Thomas E. Edwards

Investigation of RNA-protein and RNA-metal ion interactions by electron paramagnetic resonance spectroscopy. The HIV TAR-Tat motif.

Electron paramagnetic resonance dynamic signatures of TAR RNA-small molecule complexes provide insight into RNA structure and recognition.

Nanometer distance measurements on RNA using PELDOR.

EPR spectroscopic analysis of TAR RNA-metal ion interactions.

A new alpha-helical extension promotes RNA binding by the dsRBD of Rnt1p RNAse III.

Identification of amino acids that promote specific and rigid TAR RNA-tat protein complex formation.

Monitoring tat peptide binding to TAR RNA by solid-state 31P-19F REDOR NMR.

EPR spectroscopic analysis of U7 hammerhead ribozyme dynamics during metal ion induced folding.

Crystal structures of the thi-box riboswitch bound to thiamine pyrophosphate analogs reveal adaptive RNA-small molecule recognition.

Riboswitches: small-molecule recognition by gene regulatory RNAs.

Site-specific incorporation of nitroxide spin-labels into 2'-positions of nucleic acids.

Structural basis for specific, high-affinity tetracycline binding by an in vitro evolved aptamer and artificial riboswitch.

Cocrystal structure of a class I preQ1 riboswitch reveals a pseudoknot recognizing an essential hypermodified nucleobase.

Thermodynamic analysis of ligand binding and ligand binding-induced tertiary structure formation by the thiamine pyrophosphate riboswitch.

X-ray structure determination of the glycine cleavage system protein H of Mycobacterium tuberculosis using an inverse Compton synchrotron X-ray source.

Structure of a Burkholderia pseudomallei trimeric autotransporter adhesin head.

Crystal structure of a DNA containing the planar, phenoxazine-derived bi-functional spectroscopic probe C.

Leveraging structure determination with fragment screening for infectious disease drug targets: MECP synthase from Burkholderia pseudomallei.

SAD phasing using iodide ions in a high-throughput structural genomics environment.

Fragment screening of infectious disease targets in a structural genomics environment.

Structural basis of the substrate specificity of bifunctional isocitrate dehydrogenase kinase/phosphatase.

Structural characterization of a ribose-5-phosphate isomerase B from the pathogenic fungus Coccidioides immitis.

Nanovolume optimization of protein crystal growth using the microcapillary protein crystallization system.

Structure of hepatitis C virus polymerase in complex with primer-template RNA.

Mycobacterium thermoresistibile as a source of thermostable orthologs of Mycobacterium tuberculosis proteins.

Unique motifs and hydrophobic interactions shape the binding of modified DNA ligands to protein targets.

Combining functional and structural genomics to sample the essential Burkholderia structome.

Structural insights into the functional role of the Hcn sub-domain of the receptor-binding domain of the botulinum neurotoxin mosaic serotype C/D.

Crystal structure of a macrophage migration inhibitory factor from Giardia lamblia.