Department of Microbiology,
Medical School,
Department of Microbiology, Medical School
Dr. Qingsheng Li is a full professor at the School of Biological Sciences and the Nebraska Center for Virology in University of Nebraska-Lincoln, USA. He is a member of American Association for the Advancement of Science (AAAS), American Associate of Immunologists (AAI), International Society for Vaccines (ISV) and American Society for Virology (ASV). Dr. Li also services as the editorial board member of Current HIV Research, Scientific Report and Virology Journal. He has over 25 years of experience in studying HIV-1 transmission, pathogenesis, microbicide, and vaccine and curative strategy development. Dr. Li’s technical expertise includes the use of SIV-rhesus macaque model, human specimens, humanized-BLT (bone marrow liver and thymus) mouse model, and single-cell in situ analyses. Dr. Li has published 87 peer-reviewed papers, including one paper in Science and two papers in Nature and three papers in Proceedings of the National Academy of Sciences (PNAS). Further, Dr. Li is the principal investigator or co-investigator on many NIH funded grants, including P01, U19, Martin Delaney, R01 and R21 grants. Additionally, Dr. Li has mentored and trained many graduate students and post-doctoral fellows.
In situ recruitment of antigen-presenting cells by intratumoral GM-CSF gene delivery.
Cancer immunology, immunotherapy : CII Jan, 2004 | Pubmed ID: 12955480
Functional genomic analysis of the response of HIV-1-infected lymphatic tissue to antiretroviral therapy.
The Journal of infectious diseases Feb, 2004 | Pubmed ID: 14767808
Role of immature myeloid Gr-1+ cells in the development of antitumor immunity.
Cancer research Feb, 2004 | Pubmed ID: 14871848
NK and CD8+ T cell-mediated eradication of poorly immunogenic B16-F10 melanoma by the combined action of IL-12 gene therapy and 4-1BB costimulation.
International journal of cancer. Journal international du cancer Apr, 2004 | Pubmed ID: 14991570
Roles of substrate availability and infection of resting and activated CD4+ T cells in transmission and acute simian immunodeficiency virus infection.
Proceedings of the National Academy of Sciences of the United States of America Apr, 2004 | Pubmed ID: 15064398
Regulation of dendritic cell function by NK cells: mechanisms underlying the synergism in the combination therapy of IL-12 and 4-1BB activation.
Journal of immunology (Baltimore, Md. : 1950) Apr, 2004 | Pubmed ID: 15067054
IL-21 enhances and sustains CD8+ T cell responses to achieve durable tumor immunity: comparative evaluation of IL-2, IL-15, and IL-21.
Journal of immunology (Baltimore, Md. : 1950) Jul, 2004 | Pubmed ID: 15240677
Peak SIV replication in resting memory CD4+ T cells depletes gut lamina propria CD4+ T cells.
Nature Apr, 2005 | Pubmed ID: 15793562
Propagation and dissemination of infection after vaginal transmission of simian immunodeficiency virus.
Journal of virology Jul, 2005 | Pubmed ID: 15994816
Potential roles of follicular dendritic cell-associated osteopontin in lymphoid follicle pathology and repair and in B cell regulation in HIV-1 and SIV infection.
The Journal of infectious diseases Oct, 2005 | Pubmed ID: 16136472
Gr-1+CD115+ immature myeloid suppressor cells mediate the development of tumor-induced T regulatory cells and T-cell anergy in tumor-bearing host.
Cancer research Jan, 2006 | Pubmed ID: 16424049
Premature induction of an immunosuppressive regulatory T cell response during acute simian immunodeficiency virus infection.
The Journal of infectious diseases Mar, 2006 | Pubmed ID: 16453267
Aspergillus fumigatus extract differentially regulates antigen-specific CD4+ and CD8+ T cell responses to promote host immunity.
Journal of leukocyte biology Sep, 2006 | Pubmed ID: 16793916
IL-12-programmed long-term CD8+ T cell responses require STAT4.
Journal of immunology (Baltimore, Md. : 1950) Dec, 2006 | Pubmed ID: 17114431
Characterizing host immune responses by monitoring fluorescently marked cells.
Immunological investigations , 2007 | Pubmed ID: 18161529
Simian immunodeficiency virus-induced intestinal cell apoptosis is the underlying mechanism of the regenerative enteropathy of early infection.
The Journal of infectious diseases Feb, 2008 | Pubmed ID: 18199035
Genital ulcers facilitate rapid viral entry and dissemination following intravaginal inoculation with cell-associated simian immunodeficiency virus SIVmac239.
Journal of virology Apr, 2008 | Pubmed ID: 18272571
Glycerol monolaurate prevents mucosal SIV transmission.
Nature Apr, 2009 | Pubmed ID: 19262509
Visualizing antigen-specific and infected cells in situ predicts outcomes in early viral infection.
Science (New York, N.Y.) Mar, 2009 | Pubmed ID: 19325114
Microarray analysis of lymphatic tissue reveals stage-specific, gene expression signatures in HIV-1 infection.
