Boston Children’s Hospital
David Breault, MD, PhD is a physician-scientists and pediatric endocrinologist at Boston CHildren's Hospital and Harvard Medical School. He is the Associate Chief of the Division of Endocrinology at Boston Children's Hospital and an Associate Professor of Pediatrics at Harvard Medical School. He is a Principal Faculty member of the Harvard Stem Cell Institute and an Affiliate Faculty member of the Department of Stem Cell and Regenerative Biology at Harvard University. He obtained his MD and PhD from the University of Connecticut School of Medicine and pediatric training at Yale-New Haven Hospital.
Small intestinal stem cell markers.
Journal of anatomy Jul, 2008 | Pubmed ID: 18638070
Generation of mTert-GFP mice as a model to identify and study tissue progenitor cells.
Proceedings of the National Academy of Sciences of the United States of America Jul, 2008 | Pubmed ID: 18650388
Regulation of gene expression in the intestinal epithelium.
Progress in molecular biology and translational science , 2010 | Pubmed ID: 21075346
Mouse telomerase reverse transcriptase (mTert) expression marks slowly cycling intestinal stem cells.
Proceedings of the National Academy of Sciences of the United States of America Jan, 2011 | Pubmed ID: 21173232
Characterization and fate of telomerase-expressing epithelia during kidney repair.
Journal of the American Society of Nephrology : JASN Dec, 2011 | Pubmed ID: 22021716
Tales from the crypt: the expanding role of slow cycling intestinal stem cells.
Cell stem cell Jan, 2012 | Pubmed ID: 22226346
Optimised protocols for the identification of the murine cardiac side population.
Stem cell reviews Oct, 2013 | Pubmed ID: 23619929
Adrenocortical zonation results from lineage conversion of differentiated zona glomerulosa cells.
Developmental cell Sep, 2013 | Pubmed ID: 24035414
Oncogenic K-Ras promotes proliferation in quiescent intestinal stem cells.
Stem cell research Jul, 2015 | Pubmed ID: 26079371
Distinct Processes and Transcriptional Targets Underlie CDX2 Requirements in Intestinal Stem Cells and Differentiated Villus Cells.
Stem cell reports Nov, 2015 | Pubmed ID: 26489894
Dormant Intestinal Stem Cells Are Regulated by PTEN and Nutritional Status.
Cell reports Dec, 2015 | Pubmed ID: 26686631
The mouse endometrium contains epithelial, endothelial and leucocyte populations expressing the stem cell marker telomerase reverse transcriptase.
Molecular human reproduction Apr, 2016 | Pubmed ID: 26740067
Reprogrammed Stomach Tissue as a Renewable Source of Functional β Cells for Blood Glucose Regulation.
Cell stem cell Mar, 2016 | Pubmed ID: 26908146
An enduring role for quiescent stem cells.
Developmental dynamics : an official publication of the American Association of Anatomists 07, 2016 | Pubmed ID: 27153394
Regulation of zonation and homeostasis in the adrenal cortex.
Molecular and cellular endocrinology 02, 2017 | Pubmed ID: 27619404
Frizzled proteins are colonic epithelial receptors for C. difficile toxin B.
Nature Oct, 2016 | Pubmed ID: 27680706
CellMapper: rapid and accurate inference of gene expression in difficult-to-isolate cell types.
Genome biology 09, 2016 | Pubmed ID: 27687735
The Circadian Clock Gene Coordinates Intestinal Regeneration.
Cellular and molecular gastroenterology and hepatology Jul, 2017 | Pubmed ID: 28593182
Bone Marrow Stem Cells Do Not Contribute to Endometrial Cell Lineages in Chimeric Mouse Models.
Stem cells (Dayton, Ohio) 01, 2018 | Pubmed ID: 28913973
JAK/STAT-1 Signaling Is Required for Reserve Intestinal Stem Cell Activation during Intestinal Regeneration Following Acute Inflammation.
Stem cell reports 01, 2018 | Pubmed ID: 29276155
PKA signaling drives reticularis differentiation and sexually dimorphic adrenal cortex renewal.
JCI insight 01, 2018 | Pubmed ID: 29367455
Development of a primary human Small Intestine-on-a-Chip using biopsy-derived organoids.
Scientific reports Feb, 2018 | Pubmed ID: 29440725
The colonic epithelium plays an active role in promoting colitis by shaping the tissue cytokine profile.
PLoS biology 03, 2018 | Pubmed ID: 29596476
Telomerase Mediates Lymphocyte Proliferation but Not the Atherosclerosis-Suppressive Potential of Regulatory T-Cells.
Arteriosclerosis, thrombosis, and vascular biology 06, 2018 | Pubmed ID: 29599138
Adrenocortical development: Lessons from mouse models.
Annales d'endocrinologie Jun, 2018 | Pubmed ID: 29673697
Move Over Caco-2 Cells: Human-Induced Organoids Meet Gut-on-a-Chip.
Cellular and molecular gastroenterology and hepatology , 2018 | Pubmed ID: 29713662
Neonatal-Onset Chronic Diarrhea Caused by Homozygous Nonsense WNT2B Mutations.
American journal of human genetics 07, 2018 | Pubmed ID: 29909964
High-dimensional immune phenotyping and transcriptional analyses reveal robust recovery of viable human immune and epithelial cells from frozen gastrointestinal tissue.
