmed ID: 29724339
Prevalence of β-methylamino-L-alanine (BMAA) and its isomers in freshwater cyanobacteria isolated from eastern Australia.
Ecotoxicology and environmental safety May, 2019 | Pubmed ID: 30682636
Cytotoxicity and mitochondrial dysfunction caused by the dietary supplement l-norvaline.
Toxicology in vitro : an international journal published in association with BIBRA Apr, 2019 | Pubmed ID: 30703532
Cell death and mitochondrial dysfunction induced by the dietary non-proteinogenic amino acid L-azetidine-2-carboxylic acid (Aze).
Amino acids Aug, 2019 | Pubmed ID: 31302779
Production of β-methylamino-L-alanine (BMAA) and Its Isomers by Freshwater Diatoms.
Toxins Sep, 2019 | Pubmed ID: 31480725
L-DOPA causes mitochondrial dysfunction in vitro: A novel mechanism of L-DOPA toxicity uncovered.
The international journal of biochemistry & cell biology Dec, 2019 | Pubmed ID: 31654750
Toxicity and bioaccumulation of two non-protein amino acids synthesised by cyanobacteria, β-N-Methylamino-L-alanine (BMAA) and 2,4-diaminobutyric acid (DAB), on a crop plant.
Ecotoxicology and environmental safety Jan, 2021 | Pubmed ID: 33099142
Misincorporation Proteomics Technologies: A Review.
Proteomes Jan, 2021 | Pubmed ID: 33494504
A Novel Method for Creating a Synthetic L-DOPA Proteome and In Vitro Evidence of Incorporation.
Proteomes May, 2021 | Pubmed ID: 34073856
Cysteine biosynthesis contributes to β-methylamino-l-alanine tolerance in Escherichia coli.
Research in microbiology , 2021 | Pubmed ID: 34246779
β-Methylamino-L-alanine-induced protein aggregation in vitro and protection by L-serine.
Amino acids Sep, 2021 | Pubmed ID: 34283312
Acetonitrile adduct analysis of underivatised amino acids offers improved sensitivity for hydrophilic interaction liquid chromatography tandem mass-spectrometry.
Journal of chromatography. A Oct, 2021 | Pubmed ID: 34517165
Correction: Steele et al. Misincorporation Proteomics Technologies: A Review. 2021, , 2.
Proteomes Jun, 2022 | Pubmed ID: 35736802
Pro-Inflammatory and Pro-Apoptotic Effects of the Non-Protein Amino Acid L-Azetidine-2-Carboxylic Acid in BV2 Microglial Cells.
Current issues in molecular biology Sep, 2022 | Pubmed ID: 36286023
The Changes in Cyanobacterial Concentration of β-Methylamino-L-Alanine during a Bloom Event.
Molecules (Basel, Switzerland) Oct, 2022 | Pubmed ID: 36364208
University of Technology Sydney
Sercan Pravadali-Cekic1,
Jake P. Violi1,
Simon M. Mitrovic2,
Kenneth J. Rodgers2,
David Bishop1
1Hyphenated Mass Spectrometry Laboratory (HyMaS), University of Technology Sydney,
2School of Life Sciences, University of Technology Sydney
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