Journal of immunology (Baltimore, Md. : 1950) Aug, 2009 | Pubmed ID: 19596987
Antigen-induced Erk1/2 activation regulates Ets-1-mediated sensitization of CD8+ T cells for IL-12 responses.
Journal of leukocyte biology Feb, 2010 | Pubmed ID: 19843578
Regulating functional cell fates in CD8 T cells.
Immunologic research Mar, 2010 | Pubmed ID: 19859830
Global genomic analysis reveals rapid control of a robust innate response in SIV-infected sooty mangabeys.
The Journal of clinical investigation Dec, 2009 | Pubmed ID: 19959874
The mTOR kinase determines effector versus memory CD8+ T cell fate by regulating the expression of transcription factors T-bet and Eomesodermin.
Immunity Jan, 2010 | Pubmed ID: 20060330
AIDS and optic neuritis in a rhesus monkey infected with the R5 clade C SHIV-1157ipd3N4.
Journal of medical primatology Oct, 2010 | Pubmed ID: 20412378
Tc17 cells are capable of mediating immunity to vaccinia virus by acquisition of a cytotoxic phenotype.
Journal of immunology (Baltimore, Md. : 1950) Aug, 2010 | Pubmed ID: 20624947
Fine-tuning CD8(+) T cell functional responses: mTOR acts as a rheostat for regulating CD8(+) T cell proliferation, survival and differentiation?
Cell cycle (Georgetown, Tex.) Aug, 2010 | Pubmed ID: 20699660
Host genes associated with HIV-1 replication in lymphatic tissue.
Journal of immunology (Baltimore, Md. : 1950) Nov, 2010 | Pubmed ID: 20935203
Differences in HIV burden and immune activation within the gut of HIV-positive patients receiving suppressive antiretroviral therapy.
The Journal of infectious diseases Nov, 2010 | Pubmed ID: 20939732
Uncertainties in stormwater runoff data collection from a small urban catchment, Southeast China.
Journal of environmental sciences (China) , 2010 | Pubmed ID: 21235157
Morphine potentiates neuropathogenesis of SIV infection in rhesus macaques.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology Dec, 2011 | Pubmed ID: 21431470
A central role for mTOR kinase in homeostatic proliferation induced CD8+ T cell memory and tumor immunity.
Immunity Apr, 2011 | Pubmed ID: 21511183
Detecting the Dynamic Linkage between Landscape Characteristics and Water Quality in a Subtropical Coastal Watershed, Southeast China.
Environmental management Nov, 2011 | Pubmed ID: 22120882
Challenges and counter challenges in HIV/AIDS.
Chinese medical journal Dec, 2010 | Pubmed ID: 22166517
Direct staining with major histocompatibility complex class II dextramers permits detection of antigen-specific, autoreactive CD4 T cells in situ.
PloS one , 2014 | Pubmed ID: 24475302
Humanized-BLT mouse model of Kaposi's sarcoma-associated herpesvirus infection.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2014 | Pubmed ID: 24516154
Construction of a live-attenuated HIV-1 vaccine through genetic code expansion.
Angewandte Chemie (International ed. in English) May, 2014 | Pubmed ID: 24715496
Deep transcriptional sequencing of mucosal challenge compartment from rhesus macaques acutely infected with simian immunodeficiency virus implicates loss of cell adhesion preceding immune activation.
Journal of virology Jul, 2014 | Pubmed ID: 24807713
Virus-host mucosal interactions during early SIV rectal transmission.
Virology Sep, 2014 | Pubmed ID: 25128762
The mucosal expression pattern of interferon-ε in rhesus macaques.
Journal of leukocyte biology Dec, 2014 | Pubmed ID: 25139290
Live simian immunodeficiency virus vaccine correlate of protection: immune complex-inhibitory Fc receptor interactions that reduce target cell availability.
Journal of immunology (Baltimore, Md. : 1950) Sep, 2014 | Pubmed ID: 25143442
Characterization of CD8+ T cell differentiation following SIVΔnef vaccination by transcription factor expression profiling.
PLoS pathogens Mar, 2015 | Pubmed ID: 25768938
SIV Infection of Lung Macrophages.
PloS one , 2015 | Pubmed ID: 25933119
Early Initiation of Antiretroviral Therapy Can Functionally Control Productive HIV-1 Infection in Humanized-BLT Mice.
Journal of acquired immune deficiency syndromes (1999) Aug, 2015 | Pubmed ID: 26167617
Next-Generation mRNA Sequencing Reveals Pyroptosis-Induced CD4+ T Cell Death in Early Simian Immunodeficiency Virus-Infected Lymphoid Tissues.
Journal of virology 01, 2016 | Pubmed ID: 26559826
Vaccine Induction of Lymph Node-Resident Simian Immunodeficiency Virus Env-Specific T Follicular Helper Cells in Rhesus Macaques.
Journal of immunology (Baltimore, Md. : 1950) Feb, 2016 | Pubmed ID: 26773147
Topical Tenofovir Disoproxil Fumarate Nanoparticles Prevent HIV-1 Vaginal Transmission in a Humanized Mouse Model.
