Multi-target Parallel Processing Approach for Gene-to-structure Determination of the Influenza Polymerase PB2 SubunitBrianna L. Armour *1, Steve R. Barnes *2, Spencer O. Moen 2, Eric Smith 3, Amy C. Raymond 4, James W. Fairman 5, Lance J. Stewart 6, Bart L. Staker 7, Darren W. Begley 5, Thomas E. Edwards 8, Donald D. Lorimer 9
1Protein Crystallization Lab, Emerald Bio, 2Molecular Biology Lab, Emerald Bio, 3Scientific Sales Representative, Emerald Bio, 4Group Leader II, Emerald Bio, 5Group Leader I, Emerald Bio, 6Chair of Advisory Board, Emerald Bio, 7Director of Multi-Target Services, Emerald Bio, 8Senior Project Leader, Emerald Bio, 9Project Leader II & SSGCID Site Manager, Emerald Bio
Structure-based drug design plays an important role in drug development. Pursuing multiple targets in parallel greatly increases the chance of success for lead discovery. The following article highlights how the Seattle Structural Genomics Center for Infectious Disease utilizes a multi-target approach for gene-to-structure determination of the PB2 influenza A subunit.
