Wellcome and Medical Research Council Cambridge Stem Cell Institute,
Department of Haematology,
Wellcome and Medical Research Council Cambridge Stem Cell Institute, Department of Haematology
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Estimating dormant and active hematopoietic stem cell kinetics through extensive modeling of bromodeoxyuridine label-retaining cell dynamics.
PloS one Sep, 2009 | Pubmed ID: 19771180
The unfolded protein response governs integrity of the haematopoietic stem-cell pool during stress.
Nature Jun, 2014 | Pubmed ID: 24776803
CDK6 levels regulate quiescence exit in human hematopoietic stem cells.
Cell stem cell Mar, 2015 | Pubmed ID: 25704240
Distinct routes of lineage development reshape the human blood hierarchy across ontogeny.
Science (New York, N.Y.) Jan, 2016 | Pubmed ID: 26541609
Molecular landscapes of human hematopoietic stem cells in health and leukemia.
Annals of the New York Academy of Sciences Apr, 2016 | Pubmed ID: 26663266
A single-cell resolution map of mouse hematopoietic stem and progenitor cell differentiation.
Blood Aug, 2016 | Pubmed ID: 27365425
DNA Methylation Dynamics of Human Hematopoietic Stem Cell Differentiation.
Cell stem cell Dec, 2016 | Pubmed ID: 27867036
Human megakaryocytes: finding the root.
Blood Jun, 2017 | Pubmed ID: 28642357
Early loss of Crebbp confers malignant stem cell properties on lymphoid progenitors.
Nature cell biology Sep, 2017 | Pubmed ID: 28825697
From haematopoietic stem cells to complex differentiation landscapes.
Nature Jan, 2018 | Pubmed ID: 29364285
Population dynamics of normal human blood inferred from somatic mutations.
Nature Sep, 2018 | Pubmed ID: 30185910
Myelo-lymphoid lineage restriction occurs in the human haematopoietic stem cell compartment before lymphoid-primed multipotent progenitors.
Nature communications Oct, 2018 | Pubmed ID: 30291229
A track of the clones: new developments in cellular barcoding.
Experimental hematology Dec, 2018 | Pubmed ID: 30448259
Decoding human fetal liver haematopoiesis.
Nature Oct, 2019 | Pubmed ID: 31597962
Sphingolipid Modulation Activates Proteostasis Programs to Govern Human Hematopoietic Stem Cell Self-Renewal.
Cell stem cell Nov, 2019 | Pubmed ID: 31631013
A transcriptomic continuum of differentiation arrest identifies myeloid interface acute leukemias with poor prognosis.
Leukemia Mar, 2021 | Pubmed ID: 32655144
Beyond "to divide or not to divide": Kinetics matters in hematopoietic stem cells.
Experimental hematology Dec, 2020 | Pubmed ID: 33188890
Chronic lymphocytic leukemia increases the pool of peripheral blood hematopoietic stem cells and skews differentiation.
Blood advances Dec, 2020 | Pubmed ID: 33351125
Blood stem cells SELect quiescence.
Blood Dec, 2020 | Pubmed ID: 33367552
Sphingosine-1-phosphate receptor 3 potentiates inflammatory programs in normal and leukemia stem cells to promote differentiation.
Blood cancer discovery Jan, 2021 | Pubmed ID: 33458693
Transcriptional characterization of human megakaryocyte polyploidization and lineage commitment.
Journal of thrombosis and haemostasis : JTH May, 2021 | Pubmed ID: 33587817
Single-cell multi-omics analysis of the immune response in COVID-19.
Nature medicine May, 2021 | Pubmed ID: 33879890
Somatic mutation landscapes at single-molecule resolution.
Nature May, 2021 | Pubmed ID: 33911282
Hematopoietic stem cells retain functional potential and molecular identity in hibernation cultures.
Stem cell reports Jun, 2021 | Pubmed ID: 33961793
Immature acute leukaemias: lessons from the haematopoietic roadmap.
The FEBS journal Aug, 2022 | Pubmed ID: 34028982
Blood and immune development in human fetal bone marrow and Down syndrome.
Nature Oct, 2021 | Pubmed ID: 34588693
Hematopoietic stem and progenitor cells outside the bone marrow: where, when, and why.
Experimental hematology Dec, 2021 | Pubmed ID: 34687807
Simultaneous Analysis of Single-Cell Transcriptomes and Cell Surface Protein Expression of Human Hematopoietic Stem Cells and Progenitors Using the 10x Genomics Platform.
Methods in molecular biology (Clifton, N.J.) , 2022 | Pubmed ID: 34766273
Unique molecular and functional features of extramedullary hematopoietic stem and progenitor cell reservoirs in humans.
Blood Jun, 2022 | Pubmed ID: 35073399
Clonal dynamics of haematopoiesis across the human lifespan.
Nature Jun, 2022 | Pubmed ID: 35650442
Hyaluronic acid-GPRC5C signalling promotes dormancy in haematopoietic stem cells.
Nature cell biology Jul, 2022 | Pubmed ID: 35725769
STAT1 is essential for HSC function and maintains MHCIIhi stem cells that resist myeloablation and neoplastic expansion.
Blood Oct, 2022 | Pubmed ID: 35767701
Diverse mutational landscapes in human lymphocytes.
Nature Aug, 2022 | Pubmed ID: 35948631
Primitive haematopoiesis in the human placenta gives rise to macrophages with epigenetically silenced HLA-DR.
Nature communications Mar, 2023 | Pubmed ID: 36997537
Yolk sac cell atlas reveals multiorgan functions during human early development.
Science (New York, N.Y.) Aug, 2023 | Pubmed ID: 37590359
Circulating IRF8-expressing CD123CD127 lymphoid progenitors: key players in human hematopoiesis.
Trends in immunology Sep, 2023 | Pubmed ID: 37591714
Convergent somatic evolution commences in utero in a germline ribosomopathy.
Nature communications Aug, 2023 | Pubmed ID: 37608017