Antimicrobial agents and chemotherapy 06, 2016 | Pubmed ID: 27044548
Recapitulating Cross-Species Transmission of Simian Immunodeficiency Virus SIVcpz to Humans by Using Humanized BLT Mice.
Journal of virology 09, 2016 | Pubmed ID: 27307566
VRC01 antibody protects against vaginal and rectal transmission of human immunodeficiency virus 1 in hu-BLT mice.
Archives of virology Sep, 2016 | Pubmed ID: 27343044
Identification of an Epitope from Adenine Nucleotide Translocator 1 That Induces Inflammation in Heart in A/J Mice.
The American journal of pathology Dec, 2016 | Pubmed ID: 27876151
Persistent Low-Level Replication of SIVΔnef Drives Maturation of Antibody and CD8 T Cell Responses to Induce Protective Immunity against Vaginal SIV Infection.
PLoS pathogens Dec, 2016 | Pubmed ID: 27959961
Characterization of founder viruses in very early SIV rectal transmission.
Virology 02, 2017 | Pubmed ID: 28027479
Controlling Multicycle Replication of Live-Attenuated HIV-1 Using an Unnatural Genetic Switch.
ACS synthetic biology 04, 2017 | Pubmed ID: 28106981
Reactivation of HIV-1 proviruses in immune-compromised mice engrafted with human VOA-negative CD4+ T cells.
Journal of virus eradication Jan, 2017 | Pubmed ID: 28275460
Distinct transcriptome profiles of Gag-specific CD8+ T cells temporally correlated with the protection elicited by SIVΔnef live attenuated vaccine.
PloS one , 2017 | Pubmed ID: 28333940
Branched chain α-ketoacid dehydrogenase kinase 111-130, a T cell epitope that induces both autoimmune myocarditis and hepatitis in A/J mice.
Immunity, inflammation and disease 12, 2017 | Pubmed ID: 28597552
Synthetic biology approach for the development of conditionally replicating HIV-1 vaccine.
Journal of chemical technology and biotechnology (Oxford, Oxfordshire : 1986) 03, 2017 | Pubmed ID: 28983143
Associations of Simian Immunodeficiency Virus (SIV)-Specific Follicular CD8 T Cells with Other Follicular T Cells Suggest Complex Contributions to SIV Viremia Control.
Journal of immunology (Baltimore, Md. : 1950) 04, 2018 | Pubmed ID: 29507105
A DNA Vaccine Expressing Consensus Hemagglutinin-Esterase Fusion Protein Protected Guinea Pigs from Infection by Two Lineages of Influenza D Virus.
Journal of virology 06, 2018 | Pubmed ID: 29514906
Altered Ratio of T Follicular Helper Cells to T Follicular Regulatory Cells Correlates with Autoreactive Antibody Response in Simian Immunodeficiency Virus-Infected Rhesus Macaques.
Journal of immunology (Baltimore, Md. : 1950) 05, 2018 | Pubmed ID: 29610141
SIVcpz closely related to the ancestral HIV-1 is less or non-pathogenic to humans in a hu-BLT mouse model.
Emerging microbes & infections Apr, 2018 | Pubmed ID: 29615603
Identification of Unequally Represented Founder Viruses Among Tissues in Very Early SIV Rectal Transmission.
Frontiers in microbiology , 2018 | Pubmed ID: 29651274
Brain is a potential sanctuary for subtype C HIV-1 irrespective of ART treatment outcome.
PloS one , 2018 | Pubmed ID: 30040863
Mucosal antibody responses to vaccines targeting SIV protease cleavage sites or full-length Gag and Env proteins in Mauritian cynomolgus macaques.
PloS one , 2018 | Pubmed ID: 30153293
Macrophages but not Astrocytes Harbor HIV DNA in the Brains of HIV-1-Infected Aviremic Individuals on Suppressive Antiretroviral Therapy.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology Mar, 2019 | Pubmed ID: 30194646
Reply to Letter to the Editor.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology Mar, 2019 | Pubmed ID: 30506435
Nanoencapsulation introduces long-acting phenomenon to tenofovir alafenamide and emtricitabine drug combination: A comparative pre-exposure prophylaxis efficacy study against HIV-1 vaginal transmission.
Journal of controlled release : official journal of the Controlled Release Society Jan, 2019 | Pubmed ID: 30576746
Persistent Viral Reservoirs in Lymphoid Tissues in SIV-Infected Rhesus Macaques of Chinese-Origin on Suppressive Antiretroviral Therapy.
Viruses 01, 2019 | Pubmed ID: 30691203
Corrigendum to "Nanoencapsulation introduces long-acting phenomenon to tenofovir alafenamide and emtricitabine drug combination: A comparative pre-exposure prophylaxis efficacy study against HIV-1 vaginal transmission" [Journal of Controlled Release 294 (2019) 216-225].
Journal of controlled release : official journal of the Controlled Release Society Jun, 2019 | Pubmed ID: 31082646
Interleukin-21 enhances the antibody avidity elicited by DNA prime and MVA boost vaccine.
Cytokine Aug, 2019 | Pubmed ID: 31450102