Slobodan Paessler

Recombinant sindbis/Venezuelan equine encephalitis virus is highly attenuated and immunogenic.

Generation and characterization of closely related epizootic and enzootic infectious cDNA clones for studying interferon sensitivity and emergence mechanisms of Venezuelan equine encephalitis virus.

The hamster as an animal model for eastern equine encephalitis--and its use in studies of virus entrance into the brain.

Experimental Everglades virus infection of cotton rats (Sigmodon hispidus).

Venezuelan equine encephalitis virus in the guinea pig model: evidence for epizootic virulence determinants outside the E2 envelope glycoprotein gene.

Venezuelan equine encephalitis virus infection of spiny rats.

Noncytopathic replication of Venezuelan equine encephalitis virus and eastern equine encephalitis virus replicons in Mammalian cells.

A novel, rapid assay for detection and differentiation of serotype-specific antibodies to Venezuelan equine encephalitis complex alphaviruses.

Envelope glycoprotein mutations mediate equine amplification and virulence of epizootic venezuelan equine encephalitis virus.

Variation in interferon sensitivity and induction among strains of eastern equine encephalitis virus.

Replication and clearance of Venezuelan equine encephalitis virus from the brains of animals vaccinated with chimeric SIN/VEE viruses.

Venezuelan encephalitis emergence mediated by a phylogenetically predicted viral mutation.

Reverse transcription-PCR-enzyme-linked immunosorbent assay for rapid detection and differentiation of alphavirus infections.

The Old World and New World alphaviruses use different virus-specific proteins for induction of transcriptional shutoff.

Recombinant alphaviruses are safe and useful serological diagnostic tools.

Comparative analysis of the alphavirus-based vectors expressing Rift Valley fever virus glycoproteins.

Alpha-beta T cells provide protection against lethal encephalitis in the murine model of VEEV infection.

Chimeric Sindbis/eastern equine encephalitis vaccine candidates are highly attenuated and immunogenic in mice.

Protection of mice by equine herpesvirus type 1 based experimental vaccine against lethal Venezuelan equine encephalitis virus infection in the absence of neutralizing antibodies.

Injectable peramivir mitigates disease and promotes survival in ferrets and mice infected with the highly virulent influenza virus, A/Vietnam/1203/04 (H5N1).

Novel linear DNA vaccines induce protective immune responses against lethal infection with influenza virus type A/H5N1.

Inhibition of alphavirus infection in cell culture and in mice with antisense morpholino oligomers.

Pathogenesis of XJ and Romero strains of Junin virus in two strains of guinea pigs.

Host immunity in the protective response to vaccination with heat-killed Burkholderia mallei.

Susceptibility of the Aotus nancymaae owl monkey to eastern equine encephalitis.

CD4+ T cells provide protection against acute lethal encephalitis caused by Venezuelan equine encephalitis virus.

Superior efficacy of a recombinant flagellin:H5N1 HA globular head vaccine is determined by the placement of the globular head within flagellin.

Encephalitic alphaviruses.

Vaccines for Venezuelan equine encephalitis.

TC83 replicon vectored vaccine provides protection against Junin virus in guinea pigs.

Mice lacking alpha/beta and gamma interferon receptors are susceptible to junin virus infection.

Antiviral activity of a small-molecule inhibitor of arenavirus glycoprotein processing by the cellular site 1 protease.

Rescue from cloned cDNAs and in vivo characterization of recombinant pathogenic Romero and live-attenuated Candid #1 strains of Junin virus, the causative agent of Argentine hemorrhagic fever disease.

Prevention of influenza virus shedding and protection from lethal H1N1 challenge using a consensus 2009 H1N1 HA and NA adenovirus vector vaccine.

Rapid, non-invasive imaging of alphaviral brain infection: reducing animal numbers and morbidity to identify efficacy of potential vaccines and antivirals.

Vγ4+ T cells regulate host immune response to West Nile virus infection.

Neuropathology of H5N1 virus infection in ferrets.

Functional interferon system is required for clearance of lassa virus.

Natural killer cell mediated pathogenesis determines outcome of central nervous system infection with Venezuelan equine encephalitis virus in C3H/HeN mice.

Junín virus infection activates the type I interferon pathway in a RIG-I-dependent manner.

Resequencing of the Puumala virus strain Sotkamo from the WHO Arbovirus collection.

Control of SIV infection and subsequent induction of pandemic H1N1 immunity in rhesus macaques using an Ad5 [E1-, E2b-] vector platform.

Pathogenesis of the Viral Hemorrhagic Fevers.

Merimepodib, an IMPDH inhibitor, suppresses replication of Zika virus and other emerging viral pathogens.

Zika virus infection elicits auto-antibodies to C1q.

Cocaine evokes a profile of oxidative stress and impacts innate antiviral response pathways in astrocytes.