A Medical Decision Support Platform for Identifying Thrombospondin 1 in Non-alcoholic Fatty Liver Disease via Immuno-Infiltration AnalysisJianyu Huang 1,2,3, Pengfei Li 1,4, Jianing Chi 1,4, Jiaman Hu 1, Hua Cai 1, Ningxia Wu 1, Min Li 1, Zhongqiu Lin 1, Yutong Ji 1, Jiajia Xu 1, Peng Liu 5, Senthil Kumar Jagatheesaperumal 6, Victor Hugo C. de Albuquerque 7, Lin Xu 1,2,3,4
1Department of Geriatric Cardiology, General Hospital of Southern Theater Command, 2Guangzhou Key Laboratory of Cardiac Rehabilitation, 3Branch of National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, 4The First School of Clinical Medicine, Southern Medical University, 5Zhujiang Hospital, Southern Medical University, Cardiovascular Department/The Second School of Clinical Medicine, Southern Medical University, 6Department of Electronics & Communication Engineering, Mepco Schlenk Engineering College, 7Department of Teleinformatics Engineering, Federal University of Ceará
This study investigated the relationships between non-alcoholic fatty liver disease (NAFLD) and myocardial infarction (MI) through co-expressed genes, identifying Thrombospondin 1 (THBS1) as a biomarker. Immuno-infiltration analysis revealed CD8+ T cells and neutrophils as key factors, with THBS1 showing potential as a diagnostic tool for NAFLD and MI.