Mucosal immunology 11, 2018 | Pubmed ID: 30111863
The Adrenal Clock Prevents Aberrant Light-Induced Alterations in Circadian Glucocorticoid Rhythms.
Endocrinology 12, 2018 | Pubmed ID: 30321360
Adrenal Tissue-Specific Deletion of TASK Channels Causes Aldosterone-Driven Angiotensin II-Independent Hypertension.
Hypertension (Dallas, Tex. : 1979) 02, 2019 | Pubmed ID: 30580687
Species-specific enhancement of enterohemorrhagic E. coli pathogenesis mediated by microbiome metabolites.
Microbiome 03, 2019 | Pubmed ID: 30890187
A complex human gut microbiome cultured in an anaerobic intestine-on-a-chip.
Nature biomedical engineering 07, 2019 | Pubmed ID: 31086325
Sulfated glycosaminoglycans and low-density lipoprotein receptor contribute to Clostridium difficile toxin A entry into cells.
Nature microbiology 10, 2019 | Pubmed ID: 31160825
Author Correction: A complex human gut microbiome cultured in an anaerobic intestine-on-a-chip.
Nature biomedical engineering Jul, 2019 | Pubmed ID: 31213704
Sex Differences in Adrenal Bmal1 Deletion-Induced Augmentation of Glucocorticoid Responses to Stress and ACTH in Mice.
Endocrinology 10, 2019 | Pubmed ID: 31398249
Chemogenetic activation of adrenocortical Gq signaling causes hyperaldosteronism and disrupts functional zonation.
The Journal of clinical investigation 01, 2020 | Pubmed ID: 31738186
Human Colon-on-a-Chip Enables Continuous In Vitro Analysis of Colon Mucus Layer Accumulation and Physiology.
Cellular and molecular gastroenterology and hepatology , 2020 | Pubmed ID: 31778828
Intestinal enteroids recapitulate the effects of short-chain fatty acids on the intestinal epithelium.
PloS one , 2020 | Pubmed ID: 32240190
β-Catenin and FGFR2 regulate postnatal rosette-based adrenocortical morphogenesis.
Nature communications 04, 2020 | Pubmed ID: 32245949
Beta-Catenin Causes Adrenal Hyperplasia by Blocking Zonal Transdifferentiation.
Cell reports 04, 2020 | Pubmed ID: 32320669
Fully synthetic matrices for in vitro culture of primary human intestinal enteroids and endometrial organoids.
Biomaterials 09, 2020 | Pubmed ID: 32502894
Wnt/β-catenin activation cooperates with loss of p53 to cause adrenocortical carcinoma in mice.
Oncogene 07, 2020 | Pubmed ID: 32561853
Organoid culture system for patient-derived lung metastatic osteosarcoma.
Medical oncology (Northwood, London, England) Oct, 2020 | Pubmed ID: 33079257
Cholinergic Activation of Primary Human Derived Intestinal Epithelium Does Not Ameliorate TNF-α Induced Injury.
Cellular and molecular bioengineering Oct, 2020 | Pubmed ID: 33184579
Telomerase expression marks transitional growth-associated skeletal progenitor/stem cells.
Stem cells (Dayton, Ohio) 03, 2021 | Pubmed ID: 33438789
Primary human colonic mucosal barrier crosstalk with super oxygen-sensitive in continuous culture.
Med (New York, N.Y.) 01, 2021 | Pubmed ID: 33511375
Rosette morphology in zona glomerulosa formation and function.
Molecular and cellular endocrinology 06, 2021 | Pubmed ID: 33891993
Coculture of primary human colon monolayer with human gut bacteria.
Nature protocols 08, 2021 | Pubmed ID: 34183870
Rapid Prototyping of Multilayer Microphysiological Systems.
ACS biomaterials science & engineering 07, 2021 | Pubmed ID: 34275297
Yersinia pseudotuberculosis YopE prevents uptake by M cells and instigates M cell extrusion in human ileal enteroid-derived monolayers.
Gut microbes Jan-Dec, 2021 | Pubmed ID: 34793276
Robust differentiation of human enteroendocrine cells from intestinal stem cells.
Nature communications 01, 2022 | Pubmed ID: 35017529
Triple-Decker Sandwich Cultures of Intestinal Organoids for Long-Term Live Imaging, Uniform Perturbation, and Statistical Sampling.
Current protocols Jan, 2022 | Pubmed ID: 35030297
Emerging enterococcus pore-forming toxins with MHC/HLA-I as receptors.
Cell Mar, 2022 | Pubmed ID: 35259335
Establishment of physiologically relevant oxygen gradients in microfluidic organ chips.
Lab on a chip 04, 2022 | Pubmed ID: 35274118
A non-dividing cell population with high pyruvate dehydrogenase kinase activity regulates metabolic heterogeneity and tumorigenesis in the intestine.
Nature communications 03, 2022 | Pubmed ID: 35314684
Telomerase Reverse Transcriptase Expression Marks a Population of Rare Adipose Tissue Stem Cells.
Stem cells (Dayton, Ohio) 03, 2022 | Pubmed ID: 35511869
Tacrolimus-binding protein FKBP8 directs myosin light chain kinase-dependent barrier regulation and is a potential therapeutic target in Crohn's disease.
Gut May, 2022 | Pubmed ID: 35537812