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Scuola Superiore Sant'Anna

3 ARTICLES PUBLISHED IN JoVE

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Bioengineering

Design and Fabrication of an Elastomeric Unit for Soft Modular Robots in Minimally Invasive Surgery
Iris De Falco 1, Giada Gerboni 1, Matteo Cianchetti 1, Arianna Menciassi 1
1The BioRobotics Institute, Scuola Superiore Sant'Anna

This paper describes the design and fabrication of a soft unit for surgical manipulators. The base module includes three flexible fluidic actuators to achieve omnidirectional bending and elongation, and a granular jamming-based mechanism to enable stiffness control. A complete mechanical characterization is also reported.

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Medicine

Ultrasound-based Pulse Wave Velocity Evaluation in Mice
Nicole Di Lascio 1,2, Claudia Kusmic 2, Francesco Stea 2,3, Francesco Faita 2
1Institute of Life Science, Scuola Superiore Sant'Anna, 2Institute of Clinical Physiology, National Research Council, 3Department of Clinical and Experimental Medicine, University of Pisa

Arterial stiffness represents a key factor in cardiovascular disease and pulse wave velocity (PWV) can be considered as a surrogate index for arterial stiffness. This protocol describes an image processing algorithm for calculating PWV in mice based on ultrasound image processing that is applicable at different arterial sites.

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Neuroscience

Assessing Pupil-linked Changes in Locus Coeruleus-mediated Arousal Elicited by Trigeminal Stimulation
Maria Paola Tramonti Fantozzi *1, Tommaso Banfi *2,3, Vincenzo De Cicco *1, Massimo Barresi 4, Enrico Cataldo 5, Davide De Cicco 1, Luca Bruschini 6, Paola d'Ascanio 1, Gastone Ciuti 2,3, Ugo Faraguna 1,7, Diego Manzoni 1
1Department of Translational Research and of New Surgical and Medical Technologies, University of Pisa, 2The BioRobotics Institute, Scuola Superiore Sant'Anna, 3Department of Excellence in Robotics & AI, Scuola Superiore Sant'Anna, 4Institut des Maladie Neurodegeneratives, University of Bordeaux, 5Department of Physics, University of Pisa, 6Department of Surgical, Medical, Molecular Pathology and Critical Care Medicine, University of Pisa, 7Department of Developmental Neuroscience, IRCCS Foundation Stella Maris

To verify whether trigeminal effects on cognitive performance involve locus coeruleus activity, two protocols are presented that aim to evaluate possible correlations between the performance and task-related pupil size changes induced by chewing. These protocols may be applied to conditions in which locus coeruleus contribution is suspected.

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