Jean-Philippe Brosseau

Development of an efficient strategy for the synthesis of the ETB receptor antagonist BQ-788 and some related analogues.

Identification of alternative splicing markers for breast cancer.

Design, synthesis and pharmacological characterization of fluorescein-derived endothelin antagonists Bq-123 and Bq-788.

High-throughput quantification of splicing isoforms.

Alternative splicing of SYK regulates mitosis and cell survival.

RBFOX2 is an important regulator of mesenchymal tissue-specific splicing in both normal and cancer tissues.

Tumor microenvironment-associated modifications of alternative splicing.

Redirecting splicing with bifunctional oligonucleotides.

Regulations on Messenger RNA: Wires and Nodes.

Translating current basic research into future therapies for neurofibromatosis type 1.

Targeted degradation of immune checkpoint proteins: emerging strategies for cancer immunotherapy.

Human cutaneous neurofibroma matrisome revealed by single-cell RNA sequencing.

Toward Understanding the Mechanisms of Malignant Peripheral Nerve Sheath Tumor Development.