Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal InjectionLei Xu *1,2, Manman Xu *3, Yinghai Xie 4, Wei You 2, Jianxin Wang 2, Liwu Xu 4, Qizhu Feng 4, Jie Sun 4, Jian Zhang 4, Huaichen Yang 4, Wang Qi 4
1The First Affiliated Hospital of Anhui University of Science & Technology, 2Medical College of Anhui University of Science & Technology, 3Endocrinology Department, The First Affiliated Hospital of Anhui University of Science & Technology, 4Department of Hepatobiliary Surgery, The First Affiliated Hospital of Anhui University of Science & Technology
Intraperitoneal drug administration is a safe and effective non-invasive approach for inducing pancreatic injury. This study compared five distinct intraperitoneal injection protocols on mice to induce varying degrees of pancreatic injury and established a model of severe pancreatic injury to investigate the pathological changes and treatment strategies for severe acute pancreatitis (SAP).
